leucine has been researched along with Benign Neoplasms in 186 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 106 (56.99) | 18.7374 |
| 1990's | 8 (4.30) | 18.2507 |
| 2000's | 12 (6.45) | 29.6817 |
| 2010's | 43 (23.12) | 24.3611 |
| 2020's | 17 (9.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y | 1 |
| Busanello, ENB; Castelucci, BG; Chiocchetti, GME; Consonni, SR; de Oliveira, ALR; de Sousa, LM; Gomes-Marcondes, MCC; Marques, AC; Oroy, L; Salgado, CM; Suarez, PS; Vercesi, AE; Viana, LR; Vieira, AS; Vieira, WF | 1 |
| Bian, C; Cao, Z; Fu, W; Li, X; Lu, J; Lv, P; Mao, Y; Sun, R; Wang, H; Wu, X; Zhao, Z | 1 |
| Bordon, Y | 1 |
| Fillatreau, S; Manfroi, B | 1 |
| Davies, FE; Gelius, SS; Heckman, CA; Holstein, SA; Lehmann, F; Morgan, GJ | 1 |
| Beaudry, AG; Law, ML | 1 |
| Alonso Echague, R; Calañas Continente, A; Chica Palomino, S; Gálvez Moreno, MÁ; Herrera-Martínez, AD; León Idougourram, S; Manzano García, G; Molina Puertas, MJ; Muñoz Jiménez, C; Rodríguez-Alonso, R; Sanz Sanz, A | 1 |
| Argilès, J; Faber, J; Laviano, A; Meijerink, J; Plas, RLC; Poland, M; van Dijk, M; van Helvoort, A; van Norren, K; Witkamp, RF | 1 |
| Balamurugan, TST; Chen, CH; Chen, GZ; Huang, ST; Kumaravel, S; Lee, YC; Lin, CM; Luo, GR | 1 |
| Sivanand, S; Vander Heiden, MG | 1 |
| Kim, HS; Sohn, YK | 1 |
| Ballmer, PE; Gaeumann, S; Gisi, D; Imoberdorf, R; Meffert, PJ; Pless, M; Ruehlin, M; Schmocker, M; Storck, LJ | 1 |
| Dos Santos, GS; Gomes-Marcondes, MCC; Manhe, BS; Miyaguti, NADS; Oliveira, SCP; Stanisic, D; Tasic, L | 1 |
| Johnson, H; Puppa, M; Tipirneni-Sajja, A; van der Merwe, M | 1 |
| Fuchs, N; Meta, M; Nuhn, L; Schirmeister, T; Schuppan, D | 1 |
| Bozzetti, F | 1 |
| Chang, JF; Gan, ZX; Liu, KN; Liu, YZ; Sun, F; Sun, J; Yang, XM; Zhang, L; Zhang, W | 1 |
| Alghamdi, Y; Bottrill, AR; Browne, G; Bushel, M; Karountzos, A; Mistry, S; Pringle, JH; Sayan, AE; Smith, E; Stevens, C; Tulchinsky, E; Wan Makhtar, WR | 1 |
| Guo, M; Han, G; Han, JM; Hwang, KY; Jang, J; Jeong, SJ; Kang, JS; Kim, HK; Kim, JH; Kim, K; Kim, S; Kwon, NH; Lee, C; Lee, CW; Lee, M; Lee, MY; Martinis, SA; Oh, SJ; Park, SJ; Wang, H; Yang, JS; Yoo, HC; Yoon, I; Yun, J; Zhao, H | 1 |
| Antoun, S; Raynard, B | 1 |
| Hiruta, Y; Kanazawa, H; Matsuura, M; Nagase, K; Nishimura, T; Ohshima, M | 1 |
| Filipowicz, A; Markowicz, J; Misiorek, M; Pieńkowska, N; Uram, Ł; Wałajtys-Rode, E; Wołowiec, S | 1 |
| Bitencourt-Ferreira, G; de Azevedo, WF; Souto, AA; Volkart, PA | 1 |
| Anand, V; Appunni, S; Gupta, N; Khandelwal, M; Rubens, M; Sharma, A | 1 |
| Cao, J; Chen, T; Dong, H; Kong, X; Ran, Y; Xu, W; Zang, J; Zhang, Y; Zhao, C | 1 |
| Ann, J; Byun, WS; Kim, C; Kim, JH; Kim, S; Kim, SE; Lee, J; Lee, S; Tran, PT; Yoon, I; Yoon, S | 1 |
| Gomes-Marcondes, MCC; Miyaguti, NADS; Oliveira, SCP | 1 |
| Naito, M; Ohoka, N; Shibata, N | 1 |
| Cao, J; Jin, K; Li, X; Ma, C; Xu, W; Zhang, L | 1 |
| Lorin, S | 1 |
| COFFEY, GL; EHRLICH, J; FISHER, MW; HILLEGAS, AB; KOHBERGER, DL; MACHAMER, HE; RIGHTSEL, WA; ROEGNER, FR | 1 |
| MAXWELL, RE; NICKEL, VS | 1 |
| Chevalier, S; Winter, A | 1 |
| Gopal, SC; Kaki, SS; Kumar, CG; Narayana Prasad, RB; Poornachandra, Y; Rao, BV | 1 |
| Eli, M; Kong, B; Mamtimin, B; Turahun, A; Upur, H | 1 |
| Adapala, RK; Cappelli, HC; Dudley, AC; Gary Meszaros, J; Kondeti, V; Paruchuri, S; Thodeti, CK; Thoppil, RJ | 1 |
| Hattori, T; Naito, M; Ohoka, N; Shibata, N | 1 |
| Han, JW; Hwang, DE; Kim, HS; Oh, JR; Park, TK; Ryou, JH | 1 |
| Aereas, MA; Ferreira Ramos, LA; Gomes-Marcondes, MC; Salomão, EM; Tomasin, R; Toneto, AT | 1 |
| Sharma, A; Srivastava, G; Tripathi, S | 1 |
| Canevarolo, R; Gomes-Marcondes, MC; Lubaczeuski, C; Luiz, AC; Soares, RF; Viana, LR; Zeri, AC | 1 |
| Choi, HK; Hyun, SH; Kim, DH; Kim, JY; Kim, SH; Lee, SG; Lim, SR; Moon, KS; Park, SJ; Sul, D | 1 |
| Goldoni, S; Iozzo, RV | 1 |
| Karamanos, NK; Katonis, P; Nikitovic, D; Tsatsakis, A; Tzanakakis, GN | 1 |
| Liu, S; Liu, Y; Shi, J; Zhang, P; Zhang, Y; Zheng, D; Zheng, Y | 1 |
| Fan, Z; Hu, D; Li, C; Liu, S; Shi, L; Wu, L | 1 |
| Artioli, GG; Blachier, F; Costa, Ados S; da Luz, CR; Lancha, AH; Nicastro, H; Solis, MY | 1 |
| Kim, S; Naito, M; Nishimaki-Mogami, T; Ohoka, N; Okuhira, K; Sai, K | 1 |
| Iozzo, RV; Schaefer, L | 2 |
| Fang, H; Wang, X; Xu, W; Yang, K; Zhang, C; Zhang, J; Zhang, L | 1 |
| de Jongh, RT; Dekkers, OM; Kramer, MH; Lips, P; Rijs, KJ; van Schoor, NM; Vandenbroucke, JP | 1 |
| Gullbo, J; Larsson, R; Nygren, P; Wickström, M | 1 |
| Fang, H; Feng, J; Jing, F; Li, M; Liu, N; Luan, Y; Ma, C; Sui, Z; Wang, X; Wang, Y; Xu, W | 1 |
| Aldawsari, H; Blatchford, DR; Dufès, C; Edrada-Ebel, R; Raj, BS; Tate, RJ; Tetley, L | 1 |
| Argilès, JM; Deutz, NE; Gorselink, M; Haagsman, HP; Kegler, D; Laviano, A; Luiking, YC; Peters, SJ; van Bergenhenegouwen, J; van Helvoort, A; van Norren, K | 1 |
| Aldawsari, H; Blatchford, DR; Dufès, C; Edrada-Ebel, R; Tate, RJ; Tetley, L | 1 |
| Cheng, YN; Cui, SX; Gao, JJ; Gao, ZH; Qu, XJ; Tang, W; Xu, WF; Xue, X | 1 |
| Deutz, NE; Ferrando, A; Memelink, R; Safar, A; Schutzler, S; Spencer, H; van Helvoort, A; Wolfe, RR | 1 |
| Fang, H; Fen, J; Gong, J; Xu, W; Yang, K; Zhang, L | 1 |
| Endo, K; Endou, H; Kaira, K; Kanai, Y; Kitashoji, T; Nagamori, S; Nakao, H; Ohgaki, R; Oriuchi, N; Sakurai, H; Tanaka, H; Tominaga, H; Wiriyasermkul, P | 1 |
| Cramer, SJ; Dautzenberg, IJ; de Groot, RJ; Hoeben, RC; van den Hengel, SK; van den Wollenberg, DJ | 1 |
| Arends, J; Avlar, M; Berkhout, M; Faber, J; Fiedler, U; Garssen, J; Henke, M; Otten, MH; van Helvoort, A; Vos, AP; Witteman, BJ | 1 |
| DuBois, RN | 1 |
| Bojesen, SE; Nordestgaard, BG; Tybjaerg-Hansen, A | 1 |
| ALBANO, A; IACONO, A; VESCIA, A | 1 |
| MAGILL, GB; MYERS, WP | 1 |
| LAW, LW; POTTER, M | 1 |
| JACQUEZ, JA | 2 |
| EMMELOT, P | 1 |
| LARSEN, A; LINDNER, A | 1 |
| GOLDBARG, JA; PINEDA, EP; RUTENBURG, AM | 1 |
| POTTER, M | 1 |
| BRAUN-FALCO, F; BRAUN-FALCO, O; SALFELD, K | 1 |
| HUTCHISON, DJ; JACQUEZ, JA | 1 |
| BAGSHAW, MA | 1 |
| GOLISCH, G | 1 |
| BAKER, BR | 1 |
| BRAUN, P; NEMETH, EP; PAPP, M; STECZEK, K | 1 |
| HASCHEN, RJ | 1 |
| MICHEL, R; ROCHE, J | 1 |
| BAUER, JM; WU, C | 1 |
| CAMMAROTA, HE | 1 |
| GENTY, N; MELONI, GA; VENDRELY, R | 1 |
| FEO, F; GABRIEL, L; GRAVELA, E; TERRANOVA, T | 1 |
| DOERMER, P; LESCH, R; OEHLERT, W | 1 |
| DOERFLER, W; FUCHS, E; PALM, P; ZILLIG, W | 1 |
| TELLER, MN; WAGSHUL, SF; WOLFF, R | 1 |
| HSIAO, SH; KEPPEL, A; PATTERSON, EK | 1 |
| CESTARI, A; DESSI, P; RIZZOLI, C | 2 |
| CHRISTENSEN, HN | 1 |
| AMOS, H; ASKONAS, B; SOEIRO, R | 1 |
