leucine has been researched along with Aging in 344 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 178 (51.74) | 18.7374 |
| 1990's | 52 (15.12) | 18.2507 |
| 2000's | 48 (13.95) | 29.6817 |
| 2010's | 55 (15.99) | 24.3611 |
| 2020's | 11 (3.20) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y | 1 |
| Hao, Z; Liu, Y; Tan, R; Xia, Y; Xu, G; Yin, X; Yuan, M | 1 |
| Castro, A; Catai, AM; De Oliveira, JM; Di Medeiros Leal, MCB; Ferreira, AG; Millan-Mattos, JC; Minatel, V; Oliveira, RV; Pantoni, CBF; Rehder-Santos, P; Signini, ÉF | 1 |
| Fischer, AM; Kressig, RW | 1 |
| Atherton, PJ; Breen, L; Ely, IA; Larsen, MS; Phillips, BE; Piasecki, M; Smith, K; Wilkinson, DJ | 1 |
| Benestad, HB; Brochmann, M; Garthe, I; Hamarsland, H; Johansen, MK; Raastad, T; Seeberg, F | 1 |
| Sinclair, M | 1 |
| Blaauw, B; Breen, L; Carmeliet, P; D'Hulst, G; De Bock, K; Deldicque, L; Fitzgerald, G; Kim, S; Koivunen, P; Masschelein, E; Smeuninx, B; Soro-Arnaiz, I; Veys, K; Zhao, SM | 1 |
| Balchin, C; Black, AD; Butterworth, M; Cooke, M; Elia, A; Harlow, PS; Harris, N; Ispoglou, T; Lees, MJ; Parker, PJ; Phillips, SM; Prior, T; Traylor, DA; Webb, EK; Wilson, OJ | 1 |
| Ball, RO; Chang, J; Courtney-Martin, G; Elango, R; Kong, D; Lebarron, M; Pencharz, PB; Rafii, M; Szwiega, S; Xu, L | 1 |
| Millward, DJ | 2 |
| Allen, SL; Breen, L; Edwards, SJ; Lavery, GG; Lord, JM; Marshall, RN | 1 |
| de Hart, NM; Drummond, MJ; Eshima, H; Ferrara, PJ; Fix, DK; Funai, K; Kelley, JJ; Mahmassani, ZS; McKenzie, AI; Montgomery, JA; Petrocelli, JJ; Reidy, PT | 1 |
| Antosiewicz, J; Gmiat, A; Jaworska, J; Kochanowicz, A; Kortas, J; Lipiński, M; Mieszkowski, J; Prusik, K; Radulska, A; Tomczyk, M; Ziemann, E | 1 |
| Cruz-Jentoft, AJ | 1 |
| Akiba, C; Arai, H; Inoue, R; Kanai, F; Kondo, A; Kunichika, M; Miura, M; Miyajima, M; Nakajima, M; Nakamura, E; Nishimura, K; Ogino, I; Sugano, H; Tada, N; Yoshida, M | 1 |
| Basisty, NB; Beyer, RP; Dai, DF; Fredrickson, J; Karunadharma, PP; Liu, Y; MacCoss, MJ; Rabinovitch, PS; Reynolds, J | 1 |
| Atherton, PJ; Greenhaff, P; Hill, I; Lund, JN; Mitchell, WK; Phillips, BE; Rankin, D; Smith, K; Wilkinson, DJ; Williams, JP | 1 |
| Cholewa, JM; Jiang, H; Shang, H; Su, Q; Xia, Z; Yang, Y; Zanchi, NE; Zhao, Y | 1 |
| de Capitani, MD; de Santana, DA; Fernandes, AL; Gualano, B; Hayashi, AP; Jambassi-Filho, JC; Roschel, H | 1 |
| Gorissen, SHM; Phillips, SM; Traylor, DA | 1 |
| Chen, Z; Cheng, G; Daugherty, SL; de Groat, WC; Liu, Y; Wen, J; Yuan, M; Zhang, X; Zu, S | 1 |
| Aran, K; Balderston, S; Conboy, IM; Conboy, MJ; Hajian, R; Liu, C; Murthy, N; Paredes, J; Sadlowski, C; Sandhu, M; Tran, TP | 1 |
| Dardevet, D; David, J; Efstathiou, T; Jarzaguet, M; Joubrel, G; Migné, C; Mosoni, L; Polakof, S; Rémond, D | 1 |
| Cameron-Smith, D; D'Souza, RF; Knowles, SO; Milan, AM; Mitchell, CJ; Mitchell, SM; Prodhan, U; Ramzan, F; Roy, NC; Sharma, P; Sjödin, A; Wagner, KH; Zeng, N | 1 |
| Aspray, TJ; Bauer, JM; Bautmans, I; Biesheuvel, E; Brandt, K; Cederholm, T; Donini, LM; Eastell, R; Hill, TR; Maggio, M; Mets, T; Seal, CJ; Sieber, C; Verlaan, S; Wijers, SL | 1 |
| Aussel, C; Cynober, L; Deutz, NE; Jourdan, M | 1 |
| Boirie, Y; Moreau, K; Walrand, S | 1 |
| Afshordel, S; Eckert, GP; Igbavboa, U; Muller, WE; Wood, WG | 1 |
| Cai, H; Chang, W; Deng, H; Liu, G; Zhang, S; Zheng, A | 1 |
| Caldow, MK; Ham, DJ; Koopman, R; Lynch, GS | 1 |
| Moore, DR | 1 |
| Basisty, N; Beyer, RP; Bielas, JH; Chiao, YA; Crispin, D; Dai, DF; Ericson, NG; Hsieh, EJ; Karunadharma, PP; MacCoss, MJ; MacKay, VL; Quarles, EK; Rabinovitch, PS | 1 |
| Phillips, SM | 1 |
| Gijsen, AP; Hamer, HM; Kouw, IW; Kramer, IF; Luiking, Y; Poeze, M; Senden, JM; van Kranenburg, J; van Loon, LJ; Verdijk, LB; Verlaan, S | 1 |
| Aoki, MS; da Cunha, FM; Miyabara, EH; Moriscot, AS; Pereira, MG; Silva, MT | 1 |
| Fujita, S; Makanae, Y | 1 |
| Ankarfeldt, MZ; Bauer, J; Capra, S; Heitmann, BL; McDonald, CK; Raymond, K | 1 |
| Agergaard, J; Bülow, J; Holm, L; Kjaer, M; Reitelseder, S | 1 |
| Balakrishnan, G; Pereira, SL; Puthan, JK; Ramesh, S; Reddy, MT; Shreeram, S; Subramanian, R | 1 |
| Cholewa, J; Guimarães-Ferreira, L; Naimo, MA; Shang, HY; Su, QS; Xia, Z; Yang, YQ; Zanchi, NE; Zhao, Y | 1 |
| Baum, JI; Brown, JL; Brown, LA; Greene, NP; Lee, DE; Perry, RA; Washington, TA | 1 |
| Breen, L; Shad, BJ; Thompson, JL | 1 |
| Borack, MS; D'Lugos, AC; Dickinson, JM; Gundermann, DM; Rasmussen, BB; Reidy, PT; Volpi, E; Walker, DK | 1 |
| Cabido, CE; Cholewa, JM; Dardevet, D; de Araújo Pessôa, K; Dos Santos Pinho, JR; Lima-Soares, F; Nicastro, H; Oliveira, PH; Xia, Z; Zanchi, NE | 1 |
| Astruc, T; Balage, M; Dardevet, D; Marzani, B; Mosoni, L; Papet, I; Vénien, A | 1 |
| Paddon-Jones, D; Rasmussen, BB | 1 |
| Atherton, PJ; Patel, R; Rankin, D; Rennie, MJ; Selby, AL; Smith, K; Wilkes, EA | 1 |
| Ito, Y; Kobayashi, H; Nagasawa, T; Nishizawa, N; Sugawara, T; Suzuki, H | 1 |
| Cecchet, D; Millioni, R; Puricelli, L; Tessari, P; Vettore, M | 1 |
| Kim, JS; Lee, SR; Wilson, JM | 1 |
| Fan, X; Giblin, FJ; Liu, X; Monnier, VM; Nemet, I; Qian, J; Strauch, C; Theves, M; Zhang, J | 1 |
| Anderson, N; Carlini, DB; Hense, W; Hutter, S; Parsch, J; Stephan, W | 1 |
| Miller, BF; Murphy, C | 1 |
| Aussel, C; Cynober, L; Daugé, V; Faure, C; Ferry, A; Moinard, C; Raynaud-Simon, A | 1 |
| Burgos, SA; Chevalier, S; Goulet, ED; Morais, JA; Wykes, LJ | 1 |
| Balage, M; Dardevet, D; Dupont, J; Hébuterne, X; Mothe-Satney, I; Schneider, SM; Zeanandin, G | 1 |
| Hartgens, F; Leenders, M; Saris, WH; van der Hoeven, L; van Kranenburg, J; van Loon, LJ; Verdijk, LB; Wodzig, WK | 1 |
| Dickinson, JM; Drummond, MJ; Fry, CS; Glynn, EL; Gundermann, DM; Rasmussen, BB; Timmerman, KL; Volpi, E; Walker, DK | 1 |
| Azen, SP; Bhasin, S; Binder, EF; Castaneda-Sceppa, C; He, J; Kawakubo, M; Roubenoff, R; Sattler, FR; Schroeder, ET; Yarasheski, KE | 1 |
| Donato, J; Pantaleão, LC; Resende, GF; Tirapegui, J; Torres-Leal, FL; Vianna, D | 1 |
| Mittendorfer, B; Shah, K; Smith, GI; Villareal, DT | 1 |
| Leenders, M; van Loon, LJ | 1 |
| Combaret, L; Dardevet, D; Magne, H; Migné, C; Peyron, MA; Rémond, D; Savary-Auzeloux, I | 1 |
| Breen, L; Churchward-Venne, TA | 1 |
| Knuiman, P; Kramer, IF | 1 |
| Coben, JR; Dickinson, JM; Drummond, MJ; Rasmussen, BB; Volpi, E | 1 |
| Alev, K; Aru, M; Kaasik, P; Seene, T | 1 |
| Bassil, MS; Gougeon, R | 1 |
| Candow, DG; Forbes, SC; Little, JP; Manders, RJ | 1 |
| Campbell, WW; Evans, WJ; Kirwan, JP; Krishnan, RK; Kullman, EL; Yarasheski, KE | 1 |
| Abel, ED; Kahn, CR; Kureishi, Y; Luo, Z; Rosenzweig, A; Shiojima, I; Takahashi, A; Tao, J; Walsh, K; Yefremashvili, M | 1 |
| Aoki, S; Itoh, S; Iwata, T; Katagiri, T; Mukae, S; Nishio, K; Sato, R | 1 |
| Bartol, FF; Braden, TD; Tarleton, BJ; Wiley, AA | 1 |
| Adeghate, EA; Draper, CE; Singh, J | 1 |
| Ballèvre, O; Beaufrère, B; Bouteloup-Demange, C; Dangin, M; Fauquant, J; Gachon, P; Garcia-Rodenas, C; Guillet, C; Reiffers-Magnani, K | 1 |
| Balage, M; Bayle, G; Dardevet, D; Grizard, J; Papet, I; Pouyet, C; Prugnaud, J; Rieu, I; Sornet, C | 1 |
| Adeghate, E; Draper, CE; Singh, J | 1 |
| KUHN, W | 1 |
| BENTOR, V; WERTHEIMER, HE | 1 |
| DICAGNO, L; PAVESIO, D | 1 |
| CAMPBELL, PL; DEIBLER, GE; GELBER, S; SOKOLOFF, L | 1 |
| WALIGORA, Z; WENDER, M | 1 |
| BASERGA, R; HINRICHS, HR; PETERSEN, RO | 1 |
| GLOWACKI, ER; MILLETTE, RL | 1 |
| KIRK, JE | 1 |
| Bigelow, ML; Nair, KS; Proctor, DN; Short, KR; Vittone, JL | 1 |
| Aleksandrova, IY; Borisova, GY; Kulikova, OG; Reikhardt, BA; Sapronov, NS | 1 |
| Ma, H; Nagata, T | 1 |
| Boirie, Y; Dardevet, D; Guillet, C; Mishellany, A; Rousset, P; Sornet, C; Zangarelli, A | 1 |
| Dardevet, D; Grizard, J; Rieu, I; Sornet, C | 1 |
| Boirie, Y; Gachon, P; Giraudet, C; Guillet, C; Morio, B; Rousset, P; Zangarelli, A | 1 |
| Atherton, P; Babraj, J; Cuthbertson, D; Leese, G; Rennie, MJ; Smith, K; Taylor, PM; Wackerhage, H; Waddell, T | 1 |
| Barrett, HR; Dolnikowski, GG; Jalbert, SM; Lamon-Fava, S; Lichtenstein, AH; Matthan, NR; Schaefer, EJ; Welty, FK | 1 |
| Contet-Audonneau, JL; Danoux, L; Maquart, FX; Pauly, G; Vuillermoz, B; Wegrowski, Y | 1 |
| Attaix, D; Béchet, D; Combaret, L; Dardevet, D; Grizard, J; Pouch, MN; Rieu, I; Taillandier, D | 1 |
| Rennie, MJ | 1 |
| Aarsland, A; Katsanos, CS; Kobayashi, H; Sheffield-Moore, M; Wolfe, RR | 1 |
| Chevalier, S; Choong, N; Gougeon, R; Lamarche, M; Morais, JA | 1 |
| Gijsen, AP; Gorselink, M; Koopman, R; Manders, RJ; Pijpers, E; van Loon, LJ; Verdijk, L; Wagenmakers, AJ | 1 |
| Johnson, JM; Rada, JA; Young, TL | 1 |
| Balage, M; Dardevet, D; Debras, E; Grizard, J; Prod'homme, M; Rieu, I | 1 |
| Balage, M; Dardevet, D; Debras, E; Grizard, J; Pouyet, C; Rieu, I; Ripes, S; Rochon-Bonhomme, C; Sornet, C | 1 |
| Buffière, C; Machebeuf, M; Mioche, L; Mosoni, L; Patureau Mirand, P; Rémond, D; Yven, C | 1 |
| Buyse, J; Decuypere, E; Janssens, G; Laroye, C; Swennen, Q; Verbeke, K | 1 |
| Beelen, M; Gorselink, M; Koopman, R; Kruseman, AN; Kuipers, H; van Loon, LJ; Verdijk, LB; Wagenmakers, AJ | 1 |
| Béchereau, F; Coudray, C; Glomot, F; Meunier, N; Obled, C; Papet, I | 1 |
| Dhanani, S; Dillon, EL; Dreyer, HC; Drummond, MJ; Fry, CS; Pennings, B; Rasmussen, BB; Sheffield-Moore, M; Volpi, E | 1 |
| Zhinkin, LN | 1 |
| Sacher, JA | 1 |
| Hilchey, SE; Lerner, J; Smagula, RM | 1 |
| Bendahan, G; Vinardell, MP | 1 |
| Adinolfi, AM; Cospito, JA; Levine, MS | 1 |
| Brot, N; Chen, JJ; Weissbach, H | 1 |
| Kim, SK | 1 |
| Calkins, DW; Hartog, VW; Kim, SK; Weinhold, PA | 1 |
| Bunch, C; Corp, MJ; Robinson, JS; Weatherall, DJ; Wood, WG | 1 |
| Price, JL; Schwob, JE | 2 |
| Freinkel, N; Grill, V; Lake, W | 1 |
| Bier, D; Matthews, DE; Munro, HN; Robert, JJ; Schoeller, D; Wolfe, R; Young, VR | 1 |
| Pajari, M | 1 |
| Claes-Reckinger, N; Delcour, J; Vandenhaute, J | 1 |
| Ibraham, NG; Levere, RD; Lutton, JD | 1 |
| Ingvar, MC; Maeder, P; Smith, CB; Sokoloff, L | 1 |
| Alpers, DH; Seetharam, B; Yeh, KY | 1 |
| Arakawa, T; Chikaoka, H; Katsushima, N; Kobayashi, M; Minagawa, A; Saito, TG; Shioji, R | 1 |
| Paul, I; Rosenfeld, RS; Spaet, TH | 1 |
| Gold, G; Reaven, E; Reaven, G | 1 |
| Andersson, A; Eriksson, U; Hellerström, C | 1 |
| Claes-Reckinger, N; Delcour, J; van Bezooijen, CF; Vandenhaute, J | 1 |
| Cooper, RL; Linnoila, M | 1 |
| Beyer, RE; Edington, DW; Starnes, JW | 1 |
| LaVelle, A; McLoon, LK | 2 |
| Butzow, JJ; Eichhorn, GL; McCool, MG | 1 |
| Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, JI | 1 |
| Kibler, RF; Shapira, R; Wilhelmi, MR | 1 |
| Moraes E Santos, T | 1 |
| Coiro, V; Goodman, HM | 1 |
| Ekstrom, R; Liu, DS; Richardson, A | 1 |
| Ashour, B; Tribe, M; Whittaker, P | 1 |
| Han, SS; Kim, SK; Wagner, DJ; Weinhold, PA | 1 |
| Goto, S; Mizuno, D; Mori, N | 1 |
| Campagnoni, AT; Hunkeler, MJ | 1 |
| Cadenhead, A; Fuller, MF; Lobley, GE; McDonald, JD; Reeds, PJ | 1 |
| Battelle, BA; LaVail, MM | 1 |
| Himukai, M; Hoshi, T; Konno, T | 1 |
