leucine and Cardiomegaly

leucine has been researched along with Cardiomegaly in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (37.14)	18.7374
1990's	10 (14.29)	18.2507
2000's	25 (35.71)	29.6817
2010's	8 (11.43)	24.3611
2020's	1 (1.43)	2.80

Authors

Authors	Studies
Hou, L; Huo, C; Jia, X; Li, X; Liu, Y; Wang, X; Xu, R	1
Hosoya, T; Ikeda, K; Ishikawa, M; Kawamura, M; Nakao, K; Otsubo, C; Tajima, N; Tojo, K; Tokudome, G; Udagawa, T	1
Caudrillier, A; Mialet-Perez, J; Ordener, C; Parini, A; Pizzinat, N; Villeneuve, C	1
Bringans, SD; Casey, TM; Hool, LC; Ingley, E; Laing, NG; Lipscombe, RJ; Ravenscroft, G; Seenarain, V; Viola, HM	1
Cook, MA; Karmazyn, M; Pang, T; Rajapurohitam, V	1
Chappell, MC; Ferrario, CM; Gallagher, PE; Ganten, D; Groban, L; Trask, AJ; Varagic, J; Westwood, BM	1
Chen, X; Meng, XM; Shi, N; Song, L; Wang, H; Wang, L; Xu, RX; Ye, J; Zhang, YW	1
Liu, C; Lu, M; Wang, H; Wong, TM; Yang, J; Yang, Y; Zhang, L	1
Aoki, H; Imaizumi, T; Kyogoku, S; Minami, T; Nagata, T; Oba, T; Ohmura, H; Ohshima, H; Sugi, Y; Yasukawa, H	1
McGaffin, KR; Witham, WG; Yester, KA	1
Garcia, JG; Gupta, MP; Kim, G; Moreno-Vinasco, L; Pillai, VB; Samant, S; Sundaresan, NR	1
Abel, ED; Kahn, CR; Kureishi, Y; Luo, Z; Rosenzweig, A; Shiojima, I; Takahashi, A; Tao, J; Walsh, K; Yefremashvili, M	1
Kawahara, Y; Maki, T; Takeo, S; Tanonaka, K; Yagi, A	1
Antos, CL; Dreitz, M; Gorczynski, RJ; Hollingsworth, LM; McKinsey, TA; Olson, EN; Rindt, H; Schreiber, K; Zhang, CL	1
Imaizumi, T; Kato, S; Kikuchi, T; Koga, A; Miyazaki, H; Oka, N	1
Pollack, JR; Sugimoto, JT; Witt, RC	1
An, W; Chen, L; Cui, W; Du, J; Hao, YM; Li, YJ; Liu, F; Liu, SY; Tian, ZJ; Zhang, H; Zu, XG	1
Cheng, FZ; Gong, LY; Hu, CX; Huang, J; Lu, ZY; Ma, YX; Qin, GH	1
Hao, DL; Huang, Y; Hui, RT; Li, HL; Liang, CC; Lin, M; Liu, DP; Liu, G; Liu, YQ; Wang, AB; Wei, C; Williams, GM; Zhang, CN	1
Imaizumi, T; Kikuchi, T; Koga, A; Miyazaki, H; Ohmura, H; Oka, N	1
Cai, DY; Chang, JK; Gerns, H; Pan, CS; Qi, YF; Tang, CS; Yang, J; Yang, JH; Zhao, J	1
Böhm, M; Custodis, F; Eberl, M; Kilter, H; Laufs, U	1
Adachi, S; Isobe, M; Ito, H; Kitajima, S; Maejima, Y; Morikawa-Futamatsu, K; Suzuki, J; Tamamori-Adachi, M	1
Jing, Y; Shan, D; Su, Y; Wang, H; Wong, TM	1
Sheng, L; Wu, SM; Yang, W; Ye, P	1
Averill, DB; Chappell, MC; Ferrario, CM; Ganten, D; Trask, AJ	1
Jia, Y; Li, XH; Liu, Y; Yuan, ZB; Zhang, HG; Zhou, JZ	1
Brüning, JC; Chang, L; Chen, YE; Cui, T; Day, SM; Ilany, J; Kahn, CR; Sun, Z; Tseng, YH; Xie, CQ; Yang, Q; Youker, KA; Zhang, J; Zhu, X	1
Han, CG; Liu, YX; Sheng, L; Ye, P; Zhang, ZY	1
Kwiatkowska-Patzer, B; Prior, G; Zak, R	1
Nagai, R; Ueda, S; Yazaki, Y	1
Adachi, S; Hirata, Y; Hiroe, M; Ito, H; Koike, A; Marumo, F; Nogami, A; Shichiri, M; Tsujino, M	1
Adachi, S; Akimoto, H; Fujisaki, H; Hata, M; Hiroe, M; Ito, H; Lin, M; Marumo, F; Tanaka, M	1
Adachi, S; Akimoto, H; Fujisaki, H; Hiroe, M; Ito, H; Lin, M; Marumo, F; Tamamori, M; Tanaka, M	1
Fujio, Y; Hirota, H; Kunisada, K; Matsui, H; Yamauchi-Takihara, K	1
Arthur, GD; Belcastro, AN	1
Carabello, BA; Hamawaki, M; Koide, M; Matsuo, T; McDermott, PJ; Nagatomo, Y; Zile, MR	1
Fujio, Y; Kishimoto, T; Kunisada, K; Matsui, H; Tone, E; Yamauchi-Takihara, K	1
Fushimi, K; Kouchi, H; Mihara, K; Miyazaki, M; Nakamura, K; Namba, M; Ohe, T	1
Ishida, T; Kawai, M; Kawashima, S; Namiki, M; Rikitake, Y; Sakoda, T; Ueyama, T; Yokoyama, M	1
Carabello, BA; Hamawaki, M; Matsuo, T; McDermott, PJ; Nagatomo, Y; Nemoto, S	1
Akashi, T; Harada, M; Hosoya, T; Ikeda, K; Nakagawa, O; Nakao, K; Tojo, K; Tokudome, G	1
Bueno, OF; De Windt, LJ; Hewett, TE; Jones, SP; Kimball, TR; Kitsis, RN; Klevitsky, R; Lefer, DJ; Molkentin, JD; Peng, CF; Tymitz, KM; Witt, SA	1
Harada, M; Hosoya, T; Ikeda, K; Nakao, K; Tojo, K; Tokudome, G	1
Andersen, PS; Bundgaard, H; Christiansen, M; Havndrup, O; Kjeldsen, K; Larsen, LA; Vuust, J	1
Ikeda, U; Lee, RT; Ohki, R; Shimada, K; Yamamoto, K	1
Anversa, P; Gandolfi, A; Loud, AV; Vitali-Mazza, L	2
Ingwall, JS; Morales, MF; Stockdale, FE; Wildenthal, K	1
Meyer, DK; Rau, E	1
Donohoe, J; Kolos, G; Lykke, A; Williams, JF	1
Alpert, NR; Litten, RZ; Low, RB; Nagai, R; Stirewalt, WS	1
