leucine has been researched along with Chediak-Higashi Syndrome in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujikado, T; Hara, T; He, L; Ito, M; Iwata, T; Kasai, H; Kin, T; Kumamoto, T; Tanabe, F | 1 |
| Ito, M; Kasai, H; Morimoto, M; Tanabe, F | 1 |
| Cui, SH; Ito, M; Tanabe, F | 1 |
| Agematsu, K; Cui, SH; Hara, T; Ito, M; Iwata, T; Iwatani, Y; Komiyama, A; Nomura, A; Nunoi, H; Onodera, T; Tanabe, F; Terunuma, H | 1 |
| Ishida, E; Ito, M; Sato, A; Shigeta, S; Takami, Y; Tanabe, F | 1 |
5 other study(ies) available for leucine and Chediak-Higashi Syndrome
| Article | Year |
|---|---|
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Topics: Benzophenanthridines; Carbazoles; Cell Line, Tumor; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Female; Humans; Killer Cells, Natural; Leucine; Male; Protein Kinase C; Protein Kinase Inhibitors; Staphylococcal Infections; Staphylococcus aureus | 2009 |
Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.
Topics: Administration, Oral; Animals; Blood Bactericidal Activity; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Disease Susceptibility; Female; Humans; Injections, Intraperitoneal; Leucine; Lysosomes; Male; Mice; Mice, Inbred C57BL; Protein Kinase C; Staphylococcal Infections; Survival Rate | 2007 |
Abnormal down-regulation of PKC is responsible for giant granule formation in fibroblasts from CHS (beige) mice--a thiol proteinase inhibitor, E-64-d, prevents giant granule formation in beige fibroblasts.
Topics: Animals; Cathepsin G; Cathepsins; Cells, Cultured; Ceramides; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytoplasmic Granules; Cytosol; Embryo, Mammalian; Fibroblasts; Leucine; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pancreatic Elastase; Protein Kinase C; Serine Endopeptidases; Sphingolipids; Tetradecanoylphorbol Acetate | 2000 |
A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity.
Topics: Calpain; Cathepsin G; Cathepsins; Cell Line, Transformed; Ceramides; Chediak-Higashi Syndrome; Child; Concanavalin A; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Antagonism; Female; Humans; Leucine; Leukocytes, Mononuclear; Lysosomes; Male; Pancreatic Elastase; Protein Kinase C; Receptor Aggregation; Serine Endopeptidases; Sphingomyelin Phosphodiesterase | 2001 |
The thiol proteinase inhibitors improve the abnormal rapid down-regulation of protein kinase C and the impaired natural killer cell activity in (Chediak-Higashi syndrome) beige mouse.
Topics: Animals; Calpain; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Disease Models, Animal; Killer Cells, Natural; Killer Factors, Yeast; Leucine; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Protein Biosynthesis; Protein Kinase C; Proteins; Tetradecanoylphorbol Acetate | 1989 |