| Castaneda, C; Crim, MC; Dallal, GE; Dolnikowski, GG; Evans, WJ | 1 |
| Ewan, RC; Gatnau, R; Nissen, SL; Wannemuehler, M; Zimmerman, DR | 1 |
| David, LL; Iwasaki, N; Shearer, TR | 1 |
| Beachy, PA; Chiang, C | 1 |
| Blakemore, WS; Brooks, SW; Gandy, RE; Geiger, JW; Long, CL; Martin, KR; Nelson, KM; Richards, EW | 1 |
| Dang, T; Deibler, GE; Dumont, I; Jehle, J; Macedonia, J; Smith, CB; Sun, Y | 1 |
| Statt, M; Thornton, C; Welle, S | 1 |
| Gonzalez, G; Vinardell, MP | 2 |
| Ichimura, T; Isobe, T; Matsuoka, K; Nakayama, H; Satozawa, N; Song, SY; Takahashi, N; Taoka, M; Yamakuni, T | 1 |
| McHenry, B; Statt, M; Thornton, C; Welle, S | 1 |
| Livne, E; Weiss, A | 1 |
| Cope, BK; McCoy, JR; Smith, SB | 1 |
| Kee, AJ; Smith, RC | 1 |
| Clark, WA; Decker, RS; LaPres, JJ; Rudnick, SJ; Simpson, DG | 1 |
| Denne, SC; Harris, RA; Zhao, Y | 1 |
| Jozefowicz, R; Statt, M; Thornton, C; Welle, S | 1 |
| Bhattiprolu, S; Burrin, D; Del Rosario, M; Frazer, M; Jahoor, F; Wykes, L | 1 |
| Christenson, RK; Vallet, JL | 1 |
| Gonzalez, E; Vinardell, MP | 1 |
| Birnbaum, D; Delapeyriere, O; Ollendorff, V; Pizette, S; Planche, J; Roubin, R | 1 |
| Aly, KB; Casciano, DA; Duffy, PH; Feuers, RJ; Hart, RW; Hinson, W; Leakey, JE; Lyn-Cook, LE; Pipkin, JL | 1 |
| Beaufrère, B; Boirie, Y; Gachon, P | 1 |
| de Groot, LC; van Staveren, WA | 1 |
| Abrams, RM; Burchfield, DJ; Smith, CB; Sun, Y | 1 |
| Ahlrichs, JA; Denne, SC; Karn, CA; Leitch, CA; Liechty, EA; Poindexter, BB; Wang, J | 1 |
| Cox, M; Fereday, A; Gibson, NR; Millward, DJ; Pacy, PJ | 1 |
| Halliday, D; Pannemans, DL; Schaafsma, G; Wagenmakers, AJ; Westerterp, KR | 1 |
| Ades, PA; Adey, DB; Balagopal, P; Nair, KS; Rooyackers, OE | 1 |
| Beharry, S; Durie, PR; Ip, WF | 1 |
| Fu, A; Nair, KS | 1 |
| Bolli, GB; De Feo, P; Lucidi, P; Santeusanio, F; Volpi, E | 1 |
| Bayliss, MT; Bolton, MC; Dudhia, J | 1 |
| Carroll, PV; Jackson, NC; Russell-Jones, DL; Sönksen, PH; Treacher, DF; Umpleby, AM | 1 |
| Darmaun, D; Deschamps, JY; Krempf, M; Marchini, JS; Maugère, P; Nguyen, P | 1 |
| Hasten, DL; Obert, KA; Pak-Loduca, J; Yarasheski, KE | 1 |
| Antoine, JM; Arnal, M; Arnal, MA; Bayle, G; Beaufrère, B; Boirie, Y; Gachon, P; Genest, M; Grizard, J; Mirand, PP; Mosoni, L | 1 |
| Akatsuka, A; Edgerton, VR; Roy, RR; Tamaki, T; Uchiyama, S; Uchiyama, Y; Yoshimura, S | 1 |
| Davis, TA; Deaver, DR; Nguyen, HV; Reeds, PJ; Steele, NC; Vann, RC | 1 |
| Balage, M; Dardevet, D; Grizard, J; Sornet, C | 1 |
| Buddington, RK; Elnif, J; Malo, C; Sangild, PT | 1 |
| Beaufrère, B; Boirie, Y; Cordat, N; Gachon, P; Ritz, P | 1 |
| Brown, G; Castro, E; Deeb, SS; Edland, SD; Erkkola, R; Lee, L; Louhija, J; Martin, GM; Ogburn, CE; Oshima, J; Panduro, A; Penttinen, R; Riestra, R; Tilvis, R; Wang, L | 1 |
| Beaufrère, B; Boirie, Y; Ritz, P | 1 |
| Campbell, WW; Evans, WJ; Trappe, TA; Wolfe, RR | 1 |
| Castellino, P; Giordano, M; Luzi, L | 1 |
| Bayle, G; Dardevet, D; Grizard, J; Pouyet, C; Prugnaud, J; Sornet, C | 1 |
| Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ | 1 |
| Campagnoni, AT; Carey, GD | 1 |
| Lane, RS; Prasanna, HR; Rothstein, M; Sharma, HK | 1 |
| Hosbach, HA; Kubli, E | 1 |
| Daniels, VG; Murphy, S | 1 |
| Griffiths, TD; Tolmach, LJ | 1 |
| Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, J | 1 |
| Hirsch, GP; Holland, JM; Popp, RA | 1 |
| Numa, S; Teraoka, H | 1 |
| Blazer-Yost, B; Cohn, R; Segal, S; Yudkoff, M | 1 |
| Bell, ME; Fuller, GN; Wiggins, RC | 1 |
| Hupp, EW; Joiner, FE | 1 |
| Rawat, AK | 1 |
| Baker, M; Holbrook, JP; Penniall, R; Viskup, RW | 1 |
| Nikodem, W | 1 |
| Weintraub, H | 1 |
| Beyer, TA; Du, JT; Lang, CA | 1 |
| Nakano, K; Sidransky, H | 1 |
| Owen, OE; Patel, MS | 1 |
| Geel, SE; Gonzales, LW | 1 |
| Cvetković, M; Genbacev, O; Sulović, V | 1 |
| Mariotti, D; Ruscitto, R | 1 |
| Johnson, MD; Nylen, EG; Quilliam, NM; Wrogemann, K | 1 |
| Myśliwski, A | 1 |
| Hellthaler, G; Reifegerste, D; Rotzsch, W | 1 |
| Fettback, G; Hellthaler, G; Rotzsch, W | 1 |
| Bradley, MO; Hayflick, L; Schimke, RT | 1 |
| Fujii, K; Kuboki, Y; Sasaki, S | 1 |
| Rotzsch, W | 1 |
| Granger, AS; Kowaloff, EM; Phang, JM | 1 |
| Hellthaler, G; Köhler, R; Reifegerste, D; Rotzsch, W | 1 |
| Britton, GW; Sherman, FG | 1 |
| Lundholm, K; Scherstén, T | 1 |
| Eapen, J; Narayanan, N | 2 |
| Asplund, K | 2 |
| Kurtz, DI | 1 |
| Fukui, HN; Kinoshita, JH; Obazawa, H | 1 |
| Dainat, J; Rebière, A | 1 |
| Carminatti, H; Rossi, S; Vargas, VI | 1 |
| Ivy, GO | 1 |
| Fukuda, H; Iritani, N | 1 |
| Buddington, RK; Puchal, AA; Vega, YM | 1 |
| Castillo, RO; Kwong, LK; Sunshine, P; Tsuboi, KK | 1 |
| Magagnin, S; Sacchi, VF | 1 |
| Martsinko, VI; Tanin, SA | 1 |
| Carlos, RQ; Seidler, FJ; Slotkin, TA | 1 |
| Cannon, JG; Evans, WJ; Fielding, RA; Frontera, WR; Meredith, CN; O'Reilly, KP | 1 |
| Boyd, RL; Sonntag, WE; Spik, KW | 1 |
| Anderson-Brown, T; Seidler, FJ; Slotkin, TA | 1 |
| Bätge, B; Bodo, M; Deutzmann, R; Diebold, J; Lehmann, H; Müller, PK; Notbohm, H | 1 |
| Fukuda, H; Iritani, N; Katsurada, A | 1 |
| Ozaki, K; Yamaguchi, M | 1 |
| Phillips, LL; Pollack, AE; Steward, O | 1 |
| Geesin, JC; Gordon, JS; Gracy, RW; Jacobson, TM; Lane, AT; Yüksel, KU | 1 |
| Robinson, ME; Samarel, AM | 1 |
| Arisumi, PP; Kim, SK | 1 |
| Fischer, HR; Goodrum, JF; Morell, P; Toews, AD; Windes, S | 1 |
| Chanderkar, LP; Kim, S; Paik, WK | 1 |
| Bonomo, L; Dell'Osso, A; Lucivero, G; Mazzini, G; Surico, G | 1 |
| Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Ohta, M; Otsubo, K; Sato, Y | 1 |
| Barka, T; Gresik, EW; van der Noen, H | 1 |
| Mathé, G | 1 |
| Bier, DM; Fukagawa, NK; Matthews, DE; Minaker, KL; Rowe, JW; Young, VR | 1 |
| Adenuga, GA; Mazzaev, AG; Olowookere, JO | 1 |
| Hariguchi, S; Morita, H; Nakamura, Y; Nishimura, T; Suzuki, H; Tada, K; Takeda, M | 1 |
| Albarède, JL; Balas, D; Bouisson, M; Guidet, M; Moreau, J; Ribet, A; Senegas, F; Vellas, B | 1 |
| D'Harlingue, AE; Fan, Q; Kwong, LK; Sunshine, P; Thompson, DJ; Tsuboi, KK | 1 |
| Wilson, RP | 1 |
| Abe, F; Hayashi, M; Horinishi, H; Ishizuka, M; Matsuda, A; Umezawa, H | 1 |
| Kato, H; Naito, H; Nam, TJ; Noguchi, T | 1 |
| Bergen, WG; Busboom, JR; Merkel, RA | 1 |
| Fómez-Pinilla, F; Hovda, DA; Sonnier, BJ; Villablanca, JR | 1 |
| Keelan, M; Thomson, AB | 1 |
| Mileusnić, R; Rakić, L; Veskov, R | 1 |
| Bruley-Rosset, M; Payelle, B; Rappaport, H | 1 |
| Markov, VN; Riashchikov, SN | 1 |
| Alperin, DM; Carminatti, H; Idoyaga-Vargas, VP | 1 |
| Hawkins, RK; Jansen, HG; Sanyal, S | 1 |
| Lopez, RR; Menon, NK | 1 |
| D'Harlingue, AE; Kerner, JA; Kwong, LK; Stevenson, DK; Sunshine, P; Tsuboi, KK | 1 |
| Thomson, AB | 1 |
| Cohen, HJ; Tollefsbol, TO | 1 |
| Harting, JK; Hashikawa, T; Huerta, MF; McHaffie, JG; Stein, BE | 1 |
| Das, K; Mazumder, A; Sarkar, PK | 1 |
| Edelstein, D; Harris, L; Kresge, D; Ove, P; Salatka, K | 1 |
| Ochs, S | 1 |
| Florini, JR; Manowitz, EJ; Saito, Y | 1 |
| Gregson, N; Hamberger, A; Lehninger, AL | 1 |
| Ashhurst, DE; Tribe, MA | 1 |
| Ichihara, A | 1 |
| Erickson, RP; Gluecksohn-Waelsch, S; Jacobs, K; Siekevitz, P | 1 |
| Bergstrand, A; Dallner, G; Nilsson, R | 1 |
| Dunlop, DS; Lajtha, A; Van Elden, W | 1 |
| Dainat, J | 1 |
| Markiewicz, L; Weinstock, IM | 1 |
| Peterson, NA; Raghupathy, E | 1 |
| Pénzes, L | 1 |
| Finch, CE; Gordon, SM | 1 |
| Nathan, I; Richmond, A | 1 |
| Hering, FJ; Hering, H; Platt, D | 1 |
| Karpatkin, S | 1 |
| Adelman, RC; Stein, GS; Wang, PL | 1 |
| Igo-Kemenes, T; Spadafora, C; Zachau, HG | 1 |
| Courtois, YG | 1 |
| Chen, J; Lansing, AI; Obenrader, M; Ove, P | 1 |
| Burdman, JA; Szijan, I | 2 |
| Goldberg, AL; Goldspink, DF | 1 |
| Peters, T | 1 |
| Bemiller, JN; Hoffmann, WE; Pappelis, AJ | 1 |
| Cherry, JH; Pillay, DT; Wright, RD | 1 |
| Buetow, DE; Gandhi, PS | 1 |
| Yeoh, GC | 1 |
| Comolli, R | 1 |
| Alvarez, C; Menaker, L; Miller, SA; Pong, RS | 1 |
| Corbin, J; Pennington, W; Roach, MK | 1 |
| Jumawan, J; Koldovský, O; McNamara, PD; Palmieri, M | 1 |
| Ilan, J | 1 |
| Delcour, J; Libion-Mannaert, M; Wattiaux, JM | 1 |
| Gold, PH; Menzies, RA | 2 |
| Jakubovic, A; McGeer, PL | 1 |
| Florini, JR; Geary, S | 1 |
| Lansing, A; Obenrader, M; Ove, P | 1 |
| Hellthaler, G; Köhler, H; Rotzsch, W | 1 |
| Bullock, GR; Christian, RA; Peters, RF; White, AM | 1 |
| Booyse, FM; Hoveke, TP; Rafelson, ME; Zschocke, D | 1 |
| Adams, MH; Midthun, RA; Rowley, PT | 1 |
| Graeber, W | 1 |
| Brooks, GT; Jurd, RD; Maclean, N | 1 |
| Dingley, F; Smith, JM | 1 |
| Lerman, S | 1 |
| Levi, G | 1 |
| Beck, G; Ebel, JP; Hentzen, D | 1 |
| Brown, DM; Peache, S; Roberts, S; Zomzely, CE | 1 |
| Spadoni, MA; Ticca, M | 1 |
| Spector, A; Wannemacher, CF | 1 |
| Ichihara, A; Takahashi, H | 1 |
| Hendley, DD; Hirsch, GP; Kutsky, R; Menzies, RA; Nordgren, RA; Strehler, BL | 1 |
| Chaudhary, KD; Srivastava, U | 1 |
| Baserga, R; Petersen, RO | 1 |
| Izak, G; Mager, J; Wilner, T | 1 |
| McCoy, JR; Wannemacher, RW | 1 |
| Clarke, JM; Smith, JM | 1 |
| Lennartz, KJ; Rudolph, G | 1 |
20 review(s) available for leucine and Aging
| Article | Year |
|---|---|
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction | 2021 |
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states.
Topics: Aging; Amino Acids, Essential; Dietary Proteins; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Muscle Proteins; Muscle, Skeletal | 2023 |
Controversies in Diagnosing Sarcopenia in Cirrhosis-Moving from Research to Clinical Practice.
Topics: Aging; Humans; Leucine; Liver Cirrhosis; Research; Sarcopenia | 2019 |
Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia.
Topics: Aged; Aged, 80 and over; Aging; Apoptosis; Cell Survival; Dietary Supplements; Frailty; Humans; Leucine; Middle Aged; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Sarcopenia; Valerates | 2018 |
Perspective: Protein Requirements and Optimal Intakes in Aging: Are We Ready to Recommend More Than the Recommended Daily Allowance?
Topics: Aged; Aging; Dietary Proteins; Humans; Leucine; Muscle, Skeletal; Muscular Diseases; Nutritional Requirements; Recommended Dietary Allowances; Sarcopenia | 2018 |
Leucine as a treatment for muscle wasting: a critical review.
Topics: Aging; Animals; Dietary Supplements; Disease Models, Animal; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Protein Biosynthesis; TOR Serine-Threonine Kinases | 2014 |
Keeping older muscle “young” through dietary protein and physical activity.
Topics: Aging; Amino Acids; Dietary Proteins; Energy Intake; Humans; Leucine; Micronutrients; Motor Activity; Muscle Proteins; Muscle, Skeletal; Nutritional Requirements; Nutritional Status; Sarcopenia; Sedentary Behavior | 2014 |
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
Topics: Aged; Aging; Creatine; Diet; Dietary Proteins; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Quality of Life; Resistance Training; Sarcopenia; Valerates | 2015 |
Role of Exercise and Nutrition in the Prevention of Sarcopenia.