Honda, M; Morioka, S; Moriyama, K; Ohoka, M; Yamada, S; Yamori, Y	1
Lee, JC; Pickett, S	1
Decker, RS; Lesch, M; Magid, NM; Parmacek, MS; Samarel, AM	1
Alpert, NR; Litten, RZ; Low, RB; Nagai, R; Pritzl, N; Stirewalt, WS; Zak, R	1
Petscher, C; Ratliff, N; Sen, S	1
Kako, KJ; Minelli, R	1
Fanburg, BL; Posner, BI	1
Kimata, S; Morkin, E; Skillman, JJ	1
Gerlach, E; Steinkopff, G; Zimmer, HG	1
Florini, JR; Manowitz, EJ; Saito, Y	1
Lindy, S; Turto, H	1
Anversa, P; Hagopian, M; Loud, AV	1
Hickie, JB; Kolos, G; Williams, JF	1
Axelrod, GB; Cohen, J; Whitbeck, AA	1
Donohoe, JA; Hickie, JB; Kolos, G; Williams, JF	1
Mead, RJ; Peterson, MB; Welty, JD	1
Dowell, RT; Martin, AF; Rabinowitz, M; Reddy, MK; Zak, R	1
Albin, R; Aschenbrenner, V; Nair, KG; Rabinowitz, M; Zak, R	1

Reviews

1 review(s) available for leucine and Cardiomegaly

Article	Year
Protein metabolism in hypertrophied heart muscle. Circulation research, 1974, Volume: 35 Suppl 3 Topics: Amino Acids; Aminolevulinic Acid; Animals; Cardiomegaly; Cytochrome c Group; Hydrolases; Kinetics; Leucine; Lysosomes; Muscle Proteins; Myocardium; Myofibrils; Myosins; Peptide Hydrolases; Protein Precursors; RNA, Transfer; Tritium	1974

Other Studies

69 other study(ies) available for leucine and Cardiomegaly

Article	Year
LRRC8A contributes to angiotensin II-induced cardiac hypertrophy by interacting with NADPH oxidases via the C-terminal leucine-rich repeat domain. Free radical biology & medicine, 2021, Volume: 165 Topics: Angiotensin II; Animals; Cardiomegaly; Leucine; Membrane Proteins; Mice; NADPH Oxidases; Reactive Oxygen Species	2021
Cellular physiology of rat cardiac myocytes in cardiac fibrosis: in vitro simulation using the cardiac myocyte/cardiac non-myocyte co-culture system. Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:4 Topics: Angiotensin II; Angiotensinogen; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cell Separation; Cells, Cultured; Coculture Techniques; Diuretics, Osmotic; Endothelin-1; Fibrosis; Leucine; Mannitol; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptors, Angiotensin; Renin; Thymidine; Transforming Growth Factor beta1; Tritium	2008
Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:2 Topics: Animals; Calcineurin; Cardiomegaly; Cell Line; Dose-Response Relationship, Drug; Gene Expression; Leucine; MAP Kinase Signaling System; Monoamine Oxidase; Myocytes, Cardiac; NFATC Transcription Factors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Serotonin; Serotonin Agents; Tritium; Ventricular Remodeling	2009
Evidence of altered guinea pig ventricular cardiomyocyte protein expression and growth in response to a 5 min in vitro exposure to H(2)O(2). Journal of proteome research, 2010, Apr-05, Volume: 9, Issue:4 Topics: Analysis of Variance; Animals; Cardiomegaly; Cell Size; Down-Regulation; Female; Guinea Pigs; Heart Ventricles; Hydrogen Peroxide; Isotope Labeling; Leucine; Male; Microscopy, Confocal; Mitochondria; Myocytes, Cardiac; NAD; Oxidative Stress; Proteome	2010
Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Cardiovascular Agents; Cell Size; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides	2010
Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. American journal of hypertension, 2010, Volume: 23, Issue:6 Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart Ventricles; Imidazoles; Leucine; Male; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Transgenic	2010
Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:4 Topics: Adenoviridae; Animals; Cardiomegaly; Cells, Cultured; Endothelin-1; Gene Expression; Green Fluorescent Proteins; Humans; Leucine; MAP Kinase Kinase Kinases; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Sarcomeres; Ventricular Myosins	2011
The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie, 2012, Volume: 67, Issue:2 Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; Calcineurin; Calcium Signaling; Cardiomegaly; Cell Size; Cytosol; Fura-2; Inflammation; Isoproterenol; Leucine; MAP Kinase Signaling System; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	2012
Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:11 Topics: Amino Acid Oxidoreductases; Aminopropionitrile; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Echocardiography; Endothelin-1; In Vitro Techniques; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Rats; Rats, Wistar	2012
A high leucine diet mitigates cardiac injury and improves survival after acute myocardial infarction. Metabolism: clinical and experimental, 2013, Volume: 62, Issue:2 Topics: Animals; Apoptosis; Cardiomegaly; Echocardiography; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Histocytochemistry; Kaplan-Meier Estimate; Leucine; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Random Allocation; Signal Transduction; TOR Serine-Threonine Kinases	2013
Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. American journal of physiology. Heart and circulatory physiology, 2013, Feb-01, Volume: 304, Issue:3 Topics: Animals; Animals, Newborn; Cardiomegaly; Coloring Agents; Echocardiography; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Immunohistochemistry; Leucine; Mice; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NFATC Transcription Factors; Nicotinamide Phosphoribosyltransferase; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Ventricular Remodeling	2013
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40 Topics: Aging; Animals; Cardiomegaly; Cells, Cultured; Enzyme Induction; Fasting; Genotype; Heart; Insulin; Leucine; Mice; Mice, Inbred Strains; Myocardium; Nutritional Status; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases	2002
Effects of tanshinone VI on the hypertrophy of cardiac myocytes and fibrosis of cardiac fibroblasts of neonatal rats. Planta medica, 2002, Volume: 68, Issue:12 Topics: Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Collagen; Endothelin-1; Female; Fibroblasts; Fibrosis; Insulin-Like Growth Factor I; Leucine; Male; Myocytes, Cardiac; Paracrine Communication; Phenanthrenes; Phenylephrine; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Salvia miltiorrhiza; Tritium	2002
Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors. The Journal of biological chemistry, 2003, Aug-01, Volume: 278, Issue:31 Topics: Adenylate Kinase; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Fluorescent Antibody Technique, Indirect; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Leucine; Myocardium; Rats; Rats, Sprague-Dawley; Tritium; Ventricular Myosins	2003
Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:2 Topics: Adenoviridae; Adrenergic alpha-1 Receptor Agonists; Animals; Cardiomegaly; Caveolin 3; Caveolins; Cell Size; Cells, Cultured; Endothelin-1; Gene Expression; Genetic Vectors; Humans; Leucine; Mitogen-Activated Protein Kinases; Mutation; Myocytes, Cardiac; Myosin Heavy Chains; Phosphorylation; Rats; Recombinant Proteins; Sarcomeres	2003
Differential effects of calpain inhibitors on hypertrophy of cardiomyocytes. Molecular and cellular biochemistry, 2003, Volume: 251, Issue:1-2 Topics: Acrylates; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calpain; Cardiomegaly; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycoproteins; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Rats; Time Factors; Ventricular Function, Left	2003
Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:9 Topics: Androstadienes; Animals; Animals, Newborn; Butadienes; Cardiomegaly; Cell Size; Cells, Cultured; Cytokines; DNA-Binding Proteins; Heart Ventricles; Leucine; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Wortmannin	2004
Effects of transforming growth factor-beta1 and signal protein Smad3 on rat cardiomyocyte hypertrophy. Chinese medical journal, 2004, Volume: 117, Issue:10 Topics: Animals; Aortic Coarctation; Cardiomegaly; Cells, Cultured; DNA-Binding Proteins; Leucine; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1	2004