| LORINCZ, AB; RYAN, WL | 1 |
| BROCKMAN, RW | 1 |
| HUTCHISON, DJ | 1 |
| BASERGA, R; LAYDE, JP | 1 |
| BENNETT, LL; SMITHERS, D; WARD, CT | 1 |
| COMSTOCK, JP; GABOUREL, JD | 1 |
| ANKER, HS; RENNERT, OM | 1 |
| GINSBERG, DM | 1 |
| BADEN, HP; PEARLMAN, C | 1 |
| TEICHMANN, B | 2 |
| VESCIA, A | 1 |
| Hahm, KS; Lee, DG; Park, Y | 1 |
| Ehrsson, H; Gullbo, J; Larsson, R; Lewensohn, R; Luthman, K; Nygren, P; Tullberg, M; Wickström, M | 1 |
| Kentsis, A; Miller, F; Osman, R; Pan, ZQ | 1 |
| Koizumi, K; Minami, T; Saiki, I; Saitoh, Y; Sakurai, H; Sekine, K | 1 |
| Fojo, T | 1 |
| Eley, HL; Russell, ST; Tisdale, MJ | 1 |
| Abe, F; Kikuchi, R; Kitagawa, M; Naito, M; Nishikawa, K; Nishimoto, M; Sekine, K; Takubo, K; Tsuruo, T | 1 |
| Edwards, RH; Emery, PW; Halliday, D; Rennie, MJ; Souhami, RL | 1 |
| Hardesty, B; Henderson, AB; Kramer, G | 1 |
| Hadden, JW | 1 |
| Wybran, J | 1 |
| Mathé, G; Reizenstein, P | 1 |
| Mathe, G | 4 |
| Akiyama, S; Ichihashi, H; Kondo, T; Sakakibara, S; Watanabe, T | 1 |
| White, MK | 1 |
| Mason, J; Waterhouse, C | 1 |
| Clark, CM; Goodlad, GA | 1 |
| Hashimoto, I; Kimura, K; Kodama, M; Kurioka, H; Matsumoto, H; Nozaki, A; Sonoyama, T; Terata, N; Tsunoda, F | 1 |
| Oka, S | 2 |
| Fishman, WH | 1 |
| Aoyagi, T; Umezawa, H | 1 |
| Blomgren, H; Jarstrand, C | 2 |
| Fishman, WH; Millán, JL; Ruoslahti, E; Stigbrand, T | 1 |
| Blomgren, H; Edsmyr, F; Strender, LE | 2 |
| Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, JI | 1 |
| Carlsson, J; Malmqvist, M; Nederman, T | 1 |
| Blomgren, H; Wasserman, J | 1 |
| Lazo, PA | 2 |
| Waterhouse, C | 1 |
| Bartlett, K; Brock, C; Craft, AW; Daley, SE; Halliday, D; Hetherington, C; Kernahan, J; Pearson, AD; Price, L; Wyllie, RA | 1 |
| Chen, PL; Chen, Y; Lee, WH; Riley, DJ | 1 |
| Batter, S; Casey, D; Febbo, PG; Giovannucci, E; Hennekens, CH; Kantoff, PW; Platz, EA; Stampfer, MJ | 1 |
| Carroll, MW; Rees, BR; Shaw, DM; Stern, PL; Wang, WW; Ward, CM; Woods, AM | 1 |
| Bylund, AC; Holm, J; Lundholm, K; Scherstén, T | 1 |
| Goto, M; Ichihara, A; Shinno, H | 1 |
| Matsumoto, M | 1 |
| Cappuccino, CC; Kadowaki, H; Knox, WE | 1 |
| Dickson, JA; Suzangar, M | 1 |
| Kitamura, M; Nakayama, T | 1 |
| Grimm, EA; Morton, DL; Roth, JA | 1 |
| Arima, T; Fujii, S; Niinobe, M; Okuda, H; Tamura, Y | 1 |
| Brennan, MF; Burt, ME; Gonenne, A; Heslin, MJ; Newman, E; Pearlstone, DB; Wolf, RF | 1 |
| Ota, K; Uzuka, Y | 1 |
| Ota, K | 1 |
| Douglas, RG; Humberstone, DA; Koea, J; Shaw, JH | 1 |
| Aoki, H; Fujii, J; Fukui, S; Hayasaka, H; Ikeyama, A; Mizushima, Y; Suzuki, Y; Taki, K | 1 |
| Ishida, M; Mega, T; Mori, T; Ogawa, M | 1 |
| Balch, CM; Itoh, K; Platsoucas, CD; Pollock, RE; Tilden, AB | 1 |
| Dale, BM; Gee, D; Kotasek, D; Morris, RG; Reece, PA; Rogerson, S; Sage, RE | 1 |
| Brienza, S; Canon, C; Mathé, G; Misset, JL; Musset, M; Reizenstein, P; Umezawa, H | 1 |
| Blazsek, I; Canon, C; Gil-Delgado, M; Mathé, G; Misset, JL | 1 |
| Himori, T; Konno, K; Kumano, N; Mitachi, Y; Oizumi, K; Suzuki, S; Wakui, A | 1 |
| Hammond, WG; Landel, AM; Meguid, MM | 1 |
| Jacob, J | 1 |
| Shimizu, T | 2 |
| Warren, L | 1 |
| Hawks, A; Hicks, RM; Holsman, JW; Magee, PN | 1 |
| Hoshi, A; Kanai, T; Kanzawa, F; Kuretani, K; Yoshida, M | 1 |
| Hahn, GM; Little, JB | 1 |
| Fishman, WH; Inglis, NR; Kirley, S; Stolbach, LL | 1 |
| Teichmann, B; Ziebarth, D | 2 |
| Inoue, M; Nagata, Y | 1 |
| Wüstenberg, PW | 1 |
| Hahn, K; Jesdinsky, HJ; Ladner, HA | 1 |
| Beckman, L; Lundgren, E; Rydelius, PA | 1 |
| Galt, RM; Knock, FE; Oester, YT; Renaud, OV; Sylvester, R | 1 |
| Björnesjö, KB | 1 |
| Graffi, A | 1 |
| Butschak, G; Graffi, A; Schneider, EJ | 1 |
31 review(s) available for leucine and Benign Neoplasms
| Article | Year |
|---|---|
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction | 2021 |
Leucine Supplementation in Cancer Cachexia: Mechanisms and a Review of the Pre-Clinical Literature.
Topics: Cachexia; Diet; Dietary Supplements; Humans; Leucine; Muscle, Skeletal; Neoplasms | 2022 |
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.
Topics: Amino Acids, Branched-Chain; Epigenomics; Humans; Intracellular Signaling Peptides and Proteins; Isoleucine; Leucine; Neoplasms | 2020 |
Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery.
Topics: Antigen Presentation; Antineoplastic Agents; Azepines; Cathepsins; Dendritic Cells; Dipeptides; Drug Carriers; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Leucine; Molecular Targeted Therapy; Nanoparticles; Neoplasms; Protease Inhibitors; Sulfones; T-Lymphocytes; Tumor Microenvironment; Tumor-Associated Macrophages | 2020 |
Cyclin-Dependent Kinase 2 in Cellular Senescence and Cancer. A Structural and Functional Review.
Topics: Asparagine; Binding Sites; Cellular Senescence; Crystallography, X-Ray; Cyclin-Dependent Kinase 2; Drug Design; Humans; Leucine; Models, Molecular; Neoplasms; Protein Kinase Inhibitors | 2019 |
Small Leucine Rich Proteoglycans (decorin, biglycan and lumican) in cancer.
Topics: Animals; Biglycan; Decorin; Gene Expression Regulation, Neoplastic; Humans; Leucine; Lumican; Neoplasms | 2019 |
SNIPERs-Hijacking IAP activity to induce protein degradation.
Topics: Animals; Humans; Inhibitor of Apoptosis Proteins; Leucine; Neoplasms; Proteolysis | 2019 |
Do patients with advanced cancer have any potential for protein anabolism in response to amino acid therapy?
Topics: Amino Acids; Amino Acids, Branched-Chain; Anabolic Agents; Cachexia; Dietary Proteins; Dietary Supplements; Humans; Inflammation; Leucine; Muscular Atrophy; Neoplasms; Proteins | 2014 |
Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle Proteins; Down-Regulation; Drug Design; Humans; Inhibitor of Apoptosis Proteins; Leucine; Ligands; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oligopeptides; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2016 |
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
Topics: Amino Acid Motifs; Animals; Decorin; Extracellular Matrix Proteins; Humans; Leucine; Leucine-Rich Repeat Proteins; Neoplasms; Proteins; Proteoglycans; Signal Transduction | 2008 |
Lumican, a small leucine-rich proteoglycan.
Topics: Animals; Chondroitin Sulfate Proteoglycans; Humans; Keratan Sulfate; Leucine; Lumican; Neoplasms; Signal Transduction | 2008 |
An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions.
Topics: Clinical Trials as Topic; Dietary Supplements; Humans; Leucine; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Neoplasms | 2011 |
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans.