Topics: Aging; Diet; Dietary Supplements; Humans; Insulin Resistance; Leucine; Muscle Proteins; Muscle, Skeletal; Nutritional Status; Protein Biosynthesis; Resistance Training; Sarcopenia | 2015 |
Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review.
Topics: Age Factors; Aging; Amino Acids; Diet; Dietary Proteins; Exercise; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis; Sarcopenia | 2016 |
Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.
Topics: Aging; Antioxidants; Betaine; Dietary Proteins; Dietary Supplements; Exercise; Glycine; Humans; Hypokinesia; Leucine; Muscle Proteins; Muscle, Skeletal; Sarcopenia; Vitamins | 2017 |
Dietary protein recommendations and the prevention of sarcopenia.
Topics: Aged; Aging; Dietary Proteins; Dietary Supplements; Exercise; Humans; Leucine; Muscle Proteins; Muscular Atrophy; Nutrition Policy; Protein Deficiency | 2009 |
Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants.
Topics: Aged; Aged, 80 and over; Aging; Amino Acids; Antioxidants; Diet; Dietary Proteins; Female; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Nutritional Requirements; Oxidative Stress; Protein Biosynthesis; Resistance Training; Sarcopenia; Sedentary Behavior | 2010 |
Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes.
Topics: Adult; Aged; Aging; Animals; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leucine; Muscle Proteins; Muscle Strength; Protein Biosynthesis; Sarcopenia; Up-Regulation | 2011 |
Muscle protein anabolism in type 2 diabetes.
Topics: Aged; Aging; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Male; Motor Activity; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Sarcopenia | 2013 |
Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia.
Topics: Aging; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin Secretion; Leucine; Muscle Proteins; Muscle, Skeletal; Sarcopenia | 2012 |
Low-protein intakes and protein turnover in elderly women.
Topics: Aged; Aging; Dietary Proteins; Female; Humans; Immunity; Leucine; Muscles; Oxidation-Reduction; Proteins | 1996 |
Postprandial protein utilization: implications for clinical nutrition.
Topics: Aging; Animals; Carbon Isotopes; Critical Illness; Enteral Nutrition; Humans; Leucine; Models, Biological; Nutritional Requirements; Oxidation-Reduction; Postoperative Care; Postprandial Period | 2000 |
Protein and amino acid requirements of fishes.
Topics: Aging; Amino Acids; Animals; Arginine; Dietary Proteins; Energy Intake; Fishes; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nutritional Requirements; Phenylalanine; Species Specificity; Threonine; Tryptophan; Valine | 1986 |
Human platelet senescence.
Topics: Aging; Blood Platelets; Blood Proteins; Cell Aggregation; Cell Survival; Chromium Isotopes; Glycogen; Glycogen Storage Disease; Humans; Isoflurophate; Kinetics; Leucine; Megakaryocytes; Osmotic Fragility; Oxidation-Reduction; Phosphates; Platelet Adhesiveness; Radioisotopes; RNA; Thrombin; Time Factors; Valine | 1972 |
22 trial(s) available for leucine and Aging
| Article | Year |
|---|---|
Native Whey Induces Similar Adaptation to Strength Training as Milk, despite Higher Levels of Leucine, in Elderly Individuals.
Topics: Adaptation, Physiological; Aged; Aging; Animals; Biopsy; Diet; Double-Blind Method; Female; Humans; Leucine; Male; Milk; Muscle, Skeletal; Resistance Training; Whey Proteins | 2019 |
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women.
Topics: Age Factors; Aged; Aging; Cholecalciferol; Dietary Supplements; Exercise Therapy; Female; Healthy Aging; HMGB1 Protein; Humans; Inflammation Mediators; Interleukin-6; Leucine; Middle Aged; Muscle Strength; Poland; Postural Balance; Sex Factors; Time Factors; Treatment Outcome; Walking | 2017 |
Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.
Topics: Adenosine Triphosphate; Age Factors; Aged; Aging; Anabolic Agents; Dietary Supplements; Energy Metabolism; Humans; Insulin; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle, Skeletal; Phosphocreatine; Phosphorylation; Postprandial Period; Prospective Studies; Protein Biosynthesis; Sex Factors; Time Factors; TOR Serine-Threonine Kinases | 2017 |
Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men.
Topics: Aged; Aged, 80 and over; Aging; Body Mass Index; Diet, High-Protein; Humans; Intracellular Signaling Peptides and Proteins; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle, Skeletal; Recommended Dietary Allowances; Ribosomal Protein S6; Signal Transduction | 2019 |
A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study.
Topics: Aged; Aging; Bone and Bones; Bone Density; Calcium; Dietary Supplements; Double-Blind Method; Female; Humans; Leucine; Male; Middle Aged; Muscle Strength; Muscle, Skeletal; Vitamin D; Whey Proteins | 2019 |
Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.
Topics: Aging; Animal Feed; Animals; Animals, Newborn; Chickens; Diet; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Leucine; Male; Muscle, Skeletal; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Impact of the Macronutrient Composition of a Nutritional Supplement on Muscle Protein Synthesis Rates in Older Men: A Randomized, Double Blind, Controlled Trial.
Topics: Aged; Aging; Blood Glucose; Dietary Carbohydrates; Dietary Fats; Dietary Supplements; Double-Blind Method; Food; Humans; Insulin; Leucine; Male; Motor Activity; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Whey Proteins | 2015 |
No additional effect of different types of physical activity on 10-hour muscle protein synthesis in elderly men on a controlled energy- and protein-sufficient diet.
Topics: Activities of Daily Living; Aged; Aging; Bed Rest; Diet; Dietary Proteins; Exercise; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Resistance Training | 2016 |
The impact of postexercise essential amino acid ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men.
Topics: Administration, Oral; Aged; Aging; Autophagosomes; Eating; Exercise; Humans; Leucine; Lysosomes; Male; Middle Aged; Muscle, Skeletal; Proteasome Endopeptidase Complex; Ubiquitin | 2017 |
Protein consumption following aerobic exercise increases whole-body protein turnover in older adults.
Topics: Aged; Aging; Beverages; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Elder Nutritional Physiological Phenomena; Exercise; Female; Humans; Leucine; Male; Middle Aged | 2010 |
Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men.
Topics: Aged; Aging; Amino Acids; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Leucine; Lipids; Male; Muscle Strength; Muscle, Skeletal | 2011 |
Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study.
Topics: Aged; Aged, 80 and over; Aging; Catalysis; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Proteasome Endopeptidase Complex | 2011 |
Age and aerobic exercise training effects on whole body and muscle protein metabolism.
Topics: Adult; Aged; Aging; Body Composition; Energy Metabolism; Exercise; Female; Follow-Up Studies; Humans; Leucine; Male; Middle Aged; Muscle Proteins; Phenylalanine; Proteins; Radioactive Tracers; Reference Values | 2004 |
TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status.
Topics: Adult; Age Factors; Aged; Aging; Apolipoprotein A-I; Apolipoprotein B-100; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Deuterium; Female; Humans; Leucine; Lipoproteins; Lipoproteins, HDL; Menopause; Middle Aged; Postmenopause; Triglycerides | 2005 |
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.
Topics: Administration, Oral; Adult; Aged; Aging; Amino Acids, Essential; Diet; Dietary Supplements; Female; Humans; Kinetics; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis | 2006 |
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
Topics: Activities of Daily Living; Adult; Aged; Aging; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Tyrosine | 2006 |
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men.
Topics: Aged; Aging; Amino Acids; Blood Glucose; Cross-Over Studies; Diet; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Exercise; Humans; Insulin; Leucine; Male; Milk Proteins; Muscle Proteins; Muscle, Skeletal; Proteins; Whey Proteins | 2008 |
Effect of zinc supplementation on protein metabolism in late-middle-aged men: The Zenith study.
Topics: Aged; Aging; Albumins; Analysis of Variance; Biomarkers; Carbon Isotopes; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fibrinogen; Humans; Leucine; Male; Middle Aged; Proteins; Trace Elements; Zinc | 2008 |
Protein turnover and energy metabolism of elderly women fed a low-protein diet.
Topics: Adaptation, Physiological; Aged; Aging; Diet, Protein-Restricted; Dietary Proteins; Eating; Energy Metabolism; Exercise; Female; Humans; Leucine | 1995 |
Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds.
Topics: Actins; Adult; Aged; Aged, 80 and over; Aging; Body Composition; Female; Humans; Keto Acids; Kinetics; Leucine; Male; Mitochondria, Muscle; Muscle Proteins; Myofibrils; Myosin Heavy Chains; Physical Fitness; Sarcoplasmic Reticulum; Weight Lifting | 2000 |
Protein turnover modifications induced by the protein feeding pattern still persist after the end of the diets.
Topics: Adaptation, Physiological; Adult; Aged; Aging; Bicarbonates; Blood Glucose; Carbon Isotopes; Deuterium; Diet; Dietary Proteins; Energy Intake; Female; Food; Humans; Insulin; Kinetics; Leucine; Proteins | 2000 |
The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle.
Topics: Aged; Aging; Body Composition; Dietary Proteins; Female; Humans; Leucine; Male; Middle Aged; Muscle, Skeletal; Nitrogen; Nutrition Policy; Thigh | 2001 |
302 other study(ies) available for leucine and Aging
| Article | Year |
|---|---|
Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis.
Topics: Aging; Animals; Dietary Supplements; Fatty Acids; Forkhead Box Protein O1; Glucose; Inflammation; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Mice; Myocytes, Smooth Muscle; Reactive Oxygen Species; Rubber; Sirtuin 1; Vascular Remodeling | 2022 |
The Aging Process: A Metabolomics Perspective.
Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Female; Humans; Isoleucine; Leucine; Male; Metabolome; Metabolomics; Middle Aged; Ornithine; Urea; Valine; Young Adult | 2022 |
[The Impact of Nutrition on Muscle Health in Older Individuals].
Topics: Aged; Aging; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Quality of Life; Sarcopenia | 2023 |
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Topics: Adult; Aged; Aging; Amino Acids; Animals; Disease Models, Animal; Female; HEK293 Cells; Humans; Hydroxylation; Hypoxia-Inducible Factor-Proline Dioxygenases; Leucine; Leucine-tRNA Ligase; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Development; Muscles; Oxygen; Procollagen-Proline Dioxygenase; Signal Transduction | 2020 |
Novel Essential Amino Acid Supplements Following Resistance Exercise Induce Aminoacidemia and Enhance Anabolic Signaling Irrespective of Age: A Proof-of-Concept Trial.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Dietary Supplements; Exercise; Female; Humans; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Muscle Proteins; Muscle, Skeletal; Resistance Training; Sarcopenia; Young Adult | 2020 |
Dietary leucine requirement of older men and women is higher than current recommendations.
Topics: Aged; Aging; Dose-Response Relationship, Drug; Female; Humans; Leucine; Male; Nutritional Requirements; Oxidation-Reduction; Phenylalanine | 2021 |
Leucine requirements for the elderly.
Topics: Aged; Aging; Female; Humans; Leucine; Male; Nutritional Requirements | 2021 |
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging.
Topics: Adult; Aged; Aging; Animals; C-Reactive Protein; Cell Line; Culture Media; Humans; Insulin Resistance; Interleukin-6; Leucine; Male; Mice; Models, Biological; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Peptide Elongation Factor 2; Protein Biosynthesis; Proteolysis; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2021 |
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; Immunoglobulin G; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Muscle Development; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Organ Size; RNA-Seq; Satellite Cells, Skeletal Muscle; Signal Transduction | 2021 |
Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment.
Topics: Aging; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glycoproteins; Hippocampus; Leucine; Long-Term Potentiation; Memory Disorders; Mice, Transgenic; Synaptic Vesicles | 2017 |
Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.
Topics: Aging; Animals; Caloric Restriction; Female; Half-Life; Isotope Labeling; Leucine; Mass Spectrometry; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Protein Aggregates; Protein Biosynthesis; Proteome; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin | 2018 |
A potential strategy for counteracting age-related sarcopenia: preliminary evidence of combined exercise training and leucine supplementation.
Topics: Aging; Animals; Combined Modality Therapy; Dietary Supplements; Humans; Leucine; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Resistance Training; Ribosomal Protein S6 Kinases, 70-kDa; Sarcopenia; TOR Serine-Threonine Kinases | 2017 |
Different protein and derivatives supplementation strategies combined with resistance training in pre-frail and frail elderly: Rationale and protocol for the "Pro-Elderly" Study.
Topics: Aged; Aging; Combined Modality Therapy; Dietary Proteins; Dietary Supplements; Double-Blind Method; Elder Nutritional Physiological Phenomena; Female; Frail Elderly; Frailty; Humans; Leucine; Male; Muscle, Skeletal; Randomized Controlled Trials as Topic; Research Design; Resistance Training; Sarcopenia; Severity of Illness Index; Sex Characteristics; Soybean Proteins; Ultrasonography; Whey Proteins | 2017 |
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity.
Topics: Administration, Intravesical; Age Factors; Aging; Animals; Calcium Signaling; Capsaicin; Female; Leucine; Mechanotransduction, Cellular; Membrane Potentials; Muscle Contraction; Neurons, Afferent; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels; Urinary Bladder; Urination; Urodynamics; Urothelium | 2018 |
Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis.
Topics: Aging; Animals; Azides; Biomarkers; Biosensing Techniques; Blood Proteins; Graphite; Leucine; Mice; Parabiosis | 2018 |
A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the age-related muscle anabolic resistance only if the protein content and leucine levels are increased.
Topics: Aging; Animals; Dietary Proteins; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Wistar; Soybean Proteins; Whey Proteins | 2018 |
Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats.
Topics: Aging; Amino Acids; Animals; Body Weight; Eating; Glutamine; Homeostasis; Intestinal Mucosa; Intestines; Kidney; Leucine; Liver; Male; Muscles; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Veins | 2013 |
Protein redistribution from skeletal muscle to splanchnic tissue on fasting and refeeding in young and older healthy individuals.
Topics: Aged; Aging; Albumins; Body Composition; Carbon Isotopes; Eating; Fasting; Female; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Protein Biosynthesis; Splanchnic Circulation; Young Adult | 2013 |
Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.
Topics: Aging; Alkyl and Aryl Transferases; Animals; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cerebrum; Cognition Disorders; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Leucine; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Naphthalenes; Nerve Tissue Proteins; Neuroblastoma; Protein Prenylation; rab GTP-Binding Proteins; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Messenger; Synaptic Membranes; Synaptic Transmission; Terpenes | 2014 |
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.
Topics: Aging; Animals; Caloric Restriction; Deuterium; Eukaryotic Initiation Factor-2; Female; Gene Expression Regulation; Half-Life; Homeostasis; Isotope Labeling; Leucine; Liver; Mice; Mice, Inbred C57BL; Polyribosomes; Protein Biosynthesis; Protein Stability; Proteolysis; Proteome; Signal Transduction; Sirolimus; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases | 2015 |
Leucine supplementation improves regeneration of skeletal muscles from old rats.
Topics: Aging; Animals; Carrier Proteins; Dietary Supplements; Eukaryotic Initiation Factor-4E; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Regeneration; Satellite Cells, Skeletal Muscle; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitinated Proteins | 2015 |
Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population.
Topics: Absorptiometry, Photon; Adult; Age Factors; Aged; Aging; Body Composition; Body Fluid Compartments; Cardiovascular Diseases; Cohort Studies; Denmark; Diet; Dietary Proteins; Electric Impedance; Energy Intake; Exercise; Female; Humans; Leucine; Male; Middle Aged; Muscle, Skeletal; Sarcopenia | 2016 |
Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aging; Animals; Dietary Supplements; Humans; Keto Acids; Leucine; Liver; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Valerates | 2016 |
Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice.
Topics: Aging; Animals; Diet; Dietary Supplements; Leucine; Male; Mice; Muscle, Skeletal; Physical Conditioning, Animal | 2016 |
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration.
Topics: Aging; Animals; Bupivacaine; Leucine; Mice; Muscle, Skeletal; Regeneration | 2016 |
Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats.
Topics: Aging; Animals; Antioxidants; Biomarkers; Dietary Supplements; Inflammation; Leucine; Muscle Proteins; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases | 2008 |
Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia.
Topics: Adult; Aged; Aging; Amino Acids; Female; Glucose Clamp Technique; Humans; Insulin; Leg; Leucine; Male; Muscle Proteins; Muscular Diseases; Proteins; Proto-Oncogene Proteins c-akt | 2009 |
Measurement of the rate of myofibrillar protein degradation using the arteriovenous difference in plasma 3-methylhistidine concentration of rats.
