leucine and Aging

leucine has been researched along with Aging in 344 studies

Research

Studies (344)

TimeframeStudies, this research(%)All Research%
pre-1990178 (51.74)18.7374
1990's52 (15.12)18.2507
2000's48 (13.95)29.6817
2010's55 (15.99)24.3611
2020's11 (3.20)2.80

Authors

AuthorsStudies
Hu, J; Ji, L; Johnston, LJ; Liu, C; Ma, X; Zhang, X; Zhao, Y1
Hao, Z; Liu, Y; Tan, R; Xia, Y; Xu, G; Yin, X; Yuan, M1
Castro, A; Catai, AM; De Oliveira, JM; Di Medeiros Leal, MCB; Ferreira, AG; Millan-Mattos, JC; Minatel, V; Oliveira, RV; Pantoni, CBF; Rehder-Santos, P; Signini, ÉF1
Fischer, AM; Kressig, RW1
Atherton, PJ; Breen, L; Ely, IA; Larsen, MS; Phillips, BE; Piasecki, M; Smith, K; Wilkinson, DJ1
Benestad, HB; Brochmann, M; Garthe, I; Hamarsland, H; Johansen, MK; Raastad, T; Seeberg, F1
Sinclair, M1
Blaauw, B; Breen, L; Carmeliet, P; D'Hulst, G; De Bock, K; Deldicque, L; Fitzgerald, G; Kim, S; Koivunen, P; Masschelein, E; Smeuninx, B; Soro-Arnaiz, I; Veys, K; Zhao, SM1
Balchin, C; Black, AD; Butterworth, M; Cooke, M; Elia, A; Harlow, PS; Harris, N; Ispoglou, T; Lees, MJ; Parker, PJ; Phillips, SM; Prior, T; Traylor, DA; Webb, EK; Wilson, OJ1
Ball, RO; Chang, J; Courtney-Martin, G; Elango, R; Kong, D; Lebarron, M; Pencharz, PB; Rafii, M; Szwiega, S; Xu, L1
Millward, DJ2
Allen, SL; Breen, L; Edwards, SJ; Lavery, GG; Lord, JM; Marshall, RN1
de Hart, NM; Drummond, MJ; Eshima, H; Ferrara, PJ; Fix, DK; Funai, K; Kelley, JJ; Mahmassani, ZS; McKenzie, AI; Montgomery, JA; Petrocelli, JJ; Reidy, PT1
Antosiewicz, J; Gmiat, A; Jaworska, J; Kochanowicz, A; Kortas, J; Lipiński, M; Mieszkowski, J; Prusik, K; Radulska, A; Tomczyk, M; Ziemann, E1
Cruz-Jentoft, AJ1
Akiba, C; Arai, H; Inoue, R; Kanai, F; Kondo, A; Kunichika, M; Miura, M; Miyajima, M; Nakajima, M; Nakamura, E; Nishimura, K; Ogino, I; Sugano, H; Tada, N; Yoshida, M1
Basisty, NB; Beyer, RP; Dai, DF; Fredrickson, J; Karunadharma, PP; Liu, Y; MacCoss, MJ; Rabinovitch, PS; Reynolds, J1
Atherton, PJ; Greenhaff, P; Hill, I; Lund, JN; Mitchell, WK; Phillips, BE; Rankin, D; Smith, K; Wilkinson, DJ; Williams, JP1
Cholewa, JM; Jiang, H; Shang, H; Su, Q; Xia, Z; Yang, Y; Zanchi, NE; Zhao, Y1
de Capitani, MD; de Santana, DA; Fernandes, AL; Gualano, B; Hayashi, AP; Jambassi-Filho, JC; Roschel, H1
Gorissen, SHM; Phillips, SM; Traylor, DA1
Chen, Z; Cheng, G; Daugherty, SL; de Groat, WC; Liu, Y; Wen, J; Yuan, M; Zhang, X; Zu, S1
Aran, K; Balderston, S; Conboy, IM; Conboy, MJ; Hajian, R; Liu, C; Murthy, N; Paredes, J; Sadlowski, C; Sandhu, M; Tran, TP1
Dardevet, D; David, J; Efstathiou, T; Jarzaguet, M; Joubrel, G; Migné, C; Mosoni, L; Polakof, S; Rémond, D1
Cameron-Smith, D; D'Souza, RF; Knowles, SO; Milan, AM; Mitchell, CJ; Mitchell, SM; Prodhan, U; Ramzan, F; Roy, NC; Sharma, P; Sjödin, A; Wagner, KH; Zeng, N1
Aspray, TJ; Bauer, JM; Bautmans, I; Biesheuvel, E; Brandt, K; Cederholm, T; Donini, LM; Eastell, R; Hill, TR; Maggio, M; Mets, T; Seal, CJ; Sieber, C; Verlaan, S; Wijers, SL1
Aussel, C; Cynober, L; Deutz, NE; Jourdan, M1
Boirie, Y; Moreau, K; Walrand, S1
Afshordel, S; Eckert, GP; Igbavboa, U; Muller, WE; Wood, WG1
Cai, H; Chang, W; Deng, H; Liu, G; Zhang, S; Zheng, A1
Caldow, MK; Ham, DJ; Koopman, R; Lynch, GS1
Moore, DR1
Basisty, N; Beyer, RP; Bielas, JH; Chiao, YA; Crispin, D; Dai, DF; Ericson, NG; Hsieh, EJ; Karunadharma, PP; MacCoss, MJ; MacKay, VL; Quarles, EK; Rabinovitch, PS1
Phillips, SM1
Gijsen, AP; Hamer, HM; Kouw, IW; Kramer, IF; Luiking, Y; Poeze, M; Senden, JM; van Kranenburg, J; van Loon, LJ; Verdijk, LB; Verlaan, S1
Aoki, MS; da Cunha, FM; Miyabara, EH; Moriscot, AS; Pereira, MG; Silva, MT1
Fujita, S; Makanae, Y1
Ankarfeldt, MZ; Bauer, J; Capra, S; Heitmann, BL; McDonald, CK; Raymond, K1
Agergaard, J; Bülow, J; Holm, L; Kjaer, M; Reitelseder, S1
Balakrishnan, G; Pereira, SL; Puthan, JK; Ramesh, S; Reddy, MT; Shreeram, S; Subramanian, R1
Cholewa, J; Guimarães-Ferreira, L; Naimo, MA; Shang, HY; Su, QS; Xia, Z; Yang, YQ; Zanchi, NE; Zhao, Y1
Baum, JI; Brown, JL; Brown, LA; Greene, NP; Lee, DE; Perry, RA; Washington, TA1
Breen, L; Shad, BJ; Thompson, JL1
Borack, MS; D'Lugos, AC; Dickinson, JM; Gundermann, DM; Rasmussen, BB; Reidy, PT; Volpi, E; Walker, DK1
Cabido, CE; Cholewa, JM; Dardevet, D; de Araújo Pessôa, K; Dos Santos Pinho, JR; Lima-Soares, F; Nicastro, H; Oliveira, PH; Xia, Z; Zanchi, NE1
Astruc, T; Balage, M; Dardevet, D; Marzani, B; Mosoni, L; Papet, I; Vénien, A1
Paddon-Jones, D; Rasmussen, BB1
Atherton, PJ; Patel, R; Rankin, D; Rennie, MJ; Selby, AL; Smith, K; Wilkes, EA1
Ito, Y; Kobayashi, H; Nagasawa, T; Nishizawa, N; Sugawara, T; Suzuki, H1
Cecchet, D; Millioni, R; Puricelli, L; Tessari, P; Vettore, M1
Kim, JS; Lee, SR; Wilson, JM1
Fan, X; Giblin, FJ; Liu, X; Monnier, VM; Nemet, I; Qian, J; Strauch, C; Theves, M; Zhang, J1
Anderson, N; Carlini, DB; Hense, W; Hutter, S; Parsch, J; Stephan, W1
Miller, BF; Murphy, C1
Aussel, C; Cynober, L; Daugé, V; Faure, C; Ferry, A; Moinard, C; Raynaud-Simon, A1
Burgos, SA; Chevalier, S; Goulet, ED; Morais, JA; Wykes, LJ1
Balage, M; Dardevet, D; Dupont, J; Hébuterne, X; Mothe-Satney, I; Schneider, SM; Zeanandin, G1
Hartgens, F; Leenders, M; Saris, WH; van der Hoeven, L; van Kranenburg, J; van Loon, LJ; Verdijk, LB; Wodzig, WK1
Dickinson, JM; Drummond, MJ; Fry, CS; Glynn, EL; Gundermann, DM; Rasmussen, BB; Timmerman, KL; Volpi, E; Walker, DK1
Azen, SP; Bhasin, S; Binder, EF; Castaneda-Sceppa, C; He, J; Kawakubo, M; Roubenoff, R; Sattler, FR; Schroeder, ET; Yarasheski, KE1
Donato, J; Pantaleão, LC; Resende, GF; Tirapegui, J; Torres-Leal, FL; Vianna, D1
Mittendorfer, B; Shah, K; Smith, GI; Villareal, DT1
Leenders, M; van Loon, LJ1
Combaret, L; Dardevet, D; Magne, H; Migné, C; Peyron, MA; Rémond, D; Savary-Auzeloux, I1
Breen, L; Churchward-Venne, TA1
Knuiman, P; Kramer, IF1
Coben, JR; Dickinson, JM; Drummond, MJ; Rasmussen, BB; Volpi, E1
Alev, K; Aru, M; Kaasik, P; Seene, T1
Bassil, MS; Gougeon, R1
Candow, DG; Forbes, SC; Little, JP; Manders, RJ1
Campbell, WW; Evans, WJ; Kirwan, JP; Krishnan, RK; Kullman, EL; Yarasheski, KE1
Abel, ED; Kahn, CR; Kureishi, Y; Luo, Z; Rosenzweig, A; Shiojima, I; Takahashi, A; Tao, J; Walsh, K; Yefremashvili, M1
Aoki, S; Itoh, S; Iwata, T; Katagiri, T; Mukae, S; Nishio, K; Sato, R1
Bartol, FF; Braden, TD; Tarleton, BJ; Wiley, AA1
Adeghate, EA; Draper, CE; Singh, J1
Ballèvre, O; Beaufrère, B; Bouteloup-Demange, C; Dangin, M; Fauquant, J; Gachon, P; Garcia-Rodenas, C; Guillet, C; Reiffers-Magnani, K1
Balage, M; Bayle, G; Dardevet, D; Grizard, J; Papet, I; Pouyet, C; Prugnaud, J; Rieu, I; Sornet, C1
Adeghate, E; Draper, CE; Singh, J1
KUHN, W1
BENTOR, V; WERTHEIMER, HE1
DICAGNO, L; PAVESIO, D1
CAMPBELL, PL; DEIBLER, GE; GELBER, S; SOKOLOFF, L1
WALIGORA, Z; WENDER, M1
BASERGA, R; HINRICHS, HR; PETERSEN, RO1
GLOWACKI, ER; MILLETTE, RL1
KIRK, JE1
Bigelow, ML; Nair, KS; Proctor, DN; Short, KR; Vittone, JL1
Aleksandrova, IY; Borisova, GY; Kulikova, OG; Reikhardt, BA; Sapronov, NS1
Ma, H; Nagata, T1
Boirie, Y; Dardevet, D; Guillet, C; Mishellany, A; Rousset, P; Sornet, C; Zangarelli, A1
Dardevet, D; Grizard, J; Rieu, I; Sornet, C1
Boirie, Y; Gachon, P; Giraudet, C; Guillet, C; Morio, B; Rousset, P; Zangarelli, A1
Atherton, P; Babraj, J; Cuthbertson, D; Leese, G; Rennie, MJ; Smith, K; Taylor, PM; Wackerhage, H; Waddell, T1
Barrett, HR; Dolnikowski, GG; Jalbert, SM; Lamon-Fava, S; Lichtenstein, AH; Matthan, NR; Schaefer, EJ; Welty, FK1
Contet-Audonneau, JL; Danoux, L; Maquart, FX; Pauly, G; Vuillermoz, B; Wegrowski, Y1
Attaix, D; Béchet, D; Combaret, L; Dardevet, D; Grizard, J; Pouch, MN; Rieu, I; Taillandier, D1
Rennie, MJ1
Aarsland, A; Katsanos, CS; Kobayashi, H; Sheffield-Moore, M; Wolfe, RR1
Chevalier, S; Choong, N; Gougeon, R; Lamarche, M; Morais, JA1
Gijsen, AP; Gorselink, M; Koopman, R; Manders, RJ; Pijpers, E; van Loon, LJ; Verdijk, L; Wagenmakers, AJ1
Johnson, JM; Rada, JA; Young, TL1
Balage, M; Dardevet, D; Debras, E; Grizard, J; Prod'homme, M; Rieu, I1
Balage, M; Dardevet, D; Debras, E; Grizard, J; Pouyet, C; Rieu, I; Ripes, S; Rochon-Bonhomme, C; Sornet, C1
Buffière, C; Machebeuf, M; Mioche, L; Mosoni, L; Patureau Mirand, P; Rémond, D; Yven, C1
Buyse, J; Decuypere, E; Janssens, G; Laroye, C; Swennen, Q; Verbeke, K1
Beelen, M; Gorselink, M; Koopman, R; Kruseman, AN; Kuipers, H; van Loon, LJ; Verdijk, LB; Wagenmakers, AJ1
Béchereau, F; Coudray, C; Glomot, F; Meunier, N; Obled, C; Papet, I1
Dhanani, S; Dillon, EL; Dreyer, HC; Drummond, MJ; Fry, CS; Pennings, B; Rasmussen, BB; Sheffield-Moore, M; Volpi, E1
Zhinkin, LN1
Sacher, JA1
Hilchey, SE; Lerner, J; Smagula, RM1
Bendahan, G; Vinardell, MP1
Adinolfi, AM; Cospito, JA; Levine, MS1
Brot, N; Chen, JJ; Weissbach, H1
Kim, SK1
Calkins, DW; Hartog, VW; Kim, SK; Weinhold, PA1
Bunch, C; Corp, MJ; Robinson, JS; Weatherall, DJ; Wood, WG1