Topics: Animals; Cell Division; Decorin; ErbB Receptors; Extracellular Matrix Proteins; Homeostasis; Humans; Inflammation; Leucine; Mammals; Neoplasms; Proteoglycans; Proto-Oncogene Proteins c-met; Receptor, IGF Type 1; Receptors, Growth Factor; Signal Transduction | 2010 |
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Topics: CD13 Antigens; Cell Proliferation; Clinical Trials as Topic; Glycine; Humans; Hydroxamic Acids; Leucine; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Prognosis; Protease Inhibitors | 2011 |
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
Topics: Angiogenesis Inhibitors; Animals; CD13 Antigens; Cell Membrane; Endothelium, Vascular; Esters; Fibroblast Growth Factor 2; Humans; Leucine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Transforming Growth Factor alpha; Umbilical Veins; Vascular Endothelial Growth Factor A | 2011 |
[ON VARIOUS USES OF RADIOIODINE IN PHYSIOLOGY AND IN THYROID BIOCHEMISTRY].
Topics: Adenosine Triphosphate; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Chromatography; Cystine; Diiodotyrosine; Dogs; Glucuronates; Iodine Isotopes; Iodine Radioisotopes; Kidney; Leucine; Liver; Metabolism; Mitochondria; Neoplasms; Rats; Research; Sodium Isotopes; Sulfur Isotopes; Thyroid Gland; Thyroid Hormones; Thyroidectomy; Thyroxine; Triiodothyronine; Valine | 1963 |
MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.
Topics: Alkylating Agents; Antineoplastic Agents; Azaserine; Dactinomycin; DNA; Drug Resistance; Drug Resistance, Microbial; Drug Tolerance; Folic Acid; Humans; Leucine; Metabolism; Mitomycin; Mitomycins; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Pyrimidines; RNA; Steroids; Tissue Culture Techniques | 1963 |
CROSS RESISTANCE AND COLLATERAL SENSITIVITY STUDIES IN CANCER CHEMOTHERAPY.
Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Azaserine; Colchicine; Drug Resistance; Drug Resistance, Microbial; Folic Acid Antagonists; Guanidines; Humans; Leucine; Metabolism; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Pyrimidines; Steroids; Tissue Culture Techniques | 1963 |
HYPOGLYCEMIA ASSOCIATED WITH EXTRAPANCREATIC NEOPLASMS, WITH A NOTE ON OTHER UNUSUAL FORMS OF HYPOGLYCEMIA.
Topics: Adrenogenital Syndrome; Carcinoma, Hepatocellular; Drug Therapy; Glycogen Storage Disease Type I; Humans; Hypoglycemia; Leucine; Liver Glycogen; Liver Neoplasms; Mesenchymoma; Neoplasms; Retroperitoneal Neoplasms; Thoracic Neoplasms; Tolbutamide | 1964 |
Biological response modifiers and differentiation inducers. Current status in cancer research.
Topics: Adjuvants, Immunologic; Aziridines; Bacterial Vaccines; Cell Differentiation; Cyclosporins; Dimethyl Sulfoxide; Glucans; Hormones; Humans; Leucine; Levamisole; Lithium; Neoplasms; Peptides; Retinoids; Selenium | 1983 |
Experience gained in immunotherapy from the immunopharmacology of BCG leading to a second generation of systemic immunity adjuvants.
Topics: Adjuvants, Immunologic; Animals; Aziridines; BCG Vaccine; Breast Neoplasms; Cyclophosphamide; Dose-Response Relationship, Immunologic; Humans; Immunotherapy; Leucine; Leukemia L1210; Leukemia, Lymphoid; Levamisole; Lymphoma, Non-Hodgkin; Melanoma; Methotrexate; Mice; Neoplasms; Propionibacterium acnes; T-Lymphocytes, Regulatory; Thymosin | 1980 |
Immunology and biochemistry of the Regan isoenzyme.
Topics: Alkaline Phosphatase; Amniotic Fluid; Animals; Butyrates; Cell Cycle; Cells, Cultured; Chorionic Gonadotropin; Dysgerminoma; Enzyme Induction; Female; Gene Expression Regulation; GPI-Linked Proteins; HeLa Cells; Humans; Isoenzymes; Leucine; Neoplasms; Ovarian Neoplasms; Phenotype; Placenta; Prednisolone; Pregnancy | 1980 |
A predictive in vitro assay for the sensitivity of human solid tumours to hyperthermia (42 degrees C) and its value in patient management.
Topics: Aged; Animals; Breast Neoplasms; Child; Child, Preschool; DNA, Neoplasm; Evaluation Studies as Topic; Female; Glycolysis; Hot Temperature; Humans; Hyperthermia, Induced; In Vitro Techniques; Leucine; Male; Mice; Middle Aged; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Oxygen Consumption; Rats; Thymidine; Transplantation, Heterologous; Uridine | 1976 |
Clinical trials of bestatin for leukemia and solid tumors.
Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms | 1992 |
Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function.
Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; HIV Infections; Humans; Leucine; Mice; Neoplasms; Neoplasms, Experimental | 1991 |
Review of ubenimex (Bestatin): clinical research.
Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies | 1991 |
Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system?
Topics: Adjuvants, Immunologic; Animals; Humans; Immunotherapy; Leucine; Neoplasms; Phagocytosis; Tuftsin | 1987 |
Aspects of amino acid and protein metabolism in cancer-bearing states.
Topics: Adenosine Triphosphate; Adult; Amino Acids; Amino Acids, Branched-Chain; Animals; Body Weight; Brain; Carcinoma 256, Walker; Clinical Trials as Topic; Humans; Leucine; Liver; Muscles; Neoplasms; Nutrition Disorders; Parenteral Nutrition, Total; Proteins; Rats; Tryptophan; Tyrosine; Valine | 1985 |
The practice and application of electron microscope autoradiography.
Topics: Animals; Autoradiography; Bacillus subtilis; Carbohydrates; Carbon Isotopes; DNA; Emulsions; Escherichia coli; Guinea Pigs; Histocytochemistry; Histological Techniques; L Cells; Leucine; Lipids; Mathematics; Mice; Microscopy, Electron; Microtomy; Neoplasms; Pancreas; Paramecium; Photomicrography; Plants; Proline; Proteins; Radiation Effects; Radioisotopes; Rats; RNA; Staining and Labeling; Sulfur Isotopes; Thymidine; Thyroid Gland; Time Factors; Tritium; Triturus; Viruses; Xenopus | 1971 |
[Regulation of DNA biosynthesis and cell division].
Topics: Arginine; Carbon Isotopes; Cell Division; Cell Membrane; DNA; DNA, Bacterial; Electrophoresis; Escherichia coli; Leucine; Neoplasms; Peptide Hydrolases; Proteins; Temperature; Thymine; Triazines; Trypsin | 1971 |
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide; Diet Therapy; Epinephrine; Gastrointestinal Diseases; Glucagon; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypoglycemia; Leucine; Metabolic Diseases; Neoplasms; Pancreatic Neoplasms; Prednisone; Tolbutamide | 1970 |
13 trial(s) available for leucine and Benign Neoplasms
| Article | Year |
|---|---|
Standard Hypercaloric, Hyperproteic vs. Leucine-Enriched Oral Supplements in Patients with Cancer-Induced Sarcopenia, a Randomized Clinical Trial.
Topics: Dietary Supplements; Humans; Leucine; Neoplasms; Nutrition Assessment; Nutritional Status; Quality of Life; Sarcopenia; Vitamin D; Whey Proteins | 2023 |
Effect of a leucine-rich supplement in combination with nutrition and physical exercise in advanced cancer patients: A randomized controlled intervention trial.
Topics: Adult; Aged; Aged, 80 and over; Cachexia; Combined Modality Therapy; Dietary Supplements; Exercise; Exercise Test; Exercise Therapy; Fatigue; Female; Hand Strength; Humans; Leucine; Male; Middle Aged; Neoplasms; Nutrition Therapy; Nutritional Status; Patient Compliance; Physical Functional Performance; Quality of Life; Treatment Outcome | 2020 |
Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food.
Topics: Aged; Biopsy; Dietary Supplements; Double-Blind Method; Food, Formulated; Humans; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Neoplasms; Statistics, Nonparametric | 2011 |
Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial.
Topics: Aged; Biomarkers; Dinoprostone; Docosahexaenoic Acids; Double-Blind Method; Eicosapentaenoic Acid; Female; Fish Oils; Food, Fortified; Humans; Interferon-gamma; Interleukin-10; Interleukin-1beta; Interleukin-8; Leucine; Leukocytes; Male; Middle Aged; Neoplasms; Oligosaccharides; Phospholipids; Tumor Necrosis Factor-alpha | 2013 |
A review of clinical studies of bestatin.
Topics: Adjuvants, Immunologic; Adult; Aged; Antibiotics, Antineoplastic; Breast Neoplasms; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Immunotherapy; Leucine; Male; Neoplasms; Penile Neoplasms | 1980 |
A review of clinical studies on bestatin, 1976--1978.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucine; Male; Middle Aged; Neoplasms | 1981 |
The V89L polymorphism in the 5alpha-reductase type 2 gene and risk of prostate cancer.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Anticarcinogenic Agents; Aspirin; beta Carotene; Boston; Double-Blind Method; Heart Diseases; Humans; Isoenzymes; Leucine; Male; Middle Aged; Neoplasms; Polymorphism, Genetic; Prostatic Neoplasms; Risk Factors; Valine; White People | 1999 |
Growth hormone and insulin reverse net whole body and skeletal muscle protein catabolism in cancer patients.
Topics: Amino Acids; Blood Glucose; Creatinine; Female; Growth Hormone; Hematocrit; Humans; Insulin; Leucine; Male; Middle Aged; Muscle Proteins; Neoplasms; Phenylalanine; Recombinant Proteins | 1992 |
Clinical trials of bestatin for leukemia and solid tumors.
Topics: Humans; Immunologic Factors; Leucine; Leukemia; Neoplasms | 1992 |
Review of ubenimex (Bestatin): clinical research.