Topics: Aging; Animals; Aorta, Abdominal; Biomarkers; Blood Flow Velocity; Caseins; Diet; Femoral Vein; Leucine; Male; Methylhistidines; Muscle Proteins; Muscle, Skeletal; Myofibrils; Rats; Rats, Wistar | 2009 |
Middle age is not associated with altered fibrinogen concentration and production in males.
Topics: Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Fibrinogen; Humans; Insulin; Leucine; Male; Middle Aged | 2010 |
Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.
Topics: 2-Aminoadipic Acid; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Cattle; Child; Crystallins; Diabetes Mellitus; Humans; Hydrogen Peroxide; Hyperbaric Oxygenation; Lens, Crystalline; Leucine; Lysine; Metals; Mice; Mice, Inbred C57BL; Middle Aged; Molecular Structure; Oxidants; Oxidation-Reduction; Rabbits; Regression Analysis; Young Adult | 2009 |
Experimentally increased codon bias in the Drosophila Adh gene leads to an increase in larval, but not adult, alcohol dehydrogenase activity.
Topics: Aging; Alcohol Dehydrogenase; Alleles; Animals; Base Sequence; Codon; Drosophila melanogaster; Drosophila Proteins; Evolution, Molecular; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Larva; Leucine; Male; Mutagenesis, Site-Directed; Mutation; Protein Biosynthesis; Transformation, Genetic; Transgenes | 2010 |
Leucine and citrulline modulate muscle function in malnourished aged rats.
Topics: Aging; Animals; Citrulline; Dietary Supplements; Humans; Leucine; Male; Malnutrition; Muscle, Skeletal; Rats; Rats, Sprague-Dawley | 2012 |
Protein anabolic responses to a fed steady state in healthy aging.
Topics: Adult; Aged; Aging; Exercise; Female; Glucose; Humans; Insulin Resistance; Leucine; Muscle Proteins; Phosphorylation; Proteins; Sarcopenia | 2011 |
Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.
Topics: Adipose Tissue; Aging; Animals; Biological Transport; Blotting, Western; Dietary Supplements; Disease Models, Animal; Follow-Up Studies; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Muscle, Skeletal; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA; Sarcopenia; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases | 2012 |
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.
Topics: Activating Transcription Factor 4; Active Transport, Cell Nucleus; Adult; Age Factors; Aged; Aging; Amino Acid Transport Systems; Amino Acids; Analysis of Variance; Biopsy; Blotting, Western; Eukaryotic Initiation Factor-2; Female; Gene Expression Regulation; Humans; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Contraction; Phenylalanine; Phosphorylation; Polymerase Chain Reaction; Quadriceps Muscle; Resistance Training; Ribosomal Protein S6; RNA, Messenger; STAT3 Transcription Factor; Time Factors; TOR Serine-Threonine Kinases | 2011 |
Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats.
Topics: Adipose Tissue; Age Factors; Aging; Animals; Blood Glucose; Body Composition; Body Fluid Compartments; Body Weight; Chronic Disease; Dietary Supplements; Leucine; Lipids; Male; Nutritional Status; Obesity; Proteins; Rats; Rats, Sprague-Dawley; Risk Factors | 2012 |
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults.
Topics: Aged; Aged, 80 and over; Aging; Blood Glucose; Energy Intake; Energy Metabolism; Fasting; Female; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Weight Loss | 2012 |
Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.
Topics: Aging; Amino Acids; Animals; Diet; Dietary Supplements; Hindlimb Suspension; Leucine; Male; Milk Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ubiquitin; Whey Proteins | 2012 |
Leucine: a nutrient 'trigger' for muscle anabolism, but what more?
Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy | 2012 |
Contributions to the understanding of the anabolic properties of different dietary proteins.
Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy | 2012 |
Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise.
Topics: Adult; Aged; Aging; Amino Acid Transport Systems; Amino Acids, Essential; Blood Glucose; Exercise; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis; Rest; RNA, Messenger | 2013 |
Aging and regenerative capacity of skeletal muscle in rats.
Topics: Actins; Age Factors; Aging; Animals; Leucine; Male; Muscle, Skeletal; Myofibrils; Myosin Heavy Chains; Organ Size; Rats; Rats, Wistar; Regeneration; Sarcoplasmic Reticulum; Transplantation, Autologous | 2012 |
Age attenuates leucine oxidation after eccentric exercise.
Topics: Age Factors; Aged; Aging; Exercise; Exercise Test; Glucose Clamp Technique; Humans; Hyperglycemia; Insulin Resistance; Leucine; Male; Middle Aged; Oxidation-Reduction; Time Factors; Young Adult | 2013 |
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
Topics: Aging; Animals; Cardiomegaly; Cells, Cultured; Enzyme Induction; Fasting; Genotype; Heart; Insulin; Leucine; Mice; Mice, Inbred Strains; Myocardium; Nutritional Status; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases | 2002 |
Mitochondrial 5178A/C genotype is associated with acute myocardial infarction.
Topics: Aged; Aging; Alleles; Amino Acid Substitution; Diabetes Complications; DNA, Mitochondrial; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypercholesterolemia; Hypertension; Leucine; Male; Methionine; Middle Aged; Myocardial Infarction; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors | 2003 |
Estrogen-induced disruption of neonatal porcine uterine development alters adult uterine function.
Topics: Aging; Animals; Animals, Newborn; Body Fluids; Corpus Luteum; Drug Administration Schedule; Endometrium; Estradiol; Female; In Vitro Techniques; Leucine; Pregnancy; Pregnancy, Animal; Proteins; RNA, Messenger; Swine; Uterus | 2003 |
Effects of ageing on secretagogue-evoked protein output, peroxidase secretion and protein synthesis in the isolated rat lacrimal gland.
Topics: Aging; Animals; Eye Proteins; In Vitro Techniques; Leucine; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2002 |
The rate of protein digestion affects protein gain differently during aging in humans.
Topics: Adult; Aged; Aging; Amino Acids; Caseins; Digestion; Hormones; Humans; Kinetics; Leucine; Male; Milk Proteins; Osmolar Concentration; Peptide Hydrolases; Time Factors; Whey Proteins | 2003 |
Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats.
Topics: Aging; Amino Acids; Animals; Insulin; Leucine; Male; Muscle Proteins; Postprandial Period; Rats; Rats, Wistar | 2003 |
Effects of age on morphology, protein synthesis and secretagogue-evoked secretory responses in the rat lacrimal gland.
Topics: Age Factors; Aging; Animals; Cytoplasm; Endoplasmic Reticulum, Rough; Golgi Apparatus; Histamine; Immunohistochemistry; Lacrimal Apparatus; Leucine; Male; Microscopy, Electron; Microscopy, Fluorescence; Peroxidases; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Time Factors; Vasoactive Intestinal Peptide | 2003 |
[A possible effect of the degree of purity of optically active substances on the process of aging].
Topics: Aging; Eye; Humans; Leucine | 1955 |
TRANSPORT AND INCORPORATION OF AMINO ACIDS INTO THE AORTIC WALL: INFLUENCE OF AGE AND HORMONES.
Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Aorta; Carbon Isotopes; Diabetes Mellitus, Experimental; Geriatrics; Glycine; Hyperthyroidism; Hypothyroidism; Insulin; Leucine; Propylthiouracil; Proteins; Rats; Research; Thyronines | 1964 |
[LEUCINE AMINOPEPTIDASE IN BLOOD SERUM. NORMAL VALUES IN VARIOUS PEDIATRIC AGES].
Topics: Aging; Aminopeptidases; Biomedical Research; Blood; Child; Infant; Infant, Newborn; Leucine; Leucyl Aminopeptidase; Reference Values; Serum | 1964 |
EFFECTS OF L-THYROXINE ON AMINO ACID INCORPORATION INTO PROTEIN IN MATURE AND IMMATURE RAT BRAIN.
Topics: Aging; Amino Acids; Brain; Glutarates; Hydroxybutyrates; Leucine; Liver; Nerve Tissue Proteins; Pharmacology; Proteins; Rats; Research; Thyroid Hormones; Thyroxine | 1964 |
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; Glycine; Guinea Pigs; Histidine; Leucine; Lysine; Nerve Tissue Proteins; Nervous System; Phenylalanine; Research; Serine; Spinal Cord; Threonine; Tyrosine; Valine | 1964 |
INCORPORATION OF THYMIDINE INTO DNA OF MOUSE ORGANS.
Topics: Aging; Amino Acids; Animals; DNA; Leucine; Metabolism; Mice; Nucleosides; Proteins; Research; RNA; Thymidine; Tritium | 1964 |
POLYRIBOSOMES AND THE LOSS OF HEMOGLOBIN SYNTHESIS IN THE MATURING RETICULOCYTE.
Topics: Aging; Animals; Carbon Isotopes; Hemoglobins; Leucine; Photomicrography; Polyribosomes; Proteins; Rabbits; Research; Reticulocytes; Ribosomes; Ultracentrifugation | 1965 |
The leucine aminopeptidase activity of arterial tissue in individuals of various ages.
Topics: Aging; Arteries; Endopeptidases; Hydrolases; Leucine; Leucyl Aminopeptidase; Peptide Hydrolases | 1960 |
Status of the "protein kinase CK2-HMG14" system in age-related amnesia in rats.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Behavior, Animal; Brain; Casein Kinases; Cell Nucleus; Disease Models, Animal; DNA-Binding Proteins; Etimizol; HMGN1 Protein; Leucine; Male; Phosphorylation; Protein Kinases; Rats; Retention, Psychology; Synaptosomes; Transcription, Genetic; Tritium; Uridine Monophosphate | 2003 |
Electron microscopic radioautographic study on protein synthesis in amitotic hepatocytes of the aging mouse.
Topics: Aging; Animals; Autoradiography; Female; Hepatocytes; Leucine; Liver; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Tritium | 2004 |
Mitochondrial and sarcoplasmic proteins, but not myosin heavy chain, are sensitive to leucine supplementation in old rat skeletal muscle.
Topics: Aging; Alanine; Animals; Diet; Leucine; Male; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; Phenylalanine; Rats; Rats, Wistar; Sarcoplasmic Reticulum | 2004 |
Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats.
Topics: Aging; Animals; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance; Eating; Glucocorticoids; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar; Tissue Culture Techniques | 2004 |
Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects.
Topics: Adult; Aged; Aging; Amino Acids; Blood Glucose; Body Composition; Carbon Dioxide; Exhalation; Glucose; Humans; Insulin; Leucine; Male; Osmolar Concentration; Pentanoic Acids; Proteins | 2004 |
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic Initiation Factors; Humans; Keto Acids; Kinetics; Leucine; Male; Muscle Proteins; Muscle, Skeletal; NF-kappa B; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Solutions; TOR Serine-Threonine Kinases | 2005 |
Influence of aging on glycosaminoglycans and small leucine-rich proteoglycans production by skin fibroblasts.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cells, Cultured; Child; Child, Preschool; Chondroitin Sulfate Proteoglycans; Female; Fibroblasts; Glycosaminoglycans; Humans; Infant; Keratan Sulfate; Leucine; Lumican; Male; Middle Aged; Proteoglycans; Skin | 2005 |
A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle.
Topics: Aging; Alanine; Animals; Body Weight; Dietary Supplements; Hydrolysis; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; RNA, Messenger; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2005 |
A role for leucine in rejuvenating the anabolic effects of food in old rats.
Topics: Aged; Aging; Animals; Dietary Supplements; Eating; Food; Humans; Insulin; Leucine; Middle Aged; Muscle Proteins; Rats | 2005 |
Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging.
Topics: Adiposity; Adult; Aged; Aging; Female; Humans; Insulin; Insulin Resistance; Leucine; Male; Protein Biosynthesis; Proteins | 2006 |
Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Child; Child, Preschool; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Immunohistochemistry; Leucine; Male; Middle Aged; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sclera; Staining and Labeling | 2006 |
Postprandial leucine deficiency failed to alter muscle protein synthesis in growing and adult rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Random Allocation; Rats; Rats, Wistar | 2007 |
Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats.
Topics: Aging; Amino Acids; Animals; Carbon Isotopes; Dose-Response Relationship, Drug; Leucine; Male; Milk Proteins; Muscle Proteins; Postprandial Period; Random Allocation; Rats; Rats, Wistar; Whey Proteins | 2007 |
Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects.
Topics: Aged; Aging; Amino Acids; Area Under Curve; Carbon Isotopes; Dentition; Denture, Complete; Dietary Proteins; Digestion; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Leucine; Male; Mastication; Meat; Middle Aged; Particle Size; Postprandial Period; Protein Biosynthesis | 2007 |
Rate of metabolic decarboxylation of leucine as assessed by a l[1-(13)C(1)]leucine breath test combined with indirect calorimetry of broiler chickens fed isocaloric diets with different protein:fat ratio.
Topics: Aging; Animal Feed; Animals; Area Under Curve; Body Weight; Breath Tests; Calorimetry, Indirect; Carbon Isotopes; Chickens; Decarboxylation; Dietary Fats; Dietary Proteins; Digestion; Dose-Response Relationship, Drug; Female; Leucine; Random Allocation | 2007 |
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.
Topics: Absorptiometry, Photon; Adult; Aged; Aging; Algorithms; Amino Acids, Essential; Anabolic Agents; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hormones; Humans; Hydrocortisone; Lactic Acid; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Phosphorylation; Physical Fitness; Protein Kinases; RNA; Signal Transduction; TOR Serine-Threonine Kinases | 2008 |
[Protein synthesis and the regulation process in the cell].
Topics: Aging; Animals; Arginine; Autoradiography; Axons; Body Weight; Cell Biology; Cytoplasmic Granules; Glycine; Golgi Apparatus; Guinea Pigs; Hippocampus; Homeostasis; Leucine; Methionine; Mice; Microscopy, Electron; Neurons; Pancreas; Photoreceptor Cells; Protein Biosynthesis; Purkinje Cells; Pyramidal Tracts; Rats; Ribosomes; RNA; RNA, Messenger; Spectrophotometry; Thyroid Gland; Time Factors; Tritium; Tyrosine | 1966 |
Studies of permeability, RNA and protein turnover during ageing of fruit and leaf tissues.
Topics: Aging; Cell Membrane Permeability; Dactinomycin; Fruit; Leucine; Orotic Acid; Plant Growth Regulators; Plant Proteins; Plants, Edible; RNA | 1967 |
Developmental changes in amino acid transport in the chicken erythrocyte.
Topics: Aging; Amino Acids; Animals; Chickens; Erythrocytes; Glycine; Kinetics; Leucine; Lysine | 1983 |
Effect of age-dependent changes on jejunal and ileal amino acid-sugar interaction in vivo.
Topics: Absorption; Aging; Animals; Biological Transport, Active; Galactose; Ileum; Jejunum; Leucine; Male; Rats; Rats, Inbred Strains | 1984 |
Organization of developing precruciate corticostriate projections in kittens.
Topics: Aging; Animals; Axonal Transport; Brain; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Leucine; Proline; Putamen | 1980 |
RNA and protein synthesis in cultured human fibroblasts derived from donors of various ages.
Topics: Adolescent; Adult; Aged; Aging; Cell Membrane Permeability; Cells, Cultured; Child; Child, Preschool; Fetus; Fibroblasts; Humans; Infant; Infant, Newborn; Kinetics; Leucine; Male; Middle Aged; Nucleotides; Octoxynol; Polyethylene Glycols; Protein Biosynthesis; RNA | 1980 |
Age-related changes in the cellular level of amylase and protein synthesis in the rat parotid gland.
Topics: Aging; alpha-Amylases; Amylases; Animals; DNA; Leucine; Male; Parotid Gland; Rats; Salivary Proteins and Peptides | 1981 |
Comparative studies of the age-related changes in protein synthesis in the rat pancreas and parotid gland.
Topics: Aging; alpha-Amylases; Amylases; Animals; Cytoplasmic Granules; Hydrogen-Ion Concentration; Leucine; Male; Pancreas; Parotid Gland; Protein Biosynthesis; Rats; Salivary Proteins and Peptides | 1981 |
Haemoglobin synthesis by fetal erythroid cells in an adult environment.
Topics: Aging; Animals; Bone Marrow; Female; Fetal Hemoglobin; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hemoglobin A; Leucine; Male; Sheep | 1981 |
The development of axonal connections in the central olfactory system of rats.
Topics: Aging; Animals; Axonal Transport; Axons; Central Nervous System; Cerebral Cortex; Female; Gestational Age; Horseradish Peroxidase; Leucine; Olfactory Bulb; Olfactory Pathways; Pregnancy; Rats; Rats, Inbred Strains | 1984 |
The development of lamination of afferent fibers to the olfactory cortex in rats, with additional observations in the adult.
Topics: Afferent Pathways; Aging; Animals; Axonal Transport; Central Nervous System; Cerebral Cortex; Horseradish Peroxidase; Leucine; Olfactory Bulb; Olfactory Pathways; Rats; Rats, Inbred Strains | 1984 |
Generalized diminution in the response to nutrients as insulin-releasing agents during the early neonatal period in the rat.