Price, JL; Schwob, JE2
Freinkel, N; Grill, V; Lake, W1
Bier, D; Matthews, DE; Munro, HN; Robert, JJ; Schoeller, D; Wolfe, R; Young, VR1
Pajari, M1
Claes-Reckinger, N; Delcour, J; Vandenhaute, J1
Ibraham, NG; Levere, RD; Lutton, JD1
Ingvar, MC; Maeder, P; Smith, CB; Sokoloff, L1
Alpers, DH; Seetharam, B; Yeh, KY1
Arakawa, T; Chikaoka, H; Katsushima, N; Kobayashi, M; Minagawa, A; Saito, TG; Shioji, R1
Paul, I; Rosenfeld, RS; Spaet, TH1
Gold, G; Reaven, E; Reaven, G1
Andersson, A; Eriksson, U; Hellerström, C1
Claes-Reckinger, N; Delcour, J; van Bezooijen, CF; Vandenhaute, J1
Cooper, RL; Linnoila, M1
Beyer, RE; Edington, DW; Starnes, JW1
LaVelle, A; McLoon, LK2
Butzow, JJ; Eichhorn, GL; McCool, MG1
Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, JI1
Kibler, RF; Shapira, R; Wilhelmi, MR1
Moraes E Santos, T1
Coiro, V; Goodman, HM1
Ekstrom, R; Liu, DS; Richardson, A1
Ashour, B; Tribe, M; Whittaker, P1
Han, SS; Kim, SK; Wagner, DJ; Weinhold, PA1
Goto, S; Mizuno, D; Mori, N1
Campagnoni, AT; Hunkeler, MJ1
Cadenhead, A; Fuller, MF; Lobley, GE; McDonald, JD; Reeds, PJ1
Battelle, BA; LaVail, MM1
Himukai, M; Hoshi, T; Konno, T1
Castaneda, C; Crim, MC; Dallal, GE; Dolnikowski, GG; Evans, WJ1
Ewan, RC; Gatnau, R; Nissen, SL; Wannemuehler, M; Zimmerman, DR1
David, LL; Iwasaki, N; Shearer, TR1
Beachy, PA; Chiang, C1
Blakemore, WS; Brooks, SW; Gandy, RE; Geiger, JW; Long, CL; Martin, KR; Nelson, KM; Richards, EW1
Dang, T; Deibler, GE; Dumont, I; Jehle, J; Macedonia, J; Smith, CB; Sun, Y1
Statt, M; Thornton, C; Welle, S1
Gonzalez, G; Vinardell, MP2
Ichimura, T; Isobe, T; Matsuoka, K; Nakayama, H; Satozawa, N; Song, SY; Takahashi, N; Taoka, M; Yamakuni, T1
McHenry, B; Statt, M; Thornton, C; Welle, S1
Livne, E; Weiss, A1
Cope, BK; McCoy, JR; Smith, SB1
Kee, AJ; Smith, RC1
Clark, WA; Decker, RS; LaPres, JJ; Rudnick, SJ; Simpson, DG1
Denne, SC; Harris, RA; Zhao, Y1
Jozefowicz, R; Statt, M; Thornton, C; Welle, S1
Bhattiprolu, S; Burrin, D; Del Rosario, M; Frazer, M; Jahoor, F; Wykes, L1
Christenson, RK; Vallet, JL1
Gonzalez, E; Vinardell, MP1
Birnbaum, D; Delapeyriere, O; Ollendorff, V; Pizette, S; Planche, J; Roubin, R1
Aly, KB; Casciano, DA; Duffy, PH; Feuers, RJ; Hart, RW; Hinson, W; Leakey, JE; Lyn-Cook, LE; Pipkin, JL1
Beaufrère, B; Boirie, Y; Gachon, P1
de Groot, LC; van Staveren, WA1
Abrams, RM; Burchfield, DJ; Smith, CB; Sun, Y1
Ahlrichs, JA; Denne, SC; Karn, CA; Leitch, CA; Liechty, EA; Poindexter, BB; Wang, J1
Cox, M; Fereday, A; Gibson, NR; Millward, DJ; Pacy, PJ1
Halliday, D; Pannemans, DL; Schaafsma, G; Wagenmakers, AJ; Westerterp, KR1
Ades, PA; Adey, DB; Balagopal, P; Nair, KS; Rooyackers, OE1
Beharry, S; Durie, PR; Ip, WF1
Fu, A; Nair, KS1
Bolli, GB; De Feo, P; Lucidi, P; Santeusanio, F; Volpi, E1
Bayliss, MT; Bolton, MC; Dudhia, J1
Carroll, PV; Jackson, NC; Russell-Jones, DL; Sönksen, PH; Treacher, DF; Umpleby, AM1
Darmaun, D; Deschamps, JY; Krempf, M; Marchini, JS; Maugère, P; Nguyen, P1
Hasten, DL; Obert, KA; Pak-Loduca, J; Yarasheski, KE1
Antoine, JM; Arnal, M; Arnal, MA; Bayle, G; Beaufrère, B; Boirie, Y; Gachon, P; Genest, M; Grizard, J; Mirand, PP; Mosoni, L1
Akatsuka, A; Edgerton, VR; Roy, RR; Tamaki, T; Uchiyama, S; Uchiyama, Y; Yoshimura, S1
Davis, TA; Deaver, DR; Nguyen, HV; Reeds, PJ; Steele, NC; Vann, RC1
Balage, M; Dardevet, D; Grizard, J; Sornet, C1
Buddington, RK; Elnif, J; Malo, C; Sangild, PT1
Beaufrère, B; Boirie, Y; Cordat, N; Gachon, P; Ritz, P1
Brown, G; Castro, E; Deeb, SS; Edland, SD; Erkkola, R; Lee, L; Louhija, J; Martin, GM; Ogburn, CE; Oshima, J; Panduro, A; Penttinen, R; Riestra, R; Tilvis, R; Wang, L1
Beaufrère, B; Boirie, Y; Ritz, P1
Campbell, WW; Evans, WJ; Trappe, TA; Wolfe, RR1
Castellino, P; Giordano, M; Luzi, L1
Bayle, G; Dardevet, D; Grizard, J; Pouyet, C; Prugnaud, J; Sornet, C1
Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ1
Campagnoni, AT; Carey, GD1
Lane, RS; Prasanna, HR; Rothstein, M; Sharma, HK1
Hosbach, HA; Kubli, E1
Daniels, VG; Murphy, S1
Griffiths, TD; Tolmach, LJ1
Bruley-Rosset, M; Florentin, I; Kiger, N; Mathé, G; Schulz, J1
Hirsch, GP; Holland, JM; Popp, RA1
Numa, S; Teraoka, H1
Blazer-Yost, B; Cohn, R; Segal, S; Yudkoff, M1
Bell, ME; Fuller, GN; Wiggins, RC1
Hupp, EW; Joiner, FE1
Rawat, AK1
Baker, M; Holbrook, JP; Penniall, R; Viskup, RW1
Nikodem, W1
Weintraub, H1
Beyer, TA; Du, JT; Lang, CA1
Nakano, K; Sidransky, H1
Owen, OE; Patel, MS1
Geel, SE; Gonzales, LW1
Cvetković, M; Genbacev, O; Sulović, V1
Mariotti, D; Ruscitto, R1
Johnson, MD; Nylen, EG; Quilliam, NM; Wrogemann, K1
Myśliwski, A1
Hellthaler, G; Reifegerste, D; Rotzsch, W1
Fettback, G; Hellthaler, G; Rotzsch, W1
Bradley, MO; Hayflick, L; Schimke, RT1
Fujii, K; Kuboki, Y; Sasaki, S1
Rotzsch, W1
Granger, AS; Kowaloff, EM; Phang, JM1
Hellthaler, G; Köhler, R; Reifegerste, D; Rotzsch, W1
Britton, GW; Sherman, FG1
Lundholm, K; Scherstén, T1
Eapen, J; Narayanan, N2
Asplund, K2
Kurtz, DI1
Fukui, HN; Kinoshita, JH; Obazawa, H1
Dainat, J; Rebière, A1
Carminatti, H; Rossi, S; Vargas, VI1
Ivy, GO1
Fukuda, H; Iritani, N1
Buddington, RK; Puchal, AA; Vega, YM1
Castillo, RO; Kwong, LK; Sunshine, P; Tsuboi, KK1
Magagnin, S; Sacchi, VF1
Martsinko, VI; Tanin, SA1
Carlos, RQ; Seidler, FJ; Slotkin, TA1
Cannon, JG; Evans, WJ; Fielding, RA; Frontera, WR; Meredith, CN; O'Reilly, KP1
Boyd, RL; Sonntag, WE; Spik, KW1
Anderson-Brown, T; Seidler, FJ; Slotkin, TA1
Bätge, B; Bodo, M; Deutzmann, R; Diebold, J; Lehmann, H; Müller, PK; Notbohm, H1
Fukuda, H; Iritani, N; Katsurada, A1
Ozaki, K; Yamaguchi, M1
Phillips, LL; Pollack, AE; Steward, O1
Geesin, JC; Gordon, JS; Gracy, RW; Jacobson, TM; Lane, AT; Yüksel, KU1
Robinson, ME; Samarel, AM1
Arisumi, PP; Kim, SK1
Fischer, HR; Goodrum, JF; Morell, P; Toews, AD; Windes, S1
Chanderkar, LP; Kim, S; Paik, WK1
Bonomo, L; Dell'Osso, A; Lucivero, G; Mazzini, G; Surico, G1
Ivy, GO; Kanai, S; Kitani, K; Nokubo, M; Ohta, M; Otsubo, K; Sato, Y1
Barka, T; Gresik, EW; van der Noen, H1
Mathé, G1
Bier, DM; Fukagawa, NK; Matthews, DE; Minaker, KL; Rowe, JW; Young, VR1
Adenuga, GA; Mazzaev, AG; Olowookere, JO1
Hariguchi, S; Morita, H; Nakamura, Y; Nishimura, T; Suzuki, H; Tada, K; Takeda, M1
Albarède, JL; Balas, D; Bouisson, M; Guidet, M; Moreau, J; Ribet, A; Senegas, F; Vellas, B1
D'Harlingue, AE; Fan, Q; Kwong, LK; Sunshine, P; Thompson, DJ; Tsuboi, KK1
Wilson, RP1
Abe, F; Hayashi, M; Horinishi, H; Ishizuka, M; Matsuda, A; Umezawa, H1
Kato, H; Naito, H; Nam, TJ; Noguchi, T1
Bergen, WG; Busboom, JR; Merkel, RA1
Fómez-Pinilla, F; Hovda, DA; Sonnier, BJ; Villablanca, JR1
Keelan, M; Thomson, AB1
Mileusnić, R; Rakić, L; Veskov, R1
Bruley-Rosset, M; Payelle, B; Rappaport, H1
Markov, VN; Riashchikov, SN1
Alperin, DM; Carminatti, H; Idoyaga-Vargas, VP1
Hawkins, RK; Jansen, HG; Sanyal, S1
Lopez, RR; Menon, NK1
D'Harlingue, AE; Kerner, JA; Kwong, LK; Stevenson, DK; Sunshine, P; Tsuboi, KK1
Thomson, AB1
Cohen, HJ; Tollefsbol, TO1
Harting, JK; Hashikawa, T; Huerta, MF; McHaffie, JG; Stein, BE1
Das, K; Mazumder, A; Sarkar, PK1
Edelstein, D; Harris, L; Kresge, D; Ove, P; Salatka, K1
Ochs, S1
Florini, JR; Manowitz, EJ; Saito, Y1
Gregson, N; Hamberger, A; Lehninger, AL1
Ashhurst, DE; Tribe, MA1
Ichihara, A1
Erickson, RP; Gluecksohn-Waelsch, S; Jacobs, K; Siekevitz, P1
Bergstrand, A; Dallner, G; Nilsson, R1
Dunlop, DS; Lajtha, A; Van Elden, W1
Dainat, J1
Markiewicz, L; Weinstock, IM1
Peterson, NA; Raghupathy, E1
Pénzes, L1
Finch, CE; Gordon, SM1
Nathan, I; Richmond, A1
Hering, FJ; Hering, H; Platt, D1
Karpatkin, S1
Adelman, RC; Stein, GS; Wang, PL1
Igo-Kemenes, T; Spadafora, C; Zachau, HG1
Courtois, YG1
Chen, J; Lansing, AI; Obenrader, M; Ove, P1
Burdman, JA; Szijan, I2
Goldberg, AL; Goldspink, DF1
Peters, T1
Bemiller, JN; Hoffmann, WE; Pappelis, AJ1
Cherry, JH; Pillay, DT; Wright, RD1
Buetow, DE; Gandhi, PS1
Yeoh, GC1
Comolli, R1
Alvarez, C; Menaker, L; Miller, SA; Pong, RS1
Corbin, J; Pennington, W; Roach, MK1
Jumawan, J; Koldovský, O; McNamara, PD; Palmieri, M1
Ilan, J1
Delcour, J; Libion-Mannaert, M; Wattiaux, JM1
Gold, PH; Menzies, RA2
Jakubovic, A; McGeer, PL1
Florini, JR; Geary, S1
Lansing, A; Obenrader, M; Ove, P1
Hellthaler, G; Köhler, H; Rotzsch, W1
Bullock, GR; Christian, RA; Peters, RF; White, AM1
Booyse, FM; Hoveke, TP; Rafelson, ME; Zschocke, D1
Adams, MH; Midthun, RA; Rowley, PT1
Graeber, W1
Brooks, GT; Jurd, RD; Maclean, N1
Dingley, F; Smith, JM1
Lerman, S1
Levi, G1
Beck, G; Ebel, JP; Hentzen, D1
Brown, DM; Peache, S; Roberts, S; Zomzely, CE1
Spadoni, MA; Ticca, M1
Spector, A; Wannemacher, CF1
Ichihara, A; Takahashi, H1
Hendley, DD; Hirsch, GP; Kutsky, R; Menzies, RA; Nordgren, RA; Strehler, BL1
Chaudhary, KD; Srivastava, U1
Baserga, R; Petersen, RO1
Izak, G; Mager, J; Wilner, T1
McCoy, JR; Wannemacher, RW1
Clarke, JM; Smith, JM1
Lennartz, KJ; Rudolph, G1