Topics: Adolescent; Adult; Age Factors; Antibiotics, Antineoplastic; Humans; Leucine; Leukemia, Myeloid, Acute; Middle Aged; Neoplasms; Prospective Studies | 1991 |
Effect of L-leucine on oral melphalan kinetics in patients.
Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Fasting; Female; Humans; Intestinal Absorption; Leucine; Male; Melphalan; Middle Aged; Neoplasms; Random Allocation; Time Factors | 1987 |
From experimental to clinical attempts in immunorestoration with bestatin and zinc.
Topics: Adjuvants, Immunologic; Age Factors; AIDS-Related Complex; Animals; Clinical Trials as Topic; Female; Hodgkin Disease; Humans; Leucine; Lymphocyte Activation; Lymphoma, Non-Hodgkin; Mice; Neoplasms; T-Lymphocytes; Zinc | 1986 |
Aspects of amino acid and protein metabolism in cancer-bearing states.
Topics: Adenosine Triphosphate; Adult; Amino Acids; Amino Acids, Branched-Chain; Animals; Body Weight; Brain; Carcinoma 256, Walker; Clinical Trials as Topic; Humans; Leucine; Liver; Muscles; Neoplasms; Nutrition Disorders; Parenteral Nutrition, Total; Proteins; Rats; Tryptophan; Tyrosine; Valine | 1985 |
145 other study(ies) available for leucine and Benign Neoplasms
| Article | Year |
|---|---|
Leucine-Rich Diet Improved Muscle Function in Cachectic Walker 256 Tumour-Bearing Wistar Rats.
Topics: Animals; Cachexia; Dietary Supplements; Forkhead Box Protein O1; Humans; Inflammation; Leucine; Muscle Proteins; Muscular Atrophy; Neoplasms; Proteolysis; Quality of Life; Rats; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2021 |
A facile turn-on chemiluminescence probe for sensitive imaging on aminopeptidase N activity.
Topics: Aminopropionitrile; Animals; CD13 Antigens; Leucine; Luminescence; Mice; Molecular Docking Simulation; Neoplasms | 2022 |
Leucine restriction limits pro-cancer B cell responses.
Topics: Humans; Leucine; Neoplasms; Precursor Cells, B-Lymphoid | 2022 |
Regulatory B cells gain muscles with a leucine-rich diet.
Topics: Animals; B-Lymphocytes, Regulatory; Colorectal Neoplasms; Diet; Leucine; Mice; Muscles; Neoplasms; Tumor Microenvironment | 2022 |
Aminopeptidases in Cancer, Biology and Prospects for Pharmacological Intervention.
Topics: Amino Acids; Aminopeptidases; Biology; Humans; Leucine; Neoplasms; Signal Transduction | 2022 |
A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice.
Topics: Animals; Cachexia; Calcium; Diet; Dinoprostone; Disease Models, Animal; Fish Oils; Hypercalcemia; Leucine; Male; Mice; Muscle, Skeletal; Neoplasms; Parathyroid Hormone-Related Protein | 2019 |
Electrochemical substrate for active profiling of cellular surface leucine aminopeptidase activity and drug resistance in cancer cells.
Topics: Biosensing Techniques; Drug Resistance, Neoplasm; Electrochemical Techniques; Enzyme Assays; Ferrous Compounds; Hep G2 Cells; Humans; Leucine; Leucyl Aminopeptidase; Limit of Detection; Metallocenes; Neoplasms | 2020 |
Targeted delivery of a human Bcl-2-specific protein binder effectively induces apoptosis of cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Surface Display Techniques; Drug Delivery Systems; Drug Discovery; Humans; Leucine; Neoplasms; Protein Binding; Proto-Oncogene Proteins c-bcl-2 | 2020 |
Serum and Muscle
Topics: Amino Acids; Animals; Cachexia; Diet; Dietary Supplements; Energy Metabolism; Female; Lactates; Leucine; Lipid Metabolism; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Metabolome; Muscle, Skeletal; Neoplasms; Pregnancy; Proton Magnetic Resonance Spectroscopy; Rats, Wistar | 2020 |
CRAFT for NMR lipidomics: Targeting lipid metabolism in leucine-supplemented tumor-bearing mice.
Topics: Animals; Bayes Theorem; Dietary Supplements; Leucine; Lipid Metabolism; Lipidomics; Liver; Magnetic Resonance Spectroscopy; Male; Mice, Inbred C57BL; Neoplasms | 2021 |
Multimodal treatment to support cancer patients.
Topics: Combined Modality Therapy; Exercise; Humans; Leucine; Neoplasms; Nutritional Status | 2020 |
Nucleotide variation in histone H2BL drives crossalk of histone modification and promotes tumour cell proliferation by upregulating c-Myc.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Genetic Variation; HEK293 Cells; Histones; Humans; Lentivirus; Leucine; Mice; Mice, Nude; Mutation; Neoplasms; Nucleotides; Proline; Proto-Oncogene Proteins c-myc; Up-Regulation; Xenograft Model Antitumor Assays | 2021 |
Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells.
Topics: Amino Acid Motifs; Cell Line, Tumor; Codon; Epithelial-Mesenchymal Transition; Glycine; Humans; Leucine; Neoplasms; Protein Biosynthesis; RNA, Transfer, Gly; RNA, Transfer, Leu; RNA, Transfer, Val; Signal Transduction; Valine; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1 | 2017 |
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Leucine; Leucine-tRNA Ligase; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred BALB C; Mice, Nude; Monomeric GTP-Binding Proteins; Neoplasms; Protein Binding; Signal Transduction; Sirolimus | 2017 |
Muscle protein anabolism in advanced cancer patients: response to protein and amino acids support, and to physical activity.
Topics: Animals; Antineoplastic Agents; Cachexia; Combined Modality Therapy; Dietary Proteins; Dietary Supplements; Disease Models, Animal; Exercise; Exercise Therapy; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Neoplasm Staging; Neoplasms; Physical Conditioning, Animal; Postoperative Complications; Protein Biosynthesis | 2018 |
LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging.
Topics: Acrylamides; Fluorescent Dyes; HeLa Cells; Hot Temperature; Humans; Hydrophobic and Hydrophilic Interactions; Large Neutral Amino Acid-Transporter 1; Leucine; Molecular Imaging; Neoplasms; Polymers | 2018 |
Biotinylated PAMAM G3 dendrimer conjugated with celecoxib and/or Fmoc-l-Leucine and its cytotoxicity for normal and cancer human cell lines.
Topics: Antineoplastic Agents; Biotinylation; Celecoxib; Cell Line; Cell Survival; Cyclooxygenase 2 Inhibitors; Dendrimers; Humans; Leucine; Neoplasms; PPAR gamma | 2018 |
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
Topics: Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Drug Design; Humans; Leucine; Neoplasms; Protease Inhibitors; Structure-Activity Relationship; Triazoles | 2019 |
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; HEK293 Cells; Humans; Leucine; Leucine-tRNA Ligase; Mechanistic Target of Rapamycin Complex 1; Neoplasms; Signal Transduction; Structure-Activity Relationship | 2019 |
Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation.
Topics: Animals; Body Weight; Cachexia; Diet; Eating; Female; Leucine; Male; Mothers; Muscle Proteins; Muscle, Skeletal; Muscles; Neoplasms; Organ Size; Pregnancy; Proteolysis; Rats; Rats, Wistar | 2019 |
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Topics: Animals; Antineoplastic Agents; CD13 Antigens; Cell Line, Tumor; Drug Design; Humans; Inhibitory Concentration 50; Leucine; Molecular Docking Simulation; Neoplasms; Protease Inhibitors; Swine | 2013 |
[Leucine sensing in the regulation of autophagy: glutamate dehydrogenase is on the way].
Topics: Autophagy; Glutamate Dehydrogenase; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Multiprotein Complexes; Neoplasms; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. I. Biologic studies.
Topics: Bacteria; Biological Products; Diazooxonorleucine; Fungi; Humans; Leucine; Neoplasms | 1956 |
6-Diazo-5-oxo-L-norleucine, a new tumor-inhibitory substance. V. Microbiologic studies of mode of action.
Topics: Antineoplastic Agents; Diazooxonorleucine; Escherichia coli; Leucine; Neoplasms | 1957 |
Synthesis of novel lipoamino acid conjugates of sapienic acid and evaluation of their cytotoxicity activities.
Topics: Amino Acids; Cell Line, Tumor; Cosmetics; Humans; Isoleucine; Leucine; Lipids; Neoplasms; Palmitic Acids; Sunscreening Agents; Ultraviolet Rays | 2014 |
[Plasma amino acid profiling of "same symptom for different disease" in Uyghur medicine based on high-performance liquid chromatography].
Topics: Amino Acids; Arginine; Aspartic Acid; Chromatography, High Pressure Liquid; Cystine; Humans; Isoleucine; Leucine; Medicine, Chinese Traditional; Neoplasms; Serine; Tyrosine; Valine | 2014 |
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Endothelial Cells; Leucine; MAP Kinase Signaling System; Mice; Neoplasms; Neovascularization, Pathologic; Sulfonamides; TRPV Cation Channels; Up-Regulation | 2015 |
Anti-Human VEGF Repebody Effectively Suppresses Choroidal Neovascularization and Vascular Leakage.
Topics: Amino Acid Sequence; Angiogenesis Inhibitors; Animals; Antibodies; Cell Movement; Cell Proliferation; Choroidal Neovascularization; Diabetic Retinopathy; Extracellular Signal-Regulated MAP Kinases; Human Umbilical Vein Endothelial Cells; Humans; Leucine; Macular Degeneration; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Neoplasms; Peptide Library; Signal Transduction; Surface Plasmon Resonance; Vascular Endothelial Growth Factor A | 2016 |
Nutritional leucine supplementation attenuates cardiac failure in tumour-bearing cachectic animals.