Topics: Aging; Animals; Animals, Newborn; Cyclic AMP; Eating; Female; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Rats | 1981 |
Effects of intravenous glucose on whole body leucine dynamics, studied with 1-13C-leucine, in healthy young and elderly adults.
Topics: Adult; Aged; Aging; Amino Acids; Blood Glucose; Carbon Isotopes; Catecholamines; Female; Glucagon; Glucose; Humans; Hydrocortisone; Infusions, Parenteral; Insulin; Kinetics; Leucine; Male; Radioimmunoassay; Sex Factors | 1984 |
Transport of branched-chain amino acids in brain slices of developing and adult rats.
Topics: Aging; Amino Acids; Amino Acids, Branched-Chain; Animals; Biological Transport; Brain; Extracellular Space; gamma-Aminobutyric Acid; In Vitro Techniques; Isoleucine; Leucine; Rats; Rats, Inbred Strains; Valine | 1984 |
Age-related functional alteration of mouse liver ribosomes.
Topics: Aging; Animals; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Polyribosomes; Ribosomal Proteins; Ribosomes | 1983 |
Erythroid colony development as a function of age: the role of marrow cellular heme.
Topics: 5-Aminolevulinate Synthetase; Aging; Animals; Erythrocytes; Erythropoiesis; Glycine; Hematopoietic Stem Cells; Heme; Heme Oxygenase (Decyclizing); Leucine; Male; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Uridine | 1983 |
The effects of aging on local rates of cerebral protein synthesis in rats.
Topics: Aging; Animals; Brain; Energy Metabolism; Leucine; Nerve Tissue Proteins; Neurons; Rats | 1984 |
Turnover of intestinal brush-border proteins during postnatal development in rat.
Topics: Aging; alpha-Glucosidases; Animals; beta-Galactosidase; Cathepsins; Cell Membrane; Intestinal Mucosa; Leucine; Lysosomes; Membrane Proteins; Microvilli; Pancreas; Peptide Hydrolases; Rats; Trehalase | 1980 |
Higher excretion of urinary bound amino acids in infants: probably related to protein-anabolic effect of growth hormone.
Topics: Aging; Alanine; Amino Acids; Arginine; Child; Child, Preschool; Cystine; Cystinuria; Glycine; Growth Hormone; Histidine; Humans; Infant; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proteins; Valine | 1982 |
Long-term effects of deendothelialization of rabbit aorta: in vitro synthesis of DNA, protein, and lipid.
Topics: Acetates; Aging; Animals; Aorta; Catheterization; Cholesterol; DNA; Endothelium; Leucine; Lipids; Male; Mevalonic Acid; Protein Biosynthesis; Rabbits; Thymidine | 1983 |
Effect of age on leucine-induced insulin secretion by the beta-cell.
Topics: Aging; Animals; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Rats | 1980 |
Diabetes in pregnancy: effects on the maturation of (pro) insulin biosynthesis in fetal and neonatal rat islets.
Topics: Aging; Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Female; Gestational Age; Glucose; Islets of Langerhans; Leucine; Pregnancy; Pregnancy in Diabetics; Proinsulin; Rats; Rats, Inbred Strains | 1981 |
Functional properties of rat liver protein synthesizing machinery in relation to aging.
Topics: Aging; Animals; Female; In Vitro Techniques; Kinetics; Leucine; Liver; Polyribosomes; Protein Biosynthesis; Rats; Ribosomes | 1982 |
Effects of centrally and systemically administered L-tyrosine and L-leucine on ovarian function in the old rat.
Topics: Aging; Animals; Catecholamines; Estrus; Female; Leucine; Levodopa; Ovary; Pregnancy; Preoptic Area; Rats; Serotonin; Tyrosine | 1980 |
Effects of age and cardiac work in vitro on mitochondrial oxidative phosphorylation and (3H)-leucine incorporation.
Topics: Aging; Animals; In Vitro Techniques; Leucine; Male; Mitochondria, Heart; Oxidative Phosphorylation; Rats; Tritium; Ventilation-Perfusion Ratio | 1981 |
Tritiated leucine incorporation in the developing hamster facial nucleus with injury: a liquid scintillation study.
Topics: Aging; Animals; Cell Nucleolus; Cricetinae; Facial Nerve; Leucine; Mesocricetus; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Tritium | 1981 |
Does the capacity of ribosomes to control translation fidelity change with age?
Topics: Aging; Animals; Dose-Response Relationship, Drug; Leucine; Magnesium; Male; Paromomycin; Peptide Chain Elongation, Translational; Phenylalanine; Poly U; Rats; Ribosomes | 1981 |
Correction of immunodeficiency in aged mice by levamisole and bestatin administration.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibody-Dependent Cell Cytotoxicity; Immunologic Deficiency Syndromes; Leucine; Levamisole; Lymphocytes; Macrophages; Mice; Neoplasms | 1980 |
Turnover of myelin proteins of rat brain, determined in fractions separated by sedimentation in a continuous sucrose gradient.
Topics: Aging; Animals; Brain; Centrifugation, Density Gradient; Female; Leucine; Male; Myelin Proteins; Rats; Time Factors | 1981 |
Dietary effects on in vitro rat neuronal protein synthesis during growth and development.
Topics: Aging; Animals; Brain; Dietary Proteins; Leucine; Nerve Tissue Proteins; Neurons; Nutrition Disorders; Rats; Rats, Inbred Strains | 1981 |
Tritiated leucine incorporation in the developing hamster facial nucleus with injury: an autoradiographic study.
Topics: Aging; Animals; Autoradiography; Axons; Cricetinae; Facial Nerve; Kinetics; Leucine; Mesocricetus; Neurons; Tritium | 1981 |
Effects of growth hormone on adipose tissue of weanling rats.
Topics: Adipose Tissue; Aging; Animals; Epinephrine; Female; Glucose; Growth Hormone; Leucine; Lipid Mobilization; Male; Rats; Rats, Inbred Strains; Sex Factors | 1981 |
Changes in brain protein synthesis during the life span of male Fischer rats.
Topics: Aging; Animals; Brain; Cell-Free System; DNA; Leucine; Male; Nerve Tissue Proteins; Phenylalanine; Rats; Ribosomes; RNA | 1980 |
The effect of chloramphenicol, ethidium bromide and cycloheximide on mortality and mitochondrial protein synthesis of adult blowflies.
Topics: Aging; Animals; Chloramphenicol; Cycloheximide; Diptera; Dose-Response Relationship, Drug; Ethidium; Leucine; Mitochondria, Muscle; Muscle Proteins | 1980 |
Age-related decline in protein synthesis in the rat parotid gland.
Topics: Aging; Animals; Glucose; In Vitro Techniques; Leucine; Microscopy, Electron; Parotid Gland; Protein Biosynthesis; Rats | 1980 |
Translational activity and fidelity of purified ribosomes from aging mouse livers.
Topics: Aging; Animals; In Vitro Techniques; Leucine; Liver; Mice; Phenylalanine; Protein Biosynthesis; RNA, Ribosomal | 1980 |
Synthesis of the myelin proteolipid protein in the developing mouse brain.
Topics: Aging; Animals; Brain; Electrophoresis, Polyacrylamide Gel; Female; Leucine; Male; Mice; Myelin Proteins; Proteolipids | 1980 |
Protein turnover in growing pigs. Effects of age and food intake.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Body Temperature Regulation; Body Weight; Diet; Dietary Proteins; Energy Metabolism; Female; Leucine; Male; Nitrogen; Protein Biosynthesis; Proteins; Swine | 1980 |
Protein synthesis in retinas of rats with inherited retinal dystrophy.
Topics: Aging; Animals; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Leucine; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Retina; Retinal Degeneration; Rod Cell Outer Segment; Solubility | 1980 |
Age-dependent change in intestinal absorption of dipeptides and their constituent amino acids in the guinea pig.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Dipeptides; Glycine; Glycylglycine; Guinea Pigs; Ileum; Intestinal Absorption; Jejunum; Leucine | 1980 |
Effects of excess dietary leucine and leucine catabolites on growth and immune responses in weanling pigs.
Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids; Animals; Avena; Blood Urea Nitrogen; Crosses, Genetic; Dexamethasone; Diet; Female; Fish Products; Food, Fortified; Hydroxybutyrates; Immunity, Cellular; Immunoglobulin G; Immunoglobulin M; Keto Acids; Leucine; Male; Milk Proteins; Random Allocation; Swine; Triticum; Weaning; Whey Proteins | 1995 |
Crystallin degradation and insolubilization in regions of young rat lens with calcium ionophore cataract.
Topics: Aging; Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Lens, Crystalline; Leucine; Molecular Sequence Data; Organ Culture Techniques; Protein Denaturation; Rats; Rats, Sprague-Dawley; Solubility | 1995 |
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
Topics: Aging; Amino Acid Sequence; Animals; Drosophila; Eye; Gene Expression; Genetic Code; Leucine; Molecular Sequence Data; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Trachea | 1994 |
Protein and energy balance following femoral neck fracture in geriatric patients.
Topics: Aged; Aged, 80 and over; Aging; Blood; Energy Metabolism; Female; Femur Neck; Hip Fractures; Humans; Leucine; Male; Nitrogen; Parenteral Nutrition, Total; Reference Values | 1995 |
Rates of local cerebral protein synthesis in the rat during normal postnatal development.
Topics: Aging; Animals; Animals, Newborn; Brain; Female; Leucine; Nerve Tissue Proteins; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Reference Values; Tissue Distribution | 1995 |
Myofibrillar protein synthesis in young and old human subjects after three months of resistance training.
Topics: Adult; Aged; Aging; Creatinine; Exercise; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Muscle Proteins; Myofibrils; Weight Lifting | 1995 |
L-leucine intestinal transport at different ages in chicken: effect of anticoccidial drugs.
Topics: Aging; Animals; Body Weight; Chickens; Coccidiostats; Diet; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Leucine; Male; Models, Biological | 1993 |
A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons.
Topics: Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cattle; Cerebellum; Consensus Sequence; Conserved Sequence; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; In Situ Hybridization; Leucine; Molecular Sequence Data; Neurons; Neuropeptides; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Purkinje Cells; Rats; Rats, Wistar; Repetitive Sequences, Nucleic Acid; Restriction Mapping | 1994 |
Postprandial myofibrillar and whole body protein synthesis in young and old human subjects.
Topics: Adult; Aging; Eating; Female; Homeostasis; Humans; Insulin; Leucine; Male; Middle Aged; Myofibrils; Osmolar Concentration; Protein Biosynthesis | 1994 |
In vitro effect of hormones and growth factors on the incorporation of [3H]leucine, [35S]sulfate and [3H]proline by chondrocytes of aging mice.
Topics: Aging; Animals; Autoradiography; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Glycosaminoglycans; Growth Substances; Hormones; Leucine; Male; Mice; Mice, Inbred ICR; Proline; Proteins; Sulfates; Sulfur Radioisotopes; Time Factors; Tritium | 1993 |
Opsin synthesis in the C57BL/6-mivit/mivit mouse model of retinal degeneration.
Topics: Aging; Animals; Dark Adaptation; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Leucine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Photoreceptor Cells; Retinal Degeneration; Rod Opsins | 1993 |
Organ clearance of tyrosyl-arginine and its effect on amino acid metabolism in young sheep.
Topics: Aging; Amino Acids; Analgesics; Animals; Arginine; Citrulline; Endorphins; Female; Hindlimb; Intestinal Mucosa; Intestines; Isoleucine; Kidney; Leucine; Liver; Metabolic Clearance Rate; Organ Specificity; Phenylalanine; Regional Blood Flow; Sheep; Tyrosine; Valine | 1993 |
Cultured adult cardiac myocytes maintain protein synthetic capacity of intact adult hearts.
Topics: Aging; Animals; Cats; Cell Count; Cells, Cultured; Hypertrophy; Kinetics; Leucine; Muscle Proteins; Myocardial Contraction; Myocardium | 1993 |
Developmental pattern of branched-chain 2-oxo acid dehydrogenase complex in rat liver and heart.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Aging; Animals; Animals, Newborn; Heart; Ketone Oxidoreductases; Leucine; Liver; Multienzyme Complexes; Myocardium; Rats; RNA, Messenger | 1993 |
Myofibrillar protein synthesis in young and old men.
Topics: Adult; Age Factors; Aged; Aging; Anthropometry; Humans; Leucine; Male; Muscle Proteins; Muscles; Myofibrils | 1993 |
Chronic protein deficiency differentially affects the kinetics of plasma proteins in young pigs.
Topics: Aging; Animals; Apolipoprotein A-I; Blood Proteins; Female; Fibrinogen; Haptoglobins; Leucine; Male; Prealbumin; Protein Deficiency; Retinol-Binding Proteins; Retinol-Binding Proteins, Plasma; Serum Albumin; Swine; Transferrin; Tritium | 1996 |
Effect of prepubertal retinyl palmitate treatment on uterine development and subsequent uterine capacity in swine.
Topics: Acid Phosphatase; Aging; Animals; Anticarcinogenic Agents; Diterpenes; Endometrium; Female; Hysterectomy; Leucine; Litter Size; Organ Size; Ovariectomy; Pregnancy; Random Allocation; Retinol-Binding Proteins; Retinyl Esters; Sexual Maturation; Swine; Tritium; Uterus; Vitamin A | 1996 |
Ontogenetic development of proline intestinal transport in the domestic fowl.
Topics: Aging; Analysis of Variance; Animals; Biological Transport, Active; Body Weight; Chickens; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Leucine; Male; Mercuric Chloride; Proline | 1996 |
Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein.
Topics: Aging; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; Cloning, Molecular; Cosmids; Embryonic and Fetal Development; Exons; Female; Gene Expression Regulation, Developmental; Humans; Leucine; Leukemia, Erythroblastic, Acute; Megakaryocytes; Membrane Proteins; Mice; Molecular Sequence Data; Muscle, Skeletal; Muscle, Smooth; Placenta; Pregnancy; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid | 1996 |
The effect of aging and dietary restriction on the retinoylation of nuclear matrix proteins in rats.
Topics: Aging; Animals; Antigens, Nuclear; Bone Marrow; Diet; Electrophoresis, Gel, Two-Dimensional; Food Deprivation; HL-60 Cells; Humans; Immunochemistry; Leucine; Male; Molecular Weight; Nuclear Proteins; Rats; Rats, Inbred F344; Receptors, Retinoic Acid; Tretinoin | 1996 |
Splanchnic and whole-body leucine kinetics in young and elderly men.
Topics: Adult; Aged; Aging; Body Composition; Diet; Humans; Intestinal Absorption; Leucine; Male; Mesentery; Postprandial Period; Proteins | 1997 |
Rates of local cerebral protein synthesis in fetal and neonatal sheep.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Brain; Carbon Radioisotopes; Electroencephalography; Embryonic and Fetal Development; Fetus; Gestational Age; Leucine; Nerve Tissue Proteins; Organ Specificity; Regression Analysis; Sheep | 1997 |
Amino acids suppress proteolysis independent of insulin throughout the neonatal period.
Topics: Aging; Amino Acids; Blood Glucose; Humans; Hydroxylation; Infant, Newborn; Infusions, Intravenous; Insulin; Leucine; Osmolar Concentration; Oxidation-Reduction; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Tyrosine | 1997 |
Protein requirements and ageing: metabolic demand and efficiency of utilization.
Topics: Adult; Aged; Aged, 80 and over; Aging; Carbon Isotopes; Dietary Proteins; Female; Humans; Infusions, Intravenous; Leucine; Male; Nitrogen; Nutritional Requirements; Oxidation-Reduction; Postprandial Period | 1997 |
The effect of an increase of protein intake on whole-body protein turnover in elderly women is tracer dependent.
Topics: Aged; Aging; Carbon Isotopes; Dietary Proteins; Fasting; Female; Glycine; Humans; Leucine; Nitrogen Isotopes | 1997 |
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans.
Topics: Adult; Aged; Aging; Analysis of Variance; Biopsy; Carbon Isotopes; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Muscle Development; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; Regression Analysis; Sarcoplasmic Reticulum; Sex Characteristics | 1997 |
Impact of protein deprivation on protein and DNA synthesis in the developing rat pancreas.
Topics: Aging; Animals; Dietary Proteins; DNA; Female; Lactation; Leucine; Pancreas; Pregnancy; Protein Biosynthesis; Protein Deficiency; Rats; Rats, Wistar; Tritium; Weaning | 1998 |
Age effect on fibrinogen and albumin synthesis in humans.
Topics: Adult; Aged; Aging; Female; Fibrinogen; Humans; Keto Acids; Leucine; Male; Middle Aged; Osmolar Concentration; Phenylalanine; Protein Precursors; Serum Albumin | 1998 |
Gender differences in basal protein kinetics in young adults.
Topics: Adult; Aging; Female; Fibrinogen; Humans; Leucine; Male; Oxidation-Reduction; Serum Albumin; Sex Characteristics | 1998 |
Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability.