Reviews

20 review(s) available for leucine and Aging

ArticleYear
Functional Amino Acids and Autophagy: Diverse Signal Transduction and Application.
    International journal of molecular sciences, 2021, Oct-22, Volume: 22, Issue:21

    Topics: Aging; Amino Acids; Arginine; Autophagy; Glutamine; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Methionine; Neoplasms; Neurodegenerative Diseases; Obesity; Signal Transduction

2021
A focus on leucine in the nutritional regulation of human skeletal muscle metabolism in ageing, exercise and unloading states.
    Clinical nutrition (Edinburgh, Scotland), 2023, Volume: 42, Issue:10

    Topics: Aging; Amino Acids, Essential; Dietary Proteins; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Muscle Proteins; Muscle, Skeletal

2023
Controversies in Diagnosing Sarcopenia in Cirrhosis-Moving from Research to Clinical Practice.
    Nutrients, 2019, Oct-14, Volume: 11, Issue:10

    Topics: Aging; Humans; Leucine; Liver Cirrhosis; Research; Sarcopenia

2019
Beta-Hydroxy-Beta-Methyl Butyrate (HMB): From Experimental Data to Clinical Evidence in Sarcopenia.
    Current protein & peptide science, 2018, Volume: 19, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Apoptosis; Cell Survival; Dietary Supplements; Frailty; Humans; Leucine; Middle Aged; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Sarcopenia; Valerates

2018
Perspective: Protein Requirements and Optimal Intakes in Aging: Are We Ready to Recommend More Than the Recommended Daily Allowance?
    Advances in nutrition (Bethesda, Md.), 2018, 05-01, Volume: 9, Issue:3

    Topics: Aged; Aging; Dietary Proteins; Humans; Leucine; Muscle, Skeletal; Muscular Diseases; Nutritional Requirements; Recommended Dietary Allowances; Sarcopenia

2018
Leucine as a treatment for muscle wasting: a critical review.
    Clinical nutrition (Edinburgh, Scotland), 2014, Volume: 33, Issue:6

    Topics: Aging; Animals; Dietary Supplements; Disease Models, Animal; Humans; Leucine; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Protein Biosynthesis; TOR Serine-Threonine Kinases

2014
Keeping older muscle “young” through dietary protein and physical activity.
    Advances in nutrition (Bethesda, Md.), 2014, Volume: 5, Issue:5

    Topics: Aging; Amino Acids; Dietary Proteins; Energy Intake; Humans; Leucine; Micronutrients; Motor Activity; Muscle Proteins; Muscle, Skeletal; Nutritional Requirements; Nutritional Status; Sarcopenia; Sedentary Behavior

2014
Nutritional supplements in support of resistance exercise to counter age-related sarcopenia.
    Advances in nutrition (Bethesda, Md.), 2015, Volume: 6, Issue:4

    Topics: Aged; Aging; Creatine; Diet; Dietary Proteins; Dietary Supplements; Fatty Acids, Omega-3; Female; Humans; Leucine; Male; Muscle Strength; Muscle, Skeletal; Quality of Life; Resistance Training; Sarcopenia; Valerates

2015
Role of Exercise and Nutrition in the Prevention of Sarcopenia.
    Journal of nutritional science and vitaminology, 2015, Volume: 61 Suppl

    Topics: Aging; Diet; Dietary Supplements; Humans; Insulin Resistance; Leucine; Muscle Proteins; Muscle, Skeletal; Nutritional Status; Protein Biosynthesis; Resistance Training; Sarcopenia

2015
Does the muscle protein synthetic response to exercise and amino acid-based nutrition diminish with advancing age? A systematic review.
    American journal of physiology. Endocrinology and metabolism, 2016, 11-01, Volume: 311, Issue:5

    Topics: Age Factors; Aging; Amino Acids; Diet; Dietary Proteins; Exercise; Humans; Leucine; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis; Sarcopenia

2016
Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response.
    Amino acids, 2017, Volume: 49, Issue:5

    Topics: Aging; Antioxidants; Betaine; Dietary Proteins; Dietary Supplements; Exercise; Glycine; Humans; Hypokinesia; Leucine; Muscle Proteins; Muscle, Skeletal; Sarcopenia; Vitamins

2017
Dietary protein recommendations and the prevention of sarcopenia.
    Current opinion in clinical nutrition and metabolic care, 2009, Volume: 12, Issue:1

    Topics: Aged; Aging; Dietary Proteins; Dietary Supplements; Exercise; Humans; Leucine; Muscle Proteins; Muscular Atrophy; Nutrition Policy; Protein Deficiency

2009
Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids and antioxidants.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Amino Acids; Antioxidants; Diet; Dietary Proteins; Female; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Nutritional Requirements; Oxidative Stress; Protein Biosynthesis; Resistance Training; Sarcopenia; Sedentary Behavior

2010
Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes.
    Nutrition reviews, 2011, Volume: 69, Issue:11

    Topics: Adult; Aged; Aging; Animals; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leucine; Muscle Proteins; Muscle Strength; Protein Biosynthesis; Sarcopenia; Up-Regulation

2011
Muscle protein anabolism in type 2 diabetes.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:1

    Topics: Aged; Aging; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Hyperglycemia; Insulin; Insulin Resistance; Leucine; Male; Motor Activity; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Sarcopenia

2013
Insulinotropic and muscle protein synthetic effects of branched-chain amino acids: potential therapy for type 2 diabetes and sarcopenia.
    Nutrients, 2012, Nov-08, Volume: 4, Issue:11

    Topics: Aging; Amino Acids, Branched-Chain; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; Insulin Secretion; Leucine; Muscle Proteins; Muscle, Skeletal; Sarcopenia

2012
Low-protein intakes and protein turnover in elderly women.
    Nutrition reviews, 1996, Volume: 54, Issue:2 Pt 1

    Topics: Aged; Aging; Dietary Proteins; Female; Humans; Immunity; Leucine; Muscles; Oxidation-Reduction; Proteins

1996
Postprandial protein utilization: implications for clinical nutrition.
    Nestle Nutrition workshop series. Clinical & performance programme, 2000, Volume: 3

    Topics: Aging; Animals; Carbon Isotopes; Critical Illness; Enteral Nutrition; Humans; Leucine; Models, Biological; Nutritional Requirements; Oxidation-Reduction; Postoperative Care; Postprandial Period

2000
Protein and amino acid requirements of fishes.
    Annual review of nutrition, 1986, Volume: 6

    Topics: Aging; Amino Acids; Animals; Arginine; Dietary Proteins; Energy Intake; Fishes; Histidine; Isoleucine; Leucine; Lysine; Methionine; Nutritional Requirements; Phenylalanine; Species Specificity; Threonine; Tryptophan; Valine

1986
Human platelet senescence.
    Annual review of medicine, 1972, Volume: 23

    Topics: Aging; Blood Platelets; Blood Proteins; Cell Aggregation; Cell Survival; Chromium Isotopes; Glycogen; Glycogen Storage Disease; Humans; Isoflurophate; Kinetics; Leucine; Megakaryocytes; Osmotic Fragility; Oxidation-Reduction; Phosphates; Platelet Adhesiveness; Radioisotopes; RNA; Thrombin; Time Factors; Valine

1972

Trials

22 trial(s) available for leucine and Aging

ArticleYear
Native Whey Induces Similar Adaptation to Strength Training as Milk, despite Higher Levels of Leucine, in Elderly Individuals.
    Nutrients, 2019, Sep-04, Volume: 11, Issue:9

    Topics: Adaptation, Physiological; Aged; Aging; Animals; Biopsy; Diet; Double-Blind Method; Female; Humans; Leucine; Male; Milk; Muscle, Skeletal; Resistance Training; Whey Proteins

2019
Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women.
    Biogerontology, 2017, Volume: 18, Issue:4

    Topics: Age Factors; Aged; Aging; Cholecalciferol; Dietary Supplements; Exercise Therapy; Female; Healthy Aging; HMGB1 Protein; Humans; Inflammation Mediators; Interleukin-6; Leucine; Middle Aged; Muscle Strength; Poland; Postural Balance; Sex Factors; Time Factors; Treatment Outcome; Walking

2017
Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.
    Clinical science (London, England : 1979), 2017, Nov-01, Volume: 131, Issue:21

    Topics: Adenosine Triphosphate; Age Factors; Aged; Aging; Anabolic Agents; Dietary Supplements; Energy Metabolism; Humans; Insulin; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle, Skeletal; Phosphocreatine; Phosphorylation; Postprandial Period; Prospective Studies; Protein Biosynthesis; Sex Factors; Time Factors; TOR Serine-Threonine Kinases