Topics: Animals; Apoptosis; Biomarkers; Body Weight; Cachexia; Dietary Supplements; Disease Models, Animal; Electrocardiography; Heart Failure; Leucine; Male; Neoplasms; Nutrition Therapy; Rats | 2016 |
Molecular dynamics simulation and free energy landscape methods in probing L215H, L217R and L225M βI-tubulin mutations causing paclitaxel resistance in cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Drug Resistance, Neoplasm; Humans; Leucine; Microtubules; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Paclitaxel; Point Mutation; Thermodynamics; Tubulin; Tubulin Modulators | 2016 |
Leucine-rich diet alters the
Topics: Animals; Cachexia; Cell Line, Tumor; Diet; Female; Leucine; Metabolome; Neoplasm Transplantation; Neoplasms; Rats, Wistar; Tumor Burden | 2016 |
Potential urinary biomarkers of nephrotoxicity in cyclophosphamide-treated rats investigated by NMR-based metabolic profiling.
Topics: Animals; Biomarkers; Cyclophosphamide; Humans; Isoleucine; Kidney; Leucine; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Metabolomics; Neoplasms; Rats; Taurine; Valine | 2017 |
Targeting a novel N-terminal epitope of death receptor 5 triggers tumor cell death.
Topics: Antibodies, Monoclonal; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Survival; Epitopes; HeLa Cells; Humans; Jurkat Cells; Leucine; Neoplasms; Protein Structure, Tertiary; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Proteins; Software; TNF-Related Apoptosis-Inducing Ligand | 2010 |
Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells.
Topics: Caspase 9; Caspases; Enzyme Activation; Gene Silencing; Granzymes; HeLa Cells; Humans; Hydrolysis; Inhibitor of Apoptosis Proteins; Jurkat Cells; Leucine; Microtubule-Associated Proteins; Neoplasms; RNA Interference; Survivin; Two-Hybrid System Techniques; X-Linked Inhibitor of Apoptosis Protein | 2010 |
Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis.
Topics: Apoptosis; Blotting, Western; Caspase 8; Cell Line, Tumor; Cycloheximide; Dose-Response Relationship, Drug; Humans; Inhibitor of Apoptosis Proteins; Leucine; Neoplasms; Protein Synthesis Inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Tumor Necrosis Factor; RNA Interference; Tumor Necrosis Factor-alpha; U937 Cells; Ubiquitination | 2010 |
The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.
Topics: Animals; Antineoplastic Agents; Binding Sites; CD13 Antigens; Cell Line, Tumor; Computer-Aided Design; Drug Design; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Leucine; Mice; Neoplasms; Oligopeptides; Structure-Activity Relationship; Swine | 2010 |
Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; CDX2 Transcription Factor; Cohort Studies; Deoxyribonucleases, Type II Site-Specific; Female; Genetic Predisposition to Disease; Genotype; Haplotypes; Homeodomain Proteins; Humans; Leucine; Male; Middle Aged; Mortality; Neoplasms; Netherlands; Odds Ratio; Polymorphism, Genetic; Receptors, Calcitriol; Risk Assessment; Risk Factors; White People | 2011 |
LYP3, a new bestatin derivative for aminopeptidase N inhibition.
Topics: CD13 Antigens; Cell Line, Tumor; Humans; Leucine; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Molecular Targeted Therapy; Neoplasms; Solubility | 2011 |
Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex.
Topics: Animals; Arginine; beta-Galactosidase; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Transfer Techniques; Genetic Therapy; Humans; Leucine; Lysine; Mice; Mice, Inbred BALB C; Neoplasms; Polyethyleneimine | 2011 |
Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice.
Topics: Amino Acids; Animals; Cachexia; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Muscle Proteins; Muscles; Neoplasm Transplantation; Neoplasms | 2011 |
Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex.
Topics: Animals; Arginine; Female; Gene Expression; Humans; Leucine; Lysine; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasms; Polypropylenes | 2011 |
Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.
Topics: Antineoplastic Agents; CD13 Antigens; Cell Proliferation; Humans; Leucine; Models, Molecular; Neoplasms; Protease Inhibitors; Serine; Structure-Activity Relationship; Tumor Cells, Cultured | 2012 |
Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation.
Topics: Disease Progression; Humans; Inflammation; Leucine; Neoplasms; Proteoglycans | 2012 |
Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biological Transport; Cell Line; Fluorine Radioisotopes; Gene Expression Regulation, Neoplastic; Humans; Large Neutral Amino Acid-Transporter 1; Leucine; Mice; Neoplasms; Positron-Emission Tomography; Tyrosine; Up-Regulation | 2012 |
Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.
Topics: Animals; Cell Adhesion Molecules; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; Glioblastoma; Host Specificity; Host-Pathogen Interactions; Humans; Leucine; Mammalian orthoreovirus 3; Molecular Sequence Data; Mutation; Neoplasms; Oncolytic Virotherapy; Protein Multimerization; Receptors, Cell Surface; Receptors, Virus; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Viral Proteins; Virus Internalization | 2012 |
Leukotriene A4 signaling, inflammation, and cancer.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Arachidonate 5-Lipoxygenase; Cell Transformation, Neoplastic; Cyclooxygenase Inhibitors; Disease Models, Animal; Epoxide Hydrolases; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Leucine; Leukotriene A4; Neoplasms; Signal Transduction; Up-Regulation | 2003 |
Integrin beta3 Leu33Pro homozygosity and risk of cancer.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Animals; Cytosine; Denmark; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Integrin beta3; Leucine; Male; Middle Aged; Neoplasm Invasiveness; Neoplasms; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proline; Proportional Hazards Models; Prospective Studies; Registries; Risk Assessment; Risk Factors; Thymine | 2003 |
Effect of D(+)-leucine on the hydrolysis of glycil-L-leucine in normal and neoplastic tissues.
Topics: Humans; Hydrolysis; Leucine; Neoplasms | 1952 |
Alterations in calcium metabolism in cancer patients treated with 6-diazo-5-oxo-L-norleucine.
Topics: Calcium; Diazooxonorleucine; Leucine; Neoplasms; Water-Electrolyte Balance | 1956 |
Studies of a plasma-cell neoplasm of the mouse. I. Characterization of neoplasm 70429, including its sensitivity to various antimetabolites with the rapid development of resistance to azaserine, DON, and N-methylformamide.
Topics: Amides; Animals; Antimetabolites; Antineoplastic Agents; Azaserine; Formamides; Leucine; Mice; Neoplasms; Neoplasms, Experimental; Serine | 1957 |
Active transport of O-diazoacetyl-L-serine and 6-diazo-5-oxo-L-norleucine in Ehrlich ascites carcinoma.
Topics: Antineoplastic Agents; Ascites; Azaserine; Biological Transport, Active; Carcinoma; Diazooxonorleucine; Leucine; Neoplasms; Serine | 1957 |
The in vitro incorporation of C14-leucine into the proteins of tumor microsomes and a note on the properties of isolated tumor mitochondria.
Topics: In Vitro Techniques; Leucine; Microsomes; Mitochondria; Neoplasms; Proteins | 1957 |
Cytochemical effects of azaserine and DON on ribonucleic acid of Ehrlich ascites tumor cells.
Topics: Animals; Antineoplastic Agents; Azaserine; Biochemical Phenomena; Carcinoma, Ehrlich Tumor; Diploidy; Leucine; Neoplasms; RNA | 1958 |
Leucine aminopeptidase activity; observations in patients with cancer of the pancreas and other diseases.
Topics: Encephalomyelitis; Leucine; Leucyl Aminopeptidase; Neoplasms; Pancreas; Pancreatic Neoplasms; Peptide Hydrolases | 1958 |
Concentrative uptake of 6-diazo-5-oxo-L-norleucine by sarcoma 180, liver and muscle in vivo.
Topics: Animals; Antineoplastic Agents; Diazooxonorleucine; Encephalomyelitis; Leucine; Liver; Muscles; Neoplasms; Sarcoma 180 | 1958 |
Variation in resistance patterns in different neoplasms.
Topics: Animals; Antineoplastic Agents; Biochemical Phenomena; Folic Acid Antagonists; Leucine; Neoplasms; Neoplasms, Experimental; Serine | 1958 |
A CLINICAL study of the comparative effect of nitrogen mustard and DON in patients with bronchogenic carcinoma, Hodgkin's disease, lymphosarcoma, and melanoma.
Topics: Antineoplastic Agents; Carcinoma, Bronchogenic; Hodgkin Disease; Humans; Leucine; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Melanoma; Neoplasms | 1959 |
[Behavior of leucine aminopeptidase activity in blood serum in patients with malignant tumors in the mouth and neck area].
Topics: Endopeptidases; Head and Neck Neoplasms; Humans; Leucine; Leucyl Aminopeptidase; Mouth Neoplasms; Neoplasms; Peptide Hydrolases; Serum | 1959 |
Resistance in L1210 ascites without change in concentrative uptake of o-diazoacetyl-L-serine or 6-diazo-5-oxo-L-norleucine.
Topics: Antineoplastic Agents; Ascites; Azaserine; Diazooxonorleucine; Leucine; Neoplasms; Serine | 1959 |
Possible role of potentiators in radiation therapy.
Topics: Biochemical Phenomena; DNA; Leucine; Neoplasms; Pyrimidines; Triethylenemelamine | 1961 |
[Leucine aminopeptidase activity in the urine of patients with malignant tumors].
Topics: Body Fluids; Endopeptidases; Humans; Hydrolases; Leucine; Leucyl Aminopeptidase; Neoplasms; Peptide Hydrolases | 1960 |
Potential anti-cancer agents--II. A proposed mechanism for the anti-cancer action of L-azaserine and 6-diazo-5-oxo-L-norleucine.
Topics: Antineoplastic Agents; Azaserine; Diazooxonorleucine; Leucine; Neoplasms; Serine | 1959 |
[Determination of leucine aminopeptidase activity in the sera of healthy and sick persons; preliminary report].
Topics: Hematologic Diseases; Leucine; Leucyl Aminopeptidase; Neoplasms; Oxidation-Reduction; Peptide Hydrolases | 1959 |
[Research on the modification of amino-peptidase in the blood of healthy subjects and tumor patients by D-leucine and D-leucyl-glycyl-glycine].
