leucine has been researched along with Anemia, Diamond-Blackfan in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Alhushki, W; Atsidaftos, E; Bernstein, J; Farrar, JE; Glader, B; Gruner, B; Hartung, H; Knoll, C; Lababidi, ML; Lipton, JM; Loew, T; Muir, E; Nalepa, G; Narla, A; Panigrahi, AR; Rogers, ZR; Sieff, CA; Vlachos, A; Walkovich, K | 1 |
| Chakraborty, A; Kenmochi, N; Uechi, T; Yadav, GV | 1 |
| Ear, J; Lin, S; Morimoto, K; Yang, Z; Zhang, B; Zhang, Y | 1 |
| Abayasekara, N; Berliner, N; Ebert, BL; Hurst, SN; Khanna-Gupta, A; Look, AT; Narla, A; Payne, EM; Raiser, DM | 1 |
| Berliner, N; Ebert, BL; Khanna-Gupta, A; Levine, M; Look, AT; Narla, A; Paw, BH; Payne, EM; Sun, H; Virgilio, M | 1 |
| Bryder, D; Debnath, S; Flygare, J; Jaako, P; Karlsson, S; Olsson, K | 1 |
| Boultwood, J; Pellagatti, A; Vuppusetty, C; Wainscoat, JS; Yip, BH | 1 |
| Adam, T; Cmejla, R; Cmejlova, J; Hak, J; Pospisilova, D | 1 |
1 review(s) available for leucine and Anemia, Diamond-Blackfan
| Article | Year |
|---|---|
Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q- syndrome and other ribosomopathies.
Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythroblasts; Gene Expression Regulation; Haploinsufficiency; Humans; Leucine; Protein Biosynthesis; Ribosomal Proteins; Ribosomes; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
1 trial(s) available for leucine and Anemia, Diamond-Blackfan
| Article | Year |
|---|---|
L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond-Blackfan Anemia Registry.
Topics: Adolescent; Adult; Anemia, Diamond-Blackfan; Blood Transfusion; Child; Child, Preschool; Combined Modality Therapy; Feasibility Studies; Female; Follow-Up Studies; Humans; Leucine; Male; Middle Aged; Pilot Projects; Prognosis; Young Adult | 2020 |
6 other study(ies) available for leucine and Anemia, Diamond-Blackfan
| Article | Year |
|---|---|
Ribosomal protein deficiency causes Tp53-independent erythropoiesis failure in zebrafish.
Topics: Anemia, Diamond-Blackfan; Animals; Arginine; Embryo, Nonmammalian; Erythrocyte Count; Erythroid Cells; Erythropoiesis; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Humans; Leucine; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Proteins; Ribosomes; Sirolimus; Tumor Suppressor Protein p53; Zebrafish; Zebrafish Proteins | 2014 |
Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19.
Topics: Anemia, Diamond-Blackfan; Animals; Disease Models, Animal; Erythroid Cells; Humans; Leucine; Mutation; Ribosomal Proteins; Zebrafish; Zebrafish Proteins | 2014 |
L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way.
Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Humans; Leucine; Ribosomal Proteins; Tumor Suppressor Protein p53; Zebrafish Proteins | 2014 |
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway.
Topics: Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Animals, Genetically Modified; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Models, Animal; Embryo, Nonmammalian; Embryonic Development; Hematinics; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leucine; Myelodysplastic Syndromes; Ribosomal Proteins; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Zebrafish; Zebrafish Proteins | 2012 |
Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.
Topics: Anemia, Diamond-Blackfan; Animals; Bone Marrow Cells; Dietary Supplements; Disease Models, Animal; Down-Regulation; Erythrocyte Count; Gene Knockdown Techniques; Hematinics; Hematopoiesis; Hematopoietic Stem Cells; Hemoglobins; Leucine; Mice; Mice, Transgenic; Molecular Targeted Therapy; Ribosomal Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
Successful treatment of a Diamond-Blackfan anemia patient with amino acid leucine.
Topics: Amino Acids, Essential; Anemia, Diamond-Blackfan; Child; Female; Humans; Leucine; Treatment Outcome | 2007 |