2017
Regulation of Amino Acid Transporters and Sensors in Response to a High protein Diet: A Randomized Controlled Trial in Elderly Men.
    The journal of nutrition, health & aging, 2019, Volume: 23, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Body Mass Index; Diet, High-Protein; Humans; Intracellular Signaling Peptides and Proteins; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle, Skeletal; Recommended Dietary Allowances; Ribosomal Protein S6; Signal Transduction

2019
A Vitamin D, Calcium and Leucine-Enriched Whey Protein Nutritional Supplement Improves Measures of Bone Health in Sarcopenic Non-Malnourished Older Adults: The PROVIDE Study.
    Calcified tissue international, 2019, Volume: 105, Issue:4

    Topics: Aged; Aging; Bone and Bones; Bone Density; Calcium; Dietary Supplements; Double-Blind Method; Female; Humans; Leucine; Male; Middle Aged; Muscle Strength; Muscle, Skeletal; Vitamin D; Whey Proteins

2019
Activation of mammalian target of rapamycin signaling in skeletal muscle of neonatal chicks: effects of dietary leucine and age.
    Poultry science, 2014, Volume: 93, Issue:1

    Topics: Aging; Animal Feed; Animals; Animals, Newborn; Chickens; Diet; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Leucine; Male; Muscle, Skeletal; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; TOR Serine-Threonine Kinases

2014
Impact of the Macronutrient Composition of a Nutritional Supplement on Muscle Protein Synthesis Rates in Older Men: A Randomized, Double Blind, Controlled Trial.
    The Journal of clinical endocrinology and metabolism, 2015, Volume: 100, Issue:11

    Topics: Aged; Aging; Blood Glucose; Dietary Carbohydrates; Dietary Fats; Dietary Supplements; Double-Blind Method; Food; Humans; Insulin; Leucine; Male; Motor Activity; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Whey Proteins

2015
No additional effect of different types of physical activity on 10-hour muscle protein synthesis in elderly men on a controlled energy- and protein-sufficient diet.
    Experimental gerontology, 2016, 06-15, Volume: 79

    Topics: Activities of Daily Living; Aged; Aging; Bed Rest; Diet; Dietary Proteins; Exercise; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Resistance Training

2016
The impact of postexercise essential amino acid ingestion on the ubiquitin proteasome and autophagosomal-lysosomal systems in skeletal muscle of older men.
    Journal of applied physiology (Bethesda, Md. : 1985), 2017, Mar-01, Volume: 122, Issue:3

    Topics: Administration, Oral; Aged; Aging; Autophagosomes; Eating; Exercise; Humans; Leucine; Lysosomes; Male; Middle Aged; Muscle, Skeletal; Proteasome Endopeptidase Complex; Ubiquitin

2017
Protein consumption following aerobic exercise increases whole-body protein turnover in older adults.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2010, Volume: 35, Issue:5

    Topics: Aged; Aging; Beverages; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Elder Nutritional Physiological Phenomena; Exercise; Female; Humans; Leucine; Male; Middle Aged

2010
Prolonged leucine supplementation does not augment muscle mass or affect glycemic control in elderly type 2 diabetic men.
    The Journal of nutrition, 2011, Volume: 141, Issue:6

    Topics: Aged; Aging; Amino Acids; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Leucine; Lipids; Male; Muscle Strength; Muscle, Skeletal

2011
Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study.
    The American journal of clinical nutrition, 2011, Volume: 94, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Catalysis; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Proteasome Endopeptidase Complex

2011
Age and aerobic exercise training effects on whole body and muscle protein metabolism.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 286, Issue:1

    Topics: Adult; Aged; Aging; Body Composition; Energy Metabolism; Exercise; Female; Follow-Up Studies; Humans; Leucine; Male; Middle Aged; Muscle Proteins; Phenylalanine; Proteins; Radioactive Tracers; Reference Values

2004
TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status.
    Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:8

    Topics: Adult; Age Factors; Aged; Aging; Apolipoprotein A-I; Apolipoprotein B-100; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Deuterium; Female; Humans; Leucine; Lipoproteins; Lipoproteins, HDL; Menopause; Middle Aged; Postmenopause; Triglycerides

2005
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:2

    Topics: Administration, Oral; Adult; Aged; Aging; Amino Acids, Essential; Diet; Dietary Supplements; Female; Humans; Kinetics; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis

2006
Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men.
    The American journal of clinical nutrition, 2006, Volume: 84, Issue:3

    Topics: Activities of Daily Living; Adult; Aged; Aging; Carbon Isotopes; Cross-Over Studies; Dietary Carbohydrates; Dietary Proteins; Double-Blind Method; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Tyrosine

2006
Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men.
    The British journal of nutrition, 2008, Volume: 99, Issue:3

    Topics: Aged; Aging; Amino Acids; Blood Glucose; Cross-Over Studies; Diet; Dietary Carbohydrates; Dietary Proteins; Dietary Supplements; Exercise; Humans; Insulin; Leucine; Male; Milk Proteins; Muscle Proteins; Muscle, Skeletal; Proteins; Whey Proteins

2008
Effect of zinc supplementation on protein metabolism in late-middle-aged men: The Zenith study.
    Nutrition (Burbank, Los Angeles County, Calif.), 2008, Volume: 24, Issue:2

    Topics: Aged; Aging; Albumins; Analysis of Variance; Biomarkers; Carbon Isotopes; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Fibrinogen; Humans; Leucine; Male; Middle Aged; Proteins; Trace Elements; Zinc

2008
Protein turnover and energy metabolism of elderly women fed a low-protein diet.
    The American journal of clinical nutrition, 1995, Volume: 62, Issue:1

    Topics: Adaptation, Physiological; Aged; Aging; Diet, Protein-Restricted; Dietary Proteins; Eating; Energy Metabolism; Exercise; Female; Humans; Leucine

1995
Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:4

    Topics: Actins; Adult; Aged; Aged, 80 and over; Aging; Body Composition; Female; Humans; Keto Acids; Kinetics; Leucine; Male; Mitochondria, Muscle; Muscle Proteins; Myofibrils; Myosin Heavy Chains; Physical Fitness; Sarcoplasmic Reticulum; Weight Lifting

2000
Protein turnover modifications induced by the protein feeding pattern still persist after the end of the diets.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:5

    Topics: Adaptation, Physiological; Adult; Aged; Aging; Bicarbonates; Blood Glucose; Carbon Isotopes; Deuterium; Diet; Dietary Proteins; Energy Intake; Female; Food; Humans; Insulin; Kinetics; Leucine; Proteins

2000
The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2001, Volume: 56, Issue:6

    Topics: Aged; Aging; Body Composition; Dietary Proteins; Female; Humans; Leucine; Male; Middle Aged; Muscle, Skeletal; Nitrogen; Nutrition Policy; Thigh

2001

Other Studies

302 other study(ies) available for leucine and Aging

ArticleYear
Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis.
    Nutrients, 2022, Sep-17, Volume: 14, Issue:18

    Topics: Aging; Animals; Dietary Supplements; Fatty Acids; Forkhead Box Protein O1; Glucose; Inflammation; Large Neutral Amino Acid-Transporter 1; Leucine; Male; Mice; Myocytes, Smooth Muscle; Reactive Oxygen Species; Rubber; Sirtuin 1; Vascular Remodeling

2022
The Aging Process: A Metabolomics Perspective.
    Molecules (Basel, Switzerland), 2022, Dec-07, Volume: 27, Issue:24

    Topics: Adult; Aged; Aging; Aspartic Acid; Biomarkers; Female; Humans; Isoleucine; Leucine; Male; Metabolome; Metabolomics; Middle Aged; Ornithine; Urea; Valine; Young Adult

2022
[The Impact of Nutrition on Muscle Health in Older Individuals].
    Praxis, 2023, Volume: 112, Issue:7-8

    Topics: Aged; Aging; Humans; Leucine; Muscle Strength; Muscle, Skeletal; Quality of Life; Sarcopenia

2023
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
    Nature communications, 2020, 01-10, Volume: 11, Issue:1

    Topics: Adult; Aged; Aging; Amino Acids; Animals; Disease Models, Animal; Female; HEK293 Cells; Humans; Hydroxylation; Hypoxia-Inducible Factor-Proline Dioxygenases; Leucine; Leucine-tRNA Ligase; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Development; Muscles; Oxygen; Procollagen-Proline Dioxygenase; Signal Transduction

2020
Novel Essential Amino Acid Supplements Following Resistance Exercise Induce Aminoacidemia and Enhance Anabolic Signaling Irrespective of Age: A Proof-of-Concept Trial.
    Nutrients, 2020, Jul-12, Volume: 12, Issue:7

    Topics: Adult; Aged; Aging; Amino Acids, Essential; Dietary Supplements; Exercise; Female; Humans; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Muscle Proteins; Muscle, Skeletal; Resistance Training; Sarcopenia; Young Adult

2020
Dietary leucine requirement of older men and women is higher than current recommendations.
    The American journal of clinical nutrition, 2021, 02-02, Volume: 113, Issue:2

    Topics: Aged; Aging; Dose-Response Relationship, Drug; Female; Humans; Leucine; Male; Nutritional Requirements; Oxidation-Reduction; Phenylalanine

2021
Leucine requirements for the elderly.
    The American journal of clinical nutrition, 2021, 04-06, Volume: 113, Issue:4

    Topics: Aged; Aging; Female; Humans; Leucine; Male; Nutritional Requirements

2021
The effect of young and old ex vivo human serum on cellular protein synthesis and growth in an in vitro model of aging.
    American journal of physiology. Cell physiology, 2021, 07-01, Volume: 321, Issue:1

    Topics: Adult; Aged; Aging; Animals; C-Reactive Protein; Cell Line; Culture Media; Humans; Insulin Resistance; Interleukin-6; Leucine; Male; Mice; Models, Biological; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Peptide Elongation Factor 2; Protein Biosynthesis; Proteolysis; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction

2021
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021, Volume: 35, Issue:9

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Body Weight; Collagen; Fibrosis; Hindlimb Suspension; Immunoglobulin G; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Mice, Inbred C57BL; Muscle Development; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Atrophy; Organ Size; RNA-Seq; Satellite Cells, Skeletal Muscle; Signal Transduction

2021
Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment.
    Neurobiology of aging, 2017, Volume: 60

    Topics: Aging; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Glycoproteins; Hippocampus; Leucine; Long-Term Potentiation; Memory Disorders; Mice, Transgenic; Synaptic Vesicles

2017
Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 04-17, Volume: 73, Issue:5

    Topics: Aging; Animals; Caloric Restriction; Female; Half-Life; Isotope Labeling; Leucine; Mass Spectrometry; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Protein Aggregates; Protein Biosynthesis; Proteome; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin

2018
A potential strategy for counteracting age-related sarcopenia: preliminary evidence of combined exercise training and leucine supplementation.
    Food & function, 2017, Dec-13, Volume: 8, Issue:12

    Topics: Aging; Animals; Combined Modality Therapy; Dietary Supplements; Humans; Leucine; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Resistance Training; Ribosomal Protein S6 Kinases, 70-kDa; Sarcopenia; TOR Serine-Threonine Kinases

2017
Different protein and derivatives supplementation strategies combined with resistance training in pre-frail and frail elderly: Rationale and protocol for the "Pro-Elderly" Study.
    Nutrition and health, 2017, Volume: 23, Issue:4

    Topics: Aged; Aging; Combined Modality Therapy; Dietary Proteins; Dietary Supplements; Double-Blind Method; Elder Nutritional Physiological Phenomena; Female; Frail Elderly; Frailty; Humans; Leucine; Male; Muscle, Skeletal; Randomized Controlled Trials as Topic; Research Design; Resistance Training; Sarcopenia; Severity of Illness Index; Sex Characteristics; Soybean Proteins; Ultrasonography; Whey Proteins

2017
Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity.
    American journal of physiology. Renal physiology, 2018, 11-01, Volume: 315, Issue:5

    Topics: Administration, Intravesical; Age Factors; Aging; Animals; Calcium Signaling; Capsaicin; Female; Leucine; Mechanotransduction, Cellular; Membrane Potentials; Muscle Contraction; Neurons, Afferent; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels; Urinary Bladder; Urination; Urodynamics; Urothelium

2018
Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis.
    Lab on a chip, 2018, 10-23, Volume: 18, Issue:21