Topics: Endopeptidases; Glycine; Healthy Volunteers; Humans; Hydrolases; Leucine; Neoplasms; Oligopeptides; Peptide Hydrolases | 1961 |
PEPITASE ACTIVITIES IN TISSUES OF TUMOR-BEARING RATS.
Topics: Animals; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Erythrocytes; Glycine; Leucine; Liver; Liver Neoplasms; Muscles; Neoplasms; Neoplasms, Experimental; Peptide Hydrolases; Peptides; Proline; Rats; Research; Sarcoma; Sarcoma, Experimental | 1963 |
[THE LEUCINE AMINOPEPTIDASE. ITS IMPORTANCE IN THE DIAGNOSIS OF BILIARY DISEASES AND IN CASES OF NEOPLASM OF THE HEAD OF THE PANCREAS].
Topics: Aminopeptidases; Blood; Clinical Enzyme Tests; Clinical Laboratory Techniques; Diagnosis, Differential; Jaundice; Jaundice, Obstructive; Leucine; Leucyl Aminopeptidase; Liver Diseases; Neoplasms; Pancreatic Neoplasms | 1963 |
[CONTRIBUTION TO THE STUDY OF RIBONUCLEOPROTEINS OF NORMAL AND NEOPLASTIC TISSUES].
Topics: Alanine; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Glutamates; Glycine; Isoleucine; Leucine; Liver; Lysine; Mice; Neoplasm Proteins; Neoplasms; Nucleoproteins; Phenylalanine; Rats; Research; Ribonucleoproteins; RNA; RNA, Neoplasm; Serine; Threonine; Tyrosine; Valine | 1963 |
[ACTION OF METABOLIC INHIBITORS ON ENERGY METABOLISM AND ON PROTEIN SYNTHESIS OF TUMOR AND EMBRYONAL CELLS].
Topics: Adenosine Triphosphate; Amino Acids; Antimetabolites; Carcinoma, Hepatocellular; Cell Biology; Chick Embryo; Dinitrophenols; Embryo, Mammalian; Embryo, Nonmammalian; Energy Metabolism; Glycine; Hexoses; Leucine; Liver Neoplasms; Manometry; Metabolism; Neoplasms; Neoplasms, Experimental; Pharmacology; Protein Biosynthesis; Proteins; Rats; Research | 1963 |
[AUTORADIOGRAPHIC STUDIES ON DNA SYNTHESIS IN BIOPSY TUMOR TISSUE IN MAN].
Topics: Autoradiography; Biopsy; Bronchial Neoplasms; DNA; DNA, Neoplasm; Humans; Laryngeal Neoplasms; Leucine; Male; Neoplasms; Paranasal Sinus Neoplasms; Research; Skin Neoplasms; Tongue Neoplasms; Tritium | 1963 |
NUCLEIC ACID-DEPENDENT INCORPORATION OF LEUCINE IN CHROMATOGRAPHICALLY FRACTIONATED EXTRACTS OF ESCHERICHIA COLI.
Topics: Adenosine Triphosphate; Bacterial Proteins; Chromatography; Dactinomycin; DNA; DNA, Neoplasm; DNA, Viral; Escherichia coli; Leucine; Neoplasms; Nucleic Acids; Pharmacology; Proteins; Research; RNA; RNA, Viral | 1963 |
HOST-TUMOR-DRUG RELATIONSHIPS IN EXPERIMENTAL CHEMOTHERAPY SYSTEMS WITH ALLOGENEIC AND XENOGENEIC HOST-TUMOR COMBINATIONS.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaserine; Carcinoma, Squamous Cell; Chelating Agents; Cortisone; Leucine; Mercaptopurine; Mice; Neoplasms; Neoplasms, Experimental; Rats; Research; Sarcoma 180; Streptomycin; Thioguanine; Transplantation | 1964 |
STUDIES ON DIPEPTIDASES AND AMINOPEPTIDASES. I. DISTINCTION BETWEEN LEUCINE AMINOPEPTIDASE AND ENZYMES THAT HYDROLYZE L-LEUCYL-BETA-NAPHTHYLAMIDE.
Topics: Amides; Amidohydrolases; Aminopeptidases; Animals; Carcinoma, Ehrlich Tumor; Chromatography; Dipeptidases; Kidney; Leucine; Leucyl Aminopeptidase; Naphthalenes; Neoplasms; Research | 1963 |
[ACTION OF THE ETHYL ESTER OF LEUCINE ON THE GROWTH OF HUMAN NEOPLASTIC CELLS IN VITRO].
Topics: Cell Division; In Vitro Techniques; Leucine; Neoplasms; Pharmacology; Proteins; Tissue Culture Techniques | 1963 |
A TRANSPORT SYSTEM SERVING FOR MONO- AND DIAMINO ACIDS.
Topics: Amino Acids; Aminobutyrates; Aminoisobutyric Acids; Arginine; Asparagine; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Glutamine; Glycine; Leucine; Lysine; Neoplasms; Ornithine; Phenylalanine; Proteins; Research | 1964 |
EVIDENCE FOR MESSENGER ACTIVITY OF ALIEN RIBONUCLEIC ACID IN CHICK CELLS.
Topics: Chick Embryo; Dactinomycin; Leucine; Metabolism; Neoplasms; Nucleotides; Pharmacology; Phenylalanine; Proteins; RNA; RNA, Bacterial; RNA, Messenger; RNA, Neoplasm | 1964 |
FREE AMINO ACIDS OF HUMAN BREAST CANCER.
Topics: Amino Acids; Asparagine; Aspartic Acid; Breast Neoplasms; Chromatography; Citrulline; Glutamates; Glutamine; Glycine; Humans; Isoleucine; Leucine; Liver Neoplasms; Lung Neoplasms; Mice; Neoplasms; Neoplasms, Experimental; Phenylalanine; Proline; Research; Serine; Threonine; Tyrosine | 1964 |
THE EFFECT OF NITROGEN MUSTARD ON THE LIFE CYCLE OF EHRLICH ASCITES TUMOR CELLS IN VIVO.
Topics: Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Cystine; DNA; DNA, Neoplasm; Leucine; Mechlorethamine; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Peritoneal Neoplasms; Pharmacology; Research; Thymidine; Tissue Culture Techniques | 1964 |
INHIBITION OF DNA SYNTHESIS IN MAMMALIAN CELLS BY ACTIDIONE.
Topics: Adenine; Adenine Nucleotides; Anti-Bacterial Agents; Aspartic Acid; Carbon Isotopes; Carcinoma, Squamous Cell; Cycloheximide; Cytosine Nucleotides; DNA; DNA Replication; DNA, Neoplasm; Formates; Glycine; Guanine Nucleotides; Leucine; Metabolism; Neoplasms; Nucleosides; Nucleotides; Nucleotidyltransferases; Orotic Acid; Pharmacology; Research; RNA; RNA, Neoplasm; Thymidine; Tissue Culture Techniques; Tritium | 1964 |
EFFECT OF HYDROCORTISONE ON AMINO ACID INCORPORATION BY MICROSOMES ISOLATED FROM MOUSE LYMPHOMA ML-388 CELLS AND RAT THYMUS.
Topics: Amino Acids; Animals; Hydrocortisone; Leucine; Lymphoma; Mice; Microsomes; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Rats; Research; RNA; RNA, Messenger; Thymus Gland | 1964 |
EFFECT OF 5',5',5'-TRIFLUOROLEUCINE ON A NUMBER OF MOUSE LEUKAEMIAS.
Topics: Amino Acids; Animals; Chromatography; Hair; Leucine; Leukemia; Leukemia, Experimental; Leukemia, Lymphoid; Liver; Lymphoma; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Pharmacology; Proteins; Research; Skin | 1964 |
[ACTION OF THE ESTER AND ACETYL DERIVATIVES OF LEUCINE ON THE GROWTH IN VITRO OF HUMAN TUMORAL ELEMENTS].
Topics: In Vitro Techniques; Leucine; Neoplasms; Pharmacology; Physiological Phenomena; Research; Tissue Culture Techniques | 1963 |
STUDIES OF EPIDERMAL PROTEIN METABOLISM. 3. PROTEIN SYNTHESIS IN AN EPIDERMAL CARCINOMA IN VIVO AND IN VITRO.
Topics: Carbon Isotopes; Cricetinae; Histological Techniques; In Vitro Techniques; Leucine; Liver; Magnesium; Microsomes; Neoplasm Proteins; Neoplasms; Neoplasms, Experimental; Pharmacology; Phenylalanine; Proteins; Research; Ribosomes; Skin Neoplasms; Uracil Nucleotides | 1965 |
[ON THE EFFECTIVENESS OF THE CRYSTALLIZATION OF L-LEUCINE IN CONTACT WITH SERA FROM CANCER PATIENTS AS A MEANS OF CANCER DIAGNOSIS].
Topics: Blood; Crystallization; Crystallography; Humans; Leucine; Neoplasms | 1964 |
[Variations in the electrophoretic behavior of peptidases from normal and neoplastic tissues].
Topics: Electrophoresis; Endopeptidases; Humans; Hydrolases; Leucine; Neoplasms; Peptide Hydrolases | 1955 |
Antibiotic activity of Leu-Lys rich model peptides.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Erythrocytes; Fungi; Hemolysis; Humans; Leucine; Lysine; Microbial Sensitivity Tests; Neoplasms; Peptide Fragments | 2003 |
Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chromatography, High Pressure Liquid; Dipeptides; Fluorometry; Humans; Hydrolysis; Indicators and Reagents; Leucine; Melphalan; Neoplasms; Oligopeptides; Peptide Hydrolases; Prodrugs; Protease Inhibitors | 2003 |
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Topics: Actins; Anaphase-Promoting Complex-Cyclosome; Antibodies, Monoclonal; Basic Helix-Loop-Helix Transcription Factors; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leucine; Lysine; Models, Molecular; Mutation; Mutation, Missense; Neoplasms; Peptides; Plasmids; Proline; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Time Factors; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin; Ubiquitin-Protein Ligase Complexes; Ubiquitin-Protein Ligases; Von Hippel-Lindau Tumor Suppressor Protein | 2005 |
A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.