Isorhapontigenin, a new resveratrol analog, attenuates cardiac hypertrophy via blocking signaling transduction pathways. Free radical biology & medicine, 2005, Jan-15, Volume: 38, Issue:2 Topics: Angiotensin II; Animals; Antioxidants; Aorta; Blood Pressure; Blotting, Western; Cardiomegaly; Dose-Response Relationship, Drug; Echocardiography; Enzyme Activation; Free Radicals; Glutathione Peroxidase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heart; Heart Ventricles; Hydrogen Peroxide; L-Lactate Dehydrogenase; Leucine; Lipid Peroxidation; Malondialdehyde; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Chemical; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Stilbenes; Superoxide Dismutase; Time Factors; Transcription Factor AP-1	2005
Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy. Journal of cardiovascular pharmacology, 2005, Volume: 45, Issue:3 Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Blotting, Northern; Cardiomegaly; Caveolae; Caveolin 3; Caveolins; Cell Size; Cells, Cultured; Immunoblotting; Leucine; Male; Microscopy, Electron; Myocytes, Cardiac; Phorbol 12,13-Dibutyrate; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation	2005
Cardiovascular effects of newly discovered peptide intermedin/adrenomedullin 2. Peptides, 2005, Volume: 26, Issue:9 Topics: Adrenomedullin; Animals; Animals, Newborn; Aorta; Blood Pressure; Cardiomegaly; Cardiovascular Physiological Phenomena; Cardiovascular System; Cells, Cultured; Coronary Circulation; Cyclic AMP; Gene Expression; Heart; Heart Rate; Leucine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Myocytes, Cardiac; Neuropeptides; Peptide Fragments; Perfusion; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ventricular Function, Left	2005
Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy. Cardiovascular research, 2006, Jul-15, Volume: 71, Issue:2 Topics: Angiotensin II; Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Fluorobenzenes; Free Radicals; Guanine Nucleotide Dissociation Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoprecipitation; Leucine; Lipid Peroxidation; Mice; Mice, Inbred C57BL; Myocardium; NADPH Oxidases; Protein Binding; Pyrimidines; rac1 GTP-Binding Protein; rho Guanine Nucleotide Dissociation Inhibitor alpha; rho-Specific Guanine Nucleotide Dissociation Inhibitors; RNA Interference; Rosuvastatin Calcium; Sulfonamides; Superoxides	2006
HMG-CoA reductase inhibitor fluvastatin prevents angiotensin II-induced cardiac hypertrophy via Rho kinase and inhibition of cyclin D1. Life sciences, 2006, Aug-29, Volume: 79, Issue:14 Topics: Adenoviridae Infections; Amides; Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Cyclin D1; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Indoles; Intracellular Signaling Peptides and Proteins; Leucine; Male; Mevalonic Acid; Myocardium; Myocytes, Cardiac; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; RNA, Messenger	2006
kappa-opioid receptor stimulation inhibits cardiac hypertrophy induced by beta1-adrenoceptor stimulation in the rat. European journal of pharmacology, 2007, Jan-26, Volume: 555, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Calcium; Cardiomegaly; Cell Size; Cells, Cultured; Imidazoles; Isoproterenol; Leucine; Myocytes, Cardiac; Propanolamines; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa	2007
Effect of pioglitazone on the expression of inflammatory cytokines in attenuating rat cardiomyocyte hypertrophy. Methods and findings in experimental and clinical pharmacology, 2006, Volume: 28, Issue:10 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Atrial Natriuretic Factor; Cardiomegaly; Cells, Cultured; Interleukin-1beta; Interleukin-6; Leucine; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; RNA, Messenger; Thiazolidinediones	2006
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats. American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6 Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Cardiomegaly; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Kinetics; Leucine; Male; Mice; Myocardium; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin	2007
G(alphaq)-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates cardiac hypertrophy in vitro and in vivo. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:12 Topics: Animals; Calcium; Cardiomegaly; Cells, Cultured; Genes, fos; Genes, jun; GTP-Binding Proteins; Leucine; Male; Mice; Myocardium; Myocytes, Cardiac; Norepinephrine; Peptides; Rats; Rats, Sprague-Dawley; RNA, Messenger	2007