    Topics: Aging; Animals; Azides; Biomarkers; Biosensing Techniques; Blood Proteins; Graphite; Leucine; Mice; Parabiosis

2018
A meal with mixed soy/whey proteins is as efficient as a whey meal in counteracting the age-related muscle anabolic resistance only if the protein content and leucine levels are increased.
    Food & function, 2018, Dec-13, Volume: 9, Issue:12

    Topics: Aging; Animals; Dietary Proteins; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Wistar; Soybean Proteins; Whey Proteins

2018
Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2013, Jul-15, Volume: 115, Issue:2

    Topics: Aging; Amino Acids; Animals; Body Weight; Eating; Glutamine; Homeostasis; Intestinal Mucosa; Intestines; Kidney; Leucine; Liver; Male; Muscles; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Veins

2013
Protein redistribution from skeletal muscle to splanchnic tissue on fasting and refeeding in young and older healthy individuals.
    Journal of the American Medical Directors Association, 2013, Volume: 14, Issue:9

    Topics: Aged; Aging; Albumins; Body Composition; Carbon Isotopes; Eating; Fasting; Female; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Protein Biosynthesis; Splanchnic Circulation; Young Adult

2013
Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain.
    Journal of neurochemistry, 2014, Volume: 129, Issue:4

    Topics: Aging; Alkyl and Aryl Transferases; Animals; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cerebrum; Cognition Disorders; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Leucine; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Naphthalenes; Nerve Tissue Proteins; Neuroblastoma; Protein Prenylation; rab GTP-Binding Proteins; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Messenger; Synaptic Membranes; Synaptic Transmission; Terpenes

2014
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.
    Aging cell, 2015, Volume: 14, Issue:4

    Topics: Aging; Animals; Caloric Restriction; Deuterium; Eukaryotic Initiation Factor-2; Female; Gene Expression Regulation; Half-Life; Homeostasis; Isotope Labeling; Leucine; Liver; Mice; Mice, Inbred C57BL; Polyribosomes; Protein Biosynthesis; Protein Stability; Proteolysis; Proteome; Signal Transduction; Sirolimus; Tandem Mass Spectrometry; TOR Serine-Threonine Kinases

2015
Leucine supplementation improves regeneration of skeletal muscles from old rats.
    Experimental gerontology, 2015, Volume: 72

    Topics: Aging; Animals; Carrier Proteins; Dietary Supplements; Eukaryotic Initiation Factor-4E; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Regeneration; Satellite Cells, Skeletal Muscle; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitinated Proteins

2015
Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population.
    The British journal of nutrition, 2016, Volume: 115, Issue:9

    Topics: Absorptiometry, Photon; Adult; Age Factors; Aged; Aging; Body Composition; Body Fluid Compartments; Cardiovascular Diseases; Cohort Studies; Denmark; Diet; Dietary Proteins; Electric Impedance; Energy Intake; Exercise; Female; Humans; Leucine; Male; Middle Aged; Muscle, Skeletal; Sarcopenia

2016
Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
    Experimental gerontology, 2016, Volume: 80

    Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aging; Animals; Dietary Supplements; Humans; Keto Acids; Leucine; Liver; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Valerates

2016
Hypertrophy-Promoting Effects of Leucine Supplementation and Moderate Intensity Aerobic Exercise in Pre-Senescent Mice.
    Nutrients, 2016, May-02, Volume: 8, Issue:5

    Topics: Aging; Animals; Diet; Dietary Supplements; Leucine; Male; Mice; Muscle, Skeletal; Physical Conditioning, Animal

2016
Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration.
    Mechanisms of ageing and development, 2016, Volume: 157

    Topics: Aging; Animals; Bupivacaine; Leucine; Mice; Muscle, Skeletal; Regeneration

2016
Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats.
    The Journal of nutrition, 2008, Volume: 138, Issue:11

    Topics: Aging; Animals; Antioxidants; Biomarkers; Dietary Supplements; Inflammation; Leucine; Muscle Proteins; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases

2008
Blunting of insulin inhibition of proteolysis in legs of older subjects may contribute to age-related sarcopenia.
    The American journal of clinical nutrition, 2009, Volume: 90, Issue:5

    Topics: Adult; Aged; Aging; Amino Acids; Female; Glucose Clamp Technique; Humans; Insulin; Leg; Leucine; Male; Muscle Proteins; Muscular Diseases; Proteins; Proto-Oncogene Proteins c-akt

2009
Measurement of the rate of myofibrillar protein degradation using the arteriovenous difference in plasma 3-methylhistidine concentration of rats.
    Journal of nutritional science and vitaminology, 2009, Volume: 55, Issue:4

    Topics: Aging; Animals; Aorta, Abdominal; Biomarkers; Blood Flow Velocity; Caseins; Diet; Femoral Vein; Leucine; Male; Methylhistidines; Muscle Proteins; Muscle, Skeletal; Myofibrils; Rats; Rats, Wistar

2009
Middle age is not associated with altered fibrinogen concentration and production in males.
    Acta diabetologica, 2010, Volume: 47, Issue:2

    Topics: Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Fibrinogen; Humans; Insulin; Leucine; Male; Middle Aged

2010
Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.
    The Journal of biological chemistry, 2009, Dec-11, Volume: 284, Issue:50

    Topics: 2-Aminoadipic Acid; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Cattle; Child; Crystallins; Diabetes Mellitus; Humans; Hydrogen Peroxide; Hyperbaric Oxygenation; Lens, Crystalline; Leucine; Lysine; Metals; Mice; Mice, Inbred C57BL; Middle Aged; Molecular Structure; Oxidants; Oxidation-Reduction; Rabbits; Regression Analysis; Young Adult

2009
Experimentally increased codon bias in the Drosophila Adh gene leads to an increase in larval, but not adult, alcohol dehydrogenase activity.
    Genetics, 2010, Volume: 184, Issue:2

    Topics: Aging; Alcohol Dehydrogenase; Alleles; Animals; Base Sequence; Codon; Drosophila melanogaster; Drosophila Proteins; Evolution, Molecular; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Larva; Leucine; Male; Mutagenesis, Site-Directed; Mutation; Protein Biosynthesis; Transformation, Genetic; Transgenes

2010
Leucine and citrulline modulate muscle function in malnourished aged rats.
    Amino acids, 2012, Volume: 42, Issue:4

    Topics: Aging; Animals; Citrulline; Dietary Supplements; Humans; Leucine; Male; Malnutrition; Muscle, Skeletal; Rats; Rats, Sprague-Dawley

2012
Protein anabolic responses to a fed steady state in healthy aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2011, Volume: 66, Issue:6

    Topics: Adult; Aged; Aging; Exercise; Female; Glucose; Humans; Insulin Resistance; Leucine; Muscle Proteins; Phosphorylation; Proteins; Sarcopenia

2011
Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach.
    Age (Dordrecht, Netherlands), 2012, Volume: 34, Issue:2

    Topics: Adipose Tissue; Aging; Animals; Biological Transport; Blotting, Western; Dietary Supplements; Disease Models, Animal; Follow-Up Studies; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Leucine; Male; Muscle, Skeletal; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Ribosomal Protein S6 Kinases; RNA; Sarcopenia; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases

2012
Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise.
    Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:1

    Topics: Activating Transcription Factor 4; Active Transport, Cell Nucleus; Adult; Age Factors; Aged; Aging; Amino Acid Transport Systems; Amino Acids; Analysis of Variance; Biopsy; Blotting, Western; Eukaryotic Initiation Factor-2; Female; Gene Expression Regulation; Humans; Leucine; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Muscle Contraction; Phenylalanine; Phosphorylation; Polymerase Chain Reaction; Quadriceps Muscle; Resistance Training; Ribosomal Protein S6; RNA, Messenger; STAT3 Transcription Factor; Time Factors; TOR Serine-Threonine Kinases

2011
Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2012, Volume: 28, Issue:2

    Topics: Adipose Tissue; Age Factors; Aging; Animals; Blood Glucose; Body Composition; Body Fluid Compartments; Body Weight; Chronic Disease; Dietary Supplements; Leucine; Lipids; Male; Nutritional Status; Obesity; Proteins; Rats; Rats, Sprague-Dawley; Risk Factors

2012
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults.
    Obesity (Silver Spring, Md.), 2012, Volume: 20, Issue:9

    Topics: Aged; Aged, 80 and over; Aging; Blood Glucose; Energy Intake; Energy Metabolism; Fasting; Female; Humans; Insulin; Leucine; Male; Muscle Proteins; Muscle Strength; Muscle, Skeletal; Obesity; Protein Biosynthesis; Weight Loss

2012
Contrarily to whey and high protein diets, dietary free leucine supplementation cannot reverse the lack of recovery of muscle mass after prolonged immobilization during ageing.
    The Journal of physiology, 2012, Apr-15, Volume: 590, Issue:8

    Topics: Aging; Amino Acids; Animals; Diet; Dietary Supplements; Hindlimb Suspension; Leucine; Male; Milk Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ubiquitin; Whey Proteins

2012
Leucine: a nutrient 'trigger' for muscle anabolism, but what more?
    The Journal of physiology, 2012, May-01, Volume: 590, Issue:9

    Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy

2012
Contributions to the understanding of the anabolic properties of different dietary proteins.
    The Journal of physiology, 2012, Jun-15, Volume: 590, Issue:12

    Topics: Aging; Animals; Leucine; Male; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy

2012
Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise.
    Clinical nutrition (Edinburgh, Scotland), 2013, Volume: 32, Issue:2

    Topics: Adult; Aged; Aging; Amino Acid Transport Systems; Amino Acids, Essential; Blood Glucose; Exercise; Humans; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Protein Biosynthesis; Rest; RNA, Messenger

2013
Aging and regenerative capacity of skeletal muscle in rats.
    Current aging science, 2012, Volume: 5, Issue:2

    Topics: Actins; Age Factors; Aging; Animals; Leucine; Male; Muscle, Skeletal; Myofibrils; Myosin Heavy Chains; Organ Size; Rats; Rats, Wistar; Regeneration; Sarcoplasmic Reticulum; Transplantation, Autologous

2012
Age attenuates leucine oxidation after eccentric exercise.
    International journal of sports medicine, 2013, Volume: 34, Issue:8

    Topics: Age Factors; Aged; Aging; Exercise; Exercise Test; Glucose Clamp Technique; Humans; Hyperglycemia; Insulin Resistance; Leucine; Male; Middle Aged; Oxidation-Reduction; Time Factors; Young Adult

2013
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
    The Journal of biological chemistry, 2002, Oct-04, Volume: 277, Issue:40

    Topics: Aging; Animals; Cardiomegaly; Cells, Cultured; Enzyme Induction; Fasting; Genotype; Heart; Insulin; Leucine; Mice; Mice, Inbred Strains; Myocardium; Nutritional Status; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases

2002
Mitochondrial 5178A/C genotype is associated with acute myocardial infarction.
    Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:1

    Topics: Aged; Aging; Alleles; Amino Acid Substitution; Diabetes Complications; DNA, Mitochondrial; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypercholesterolemia; Hypertension; Leucine; Male; Methionine; Middle Aged; Myocardial Infarction; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors

2003
Estrogen-induced disruption of neonatal porcine uterine development alters adult uterine function.
    Biology of reproduction, 2003, Volume: 68, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Body Fluids; Corpus Luteum; Drug Administration Schedule; Endometrium; Estradiol; Female; In Vitro Techniques; Leucine; Pregnancy; Pregnancy, Animal; Proteins; RNA, Messenger; Swine; Uterus

2003
Effects of ageing on secretagogue-evoked protein output, peroxidase secretion and protein synthesis in the isolated rat lacrimal gland.
    Advances in experimental medicine and biology, 2002, Volume: 506, Issue:Pt A

    Topics: Aging; Animals; Eye Proteins; In Vitro Techniques; Leucine; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Stimulation, Chemical

2002
The rate of protein digestion affects protein gain differently during aging in humans.
    The Journal of physiology, 2003, Jun-01, Volume: 549, Issue:Pt 2

    Topics: Adult; Aged; Aging; Amino Acids; Caseins; Digestion; Hormones; Humans; Kinetics; Leucine; Male; Milk Proteins; Osmolar Concentration; Peptide Hydrolases; Time Factors; Whey Proteins