Topics: Aminopeptidases; Animals; Antibiotics, Antineoplastic; Capillaries; Cell Line; Cell Movement; Cell Survival; Endothelial Cells; Extracellular Matrix; Humans; Leucine; Melanoma, Experimental; Mice; Neoplasm Invasiveness; Neoplasms; Protease Inhibitors; Wound Healing | 2006 |
Can mutations in gamma-actin modulate the toxicity of microtubule targeting agents?
Topics: Actins; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leucine; Microtubules; Mutation; Neoplasms; Proline; RNA, Small Interfering; Tubulin; Tubulin Modulators; Valine; Vincristine | 2006 |
Effect of branched-chain amino acids on muscle atrophy in cancer cachexia.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids, Branched-Chain; Animals; Cachexia; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Eukaryotic Initiation Factors; Leucine; Mice; Mice, Inbred Strains; Muscular Atrophy; Myoblasts; Neoplasms; Phosphoproteins; Phosphorylation; Protein Kinases; Proteoglycans; Time Factors; Valine | 2007 |
Small molecules destabilize cIAP1 by activating auto-ubiquitylation.
Topics: Antineoplastic Agents; Apoptosis; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Leucine; Neoplasms; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Ubiquitin; Ubiquitination | 2008 |
Protein synthesis in muscle measured in vivo in cachectic patients with cancer.
Topics: Aged; Cachexia; Carcinoma, Bronchogenic; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Kidney Neoplasms; Leucine; Lung Neoplasms; Male; Middle Aged; Muscle Proteins; Neoplasms; Protein Biosynthesis; Wilms Tumor | 1984 |
A possible biochemical basis for the use of hyperthermia in the treatment of cancer and virus infection.
Topics: Enzyme Activation; Fever; Heme; Hot Temperature; Humans; Interferons; Leucine; Neoplasms; Protein Biosynthesis; Protein Kinases | 1981 |
Chemically defined immunotherapeutic agents.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Benzimidazoles; Cimetidine; Ditiocarb; Humans; Hypoxanthines; Inosine Pranobex; Leucine; Levamisole; Mice; Neoplasms; Pyran Copolymer; Tuftsin | 1983 |
The immunopharmacology of synthetic immunomodulators.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Aziridines; Ditiocarb; Glucans; Humans; Hypoxanthines; Immunity; Inosine Pranobex; Interferon Inducers; Leucine; Levamisole; Lynestrenol; Neoplasms | 1983 |
Application of radioactive precursors for the evaluation of sensitivity of cancer cells to anticancer drugs.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cell Survival; DNA Repair; Drug Evaluation, Preclinical; Drug Resistance; Female; Gastrointestinal Neoplasms; Humans; Leucine; Male; Mice; Middle Aged; Neoplasm Transplantation; Neoplasms; Prognosis; Thymidine; Tritium; Uridine | 1984 |
Kinetic parameters of neutral amino acid transport in hybrids between malignant and non-malignant cells.
Topics: Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Humans; Hybrid Cells; Kinetics; Leucine; Mice; Neoplasms; Sodium | 1984 |
Leucine metabolism in patients with malignant disease.
Topics: Body Weight; Carbon Dioxide; Fasting; Female; Glucose; Humans; Kinetics; Leucine; Male; Neoplasms; Oxidation-Reduction; Starvation; Time Factors | 1981 |
Protein metabolism in the tumour-bearing host.
Topics: Animals; Carcinoma 256, Walker; Humans; Leucine; Liver; Muscle Proteins; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Proteins | 1980 |
[Study on the antitumor effect of an inhibitor against cell surface enzyme (Bestatin)].
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mitogens; Neoplasms; T-Lymphocytes | 1982 |
The relationships between enzyme inhibitors and function of mammalian cells.
Topics: Animals; Arthritis; Binding, Competitive; Cell Membrane; Chickens; Humans; Leucine; Mice; Muscular Dystrophy, Animal; Neoplasms; Peptide Hydrolases; Protease Inhibitors | 1981 |
Increased granulocyte phagocytosis after oral administration of bestatin, a new immunomodulator.
Topics: Adjuvants, Immunologic; Adult; Aged; Female; Granulocytes; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Neoplasms; Phagocytosis | 1982 |
Characterization and use of an allotype-specific monoclonal antibody to placental alkaline phosphatase in the study of cancer-related phosphatase polymorphism.
Topics: Alkaline Phosphatase; Alleles; Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hybridomas; Kinetics; Leucine; Mice; Mice, Inbred BALB C; Neoplasms; Phenotype; Phenylalanine; Placenta; Polymorphism, Genetic; Pregnancy | 1982 |
Influence of Bestatin, a new immunomodulator, on various functions of human monocytes.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Cell Movement; Chemotaxis, Leukocyte; Cytotoxicity, Immunologic; Female; Humans; In Vitro Techniques; Leucine; Male; Middle Aged; Monocytes; Neoplasms; Nitroblue Tetrazolium; Phagocytosis | 1982 |
Bestatin treatment and the peripheral lymphocyte population in cancer patients.
Topics: Adjuvants, Immunologic; Antibiotics, Antineoplastic; Cells, Cultured; Humans; Killer Cells, Natural; Leucine; Lymphocytes; Neoplasms; Streptomyces | 1980 |
Correction of immunodeficiency in aged mice by levamisole and bestatin administration.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibody-Dependent Cell Cytotoxicity; Immunologic Deficiency Syndromes; Leucine; Levamisole; Lymphocytes; Macrophages; Mice; Neoplasms | 1980 |
Penetration of substances into tumor tissue--a methodological study on cellular spheroids.
Topics: Albumins; Biological Transport; Cell Line; Clone Cells; Fluorouracil; Glioma; Humans; Leucine; Models, Biological; Neoplasms; Thymidine; Vinblastine | 1981 |
Bestatin treatment of human lymphocytes increases the frequency of sheep red blood cell-binding cells.
Topics: Adjuvants, Immunologic; Adult; Animals; Erythrocytes; Humans; Leucine; Lymphocytes; Neoplasms; Rosette Formation; Sheep | 1981 |
Tumour induction of host leucine starvation.
Topics: Amino Acids; Animals; Biological Transport, Active; Humans; Leucine; Models, Biological; Muscles; Neoplasms | 1981 |
Oxidation and metabolic interconversion in malignant cachexia.
Topics: Amino Acids; Cachexia; Energy Metabolism; Fatty Acids; Gluconeogenesis; Glucose; Humans; Leucine; Neoplasms; Oxidation-Reduction; Proteins | 1981 |
Changes of the blood lymphocyte population in cancer patients treated with bestatin, a new immunomodulator. A phase I study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Cytotoxicity, Immunologic; Drug Evaluation; Female; Humans; Leucine; Leukocyte Count; Lymphocytes; Male; Middle Aged; Neoplasms; Phytohemagglutinins; Rosette Formation | 1980 |
Whole body protein metabolism in children with cancer.
Topics: Adolescent; Amino Acids; Carbon Isotopes; Child; Child, Preschool; Deuterium; Female; Humans; Kinetics; Leucine; Male; Neoplasms; Phenylalanine; Protein Biosynthesis; Proteins; Tyrosine | 1996 |
HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; Cytoskeletal Proteins; Haplorhini; Humans; Kidney; Leucine; Mice; Mitosis; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Neoplasms; Nuclear Proteins; Organ Specificity; RNA, Messenger; RNA, Neoplasm; Sequence Analysis, DNA; Tumor Cells, Cultured | 1997 |
Characterization of the murine 5T4 oncofoetal antigen: a target for immunotherapy in cancer.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Blotting, Western; Cell Division; Cell Line; Cell Membrane; Cell Movement; Cell Separation; Cytoskeleton; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Epitopes; Flow Cytometry; Humans; Immunohistochemistry; Immunotherapy; Leucine; Membrane Glycoproteins; Mice; Microscopy, Fluorescence; Neoplasms; Precipitin Tests; Rats; Recombinant Fusion Proteins | 2002 |
Skeletal muscle metabolism in patients with malignant tumor.
Topics: Acid Phosphatase; Aged; Alcohol Oxidoreductases; Cathepsins; Electron Transport Complex IV; Female; Glucose; Glucosephosphate Dehydrogenase; Glucuronidase; Hexokinase; Humans; L-Lactate Dehydrogenase; Leucine; Male; Middle Aged; Muscle Proteins; Muscles; Neoplasm Proteins; Neoplasms; Phosphofructokinase-1; Phosphorylases; RNA, Neoplasm | 1976 |
Isozyme patterns of branched-chain amino acid transaminase in human tissues and tumors.
Topics: Animals; Binding, Competitive; Carcinoma, Hepatocellular; Female; Fetus; Humans; In Vitro Techniques; Isoenzymes; Isoleucine; Kidney Neoplasms; Leucine; Liver Neoplasms; Male; Neoplasms; Rats; Species Specificity; Stomach Neoplasms; Substrate Specificity; Tissue Distribution; Transaminases; Valine | 1977 |
[Experimental and clinical application of amino acid imbalance for the treatment of malignant diseases, with special reference to phenylalanine imbalance (author's transl)].
Topics: Adult; Amino Acids; Animals; Blood Cell Count; Carcinoma, Ehrlich Tumor; Child; Female; Humans; Leucine; Leukemia, Myeloid; Liver; Male; Mice; Neoplasm Proteins; Neoplasms; Organ Size; Phenylalanine; Phenylalanine Hydroxylase | 1977 |
Assay of leucine aminotransferase in rat tissues and tumors.
Topics: Amino Acids, Branched-Chain; Animals; Carbon Dioxide; Female; In Vitro Techniques; Ketoglutaric Acids; Leucine; Neoplasms; Pregnancy; Rats; Rats, Inbred Strains; Spectrophotometry; Transaminases | 1978 |
L-leucine sensitive alkaline phosphatase isozyme from cancer tissue.
Topics: Alkaline Phosphatase; Drug Stability; Edetic Acid; Female; Hot Temperature; Humans; Isoenzymes; Kinetics; Leucine; Neoplasms; Phenylalanine; Placenta; Precipitin Tests; Pregnancy | 1975 |
A rapid assay for stimulation of human lymphocytes by tumor-associated antigens.