Rad GTPase deficiency leads to cardiac hypertrophy. Circulation, 2007, Dec-18, Volume: 116, Issue:25 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Humans; Leucine; Mice; Mice, Knockout; Myocardium; Myocytes, Cardiac; ras Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Tritium	2007
Peroxisome proliferator-activated receptor beta/delta activation improves angiotensin II-induced cardiac hypertrophy in vitro. Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:2 Topics: Angiotensin II; Animals; Cardiomegaly; Cell Membrane; Cells, Cultured; Cytokines; Down-Regulation; Fluorescent Antibody Technique; In Vitro Techniques; Leucine; Myocytes, Cardiac; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Thiazoles	2008
Increased synthesis of the phosphorylated form of the myosin light chains in cardiac hypertrophy in the rat. Advances in myocardiology, 1983, Volume: 4 Topics: Animals; Cardiomegaly; Constriction; Female; Leucine; Myosins; Phosphorylation; Rats; Rats, Inbred Strains	1983
Synthesis and enzymatic properties of myosin from hypertrophied and failing hearts: difference in behavior of right and left ventricular free walls and interventricular septum. Advances in myocardiology, 1980, Volume: 1 Topics: Adenosine Triphosphatases; Animals; Body Weight; Cardiomegaly; Heart Failure; Heart Septal Defects, Ventricular; Heart Ventricles; Leucine; Male; Myosins; Organ Size; Rabbits	1980
Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulation, 1993, Volume: 87, Issue:5 Topics: Actins; Animals; Binding, Competitive; Cardiomegaly; Carrier Proteins; Cells, Cultured; Gene Expression Regulation; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Isomerism; Leucine; Muscles; Myocardium; Myosins; Rats; RNA, Messenger; Troponin; Troponin I	1993
Heparin and heparan sulfate block angiotensin II-induced hypertrophy in cultured neonatal rat cardiomyocytes. A possible role of intrinsic heparin-like molecules in regulation of cardiomyocyte hypertrophy. Circulation, 1996, Feb-15, Volume: 93, Issue:4 Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Heart; Heparin; Heparin Lyase; Heparitin Sulfate; Humans; Hypertrophy; Leucine; Myocardium; Polysaccharide-Lyases; Rats; Recombinant Proteins	1996
Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes: a possible endogenous endothelin-1-mediated mechanism. Journal of molecular and cellular cardiology, 1996, Volume: 28, Issue:6 Topics: Actins; Animals; Animals, Newborn; Cardiomegaly; Cell Hypoxia; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Gene Expression Regulation; Genetic Markers; Heart; Kinetics; Leucine; Myocardium; Peptides, Cyclic; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transcription, Genetic	1996
Leukemia inhibitory factor induces a hypertrophic response mediated by gp130 in murine cardiac myocytes. Research communications in molecular pathology and pharmacology, 1996, Volume: 93, Issue:2 Topics: Animals; Cardiomegaly; Cells, Cultured; Growth Inhibitors; Interleukin-6; Leucine; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; Lymphokines; Mice; Mice, Inbred ICR; Receptors, Cytokine; Receptors, OSM-LIF; Signal Transduction	1996
A calcium stimulated cysteine protease involved in isoproterenol induced cardiac hypertrophy. Molecular and cellular biochemistry, 1997, Volume: 176, Issue:1-2 Topics: Adrenergic beta-Agonists; Animals; Calcium; Calpain; Cardiomegaly; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Isoproterenol; Leucine; Male; Rats; Rats, Wistar; RNA; Ventricular Function, Left	1997
Mechanisms of cardiac hypertrophy in canine volume overload. The American journal of physiology, 1998, Volume: 275, Issue:1 Pt 2 Topics: Animals; Body Weight; Cardiomegaly; Dogs; Female; Heart Ventricles; Leucine; Male; Mitral Valve Insufficiency; Myocardium; Myosin Heavy Chains; Organ Size; Polyribosomes; Protein Biosynthesis; Ribosomes; RNA, Messenger; Time Factors; Transcription, Genetic; Ventricular Function, Left	1998
Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. Circulation, 1998, Jul-28, Volume: 98, Issue:4 Topics: Adenoviridae; Animals; Antigens, CD; Atrial Natriuretic Factor; Cardiomegaly; Cytokine Receptor gp130; DNA-Binding Proteins; Genetic Vectors; Growth Inhibitors; Interleukin-6; Leucine; Leukemia Inhibitory Factor; Lymphokines; Membrane Glycoproteins; Mice; Mutation; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine	1998
Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation, 1998, Aug-25, Volume: 98, Issue:8 Topics: Angiotensin II; Animals; Animals, Newborn; Antioxidants; Butylated Hydroxyanisole; Cardiomegaly; Catalase; Cells, Cultured; Leucine; Rats; Rats, Wistar; Reactive Oxygen Species; Recombinant Proteins; Tritium; Tumor Necrosis Factor-alpha; Vitamin E	1998
Endothelin-1 activates p38 mitogen-activated protein kinase via endothelin-A receptor in rat myocardial cells. Molecular and cellular biochemistry, 1999, Volume: 199, Issue:1-2 Topics: Animals; Blotting, Western; Cardiomegaly; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Myocardium; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphorylation; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin; Sarcomeres	1999
Translational mechanisms accelerate the rate of protein synthesis during canine pressure-overload hypertrophy. The American journal of physiology, 1999, Volume: 277, Issue:6 Topics: Animals; Aortic Valve Stenosis; Blood Pressure; Cardiomegaly; Dogs; Heart Rate; Hemodynamics; Kinetics; Leucine; Myocardium; Myosin Heavy Chains; Radioisotope Dilution Technique; Ribosomes; Stroke Volume; Tritium; Ventricular Function, Left	1999
Possible involvement of endothelin-1 in cardioprotective effects of benidipine. Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:5 Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Cardiomegaly; Cells, Cultured; Dihydropyridines; Endothelin-1; Hypertension; Leucine; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Rats; Rats, Wistar; Thymidine; Tritium	2000
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. The EMBO journal, 2000, Dec-01, Volume: 19, Issue:23 Topics: Actinin; Adenoviridae; Age Factors; Animals; Animals, Newborn; Apoptosis; Body Weight; Cardiomegaly; Caspase 3; Caspases; Cells, Cultured; DNA Fragmentation; DNA, Complementary; Echocardiography; Electrophoresis, Polyacrylamide Gel; Immunohistochemistry; In Situ Nick-End Labeling; Leucine; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Organ Size; Plasmids; Protein Serine-Threonine Kinases; Rats; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction	2000
The effects of sarpogrelate on cardiomyocyte hypertrophy. Life sciences, 2000, Nov-03, Volume: 67, Issue:24 Topics: Angiotensin II; Animals; Animals, Newborn; Cardiomegaly; Cells, Cultured; Endothelin-1; Fibroblasts; Heart Ventricles; Leucine; Myocardium; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Succinates; Tritium	2000
A novel missense mutation, Leu390Val, in the cardiac beta-myosin heavy chain associated with pronounced septal hypertrophy in two families with hypertrophic cardiomyopathy. Scandinavian cardiovascular journal : SCJ, 2000, Volume: 34, Issue:6 Topics: Adolescent; Adult; Aged; Cardiomegaly; Cardiomyopathy, Hypertrophic; Electrocardiography; Exons; Humans; Leucine; Middle Aged; Mutation, Missense; Myosin Heavy Chains; Pedigree; Phenotype; Polymorphism, Single-Stranded Conformational; Sarcomeres; Valine	2000
Peroxisome proliferator-activated receptor gamma activators inhibit cardiac hypertrophy in cardiac myocytes. Circulation, 2001, Oct-02, Volume: 104, Issue:14 Topics: Angiotensin II; Animals; Animals, Newborn; Biological Transport; Cardiomegaly; Cells, Cultured; Chromans; Heart; Leucine; Myocardium; Natriuretic Peptide, Brain; NF-kappa B; Phenylephrine; Prostaglandin D2; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Stress, Mechanical; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone	2001
Morphometry and autoradiography of early hypertrophic changes in the ventricular myocardium of adult rat. A light microscopic study. Laboratory investigation; a journal of technical methods and pathology, 1975, Volume: 33, Issue:2 Topics: Amino Acids; Animals; Aortic Valve Stenosis; Cardiomegaly; Cycloheximide; Leucine; Male; Muscle Proteins; Myocardium; Protein Binding; Rats; Sodium Chloride	1975