2003
Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats.
    The Journal of nutrition, 2003, Volume: 133, Issue:4

    Topics: Aging; Amino Acids; Animals; Insulin; Leucine; Male; Muscle Proteins; Postprandial Period; Rats; Rats, Wistar

2003
Effects of age on morphology, protein synthesis and secretagogue-evoked secretory responses in the rat lacrimal gland.
    Molecular and cellular biochemistry, 2003, Volume: 248, Issue:1-2

    Topics: Age Factors; Aging; Animals; Cytoplasm; Endoplasmic Reticulum, Rough; Golgi Apparatus; Histamine; Immunohistochemistry; Lacrimal Apparatus; Leucine; Male; Microscopy, Electron; Microscopy, Fluorescence; Peroxidases; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Time Factors; Vasoactive Intestinal Peptide

2003
[A possible effect of the degree of purity of optically active substances on the process of aging].
    Schweizerische medizinische Wochenschrift, 1955, Jul-09, Volume: 85, Issue:28

    Topics: Aging; Eye; Humans; Leucine

1955
TRANSPORT AND INCORPORATION OF AMINO ACIDS INTO THE AORTIC WALL: INFLUENCE OF AGE AND HORMONES.
    Angiologica, 1964, Volume: 1

    Topics: Aging; Alanine; Amino Acids; Aminobutyrates; Animals; Aorta; Carbon Isotopes; Diabetes Mellitus, Experimental; Geriatrics; Glycine; Hyperthyroidism; Hypothyroidism; Insulin; Leucine; Propylthiouracil; Proteins; Rats; Research; Thyronines

1964
[LEUCINE AMINOPEPTIDASE IN BLOOD SERUM. NORMAL VALUES IN VARIOUS PEDIATRIC AGES].
    Minerva pediatrica, 1964, Jan-28, Volume: 16

    Topics: Aging; Aminopeptidases; Biomedical Research; Blood; Child; Infant; Infant, Newborn; Leucine; Leucyl Aminopeptidase; Reference Values; Serum

1964
EFFECTS OF L-THYROXINE ON AMINO ACID INCORPORATION INTO PROTEIN IN MATURE AND IMMATURE RAT BRAIN.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Amino Acids; Brain; Glutarates; Hydroxybutyrates; Leucine; Liver; Nerve Tissue Proteins; Pharmacology; Proteins; Rats; Research; Thyroid Hormones; Thyroxine

1964
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG. III. SPINAL CORD.
    Journal of neurochemistry, 1964, Volume: 11

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Aspartic Acid; Cystine; Fetus; Glutamates; Glycine; Guinea Pigs; Histidine; Leucine; Lysine; Nerve Tissue Proteins; Nervous System; Phenylalanine; Research; Serine; Spinal Cord; Threonine; Tyrosine; Valine

1964
INCORPORATION OF THYMIDINE INTO DNA OF MOUSE ORGANS.
    Archives of pathology, 1964, Volume: 78

    Topics: Aging; Amino Acids; Animals; DNA; Leucine; Metabolism; Mice; Nucleosides; Proteins; Research; RNA; Thymidine; Tritium

1964
POLYRIBOSOMES AND THE LOSS OF HEMOGLOBIN SYNTHESIS IN THE MATURING RETICULOCYTE.
    Journal of molecular biology, 1965, Volume: 11

    Topics: Aging; Animals; Carbon Isotopes; Hemoglobins; Leucine; Photomicrography; Polyribosomes; Proteins; Rabbits; Research; Reticulocytes; Ribosomes; Ultracentrifugation

1965
The leucine aminopeptidase activity of arterial tissue in individuals of various ages.
    Journal of gerontology, 1960, Volume: 15

    Topics: Aging; Arteries; Endopeptidases; Hydrolases; Leucine; Leucyl Aminopeptidase; Peptide Hydrolases

1960
Status of the "protein kinase CK2-HMG14" system in age-related amnesia in rats.
    Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:8

    Topics: Aging; Amnesia; Animals; Avoidance Learning; Behavior, Animal; Brain; Casein Kinases; Cell Nucleus; Disease Models, Animal; DNA-Binding Proteins; Etimizol; HMGN1 Protein; Leucine; Male; Phosphorylation; Protein Kinases; Rats; Retention, Psychology; Synaptosomes; Transcription, Genetic; Tritium; Uridine Monophosphate

2003
Electron microscopic radioautographic study on protein synthesis in amitotic hepatocytes of the aging mouse.
    Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan, 2004, Volume: 37, Issue:1

    Topics: Aging; Animals; Autoradiography; Female; Hepatocytes; Leucine; Liver; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Tritium

2004
Mitochondrial and sarcoplasmic proteins, but not myosin heavy chain, are sensitive to leucine supplementation in old rat skeletal muscle.
    Experimental gerontology, 2004, Volume: 39, Issue:5

    Topics: Aging; Alanine; Animals; Diet; Leucine; Male; Mitochondrial Proteins; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; Phenylalanine; Rats; Rats, Wistar; Sarcoplasmic Reticulum

2004
Glucocorticoid excess induces a prolonged leucine resistance on muscle protein synthesis in old rats.
    Experimental gerontology, 2004, Volume: 39, Issue:9

    Topics: Aging; Animals; Dexamethasone; Dose-Response Relationship, Drug; Drug Resistance; Eating; Glucocorticoids; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Rats; Rats, Wistar; Tissue Culture Techniques

2004
Whole body protein breakdown is less inhibited by insulin, but still responsive to amino acid, in nondiabetic elderly subjects.
    The Journal of clinical endocrinology and metabolism, 2004, Volume: 89, Issue:12

    Topics: Adult; Aged; Aging; Amino Acids; Blood Glucose; Body Composition; Carbon Dioxide; Exhalation; Glucose; Humans; Insulin; Leucine; Male; Osmolar Concentration; Pentanoic Acids; Proteins

2004
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:3

    Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic Initiation Factors; Humans; Keto Acids; Kinetics; Leucine; Male; Muscle Proteins; Muscle, Skeletal; NF-kappa B; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Solutions; TOR Serine-Threonine Kinases

2005
Influence of aging on glycosaminoglycans and small leucine-rich proteoglycans production by skin fibroblasts.
    Molecular and cellular biochemistry, 2005, Volume: 277, Issue:1-2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cells, Cultured; Child; Child, Preschool; Chondroitin Sulfate Proteoglycans; Female; Fibroblasts; Glycosaminoglycans; Humans; Infant; Keratan Sulfate; Leucine; Lumican; Male; Middle Aged; Proteoglycans; Skin

2005
A leucine-supplemented diet restores the defective postprandial inhibition of proteasome-dependent proteolysis in aged rat skeletal muscle.
    The Journal of physiology, 2005, Dec-01, Volume: 569, Issue:Pt 2

    Topics: Aging; Alanine; Animals; Body Weight; Dietary Supplements; Hydrolysis; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; RNA, Messenger; Ubiquitin; Ubiquitin-Conjugating Enzymes

2005
A role for leucine in rejuvenating the anabolic effects of food in old rats.
    The Journal of physiology, 2005, Dec-01, Volume: 569, Issue:Pt 2

    Topics: Aged; Aging; Animals; Dietary Supplements; Eating; Food; Humans; Insulin; Leucine; Middle Aged; Muscle Proteins; Rats

2005
Influence of adiposity in the blunted whole-body protein anabolic response to insulin with aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:2

    Topics: Adiposity; Adult; Aged; Aging; Female; Humans; Insulin; Insulin Resistance; Leucine; Male; Protein Biosynthesis; Proteins

2006
Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP.
    Molecular vision, 2006, Sep-13, Volume: 12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Blotting, Western; Child; Child, Preschool; Extracellular Matrix Proteins; Female; Glycoproteins; Humans; Immunohistochemistry; Leucine; Male; Middle Aged; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sclera; Staining and Labeling

2006
Postprandial leucine deficiency failed to alter muscle protein synthesis in growing and adult rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2007, Volume: 23, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Random Allocation; Rats; Rats, Wistar

2007
Increased availability of leucine with leucine-rich whey proteins improves postprandial muscle protein synthesis in aging rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2007, Volume: 23, Issue:4

    Topics: Aging; Amino Acids; Animals; Carbon Isotopes; Dose-Response Relationship, Drug; Leucine; Male; Milk Proteins; Muscle Proteins; Postprandial Period; Random Allocation; Rats; Rats, Wistar; Whey Proteins

2007
Postprandial whole-body protein metabolism after a meat meal is influenced by chewing efficiency in elderly subjects.
    The American journal of clinical nutrition, 2007, Volume: 85, Issue:5

    Topics: Aged; Aging; Amino Acids; Area Under Curve; Carbon Isotopes; Dentition; Denture, Complete; Dietary Proteins; Digestion; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Leucine; Male; Mastication; Meat; Middle Aged; Particle Size; Postprandial Period; Protein Biosynthesis

2007
Rate of metabolic decarboxylation of leucine as assessed by a l[1-(13)C(1)]leucine breath test combined with indirect calorimetry of broiler chickens fed isocaloric diets with different protein:fat ratio.
    Journal of animal physiology and animal nutrition, 2007, Volume: 91, Issue:7-8

    Topics: Aging; Animal Feed; Animals; Area Under Curve; Body Weight; Breath Tests; Calorimetry, Indirect; Carbon Isotopes; Chickens; Decarboxylation; Dietary Fats; Dietary Proteins; Digestion; Dose-Response Relationship, Drug; Female; Leucine; Random Allocation

2007
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 104, Issue:5

    Topics: Absorptiometry, Photon; Adult; Aged; Aging; Algorithms; Amino Acids, Essential; Anabolic Agents; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hormones; Humans; Hydrocortisone; Lactic Acid; Leucine; Male; Middle Aged; Muscle Proteins; Muscle, Skeletal; Phenylalanine; Phosphorylation; Physical Fitness; Protein Kinases; RNA; Signal Transduction; TOR Serine-Threonine Kinases

2008
[Protein synthesis and the regulation process in the cell].
    Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 50, Issue:5

    Topics: Aging; Animals; Arginine; Autoradiography; Axons; Body Weight; Cell Biology; Cytoplasmic Granules; Glycine; Golgi Apparatus; Guinea Pigs; Hippocampus; Homeostasis; Leucine; Methionine; Mice; Microscopy, Electron; Neurons; Pancreas; Photoreceptor Cells; Protein Biosynthesis; Purkinje Cells; Pyramidal Tracts; Rats; Ribosomes; RNA; RNA, Messenger; Spectrophotometry; Thyroid Gland; Time Factors; Tritium; Tyrosine

1966
Studies of permeability, RNA and protein turnover during ageing of fruit and leaf tissues.
    Symposia of the Society for Experimental Biology, 1967, Volume: 21

    Topics: Aging; Cell Membrane Permeability; Dactinomycin; Fruit; Leucine; Orotic Acid; Plant Growth Regulators; Plant Proteins; Plants, Edible; RNA

1967
Developmental changes in amino acid transport in the chicken erythrocyte.
    Comparative biochemistry and physiology. A, Comparative physiology, 1983, Volume: 74, Issue:4

    Topics: Aging; Amino Acids; Animals; Chickens; Erythrocytes; Glycine; Kinetics; Leucine; Lysine

1983
Effect of age-dependent changes on jejunal and ileal amino acid-sugar interaction in vivo.
    Comparative biochemistry and physiology. A, Comparative physiology, 1984, Volume: 78, Issue:2

    Topics: Absorption; Aging; Animals; Biological Transport, Active; Galactose; Ileum; Jejunum; Leucine; Male; Rats; Rats, Inbred Strains

1984
Organization of developing precruciate corticostriate projections in kittens.
    Experimental neurology, 1980, Volume: 67, Issue:2

    Topics: Aging; Animals; Axonal Transport; Brain; Cats; Caudate Nucleus; Cerebral Cortex; Corpus Striatum; Leucine; Proline; Putamen

1980
RNA and protein synthesis in cultured human fibroblasts derived from donors of various ages.
    Mechanisms of ageing and development, 1980, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Cell Membrane Permeability; Cells, Cultured; Child; Child, Preschool; Fetus; Fibroblasts; Humans; Infant; Infant, Newborn; Kinetics; Leucine; Male; Middle Aged; Nucleotides; Octoxynol; Polyethylene Glycols; Protein Biosynthesis; RNA