Topics: Antigens, Neoplasm; Carcinoma; Female; Hemagglutination Tests; Hemocyanins; Humans; Leucine; Lung; Lung Neoplasms; Lymphocyte Activation; Lymphocytes; Male; Melanoma; Neoplasm Proteins; Neoplasms; Protein Biosynthesis; Sarcoma; Skin Tests; Thymidine | 1976 |
Aminopeptidases and arylamidases in normal and cancer tissues in humans.
Topics: Alanine; Amides; Aminopeptidases; Colon; Digestive System; Humans; Ileum; Kidney; Leucine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Methionine; Naphthalenes; Neoplasms; Phenylalanine; Rectum; Stomach; Stomach Neoplasms | 1975 |
Leucine kinetics in patients with benign disease, non-weight-losing cancer, and cancer cachexia: studies at the whole-body and tissue level and the response to nutritional support.
Topics: Adult; Aged; Aged, 80 and over; Cachexia; Clinical Protocols; Fat Emulsions, Intravenous; Female; Humans; Hydrocortisone; Insulin; Intraoperative Period; Kinetics; Leucine; Male; Middle Aged; Muscles; Neoplasms; Proteins; Weight Loss | 1991 |
[A clinical study of amino acid metabolism in cancerous hypoproteinemia--the role of branched chain amino acids (BCAA) and appropriate compositions of BCAA in parenteral nutrition].
Topics: Amino Acids; Amino Acids, Branched-Chain; Female; Humans; Hypoproteinemia; Isoleucine; Leucine; Male; Middle Aged; Neoplasms; Nitrogen; Parenteral Nutrition, Total; Prealbumin; Retinol-Binding Proteins; Transferrin; Valine | 1989 |
Immunity, infection, malignancy and aging: possible immunity restoration and tumor prevention.
Topics: Adult; Aged; Aging; Animals; Antibiotics, Antineoplastic; Humans; Immunity; Infections; Leucine; Mice; Middle Aged; Neoplasms | 1989 |
Determination and characterization of succinyl tri-alanine p-nitroanilide hydrolyzing metalloendopeptidase in serum.
Topics: Adult; Aminopeptidases; Anti-Bacterial Agents; Cholestasis; Chromatography, High Pressure Liquid; Diabetes Mellitus; Endopeptidases; Female; Glycopeptides; Humans; Immunodiffusion; Kidney; Leucine; Male; Metalloendopeptidases; Neoplasms; Oligopeptides; Peptides; Protease Inhibitors | 1987 |
Lysis of fresh solid tumor targets in the presence of Con A is mediated primarily by Leu 7+ peripheral blood T lymphocytes: blocking by the anti-CD3 monoclonal antibody and comparison with recombinant interleukin 2-induced lysis by natural killer cells.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Concanavalin A; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; Interleukin-2; Killer Cells, Natural; Leucine; Neoplasms; Phytohemagglutinins; T-Lymphocytes | 1987 |
Immunomodulating properties of bestatin in cancer patients. A phase II trial.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; Drug Evaluation; Humans; Leucine; Neoplasms; T-Lymphocytes | 1986 |
Imbalance of T cell subsets in cancer patients and its modification with bestatin, a small molecular immunomodifier.
Topics: Adjuvants, Immunologic; Aged; Antibodies, Monoclonal; Female; Fluorescent Antibody Technique; Homeostasis; Humans; Leucine; Male; Middle Aged; Neoplasms; T-Lymphocytes | 1985 |
Tumour-host metabolic interaction and cachexia.
Topics: Amino Acids; Cachexia; Cell Division; Humans; Leucine; Models, Biological; Neoplasm Proteins; Neoplasms | 1985 |
[Clinical studies on serum leucyl glycyl glycine hydrolyzing enzyme in cancer. I].
Topics: Adult; Aged; Carcinoma, Hepatocellular; Cobalt; Edetic Acid; Electrophoresis; Female; Glycine; Hepatitis; Humans; Leucine; Liver Neoplasms; Male; Manganese; Middle Aged; Neoplasms; Peptide Hydrolases; Pregnancy | 1971 |
The biological significance of turnover of the surface membrane of animal cells.
Topics: Adenoviridae; Animals; Carbon Isotopes; Carcinoma; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Depression, Chemical; Glucosamine; Glucose; In Vitro Techniques; L Cells; Leucine; Mice; Mitosis; Mouth Neoplasms; Neoplasms; Simian virus 40; Surface Properties; Valine; Vinblastine | 1969 |
Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice.
Topics: Animals; Colonic Neoplasms; Dimethylhydrazines; Endoplasmic Reticulum; Hydrazines; Kidney Neoplasms; Lethal Dose 50; Leucine; Liver; Male; Mice; Mitochondria; Monomethylhydrazine; Neoplasms; Neoplasms, Experimental; Rats; Ribosomes | 1974 |
Specific inhibition of DNA synthesis by cyclocytidine.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cells, Cultured; Cyclization; Cytidine; Depression, Chemical; DNA; Leucine; Leukemia L1210; Mice; Neoplasms; Thymidine; Uridine | 1972 |
Plateau-phase cultures of mammalian cells: an in vitro model for human cancer.
Topics: Animals; Antineoplastic Agents; Carbon Isotopes; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Contact Inhibition; Cricetinae; Culture Media; DNA; Humans; Leucine; Liver; Mitosis; Models, Biological; Neoplasms; Proteins; Radiation-Sensitizing Agents; RNA; Sulfhydryl Compounds; Thymidine; Time Factors; Tritium; Uridine; Valine | 1972 |
Phenotypes of the Regan isoenzyme and identity between the placental D-variant and the Nagao isoenzyme.
Topics: Alkaline Phosphatase; Electrophoresis, Starch Gel; Female; Genetic Variation; Humans; Isoenzymes; Leucine; Neoplasms; Phenotype; Placenta; Pregnancy | 1973 |
[The influence of lactic acid on crystallization patterns in cancer diagnosis. I. Cryoscopic measurements and studies on crystallization].
Topics: Alanine; Albumins; Animals; Chemical Phenomena; Chemistry, Physical; Chlorides; Copper; Crystallization; Freezing; Horses; Humans; Hydrogen-Ion Concentration; Lactates; Leucine; Neoplasms | 1973 |
[Effect of acid on crystallizator tests in tumor diagnosis. Cryoscopic measurements and crystallization tests. II. Crystallization studies].
Topics: Acetates; Animals; Blood Donors; Breast Neoplasms; Bronchial Neoplasms; Chlorides; Copper; Crystallization; Female; Horses; Humans; Leucine; Methods; Neoplasms; Serum Albumin; Tuberculosis; Uterine Cervical Neoplasms | 1973 |
[Concentration changes of free amino acids in blood plasma of patients under radiotherapy. (With reference to statistical results)].
Topics: Alanine; Amino Acids; Bronchial Neoplasms; Carcinoma; Cobalt Isotopes; Dysgerminoma; Esophageal Neoplasms; Female; Genital Neoplasms, Female; Hodgkin Disease; Humans; Leucine; Male; Neoplasms; Phenylalanine; Proline; Radiation Injuries; Sex Factors; Statistics as Topic; Tyrosine; Urinary Bladder Neoplasms; Valine | 1972 |
[Clinical studies on serum leucyl glycyl glycine hydrolyzing enzyme in cancer. II].
Topics: Adult; Aged; Amino Acids; Aminopeptidases; Female; Glycine; Humans; Leucine; Leucyl Aminopeptidase; Liver Neoplasms; Male; Neoplasms; Peptide Hydrolases; Peptides; Pregnancy; Protease Inhibitors; Stomach Neoplasms | 1971 |
Amino acid naphthylamidase isozymes in cancer cells and normal cells.
Topics: Aged; Aminopeptidases; Autopsy; Cell Line; Cells, Cultured; Copper; Electrophoresis; Female; Gels; Humans; Isoenzymes; Leucine; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Middle Aged; Naphthalenes; Neoplasm Metastasis; Neoplasms; Starch; Tissue Extracts | 1971 |
The use of selected sulfhydryl inhibitors in a preferential drug attack on cancer.
Topics: Adenocarcinoma; Adult; Agar; Animals; Antineoplastic Agents; Anus Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; DNA; Dogs; Humans; Leucine; Leukocytes; Liver; Mice; Middle Aged; Neoplasms; Neoplasms, Experimental; Parotid Neoplasms; Proteins; Radioisotopes; Rectal Neoplasms; RNA; Sulfhydryl Compounds; Thoracic Neoplasms; Thymidine; Uridine | 1971 |
The erythrocyte plasma distribution of amino acids in health and disease.
Topics: Acute Disease; Adolescent; Adult; Alanine; Amino Acids; Anemia, Hemolytic; Anemia, Pernicious; Bronchitis; Bronchopneumonia; Chromatography, Paper; Erythrocytes; Female; Glutamates; Glutamine; Glycine; Hepatitis; Humans; Hyperthyroidism; Infections; Inflammation; Isoleucine; Leucine; Male; Methionine; Neoplasms; Plasma; Pyelitis; Serine; Threonine; Valine | 1968 |
[Is mutation of mitochondria the cause of malignant degeneration?].
Topics: Animals; Carbon Isotopes; Cricetinae; Cytogenetics; DNA; DNA, Neoplasm; Leucine; Lipids; Mice; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Mutation; Neoplasms; Neoplastic Cells, Circulating; Protein Biosynthesis; Rats | 1968 |
[On the use of the crystallization test in cancer diagnosis].
Topics: Chlorides; Copper; Crystallization; Humans; Leucine; Neoplasms | 1965 |
[On the differences of in vitro incorporation of C14-arginine and C14-leucine in the mitochondrial protein of various tumor and normal tissues].
Topics: Animals; Arginine; Carbon Isotopes; Cattle; In Vitro Techniques; Leucine; Mice; Mitochondria; Neoplasm Proteins; Neoplasms; Poultry; Rats | 1965 |