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 8 Topics: Actins; Animals; Cardiomegaly; Chick Embryo; Creatine; Culture Techniques; DNA; Hypertrophy; Leucine; Muscle Proteins; Muscular Diseases; Myocardial Contraction; Myofibrils; Myosins; Organ Culture Techniques; Time Factors	1975
A diurnal rhythm of incorporation of L-[3H] leucine in myocardium of the rat. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 7 Topics: Animals; Body Weight; Cardiomegaly; Circadian Rhythm; Heart; Heart Ventricles; In Vitro Techniques; Isoproterenol; Leucine; Myocardium; Organ Size; Rats	1975
Studies using orotic acid for improving the controlled development of myocardial hypertrophy. Australian and New Zealand journal of medicine, 1976, Volume: 6 suppl 2 Topics: Animals; Cardiomegaly; Energy Metabolism; Glycogen; Leucine; Male; Myocardial Contraction; Myocardium; Orotic Acid; Protein Biosynthesis; Rats; Uracil; Uridine	1976
Protein synthesis in the atrioventricular node during acute experimental cardiac hypertrophy in the rat. Journal of molecular and cellular cardiology, 1976, Volume: 8, Issue:12 Topics: Animals; Atrioventricular Node; Cardiomegaly; Heart Conduction System; Leucine; Male; Protein Biosynthesis; Rats	1976
Efficiency and capacity of protein synthesis are increased in pressure overload cardiac hypertrophy. The American journal of physiology, 1988, Volume: 255, Issue:2 Pt 2 Topics: Animals; Cardiomegaly; Heart; Heart Ventricles; Kinetics; Leucine; Male; Myocardium; Organ Size; Protein Biosynthesis; Pulmonary Artery; Rabbits; Reference Values; RNA; Tritium	1988
Study of the pathogenesis of cardiac hypertrophy--biochemical differences of cultured heart cells from normotensive and spontaneously hypertensive rats. Japanese circulation journal, 1989, Volume: 53, Issue:10 Topics: Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Hypertension; Isoproterenol; Leucine; Myocardium; Protein Biosynthesis; Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stimulation, Chemical; Uridine	1989
Phosphorylation of ribosomal and ribosome-associated proteins in isoproterenol-induced cardiac hypertrophy. The International journal of biochemistry, 1985, Volume: 17, Issue:9 Topics: Animals; Cardiomegaly; Isoproterenol; Kinetics; Leucine; Male; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Rabbits; Ribosomal Proteins; Ribosomes; Tritium	1985
Cardiac protein synthesis and degradation during thyroxine-induced left ventricular hypertrophy. The American journal of physiology, 1986, Volume: 251, Issue:5 Pt 1 Topics: Animals; Cardiomegaly; Kinetics; Leucine; Male; Myocardium; Organ Size; Protein Biosynthesis; Proteins; Rabbits; Thyrotoxicosis; Thyroxine	1986
Myosin isozyme synthesis and mRNA levels in pressure-overloaded rabbit hearts. Circulation research, 1987, Volume: 60, Issue:5 Topics: Animals; Body Weight; Cardiomegaly; Constriction; Leucine; Male; Muscle Proteins; Myocardium; Myosins; Organ Size; Pulmonary Artery; Rabbits; RNA, Messenger	1987
A factor that initiates myocardial hypertrophy in hypertension. Hypertension (Dallas, Tex. : 1979), 1987, Volume: 9, Issue:3 Topics: Animals; Cardiomegaly; Chromatography, High Pressure Liquid; Cyclic AMP; Hypertension; Leucine; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Myocardium; Norepinephrine; Protein Biosynthesis; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Tissue Extracts	1987
The relationship between amino acid incorporation and cardiac work level in the rat heart-lung preparation. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1969, Volume: 264, Issue:2 Topics: Amino Acids; Animals; Carbon Isotopes; Cardiomegaly; Cycloheximide; Dactinomycin; Depression, Chemical; Extracorporeal Circulation; Heart; Heart Ventricles; Hemodynamics; Hypertrophy; Leucine; Lysine; Muscle Proteins; Myocardium; Puromycin; Rats	1969