1980
Age-related changes in the cellular level of amylase and protein synthesis in the rat parotid gland.
    Journal of dental research, 1981, Volume: 60, Issue:3

    Topics: Aging; alpha-Amylases; Amylases; Animals; DNA; Leucine; Male; Parotid Gland; Rats; Salivary Proteins and Peptides

1981
Comparative studies of the age-related changes in protein synthesis in the rat pancreas and parotid gland.
    Experimental gerontology, 1981, Volume: 16, Issue:1

    Topics: Aging; alpha-Amylases; Amylases; Animals; Cytoplasmic Granules; Hydrogen-Ion Concentration; Leucine; Male; Pancreas; Parotid Gland; Protein Biosynthesis; Rats; Salivary Proteins and Peptides

1981
Haemoglobin synthesis by fetal erythroid cells in an adult environment.
    British journal of haematology, 1981, Volume: 49, Issue:3

    Topics: Aging; Animals; Bone Marrow; Female; Fetal Hemoglobin; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Hemoglobin A; Leucine; Male; Sheep

1981
The development of axonal connections in the central olfactory system of rats.
    The Journal of comparative neurology, 1984, Feb-20, Volume: 223, Issue:2

    Topics: Aging; Animals; Axonal Transport; Axons; Central Nervous System; Cerebral Cortex; Female; Gestational Age; Horseradish Peroxidase; Leucine; Olfactory Bulb; Olfactory Pathways; Pregnancy; Rats; Rats, Inbred Strains

1984
The development of lamination of afferent fibers to the olfactory cortex in rats, with additional observations in the adult.
    The Journal of comparative neurology, 1984, Feb-20, Volume: 223, Issue:2

    Topics: Afferent Pathways; Aging; Animals; Axonal Transport; Central Nervous System; Cerebral Cortex; Horseradish Peroxidase; Leucine; Olfactory Bulb; Olfactory Pathways; Rats; Rats, Inbred Strains

1984
Generalized diminution in the response to nutrients as insulin-releasing agents during the early neonatal period in the rat.
    Diabetes, 1981, Volume: 30, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Cyclic AMP; Eating; Female; Glucose; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Rats

1981
Effects of intravenous glucose on whole body leucine dynamics, studied with 1-13C-leucine, in healthy young and elderly adults.
    Journal of gerontology, 1984, Volume: 39, Issue:6

    Topics: Adult; Aged; Aging; Amino Acids; Blood Glucose; Carbon Isotopes; Catecholamines; Female; Glucagon; Glucose; Humans; Hydrocortisone; Infusions, Parenteral; Insulin; Kinetics; Leucine; Male; Radioimmunoassay; Sex Factors

1984
Transport of branched-chain amino acids in brain slices of developing and adult rats.
    Acta physiologica Scandinavica, 1984, Volume: 122, Issue:3

    Topics: Aging; Amino Acids; Amino Acids, Branched-Chain; Animals; Biological Transport; Brain; Extracellular Space; gamma-Aminobutyric Acid; In Vitro Techniques; Isoleucine; Leucine; Rats; Rats, Inbred Strains; Valine

1984
Age-related functional alteration of mouse liver ribosomes.
    Experimental gerontology, 1983, Volume: 18, Issue:5

    Topics: Aging; Animals; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Polyribosomes; Ribosomal Proteins; Ribosomes

1983
Erythroid colony development as a function of age: the role of marrow cellular heme.
    Journal of gerontology, 1983, Volume: 38, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Aging; Animals; Erythrocytes; Erythropoiesis; Glycine; Hematopoietic Stem Cells; Heme; Heme Oxygenase (Decyclizing); Leucine; Male; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Uridine

1983
The effects of aging on local rates of cerebral protein synthesis in rats.
    Monographs in neural sciences, 1984, Volume: 11

    Topics: Aging; Animals; Brain; Energy Metabolism; Leucine; Nerve Tissue Proteins; Neurons; Rats

1984
Turnover of intestinal brush-border proteins during postnatal development in rat.
    The American journal of physiology, 1980, Volume: 239, Issue:6

    Topics: Aging; alpha-Glucosidases; Animals; beta-Galactosidase; Cathepsins; Cell Membrane; Intestinal Mucosa; Leucine; Lysosomes; Membrane Proteins; Microvilli; Pancreas; Peptide Hydrolases; Rats; Trehalase

1980
Higher excretion of urinary bound amino acids in infants: probably related to protein-anabolic effect of growth hormone.
    The Tohoku journal of experimental medicine, 1982, Volume: 137, Issue:1

    Topics: Aging; Alanine; Amino Acids; Arginine; Child; Child, Preschool; Cystine; Cystinuria; Glycine; Growth Hormone; Histidine; Humans; Infant; Isoleucine; Leucine; Lysine; Male; Methionine; Phenylalanine; Proteins; Valine

1982
Long-term effects of deendothelialization of rabbit aorta: in vitro synthesis of DNA, protein, and lipid.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1983, Volume: 173, Issue:3

    Topics: Acetates; Aging; Animals; Aorta; Catheterization; Cholesterol; DNA; Endothelium; Leucine; Lipids; Male; Mevalonic Acid; Protein Biosynthesis; Rabbits; Thymidine

1983
Effect of age on leucine-induced insulin secretion by the beta-cell.
    Journal of gerontology, 1980, Volume: 35, Issue:3

    Topics: Aging; Animals; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Rats

1980
Diabetes in pregnancy: effects on the maturation of (pro) insulin biosynthesis in fetal and neonatal rat islets.
    Diabete & metabolisme, 1981, Volume: 7, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Diabetes Mellitus, Experimental; Female; Gestational Age; Glucose; Islets of Langerhans; Leucine; Pregnancy; Pregnancy in Diabetics; Proinsulin; Rats; Rats, Inbred Strains

1981
Functional properties of rat liver protein synthesizing machinery in relation to aging.
    Experimental gerontology, 1982, Volume: 17, Issue:4

    Topics: Aging; Animals; Female; In Vitro Techniques; Kinetics; Leucine; Liver; Polyribosomes; Protein Biosynthesis; Rats; Ribosomes

1982
Effects of centrally and systemically administered L-tyrosine and L-leucine on ovarian function in the old rat.
    Gerontology, 1980, Volume: 26, Issue:5

    Topics: Aging; Animals; Catecholamines; Estrus; Female; Leucine; Levodopa; Ovary; Pregnancy; Preoptic Area; Rats; Serotonin; Tyrosine

1980
Effects of age and cardiac work in vitro on mitochondrial oxidative phosphorylation and (3H)-leucine incorporation.
    Journal of gerontology, 1981, Volume: 36, Issue:2

    Topics: Aging; Animals; In Vitro Techniques; Leucine; Male; Mitochondria, Heart; Oxidative Phosphorylation; Rats; Tritium; Ventilation-Perfusion Ratio

1981
Tritiated leucine incorporation in the developing hamster facial nucleus with injury: a liquid scintillation study.
    Brain research, 1981, Volume: 227, Issue:2

    Topics: Aging; Animals; Cell Nucleolus; Cricetinae; Facial Nerve; Leucine; Mesocricetus; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Tritium

1981
Does the capacity of ribosomes to control translation fidelity change with age?
    Mechanisms of ageing and development, 1981, Volume: 15, Issue:2

    Topics: Aging; Animals; Dose-Response Relationship, Drug; Leucine; Magnesium; Male; Paromomycin; Peptide Chain Elongation, Translational; Phenylalanine; Poly U; Rats; Ribosomes

1981
Correction of immunodeficiency in aged mice by levamisole and bestatin administration.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 75

    Topics: Adjuvants, Immunologic; Aging; Animals; Antibody-Dependent Cell Cytotoxicity; Immunologic Deficiency Syndromes; Leucine; Levamisole; Lymphocytes; Macrophages; Mice; Neoplasms

1980
Turnover of myelin proteins of rat brain, determined in fractions separated by sedimentation in a continuous sucrose gradient.
    Journal of neurochemistry, 1981, Volume: 36, Issue:4

    Topics: Aging; Animals; Brain; Centrifugation, Density Gradient; Female; Leucine; Male; Myelin Proteins; Rats; Time Factors

1981
Dietary effects on in vitro rat neuronal protein synthesis during growth and development.
    Brain research bulletin, 1981, Volume: 7, Issue:4

    Topics: Aging; Animals; Brain; Dietary Proteins; Leucine; Nerve Tissue Proteins; Neurons; Nutrition Disorders; Rats; Rats, Inbred Strains

1981
Tritiated leucine incorporation in the developing hamster facial nucleus with injury: an autoradiographic study.
    Experimental neurology, 1981, Volume: 74, Issue:2

    Topics: Aging; Animals; Autoradiography; Axons; Cricetinae; Facial Nerve; Kinetics; Leucine; Mesocricetus; Neurons; Tritium

1981
Effects of growth hormone on adipose tissue of weanling rats.
    Endocrinology, 1981, Volume: 109, Issue:6

    Topics: Adipose Tissue; Aging; Animals; Epinephrine; Female; Glucose; Growth Hormone; Leucine; Lipid Mobilization; Male; Rats; Rats, Inbred Strains; Sex Factors

1981
Changes in brain protein synthesis during the life span of male Fischer rats.
    Gerontology, 1980, Volume: 26, Issue:3

    Topics: Aging; Animals; Brain; Cell-Free System; DNA; Leucine; Male; Nerve Tissue Proteins; Phenylalanine; Rats; Ribosomes; RNA

1980
The effect of chloramphenicol, ethidium bromide and cycloheximide on mortality and mitochondrial protein synthesis of adult blowflies.
    Journal of cell science, 1980, Volume: 41

    Topics: Aging; Animals; Chloramphenicol; Cycloheximide; Diptera; Dose-Response Relationship, Drug; Ethidium; Leucine; Mitochondria, Muscle; Muscle Proteins

1980
Age-related decline in protein synthesis in the rat parotid gland.
    Experimental gerontology, 1980, Volume: 15, Issue:2

    Topics: Aging; Animals; Glucose; In Vitro Techniques; Leucine; Microscopy, Electron; Parotid Gland; Protein Biosynthesis; Rats

1980
Translational activity and fidelity of purified ribosomes from aging mouse livers.
    Advances in experimental medicine and biology, 1980, Volume: 129

    Topics: Aging; Animals; In Vitro Techniques; Leucine; Liver; Mice; Phenylalanine; Protein Biosynthesis; RNA, Ribosomal

1980
Synthesis of the myelin proteolipid protein in the developing mouse brain.
    Journal of neurobiology, 1980, Volume: 11, Issue:4

    Topics: Aging; Animals; Brain; Electrophoresis, Polyacrylamide Gel; Female; Leucine; Male; Mice; Myelin Proteins; Proteolipids

1980
Protein turnover in growing pigs. Effects of age and food intake.
    The British journal of nutrition, 1980, Volume: 43, Issue:3

    Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Body Temperature Regulation; Body Weight; Diet; Dietary Proteins; Energy Metabolism; Female; Leucine; Male; Nitrogen; Protein Biosynthesis; Proteins; Swine

1980
Protein synthesis in retinas of rats with inherited retinal dystrophy.
    Experimental eye research, 1980, Volume: 31, Issue:3

    Topics: Aging; Animals; Electrophoresis, Polyacrylamide Gel; Eye Proteins; Leucine; Pigment Epithelium of Eye; Rats; Rats, Inbred Strains; Retina; Retinal Degeneration; Rod Cell Outer Segment; Solubility

1980
Age-dependent change in intestinal absorption of dipeptides and their constituent amino acids in the guinea pig.
    Pediatric research, 1980, Volume: 14, Issue:11

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Dipeptides; Glycine; Glycylglycine; Guinea Pigs; Ileum; Intestinal Absorption; Jejunum; Leucine

1980
Effects of excess dietary leucine and leucine catabolites on growth and immune responses in weanling pigs.
    Journal of animal science, 1995, Volume: 73, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids; Animals; Avena; Blood Urea Nitrogen; Crosses, Genetic; Dexamethasone; Diet; Female; Fish Products; Food, Fortified; Hydroxybutyrates; Immunity, Cellular; Immunoglobulin G; Immunoglobulin M; Keto Acids; Leucine; Male; Milk Proteins; Random Allocation; Swine; Triticum; Weaning; Whey Proteins