Topics: Adolescent; Adult; Aged; Aggrecans; Aging; Cartilage, Articular; Child; Extracellular Matrix Proteins; Humans; Kinetics; Lectins, C-Type; Leucine; Middle Aged; Protein Biosynthesis; Proteins; Proteoglycans; RNA, Messenger | 1999 |
The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism.
Topics: Adult; Aged; Aged, 80 and over; Aging; Critical Care; Critical Illness; Female; Glutamine; Humans; Kinetics; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Osmolar Concentration; Protein Biosynthesis; Proteins; Reference Values; Time Factors | 1999 |
Effect of intravenous glutamine on duodenal mucosa protein synthesis in healthy growing dogs.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Carbon Isotopes; Dogs; Duodenum; Glutamine; Glycine; Infusions, Intravenous; Intestinal Mucosa; Kinetics; Leucine; Protein Biosynthesis | 1999 |
Limited myogenic response to a single bout of weight-lifting exercise in old rats.
Topics: Aging; Animals; Body Weight; Cell Division; DNA; Gene Expression Regulation; Leucine; Male; Muscle Contraction; Muscle Development; Muscle, Skeletal; MyoD Protein; Organ Size; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Weight Lifting | 2000 |
Somatotropin increases protein balance independent of insulin's effects on protein metabolism in growing pigs.
Topics: Aging; Animals; Glucose; Growth Hormone; Hormones; Hypoglycemic Agents; Insulin; Insulin Antagonists; Leucine; Oxidation-Reduction; Reference Values; Swine | 2000 |
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leucine; Male; Morpholines; Muscle Proteins; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Sirolimus | 2000 |
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Lysine; Male; Methionine; Microvilli; Mink; Monosaccharides; Proline | 2000 |
Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women.
Topics: Adult; Age Factors; Aged; Aging; Amino Acids; Blood Glucose; Body Mass Index; Carbon Isotopes; Female; Glucose; Glucose Clamp Technique; Homeostasis; Humans; Infusions, Intravenous; Insulin; Leucine; Male; Proteins; Serum Albumin | 2001 |
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Substitution; Arginine; Arteriosclerosis; Coronary Artery Disease; Cysteine; Finland; Gene Frequency; Genotype; Haplotypes; Humans; Infant, Newborn; Leucine; Longevity; Mexico; Middle Aged; Phenylalanine; Polymorphism, Genetic; Werner Syndrome | 2000 |
Energetic cost of protein turnover in healthy elderly humans.
Topics: Adipose Tissue; Adult; Aged; Aging; Basal Metabolism; Body Composition; Calorimetry, Indirect; Carbon Isotopes; Electric Impedance; Female; Humans; Indicator Dilution Techniques; Leucine; Male; Proteins | 2001 |
Effects of insulin and amino acids on leucine metabolism in young and middle-aged humans.
Topics: Adult; Aging; Amino Acids; Carbon Isotopes; Fasting; Female; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Leucine; Male; Middle Aged; Oxidation-Reduction; Radioisotope Dilution Technique | 2001 |
Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal.
Topics: Aging; Alanine; Amino Acids; Animals; Carbon Isotopes; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Rats; Rats, Wistar; Time Factors | 2002 |
Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant.
Topics: Aging; Birth Weight; Carbon Isotopes; Dietary Proteins; Energy Intake; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Keto Acids; Leucine; Pre-Eclampsia; Pregnancy; Proteins | 2002 |
In vitro synthesis of the myelin basic proteins in the developing mouse brain: properties of a homogenate system.
Topics: Aging; Animals; Animals, Newborn; Brain; Kinetics; Leucine; Mice; Myelin Basic Protein; Protein Biosynthesis | 1979 |
The effect of age on enolase turnover in the free-living nematode, Turbatrix aceti.
Topics: Aging; Animals; Immunodiffusion; Kinetics; Leucine; Nematoda; Phosphopyruvate Hydratase | 1979 |
Transfer RNA in aging Drosophila: II. Isoacceptor patterns.
Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Asparagine; Drosophila melanogaster; Histidine; Leucine; Male; RNA, Transfer; Tyrosine | 1979 |
Postnatal amino acid uptake by the rat small intestine. Changes in membrane transport systems for amino acids associated with maturation of jejunal morphology.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Biological Transport, Active; gamma-Aminobutyric Acid; In Vitro Techniques; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Lysine; Methionine; Phenylalanine; Rats; Valine | 1979 |
Age-dependence of the x-ray-induced deficiency in DNA synthesis in HeLa S3 cells during Generation 1.
Topics: Aging; Cell Division; DNA; DNA, Neoplasm; Dose-Response Relationship, Radiation; Floxuridine; HeLa Cells; Hydroxyurea; Leucine; Mitosis; Protein Biosynthesis; Radiation Effects; Thymidine; X-Rays | 1975 |
Restoration of impaired immune functions of aged animals by chronic bestatin treatment.
Topics: Aging; Animals; Antibody Formation; Antibody-Dependent Cell Cytotoxicity; Hypersensitivity, Delayed; Immunity; Leucine; Life Expectancy; Lymphocyte Activation; Lymphoma, Non-Hodgkin; Macrophages; Mice; Spleen; T-Lymphocytes, Regulatory | 1979 |
Amino acid analog incorporation into protein in dimethyl sulfoxide and mutagen-treated aging mice.
Topics: Aging; Aminoisobutyric Acids; Animals; Dimethyl Sulfoxide; Female; Genetic Code; Hemoglobins; Leucine; Ligases; Male; Mesylates; Methyl Methanesulfonate; Mice; Radiation Injuries, Experimental; RNA, Transfer, Amino Acyl | 1978 |
Content, synthesis and degradation of acetyl-coenzyme A carboxylase in the liver of growing chicks.
Topics: Acetyl-CoA Carboxylase; Aging; Animals; Antigen-Antibody Reactions; Chickens; Immunodiffusion; Leucine; Ligases; Liver; Time Factors | 1975 |
On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio.
Topics: Adult; Aging; Aminobutyrates; Child; Child, Preschool; Humans; Infant; Leucine; Liver Diseases; Metabolism, Inborn Errors | 1979 |
Incorporation of leucine metabolites into brain and sciatic nerve myelin.
Topics: Aging; Animals; Brain; Female; Leucine; Male; Myelin Proteins; Rats; Sciatic Nerve | 1979 |
Developmental and methylmercury effects on brain protein synthesis.
Topics: Aging; Animals; Brain; Leucine; Methylmercury Compounds; Nerve Tissue Proteins; Rats; Time Factors | 1979 |
Derangement in cardiac protein metabolism in fetal alcohol syndrome.
Topics: Aging; Animals; Animals, Newborn; Diet; DNA; Female; Fetal Alcohol Spectrum Disorders; In Vitro Techniques; Leucine; Muscle Proteins; Myocardium; Pregnancy; Rats; Ribosomes; RNA | 1979 |
Age-associated changes in activities of rat hepatocytes. I. Protein synthesis.
Topics: Aging; Animals; Leucine; Liver; Male; Peptide Biosynthesis; Protein Biosynthesis; Rats; Subcellular Fractions | 1979 |
[Activity of blood serum leucine aminopeptidase (LAP) and lactate dehydrogenase (LDH) in healthy non-pregnant women depending on their age].
Topics: Adolescent; Adult; Aging; Female; Humans; L-Lactate Dehydrogenase; Lactates; Leucine; Leucyl Aminopeptidase; Menstruation | 1979 |
The nucleosome repeat length increases during erythropoiesis in the chick.
Topics: Aging; Animals; Chick Embryo; Chickens; DNA; Erythroblasts; Erythrocytes; Erythropoiesis; Histones; Leucine; Lysine; Nucleoproteins | 1978 |
Protein biosynthesis in aging mouse tissues.
Topics: Aging; Aminolevulinic Acid; Animals; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes; Microsomes, Liver; Muscle Proteins; Myocardium; Protein Biosynthesis; Subcellular Fractions | 1977 |
Age-related changes in ribosomal profiles and in vitro protein synthesis in skeletal muscle during fasting and subsequent refeeding of rats.
Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Centrifugation, Density Gradient; Fasting; Leucine; Male; Muscle Proteins; Muscles; Rats; Ribosomes; RNA; RNA, Ribosomal | 1978 |
The metabolism of leucine by developing rat brain: effect of leucine and 2-oxo-4-methylvalerate on lipid synthesis from glucose and ketone bodies.
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Female; Glucose; Keto Acids; Ketone Bodies; Leucine; Lipids; Male; Pregnancy; Rats; Valerates | 1978 |
Enhanced cerebral protein synthesis in developing hypothyroid rats: evidence for delayed maturation.
Topics: Aging; Animals; Cerebral Cortex; Hypothyroidism; In Vitro Techniques; Kinetics; Leucine; Nerve Tissue Proteins; Rats | 1978 |
[Regulation of the synthesis and secretion of prolactin (LTH) and growth hormone (STH) in rats].
Topics: Aging; Animals; Chorionic Gonadotropin; Female; Growth Hormone; In Vitro Techniques; Leucine; Male; Organ Size; Ovary; Pituitary Gland; Progesterone; Prolactin; Rats | 1978 |
Age-related changes of accuracy and efficiency of protein synthesis machinery in rat.
Topics: Aging; Animals; Carbon Radioisotopes; Isotope Labeling; Kinetics; Leucine; Liver; Phenylalanine; Poly U; Protein Biosynthesis; Rats; Ribosomes; Tritium | 1977 |
Altered amounts of hemoglobin synthesis in livers of dystrophic hamsters.
Topics: Aging; Animals; Cricetinae; Hemoglobins; Leucine; Liver; Muscular Dystrophy, Animal | 1977 |
Age-related changes in course of restitution of secretory material in rat submandibular gland stimulated with isoproterenol.
Topics: Aging; Animals; Histocytochemistry; Isoproterenol; Leucine; Male; Rats; Submandibular Gland | 1977 |
[Molecular biology of aging. Part 9: Age-dependent effects of 2-mercapto-ethanol on protein synthesis in the cell-free system of the rat liver].
Topics: Aging; Animals; Cell-Free System; Female; Leucine; Mercaptoethanol; Microsomes, Liver; Protein Biosynthesis; Rats | 1977 |
[Molecular biology of aging. 8. Aging of intermitotic cells--relationship to protein synthesis in the mucosa of the small intestine].
Topics: Aging; Animals; Cytosol; Female; Interphase; Intestinal Mucosa; Leucine; Microsomes; Protein Biosynthesis; Rats | 1977 |
Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.
Topics: Aging; Amino Acids; Biological Transport; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Kinetics; Leucine; Mathematics; Protein Biosynthesis; Proteins; Time Factors | 1976 |
Aging of human bone and articular cartilage collagen: changes in the reducible cross-links and their precursors.
Topics: Adolescent; Adult; Aged; Aging; Bone and Bones; Cartilage, Articular; Child; Child, Preschool; Collagen; Humans; Leucine; Lysine; Middle Aged; Solubility | 1976 |
[Biochemical basis of aging].
Topics: Aging; Animals; Collagen; Connective Tissue; DNA; Free Radicals; Genes; Humans; Leucine; Protein Biosynthesis; Proteins; Rats; RNA | 1976 |
Alterations in proline metabolic enzymes with mammalian development.
Topics: Aging; Animals; Carboxylic Acids; Female; Kidney; Kinetics; Leucine; Liver; Mitochondria, Liver; Organ Specificity; Oxidoreductases; Oxygenases; Pregnancy; Proline; Pyrroles; Rats; Stereoisomerism; Valine | 1976 |
[Influence of cytosolic fraction on incorporation of aminoacids into microsomal system of rat liver (author's transl)].
Topics: Age Factors; Aging; Animals; Cytosol; Leucine; Microsomes, Liver; Molecular Biology; Rats | 1976 |
Altered regulation of protein synthesis during aging as determined by in vitro ribosomal assays.
Topics: Aging; Animals; Centrifugation, Density Gradient; Leucine; Male; Mice; Mice, Inbred C57BL; Muscles; Rats; Ribonucleases; Ribosomal Proteins; Ribosomes; RNA, Transfer; Tritium | 1975 |
Leucine incorporation into proteins and cathepsin -D activity in human skeletal muscles. The influence of the age of the subject.
Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Biopsy; Carbon Radioisotopes; Cathepsins; Cell Fractionation; Cell Nucleus; Female; Humans; Leucine; Male; Microsomes; Middle Aged; Muscle Proteins; Muscles; Regression Analysis; Stimulation, Chemical | 1975 |
Age-related changes in the incorporation of [14-C] leucine into myofibrillar and sarcoplasmic proteins of red and white muscles of chicks.
Topics: Aging; Animals; Carbon Radioisotopes; Chickens; Color; Cytoplasm; Leucine; Male; Muscle Proteins; Muscles; Myofibrils; Myosins | 1975 |
Protein synthesis and amino acid accumulation during development in the rat: dissociation of diaphragm and heart muscle sensitivity to insulin.
Topics: Aging; Aminoacylation; Animals; Animals, Newborn; Diaphragm; Female; Fetus; Heart; Insulin; Leucine; Muscle Development; Muscle Proteins; Myocardium; Pregnancy; Protein Biosynthesis; Rats | 1975 |
The effect of ageing on in vitro fidelity of translation in mouse liver.
Topics: Aging; Animals; Leucine; Liver; Magnesium; Mice; Microsomes, Liver; Phenylalanine; Poly U; Protein Biosynthesis | 1975 |
Lens growth in the Nakano mouse.
Topics: Aging; Animals; Cataract; Crystallins; Lens, Crystalline; Leucine; Mice | 1976 |
[Variations in the in vivo incorporation of L-(3H)leucine into the proteins of the cerebellum of normal hypo- and hyperthyroid rats during the first ten days of postnatal life (author's transl)].
Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Hyperthyroidism; Hypothyroidism; Leucine; Nerve Tissue Proteins; Protein Biosynthesis; Rats | 1976 |
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: the possible role of glia.
Topics: Aging; Animals; Blood; Cells, Cultured; Chick Embryo; Chickens; Culture Media; Glucose-6-Phosphate; Glucosephosphates; Glycoproteins; Leucine; Mannose; Nerve Tissue Proteins; Neuroglia; Neurons; Superior Colliculi; Tritium | 1992 |
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins | 1992 |
Effects of aging on gene expression of acetyl-CoA carboxylase and fatty acid synthase in rat liver.
Topics: Acetyl-CoA Carboxylase; Aging; Animals; Autoradiography; Enzyme Induction; Fatty Acid Synthases; Gene Expression; Leucine; Liver; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger; Transcription, Genetic | 1992 |
Research note: age-dependent changes in 3-oxy-methyl-D-glucose and leucine intestinal absorption in chickens.
Topics: 3-O-Methylglucose; Aging; Animals; Chickens; Intestinal Absorption; Leucine; Male; Methylglucosides | 1992 |
Intestinal amino acid and monosaccharide transport in suckling pigs fed milk replacers with different sources of carbohydrate.
Topics: Aging; Amino Acids; Animals; Animals, Suckling; Biological Transport; Dietary Carbohydrates; Female; Food, Formulated; Fructose; Galactose; Glucose; Intestinal Absorption; Intestinal Mucosa; Lactose; Leucine; Male; Milk; Monosaccharides; Polysaccharides; Proline; Sucrose; Swine; Weight Gain | 1992 |
Mechanism of maturational decline of rat intestinal lactase-phlorizin hydrolase.
Topics: Aging; alpha-Glucosidases; Animals; Carbohydrate Metabolism; Carbon Radioisotopes; Intestine, Small; Kinetics; Lactase-Phlorizin Hydrolase; Leucine; Protein Biosynthesis; Proteins; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Sucrase-Isomaltase Complex; Tritium | 1992 |
Age-related modifications of leucine uptake in brush-border membrane vesicles from rat jejunum.
Topics: Aging; Animals; Biological Transport, Active; In Vitro Techniques; Jejunum; Kinetics; Leucine; Male; Membrane Potentials; Microvilli; Potassium; Rats; Rats, Inbred Strains; Sodium | 1992 |
[The comparative characteristics of the age-related changes in the rate of fast axonal transport in the vagus and hypoglossal nerves and in the ventral spinal cord roots of rats].
Topics: Aging; Animals; Axonal Transport; Hypoglossal Nerve; Leucine; Male; Rats; Spinal Nerve Roots; Time Factors; Tritium; Vagus Nerve | 1990 |
Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis.
Topics: Aging; Animals; Animals, Newborn; Brain; Dexamethasone; DNA; Dose-Response Relationship, Drug; Female; Fetus; Hypoxia; Leucine; Nerve Tissue Proteins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Thymidine | 1991 |
Enhanced protein breakdown after eccentric exercise in young and older men.