Ribonucleic acid synthesis in experimental cardiac hypertrophy in rats. II. Aspects of regulation. Circulation research, 1968, Volume: 23, Issue:1 Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aorta; Blood Pressure; Cardiomegaly; Dactinomycin; Digitoxin; Kinetics; Leucine; Male; Myocardium; Phenylalanine; Phosphoric Acids; Phosphorus Isotopes; Puromycin; Rats; RNA; Time Factors; Tritium	1968
Myosin synthesis and degradation during development of cardiac hypertrophy in the rabbit. Circulation research, 1972, Volume: 30, Issue:6 Topics: Acrylamides; Animals; Aortic Coarctation; Aortic Valve Stenosis; Arginine; Blood Pressure; Body Weight; Carbon Isotopes; Cardiomegaly; Electrophoresis; Guanidines; Heart Ventricles; Hypertrophy; Kinetics; Leucine; Lysine; Male; Muscle Proteins; Myocardium; Myosins; Organ Size; Rabbits; Sodium Dodecyl Sulfate; Tritium	1972
Changes of protein synthesis in the hypertrophying rat heart. Pflugers Archiv : European journal of physiology, 1972, Volume: 336, Issue:4 Topics: Adenosine Triphosphate; Animals; Body Weight; Carbon Isotopes; Cardiomegaly; Female; Glycine; Leucine; Muscle Proteins; Organ Size; Phosphocreatine; Rats	1972
Effect of age on thyroxine-induced cardiac hypertrophy in mice. Journal of gerontology, 1973, Volume: 28, Issue:3 Topics: Aging; Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Leucine; Male; Mice; Mice, Inbred C57BL; Myocardium; Organ Size; Protein Biosynthesis; Thyroxine; Time Factors; Tritium	1973
Digitoxin treatment and experimental cardiac hypertrophy in the rat. Cardiovascular research, 1973, Volume: 7, Issue:4 Topics: Animals; Aorta, Abdominal; Cardiomegaly; Constriction; Digitoxin; DNA; Leucine; Ligation; Male; Myocardium; Organ Size; Protein Biosynthesis; Rats; RNA; Time Factors; Tritium; Uridine; Water	1973
Quantitative radioautographic localization of protein synthesis in experimental cardiac hypertrophy. Laboratory investigation; a journal of technical methods and pathology, 1973, Volume: 29, Issue:3 Topics: Animals; Aortic Valve Stenosis; Autoradiography; Cardiomegaly; Collagen; Cytoplasm; Endothelium; Fibroblasts; Golgi Apparatus; Heart Ventricles; Leucine; Male; Mathematics; Microscopy, Electron; Microscopy, Phase-Contrast; Mitochondria, Muscle; Muscle Proteins; Myocardium; Myofibrils; Rats; Sarcoplasmic Reticulum; Tritium	1973
Biochemical studies in myocardial hypertrophy and metabolic support of the acutely stressed myocardium. Advances in cardiology, 1974, Volume: 12, Issue:0 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiomegaly; Creatine Kinase; Heart; Hypertrophy; L-Lactate Dehydrogenase; Leucine; Male; Microscopy, Electron; Muscle Tonus; Muscles; Myocardium; Orotic Acid; Papillary Muscles; Rats; Time Factors; Uridine; Vitamin B 12	1974
Hemodynamic effects and hypertrophy-inducing potential of D- and L-thyroxine. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Albumins; Animals; Blood Pressure; Carbon Radioisotopes; Cardiac Output; Cardiomegaly; Heart Atria; Heart Rate; Hemodynamics; Iodine Radioisotopes; Leucine; Male; Muscle Proteins; Myocardium; Organ Size; Rats; Stereoisomerism; Thyroxine	1974
The action of orotic acid as a positive inotropic agent during the acute phase of myocardial hypertrophy. Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:6 Topics: Acute Disease; Animals; Cardiomegaly; Folic Acid; Leucine; Male; Myocardial Contraction; Myocardium; Orotic Acid; Protein Biosynthesis; Rats; Stimulation, Chemical; Uridine; Vitamin B 12	1974
Protein and free amino acid metabolism in the failing canine heart. Recent advances in studies on cardiac structure and metabolism, 1973, Volume: 3 Topics: Amino Acids; Animals; Blood Pressure; Cardiomegaly; Dogs; Heart; Heart Failure; Leucine; Muscle Proteins; Organ Size	1973
Increased turnover of mitochondrial constituents in cardiac hypertrophy and acute hypoxia in the rat. Recent advances in studies on cardiac structure and metabolism, 1972, Volume: 1 Topics: Acute Disease; Animals; Cardiomegaly; Cytochrome Reductases; Electron Transport Complex IV; Hypoxia; Leucine; Mitochondria, Muscle; Muscle Proteins; Myocardium; Organ Size; Oxygen Consumption; Protein Biosynthesis; Rats; Subcellular Fractions; Succinate Dehydrogenase	1972