Topics: Adult; Aging; Calorimetry; Carbon Dioxide; Creatine Kinase; Exercise; Humans; Kinetics; Leucine; Male; Methylhistidines; Middle Aged; Nitrogen; Oxygen Consumption; Proteins | 1991 |
Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
Topics: Aging; Animals; Cell Count; Cells, Cultured; Endopeptidases; Growth Hormone; Growth Hormone-Releasing Hormone; Leucine; Male; Pituitary Gland, Anterior; Proteins; Rats; Rats, Inbred F344; Tritium; Trypsin | 1991 |
Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions.
Topics: Aging; Animals; Brain; Cell Division; Cocaine; DNA; Female; Leucine; Lidocaine; Methoxamine; Nerve Tissue Proteins; Phenoxybenzamine; Pregnancy; Rats; Rats, Inbred Strains; Thymidine | 1990 |
A critical crosslink region in human-bone-derived collagen type I. Specific cleavage site at residue Leu95.
Topics: Adult; Aging; Amino Acid Sequence; Bone and Bones; Bony Callus; Collagen; Cross-Linking Reagents; Electrophoresis; Hot Temperature; Humans; Leucine; Microbial Collagenase; Molecular Sequence Data; Osteogenesis Imperfecta; Pepsin A; Peptides; Skin | 1990 |
Effects of ageing on transcriptional and post-transcriptional regulation of malic enzyme and glucose-6-phosphate dehydrogenase in rat liver.
Topics: Aging; Animals; Blotting, Northern; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Insulin; Leucine; Liver; Malate Dehydrogenase; Male; Nucleic Acid Hybridization; Polyribosomes; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic; Triiodothyronine | 1990 |
Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats.
Topics: Aging; Animals; Cycloheximide; Femur; Leucine; Male; Picolinic Acids; Protein Biosynthesis; Rats; Rats, Inbred Strains; Tritium; Zinc | 1990 |
Protein synthesis in the neuropil of the rat dentate gyrus during synapse development.
Topics: Aging; Amino Acids; Animals; Electrophoresis, Polyacrylamide Gel; Female; Hippocampus; In Vitro Techniques; Leucine; Male; Molecular Weight; Nerve Tissue Proteins; Neurons; Peptide Biosynthesis; Polyribosomes; Rats; Synapses | 1990 |
Effects of aging and xerosis on the amino acid composition of human skin.
Topics: Aging; Amino Acids; Female; Filaggrin Proteins; Glycine; Humans; Ichthyosis; Leucine; Phenylalanine; Skin; Tyrosine | 1990 |
Regional differences in in vivo myocardial protein synthesis in the neonatal rabbit heart.
Topics: Aging; Animals; Animals, Newborn; Female; Hemodynamics; Leucine; Myocardium; Myosins; Pregnancy; Protein Biosynthesis; Rabbits; RNA, Transfer, Leu | 1990 |
The synthesis of amylase in parotid glands of young and old rats.
Topics: Aging; Amylases; Animals; Leucine; Male; Parotid Gland; Rats; Rats, Inbred Strains; Tritium | 1985 |
Metabolism of phosphate and sulfate groups modifying the P0 protein of peripheral nervous system myelin.
Topics: Aging; Animals; Kinetics; Leucine; Myelin P0 Protein; Myelin Proteins; Myelin Sheath; Peripheral Nerves; Phosphates; Rats; Rats, Inbred Strains; Sciatic Nerve; Sulfates | 1987 |
Studies on myelin-basic-protein methylation during mouse brain development.
Topics: Aging; Amino Acids; Animals; Brain; Electrophoresis, Polyacrylamide Gel; Leucine; Methionine; Methylation; Mice; Mice, Inbred Strains; Myelin Basic Protein | 1986 |
Age-related changes in the proliferative kinetics of phytohemagglutinin-stimulated lymphocytes. Analysis by uptake of tritiated precursors of DNA, RNA and proteins, and by flow cytometry.
Topics: Adult; Aged; Aging; Biological Transport; DNA; Female; Fetal Blood; Flow Cytometry; Humans; Infant, Newborn; Kinetics; Leucine; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Pregnancy; Protein Biosynthesis; Reference Values; RNA; Thymidine; Tritium; Uridine | 1988 |
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
Topics: Aging; Animals; Biological Transport; Dolichols; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred C57BL; Ouabain; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfobromophthalein | 1989 |
Monoclonal antibodies against rat saliva and salivary gland antigens.
Topics: Aging; Animals; Antibodies, Monoclonal; Cell Differentiation; Chemical Precipitation; Chromatography, Affinity; Collodion; Electrophoresis, Polyacrylamide Gel; Female; Histocytochemistry; Immunochemistry; Immunoenzyme Techniques; Leucine; Rats; Rats, Inbred Strains; Saliva; Salivary Glands; Staining and Labeling; Submandibular Gland | 1985 |
Immunity, infection, malignancy and aging: possible immunity restoration and tumor prevention.
Topics: Adult; Aged; Aging; Animals; Antibiotics, Antineoplastic; Humans; Immunity; Infections; Leucine; Mice; Middle Aged; Neoplasms | 1989 |
Leucine metabolism in aging humans: effect of insulin and substrate availability.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Carbon Isotopes; Humans; Insulin; Isotope Labeling; Leucine; Male; Reference Values | 1989 |
Mechanism of action of thyroxine (T4) on the biogenesis of mitochondria using antibiotic-free system: a gerontological survey.
Topics: Aging; Animals; Carbon Radioisotopes; DNA; DNA, Mitochondrial; Germ-Free Life; Leucine; Male; Mitochondria, Liver; Organelle Biogenesis; Protein Biosynthesis; Rats; Rats, Inbred Strains; Thyroxine | 1989 |
Lysosome instability in aged rat brain.
Topics: Aging; Animals; Brain; Cathepsin D; Cytosol; Glucuronidase; Leucine; Lysosomes; Rats; Rats, Inbred Strains | 1989 |
[Aging of the pancreas. Its implication in malnutrition states in elderly persons].
Topics: Adult; Aged; Aging; Animals; Humans; Leucine; Male; Nutrition Disorders; Pancreas; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1988 |
Effects of hydrocortisone on carbohydrase concentrations, de novo synthesis and turnover patterns in immature rat intestine.
Topics: Aging; alpha-Glucosidases; Animal Population Groups; Animals; Animals, Suckling; Antibodies; Antigens; beta-Galactosidase; Glucan 1,4-alpha-Glucosidase; Glycoside Hydrolases; Humans; Hydrocortisone; Infant, Newborn; Injections, Subcutaneous; Intestine, Small; Leucine; Microvilli; Oligo-1,6-Glucosidase; Proteins; Radioimmunoassay; Rats; Rats, Inbred Strains; Sucrase; Trehalase | 1986 |
Enhancement of graft-versus-host reaction and delayed cutaneous hypersensitivity in mice by ubenimex.
Topics: Adjuvants, Immunologic; Aging; Animals; Dose-Response Relationship, Drug; Graft vs Host Reaction; Hypersensitivity, Delayed; Leucine; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins | 1986 |
Further studies on the nutritional factors affecting the urinary excretion of acid-soluble peptides in rats.
Topics: Aging; Amino Acids; Animals; Caseins; Dietary Proteins; Leucine; Lysine; Male; Methylhistidines; Nitrogen; Peptides; Proline; Rats; Rats, Inbred Strains; Tryptophan; Valine | 1988 |
Leucine degradation in sheep.
Topics: Adipose Tissue; Aging; Animals; Deamination; Decarboxylation; Dietary Proteins; Kidney; Leucine; Liver; Male; Muscles; Sheep | 1988 |
Bilateral pericruciate cortical innervation of the red nucleus in cats with adult or neonatal cerebral hemispherectomy.
Topics: Aging; Animals; Autoradiography; Cats; Cerebral Cortex; Cerebral Decortication; Female; Leucine; Male; Neural Pathways; Neuronal Plasticity; Proline; Red Nucleus | 1988 |
Late effects of early feeding of a low cholesterol diet on the intestinal active and passive transport properties in the rabbit.
Topics: Aging; Animals; Bile Acids and Salts; Body Weight; Cholesterol, Dietary; Colon; Fatty Acids, Nonesterified; Female; Galactose; Glucose; Ileum; Intestinal Absorption; Jejunum; Kinetics; Leucine; Rabbits | 1987 |
The effect of electroconvulsive shock on brain tubulin during development and aging.
Topics: Aging; Animals; Brain; Colchicine; Electroshock; Leucine; Male; Microtubules; Polyribosomes; Rats; Rats, Inbred Lew; Synaptosomes; Tubulin | 1986 |
Acceleration of age-associated immune decline and mortality by early repeated administration of bestatin to C57BL/6 mice.
Topics: Adjuvants, Immunologic; Aging; Animals; Cytotoxicity Tests, Immunologic; Female; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Injections, Intraperitoneal; Interleukin-1; Interleukin-2; Killer Cells, Natural; Leucine; Life Expectancy; Lymphoma; Macrophages; Mice; Mice, Inbred C57BL; Rodent Diseases; T-Lymphocytes | 1986 |
[Effect of different fixation methods and partial chemical sympathetic denervation on cell size and 3H-leucine incorporation by rat sympathetic neurocytes].
Topics: Aging; Animals; Autoradiography; Cell Nucleus; Cytological Techniques; Leucine; Neurons; Rats; Sympathectomy, Chemical; Sympathetic Nervous System; Tritium | 1987 |
Rate of protein glycosylation in rat cerebral cortex.
Topics: Aging; Animals; Cerebral Cortex; Diffusion; Glucose; Glycoproteins; Kinetics; Leucine; Mannose; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Tritium | 1986 |
Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes.
Topics: Aging; Animals; Cell Count; Heterozygote; Leucine; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Microscopy, Electron; Phagosomes; Photoreceptor Cells; Pigment Epithelium of Eye; Retina; Retinal Degeneration; Rod Cell Outer Segment; Time Factors; Vision Disorders | 1985 |
The effects of mild congenital methylmercury intoxication on the metabolism of 3-hydroxybutyrate and glucose in the brains of suckling rats.
Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Body Weight; Brain; Female; Glucose; Hydroxybutyrates; Leucine; Lipid Metabolism; Methylmercury Compounds; Nerve Tissue Proteins; Organ Size; Oxidation-Reduction; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1985 |
The nature of maturational decline of intestinal lactase activity.
Topics: Aging; Animals; Antigen-Antibody Complex; beta-Galactosidase; Galactosidases; Immune Sera; Intestine, Small; Kinetics; Leucine; Molecular Weight; Rats; Rats, Inbred Strains; Sucrase-Isomaltase Complex | 1985 |
Early nutrition and intestinal transport function: effect of low-cholesterol diet.
Topics: Aging; Animals; Bile Acids and Salts; Cholesterol, Dietary; Colon; Fatty Acids; Galactose; Glucose; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Kinetics; Leucine; Nutritional Physiological Phenomena; Rabbits; Weaning | 1986 |
Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age.
Topics: Adult; Aged; Aging; Cycloheximide; Glycolysis; Humans; Leucine; Lymphocyte Activation; Lymphocytes; Mitosis; Models, Biological; Phytohemagglutinins; Protein Biosynthesis; Time Factors | 1985 |
Transient tectogeniculate projections in neonatal kittens: an autoradiographic study.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cats; Geniculate Bodies; Histocytochemistry; Leucine; Superior Colliculi; Visual Pathways | 1985 |
Regulation of tubulin by triiodothyronine in hypothyroid rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Colchicine; Female; Fetus; Hypothyroidism; Kinetics; Leucine; Organ Culture Techniques; Pregnancy; Rats; Triiodothyronine; Tubulin | 1985 |
Rat serum protein changes with age.
Topics: Adult; Aged; Aging; Alpha-Globulins; Animals; Blood Protein Electrophoresis; Blood Proteins; Carbon Isotopes; Female; gamma-Globulins; Humans; Leucine; Liver; Male; Rats; Serum Albumin; Serum Globulins; Tritium | 1971 |
Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Axonal Transport; Cats; Dogs; Ganglia, Spinal; Leucine; Neurons; Sciatic Nerve; Tritium | 1973 |
Effect of age on thyroxine-induced cardiac hypertrophy in mice.
Topics: Aging; Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Leucine; Male; Mice; Mice, Inbred C57BL; Myocardium; Organ Size; Protein Biosynthesis; Thyroxine; Time Factors; Tritium | 1973 |
The effect of acute exercise on amino acid incorporation into mitochondria of rabbit tissues.
Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Aging; Amino Acids; Animals; Brain; Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Hypoxia; Leucine; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen; Physical Exertion; Proline; Protein Biosynthesis; Quaternary Ammonium Compounds; Rabbits; Swimming; Testosterone | 1969 |
Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala.
Topics: Aging; Animals; Cytochromes; Diptera; Flight, Animal; Glycerophosphates; Leucine; Malates; Microscopy, Electron; Mitochondria, Muscle; Muscle Proteins; Myofibrils; NAD; Oxidative Phosphorylation; Pyruvates; Tritium | 1972 |
Cellular differentiation and isozymes of branched-chain amino acid transaminase.
Topics: Adrenal Glands; Adrenalectomy; Aging; Animals; Brain; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Chromatography, DEAE-Cellulose; Diabetes Mellitus; Female; Hydrocortisone; Hypophysectomy; Isoenzymes; Kidney; Lactation; Leucine; Liver; Liver Neoplasms; Liver Regeneration; Mammary Glands, Animal; Molecular Weight; Organ Specificity; Pituitary Gland; Pregnancy; Rats; Transaminases | 1973 |
Chemical and immunological studies of liver microsomes from mouse mutants with ultrastructurally abnormal hepatic endoplasmic reticulum.
Topics: Aging; Alleles; Animals; Animals, Newborn; Carbon Radioisotopes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Female; Fetus; Genes, Lethal; Glucose-6-Phosphatase; Immunodiffusion; Immunoelectrophoresis; Isotope Labeling; Leucine; Liver; Membranes; Mice; Microsomes, Liver; Mutation; Pregnancy; Proteins; Rabbits; Tritium | 1974 |
Heterogeneity of rough-surfaced liver microsomal membranes of adult, phenobarbital-treated, and newborn rats.
Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Centrifugation, Density Gradient; Electron Transport Complex IV; Fasting; Glucose-6-Phosphatase; Glycerol; Leucine; Liver; Membranes; Microscopy, Electron; Microsomes; NAD; NADP; Osmosis; Phenobarbital; Proteins; Rats; Tritium | 1968 |
Measurements of rates of protein synthesis in rat brain slices.
Topics: Aging; Amino Acids; Animals; Brain; Carbon Radioisotopes; Histidine; In Vitro Techniques; Kinetics; Leucine; Lysine; Male; Nerve Tissue Proteins; Phenylalanine; Time Factors; Tritium; Valine | 1974 |
[The incorporation in vivo of l-(3H)leucine into cerebellar proteins, in the young normal, underfed, hyperthyroid and hypothyroid rat (author's transl)].
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Fasting; Hyperthyroidism; Hypothyroidism; Leucine; Nerve Tissue Proteins; Propylthiouracil; Rats; Thyroxine; Time Factors; Tritium | 1974 |
Muscle protein synthesis during development of the normal and dystrophic chicken. Activity of supernatant elongation factors.
Topics: Acyltransferases; Aging; Animals; Carbon Radioisotopes; Chick Embryo; Chickens; Chromatography, Ion Exchange; Cytosol; Ethylmaleimide; Hydroxyapatites; Leucine; Muscle Development; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; Peptide Elongation Factors; Phenylalanine; Ribosomes; RNA, Transfer; Spectrophotometry, Ultraviolet; Time Factors; Transfer RNA Aminoacylation | 1974 |
Postnatal changes in the temperature dependence of synaptosomal amino acid uptake.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Calorimetry; Cerebral Cortex; Glycine; Kinetics; Leucine; Rats; Synaptosomes; Temperature; Thermodynamics; Threonine; Time Factors | 1974 |
Intestinal absorption of glycine, L-alanine and L-leucine in the old rat.
Topics: Aging; Alanine; Animals; Biological Transport; Carbon Radioisotopes; Female; Glycine; Intestinal Absorption; Intestines; Kinetics; Leucine; Liver; Organ Size; Rats | 1974 |
An electrophoretic study of protein synthesis in brain regions of senescent male mice.
Topics: Aging; Animals; Brain; Brain Stem; Carbon Radioisotopes; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Hippocampus; Hydrolysis; Hypothalamus; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Sodium Dodecyl Sulfate; Superior Colliculi; Tritium | 1974 |
Leucyl-transfer ribonucleic acid synthetase in senescing tobacco leaves.
Topics: Aging; Amino Acyl-tRNA Synthetases; Centrifugation; Chromatography; Chromatography, DEAE-Cellulose; Dialysis; Leucine; Nicotiana; Plants; Plants, Toxic; Tritium | 1974 |
A comparative study on age-related changes in protein synthesis by cardiac, red & white muscles of developing chicks.
Topics: Aging; Animals; Chickens; Leucine; Male; Muscle Proteins; Muscles; Myocardium | 1974 |
Basic mechanisms of aging.
Topics: Acetylglucosaminidase; Aging; Animals; Brain; Cathepsins; Cytoplasm; Diaphragm; DNA; Glucuronidase; Humans; Immunologic Memory; Leucine; Liver; Lysosomes; Mice; Muscles; Piracetam; Rats; RNA; Thymus Gland | 1974 |
[Measurements of lysosomal enzyme activities and leucine incorporation rates in the brains of young and old rats after application of piracetam].
Topics: Acetamides; Aging; Animals; Brain; Carbon Radioisotopes; Cathepsins; Glucuronidase; Hexosaminidases; Leucine; Lysosomes; Male; Nerve Tissue Proteins; Protein Binding; Pyrrolidinones; Rats | 1974 |
Age-dependent changes in the structure and function of mammalian chromatin. I. Variations in chromatin template activity.
Topics: Adenosine Monophosphate; Aging; Animals; Carbon Isotopes; Chromatin; Deoxycholic Acid; DNA; DNA-Directed RNA Polymerases; Escherichia coli; Histones; Leucine; Liver; Male; Protein Binding; Proteins; Rats; Ribonucleases; RNA; Submandibular Gland; Templates, Genetic; Trichloroacetic Acid; Tritium | 1973 |
Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development.
Topics: Aging; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Isotopes; Chromatography, DEAE-Cellulose; Electrophoresis, Disc; Embryo, Nonmammalian; Female; Fertilization; Leucine; Lysine; Ovum; RNA, Transfer; Saccharomyces cerevisiae; Sea Urchins; Serine; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1973 |
Effects of glucose on insulin biosynthesis in foetal and newborn rats.
Topics: Aging; Animals; Animals, Newborn; Cattle; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Female; Fetus; Gestational Age; Glucose; Insulin; Iodine Radioisotopes; Islets of Langerhans; Leucine; Molecular Weight; Pregnancy; Proinsulin; Rats; Time Factors; Tritium | 1973 |
Chromatin modification of chick embryo cells during in vitro senescence.
Topics: Aging; Animals; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Chromatin; Electrophoresis, Disc; Fibroblasts; Histones; In Vitro Techniques; Isotope Labeling; Leucine; Microscopy, Electron; Microscopy, Phase-Contrast; RNA; Tritium | 1974 |
Functional regeneration in liver of old rats after partial hepatectomy.
Topics: Aging; Animals; Carbon Radioisotopes; Female; Ferritins; Germ-Free Life; Half-Life; Hepatectomy; Histological Techniques; In Vitro Techniques; Leucine; Liver; Liver Regeneration; Microsomes, Liver; Protein Biosynthesis; Rats; RNA, Transfer; Serum Albumin; Serum Globulins; Thymidine; Time Factors; Tritium | 1974 |
The relationship between DNA synthesis and the synthesis of nuclear proteins in rat brain. Effect of hydrocortisone acetate.
Topics: Aging; Animals; Brain; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Centrifugation, Density Gradient; DNA; Female; Hydrocortisone; Leucine; Liver; Male; Nerve Tissue Proteins; Nucleoproteins; Organ Specificity; Rats; Rats, Inbred Strains; Subcellular Fractions; Thymidine; Time Factors; Tritium | 1973 |
Problems in the use of (Me- 3H) thymidine for the measurement of DNA synthesis.
Topics: Aging; Animals; Brain; Carbon Isotopes; Cycloheximide; Cytarabine; Dactinomycin; Diaphragm; DNA; Fasting; Kidney; Kinetics; Leucine; Lipids; Liver; Liver Regeneration; Male; Methods; Protein Biosynthesis; Rats; RNA; Thymidine; Tritium | 1973 |
Biosynthesis of rat serum albumin. VII. Effects observed in liver slices.
Topics: Aging; Albumins; Amino Acids; Animals; Carbon Isotopes; Carbon Tetrachloride; Fasting; Female; Globulins; In Vitro Techniques; Incubators; Leucine; Liver; Male; Nephrosis; Proteins; Rats; Serum Albumin | 1973 |
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomycin; Glutamine; Leucine; Models, Biological; Ornithine; Phenylalanine; Plant Proteins; Plants; Ribonucleases; Ribosomes; RNA; RNA, Messenger; Threonine; Time Factors; Tyrosine | 1973 |
Changes in leucyl-tRNA species of pea leaves during senescence and after zeatin treatment.
Topics: Acylation; Aging; Amino Alcohols; Carbon Isotopes; Chlorophyll; Chloroplasts; Glycine max; Leucine; Models, Biological; Nucleic Acid Conformation; Plant Growth Regulators; Plant Physiological Phenomena; Plant Proteins; Purines; RNA, Transfer; Tritium | 1973 |
Nuclear proteins in brain of 7-day-old and adult rats.
Topics: Aging; Animals; Brain; Cell Nucleus; Chromatin; DNA; Electrophoresis, Polyacrylamide Gel; Histones; Leucine; Microsomes; Mitochondria; Nerve Tissue Proteins; Nucleoproteins; Rats; Subcellular Fractions; Time Factors; Tritium | 1973 |
Decreased protein synthesis by microsomes isolated from senescent rat liver.
Topics: Age Factors; Aging; Amino Acids; Animals; Carbon Radioisotopes; Cell Fractionation; Cell-Free System; Cytosol; Female; In Vitro Techniques; Leucine; Microsomes, Liver; Protein Biosynthesis; Proteins; Rats; RNA | 1973 |
Albumin and transferrin synthesis in the liver of rats in the immediate postnatal period.
Topics: Aging; Albumins; Animals; Animals, Newborn; Blood Proteins; Carbon Radioisotopes; Female; Fetus; Leucine; Liver; Pregnancy; Protein Biosynthesis; Rats; Time Factors; Transferrin | 1973 |
Polyamine effects on 14C-leucine transfer to microsomal protein in a rat liver cell free system during ageing.
Topics: Aging; Animals; Carbon Radioisotopes; Cell-Free System; Centrifugation; Cytoplasm; Isotope Labeling; Leucine; Microsomes, Liver; Polyamines; Protein Biosynthesis; Rats; Ribonucleases; RNA, Transfer; Spermidine; Spermine | 1973 |
A method for the isolation of rat submandibular salivary gland polysomes on linear sucrose density gradients.
Topics: Aging; Aminoacylation; Animals; Carbon Radioisotopes; Cattle; Cell Fractionation; Centrifugation, Density Gradient; Evaluation Studies as Topic; Female; Leucine; Methods; Microscopy, Electron; Pancreas; Polyribosomes; Pregnancy; Protein Biosynthesis; Rats; Ribonucleases; Submandibular Gland; Ultracentrifugation | 1974 |
Effect of undernutrition on amino acid compartimentation in the developing rat brain.
Topics: Aging; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Body Weight; Brain; Carbon Radioisotopes; Chromatography, Ion Exchange; Citric Acid Cycle; Glutamates; Glutamine; Leucine; Organ Size; Protein Deficiency; Rats; Statistics as Topic | 1974 |
Isolation of microvilli fraction from jejunal mucosa and in vivo incorporation of 14C-leucine into microvilli and total homogenate protein of suckling rats.
Topics: Aging; Animals; Carbon Radioisotopes; DNA; Female; Galactosidases; Glucosidases; Intestinal Mucosa; Isotope Labeling; Jejunum; Lactation; Leucine; Milk; Pregnancy; Protein Biosynthesis; Proteinuria; Rats; RNA; Succinate Dehydrogenase; Sucrase; Time Factors | 1974 |
Amino acid incorporation and aminoacyl transfer in an insect pupal system.
Topics: Adenosine Triphosphate; Aging; Amino Acids; Animals; Carbon Isotopes; Coleoptera; Escherichia coli; Guanine Nucleotides; Leucine; Liver; Magnesium; Metamorphosis, Biological; Microsomes; Potassium; Puromycin; Rabbits; Ribonucleases; Ribosomes; RNA, Transfer; Tyrosine; Ultracentrifugation | 1968 |
Protein turnover and protein synthesis following actinomycin-D injection as a function of age in Drosophila melanogaster.
Topics: Aging; Dactinomycin; Drosophila melanogaster; Female; Leucine; Ovary; Protein Biosynthesis; Proteins; RNA; RNA, Messenger; Thorax; Tritium | 1971 |
The apparent turnover of mitochondria, ribosomes and sRNA of the brain in young adult and aged rats.
Topics: Aging; Animals; Brain; Carbon Isotopes; Cell Fractionation; Half-Life; Kinetics; Leucine; Male; Mitochondria; Nerve Tissue Proteins; Orotic Acid; Rats; Ribosomes; RNA; RNA, Ribosomal; RNA, Transfer; Tritium | 1972 |
Inhibition of rat brain protein and nucleic acid synthesis by cannabinoids in vitro.
Topics: Aging; Animals; Animals, Newborn; Cannabis; Carbon Dioxide; Carbon Isotopes; Cerebral Cortex; Depression, Chemical; Dronabinol; In Vitro Techniques; Kinetics; Leucine; Male; Nerve Tissue Proteins; Nucleic Acids; Oxygen Consumption; Potassium; Protoveratrines; Rats; Stimulation, Chemical; Uracil; Uracil Nucleotides; Uridine | 1972 |
Effect of age on rate of protein synthesis in isolated perfused mouse hearts.
Topics: Aging; Animals; Body Water; Extracellular Space; Leucine; Mice; Myocardium; Perfusion; Protein Biosynthesis; Radioisotopes | 1972 |
Synthesis and degradation of liver proteins in young and old rats.
Topics: Aging; Animals; Bloodletting; Carbon Isotopes; Cycloheximide; Ferritins; Iron; Kinetics; Leucine; Liver; Protein Biosynthesis; Proteins; Rats; Serum Albumin; Tritium | 1972 |
[Age-dependent changes of protein synthesis in small intestine rings].
Topics: Aging; Amino Acids; Animals; Carbon Isotopes; Culture Techniques; Female; Intestinal Mucosa; Intestine, Small; Leucine; Protein Biosynthesis; Rats | 1971 |
Rapid mitochondrial enlargement in muscle as a response to triamcinolone acetonide and its relationship to the ribosomal defect.
Topics: Aging; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Drug Antagonism; Leucine; Male; Methandrostenolone; Microscopy, Electron; Mitochondria, Muscle; Muscle Proteins; Muscles; Muscular Diseases; Rats; Ribosomes; Time Factors; Triamcinolone Acetonide | 1971 |
Studies on human platelets. IV. Protein synthesis in maturing human platelets.
Topics: Aging; Amino Acids; Autoradiography; Blood Platelets; Blood Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chronic Disease; Humans; Leucine; Purpura, Thrombocytopenic; Splenectomy; Tritium | 1971 |
Solubilization of a reticulocyte ribosomal fraction responsible for the decline in ribosomal activity with cell maturation.
Topics: Aging; Animals; Blood Proteins; Carbon Isotopes; Cattle; Centrifugation, Density Gradient; Chlorides; Deuterium; Electrophoresis; Hemoglobins; Leucine; Magnesium; Phenylalanine; Polynucleotides; Potassium Chloride; Reticulocytes; Ribonucleases; Ribosomes; RNA, Messenger; RNA, Viral; Serum Albumin, Bovine; Solubility; Spectrophotometry; Time Factors; Tritium; Ultraviolet Rays; Uracil Nucleotides | 1971 |
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups].
Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins; Glutamates; Glycine; Humans; Isoleucine; Lens, Crystalline; Leucine; Lysine; Middle Aged; Nitrogen; Peptide Hydrolases; Phenylalanine; Tyrosine | 1966 |
Haemoglobin synthesis in vitro by erythrocytes from Xenopus laevis.
Topics: Aging; Animals; Anura; Autoradiography; Chromatography, Ion Exchange; Erythrocytes; Female; Hemoglobins; Hydrogen-Ion Concentration; Leucine; Male; Tritium | 1969 |
Absence of a life-shortening effect of amino-acid analogues on adult Drosophila.
Topics: Aging; Amino Acids; Animals; Antimetabolites; Dietary Proteins; Drosophila; Hydrocarbons, Halogenated; Leucine; Longevity; Male; Phenylalanine; Protein Biosynthesis; Tritium | 1969 |
Composition and formation of the insoluble protein fraction in the ocular lens.
Topics: Aging; Albumins; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Crystallins; Electrophoresis; Humans; Immunoelectrophoresis; Leucine; Rats; Sharks; Species Specificity; Spectrophotometry | 1970 |
Cerebral amino acid transport in vitro during development: a kinetic analysis.
Topics: Aging; Amino Acids; Aminobutyrates; Animals; Biological Transport; Brain; Brain Chemistry; Chick Embryo; Chickens; Glutamates; In Vitro Techniques; Kinetics; Leucine; Lysine | 1970 |
[Hormonal regulation at the level of transfer RNA. I. Comparative study of transfer RNA from the liver of immature hens and laying hens].
Topics: Aging; Alanine; Animals; Carbon Isotopes; Chickens; Chromatography, Ion Exchange; Estradiol; Female; Isoleucine; Kinetics; Leucine; Ligases; Liver; Phenols; RNA, Transfer; Serine; Tritium; Valine | 1970 |
The turnover of mitochondria in a variety of tissues of young adult and aged rats.
Topics: Aging; Animals; Brain; Half-Life; Intestinal Mucosa; Intestine, Small; Kidney; Leucine; Lung; Macromolecular Substances; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Proteins; Rats; Testis; Tritium | 1971 |
Cerebral protein synthesis. 3. Developmental alteratons in the stability of cerebral messenger ribonucleic acid-ribosome complexes.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Bile Acids and Salts; Cerebral Cortex; Detergents; Kinetics; Leucine; Magnesium; Male; Nerve Tissue Proteins; Rats; Ribonucleases; Ribosomes; RNA, Messenger; Tritium; Ultracentrifugation | 1971 |
Effect of the administration of xanthine on the appearance of xanthine oxidase activity in the liver of growing rats.
Topics: Aging; Animals; Carbon Isotopes; Cortisone; Cycloheximide; Dactinomycin; Leucine; Liver; Orotic Acid; Phenylalanine; Rats; RNA; Xanthine Oxidase; Xanthines | 1968 |
Protein synthesis in the core of calf lens.
Topics: Aging; Albumins; Animals; Carbon Isotopes; Cattle; Crystallins; Lens, Crystalline; Leucine | 1968 |
Transaminases of branched-chain amino acids. V. Activity change in developing and regenerating rat liver.
Topics: Adrenalectomy; Aging; Animals; Chromatography, Ion Exchange; Female; Fetus; Hepatectomy; Isoleucine; Leucine; Liver; Liver Regeneration; Male; Rats; Transaminases; Valine | 1968 |
Evidence for long-lived components in developing mouse tissues labeled with leucine.
Topics: Adipose Tissue; Aging; Animals; Brain Chemistry; Carbon Isotopes; Growth; Intestine, Small; Kidney; Leucine; Lipids; Liver; Lung; Mice; Muscles; Myocardium; Protein Biosynthesis; Proteins; Skin; Spleen; Tendons; Time Factors; Tritium | 1969 |
Effect of age on protein and ribonucleic acid metabolism in mouse skeletal muscle.
Topics: Aging; Animals; Carbon Isotopes; Cell Nucleus; DNA; Leucine; Mice; Mitochondria, Muscle; Muscle Proteins; Muscles; Myofibrils; RNA; Uridine | 1969 |
Nucleic acid and protein synthesis in cardiac muscle of growing and adult mice.
Topics: Aging; Animals; DNA; In Vitro Techniques; Leucine; Mice; Myocardium; Nucleosides; Protein Biosynthesis; RNA; Tritium | 1965 |
Observations on reticulocyte maturation.
Topics: Aging; Animals; Blood Proteins; Cell Aggregation; Chelating Agents; Dactinomycin; In Vitro Techniques; Leucine; Magnesium; Nucleotides; Rabbits; Reticulocytes; RNA | 1965 |
Determination of optimal dietary protein requirements of young and old dogs.
Topics: Aging; Animals; Dietary Proteins; DNA; Dogs; Kinetics; Leucine; Liver; Muscles; Nitrogen; Proteins; RNA | 1966 |
Increase in the rate of protein synthesis with age in Drosophila subobscura.
Topics: Aging; Animals; Drosophila; Leucine; Male; Protein Biosynthesis | 1966 |
[Enzyme histochemical and autoradiographic studies on bradytrophic tissues].
Topics: Aging; Alcohol Oxidoreductases; Animals; Aorta; Autoradiography; Histocytochemistry; Intestinal Mucosa; Kidney; Leucine; Liver; Male; N-Glycosyl Hydrolases; Pancreas; Rats; Succinate Dehydrogenase; Tendons; Tritium | 1966 |