1995
Crystallin degradation and insolubilization in regions of young rat lens with calcium ionophore cataract.
    Investigative ophthalmology & visual science, 1995, Volume: 36, Issue:2

    Topics: Aging; Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Lens, Crystalline; Leucine; Molecular Sequence Data; Organ Culture Techniques; Protein Denaturation; Rats; Rats, Sprague-Dawley; Solubility

1995
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila.
    Mechanisms of development, 1994, Volume: 47, Issue:3

    Topics: Aging; Amino Acid Sequence; Animals; Drosophila; Eye; Gene Expression; Genetic Code; Leucine; Molecular Sequence Data; Protein Structure, Tertiary; Repetitive Sequences, Nucleic Acid; Trachea

1994
Protein and energy balance following femoral neck fracture in geriatric patients.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Blood; Energy Metabolism; Female; Femur Neck; Hip Fractures; Humans; Leucine; Male; Nitrogen; Parenteral Nutrition, Total; Reference Values

1995
Rates of local cerebral protein synthesis in the rat during normal postnatal development.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Brain; Female; Leucine; Nerve Tissue Proteins; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Reference Values; Tissue Distribution

1995
Myofibrillar protein synthesis in young and old human subjects after three months of resistance training.
    The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1

    Topics: Adult; Aged; Aging; Creatinine; Exercise; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Muscle Proteins; Myofibrils; Weight Lifting

1995
L-leucine intestinal transport at different ages in chicken: effect of anticoccidial drugs.
    Comparative biochemistry and physiology. Comparative physiology, 1993, Volume: 106, Issue:4

    Topics: Aging; Animals; Body Weight; Chickens; Coccidiostats; Diet; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Leucine; Male; Models, Biological

1993
A nuclear factor containing the leucine-rich repeats expressed in murine cerebellar neurons.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Oct-11, Volume: 91, Issue:21

    Topics: Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cattle; Cerebellum; Consensus Sequence; Conserved Sequence; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; In Situ Hybridization; Leucine; Molecular Sequence Data; Neurons; Neuropeptides; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Purkinje Cells; Rats; Rats, Wistar; Repetitive Sequences, Nucleic Acid; Restriction Mapping

1994
Postprandial myofibrillar and whole body protein synthesis in young and old human subjects.
    The American journal of physiology, 1994, Volume: 267, Issue:4 Pt 1

    Topics: Adult; Aging; Eating; Female; Homeostasis; Humans; Insulin; Leucine; Male; Middle Aged; Myofibrils; Osmolar Concentration; Protein Biosynthesis

1994
In vitro effect of hormones and growth factors on the incorporation of [3H]leucine, [35S]sulfate and [3H]proline by chondrocytes of aging mice.
    Mechanisms of ageing and development, 1993, Dec-31, Volume: 72, Issue:3

    Topics: Aging; Animals; Autoradiography; Cartilage, Articular; Collagen; Dose-Response Relationship, Drug; Glycosaminoglycans; Growth Substances; Hormones; Leucine; Male; Mice; Mice, Inbred ICR; Proline; Proteins; Sulfates; Sulfur Radioisotopes; Time Factors; Tritium

1993
Opsin synthesis in the C57BL/6-mivit/mivit mouse model of retinal degeneration.
    Current eye research, 1993, Volume: 12, Issue:8

    Topics: Aging; Animals; Dark Adaptation; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Leucine; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Photoreceptor Cells; Retinal Degeneration; Rod Opsins

1993
Organ clearance of tyrosyl-arginine and its effect on amino acid metabolism in young sheep.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:8

    Topics: Aging; Amino Acids; Analgesics; Animals; Arginine; Citrulline; Endorphins; Female; Hindlimb; Intestinal Mucosa; Intestines; Isoleucine; Kidney; Leucine; Liver; Metabolic Clearance Rate; Organ Specificity; Phenylalanine; Regional Blood Flow; Sheep; Tyrosine; Valine

1993
Cultured adult cardiac myocytes maintain protein synthetic capacity of intact adult hearts.
    The American journal of physiology, 1993, Volume: 264, Issue:2 Pt 2

    Topics: Aging; Animals; Cats; Cell Count; Cells, Cultured; Hypertrophy; Kinetics; Leucine; Muscle Proteins; Myocardial Contraction; Myocardium

1993
Developmental pattern of branched-chain 2-oxo acid dehydrogenase complex in rat liver and heart.
    The Biochemical journal, 1993, Mar-01, Volume: 290 ( Pt 2)

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Aging; Animals; Animals, Newborn; Heart; Ketone Oxidoreductases; Leucine; Liver; Multienzyme Complexes; Myocardium; Rats; RNA, Messenger

1993
Myofibrillar protein synthesis in young and old men.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: Adult; Age Factors; Aged; Aging; Anthropometry; Humans; Leucine; Male; Muscle Proteins; Muscles; Myofibrils

1993
Chronic protein deficiency differentially affects the kinetics of plasma proteins in young pigs.
    The Journal of nutrition, 1996, Volume: 126, Issue:5

    Topics: Aging; Animals; Apolipoprotein A-I; Blood Proteins; Female; Fibrinogen; Haptoglobins; Leucine; Male; Prealbumin; Protein Deficiency; Retinol-Binding Proteins; Retinol-Binding Proteins, Plasma; Serum Albumin; Swine; Transferrin; Tritium

1996
Effect of prepubertal retinyl palmitate treatment on uterine development and subsequent uterine capacity in swine.
    Journal of animal science, 1996, Volume: 74, Issue:3

    Topics: Acid Phosphatase; Aging; Animals; Anticarcinogenic Agents; Diterpenes; Endometrium; Female; Hysterectomy; Leucine; Litter Size; Organ Size; Ovariectomy; Pregnancy; Random Allocation; Retinol-Binding Proteins; Retinyl Esters; Sexual Maturation; Swine; Tritium; Uterus; Vitamin A

1996
Ontogenetic development of proline intestinal transport in the domestic fowl.
    British poultry science, 1996, Volume: 37, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Biological Transport, Active; Body Weight; Chickens; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Jejunum; Kinetics; Leucine; Male; Mercuric Chloride; Proline

1996
Structure and developmental expression of mouse Garp, a gene encoding a new leucine-rich repeat-containing protein.
    The International journal of developmental biology, 1996, Volume: 40, Issue:3

    Topics: Aging; Amino Acid Sequence; Animals; Cell Line; Cells, Cultured; Cloning, Molecular; Cosmids; Embryonic and Fetal Development; Exons; Female; Gene Expression Regulation, Developmental; Humans; Leucine; Leukemia, Erythroblastic, Acute; Megakaryocytes; Membrane Proteins; Mice; Molecular Sequence Data; Muscle, Skeletal; Muscle, Smooth; Placenta; Pregnancy; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid

1996
The effect of aging and dietary restriction on the retinoylation of nuclear matrix proteins in rats.
    Aging (Milan, Italy), 1996, Volume: 8, Issue:4

    Topics: Aging; Animals; Antigens, Nuclear; Bone Marrow; Diet; Electrophoresis, Gel, Two-Dimensional; Food Deprivation; HL-60 Cells; Humans; Immunochemistry; Leucine; Male; Molecular Weight; Nuclear Proteins; Rats; Rats, Inbred F344; Receptors, Retinoic Acid; Tretinoin

1996
Splanchnic and whole-body leucine kinetics in young and elderly men.
    The American journal of clinical nutrition, 1997, Volume: 65, Issue:2

    Topics: Adult; Aged; Aging; Body Composition; Diet; Humans; Intestinal Absorption; Leucine; Male; Mesentery; Postprandial Period; Proteins

1997
Rates of local cerebral protein synthesis in fetal and neonatal sheep.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Brain; Carbon Radioisotopes; Electroencephalography; Embryonic and Fetal Development; Fetus; Gestational Age; Leucine; Nerve Tissue Proteins; Organ Specificity; Regression Analysis; Sheep

1997
Amino acids suppress proteolysis independent of insulin throughout the neonatal period.
    The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 1

    Topics: Aging; Amino Acids; Blood Glucose; Humans; Hydroxylation; Infant, Newborn; Infusions, Intravenous; Insulin; Leucine; Osmolar Concentration; Oxidation-Reduction; Peptide Hydrolases; Phenylalanine; Protease Inhibitors; Tyrosine

1997
Protein requirements and ageing: metabolic demand and efficiency of utilization.
    The British journal of nutrition, 1997, Volume: 77, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Carbon Isotopes; Dietary Proteins; Female; Humans; Infusions, Intravenous; Leucine; Male; Nitrogen; Nutritional Requirements; Oxidation-Reduction; Postprandial Period

1997
The effect of an increase of protein intake on whole-body protein turnover in elderly women is tracer dependent.
    The Journal of nutrition, 1997, Volume: 127, Issue:9

    Topics: Aged; Aging; Carbon Isotopes; Dietary Proteins; Fasting; Female; Glycine; Humans; Leucine; Nitrogen Isotopes

1997
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans.
    The American journal of physiology, 1997, Volume: 273, Issue:4

    Topics: Adult; Aged; Aging; Analysis of Variance; Biopsy; Carbon Isotopes; Female; Humans; Kinetics; Leucine; Male; Middle Aged; Muscle Development; Muscle Proteins; Muscle, Skeletal; Myosin Heavy Chains; Regression Analysis; Sarcoplasmic Reticulum; Sex Characteristics

1997
Impact of protein deprivation on protein and DNA synthesis in the developing rat pancreas.
    Biology of the neonate, 1998, Volume: 74, Issue:4

    Topics: Aging; Animals; Dietary Proteins; DNA; Female; Lactation; Leucine; Pancreas; Pregnancy; Protein Biosynthesis; Protein Deficiency; Rats; Rats, Wistar; Tritium; Weaning

1998
Age effect on fibrinogen and albumin synthesis in humans.
    The American journal of physiology, 1998, Volume: 275, Issue:6

    Topics: Adult; Aged; Aging; Female; Fibrinogen; Humans; Keto Acids; Leucine; Male; Middle Aged; Osmolar Concentration; Phenylalanine; Protein Precursors; Serum Albumin

1998
Gender differences in basal protein kinetics in young adults.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:12

    Topics: Adult; Aging; Female; Fibrinogen; Humans; Leucine; Male; Oxidation-Reduction; Serum Albumin; Sex Characteristics

1998
Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability.
    The Biochemical journal, 1999, Jan-01, Volume: 337 ( Pt 1)

    Topics: Adolescent; Adult; Aged; Aggrecans; Aging; Cartilage, Articular; Child; Extracellular Matrix Proteins; Humans; Kinetics; Lectins, C-Type; Leucine; Middle Aged; Protein Biosynthesis; Proteins; Proteoglycans; RNA, Messenger

1999
The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism.
    The American journal of physiology, 1999, Volume: 276, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Critical Care; Critical Illness; Female; Glutamine; Humans; Kinetics; Leucine; Male; Metabolic Clearance Rate; Middle Aged; Osmolar Concentration; Protein Biosynthesis; Proteins; Reference Values; Time Factors

1999
Effect of intravenous glutamine on duodenal mucosa protein synthesis in healthy growing dogs.
    The American journal of physiology, 1999, Volume: 276, Issue:4

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Carbon Isotopes; Dogs; Duodenum; Glutamine; Glycine; Infusions, Intravenous; Intestinal Mucosa; Kinetics; Leucine; Protein Biosynthesis

1999
Limited myogenic response to a single bout of weight-lifting exercise in old rats.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:6

    Topics: Aging; Animals; Body Weight; Cell Division; DNA; Gene Expression Regulation; Leucine; Male; Muscle Contraction; Muscle Development; Muscle, Skeletal; MyoD Protein; Organ Size; Physical Conditioning, Animal; Physical Exertion; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Weight Lifting

2000
Somatotropin increases protein balance independent of insulin's effects on protein metabolism in growing pigs.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:1

    Topics: Aging; Animals; Glucose; Growth Hormone; Hormones; Hypoglycemic Agents; Insulin; Insulin Antagonists; Leucine; Oxidation-Reduction; Reference Values; Swine

2000
Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age.
    The Journal of nutrition, 2000, Volume: 130, Issue:11

    Topics: Aging; Amino Acids; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Immunosuppressive Agents; Leucine; Male; Morpholines; Muscle Proteins; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Wistar; Sirolimus

2000
Intestinal transport of monosaccharides and amino acids during postnatal development of mink.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:6

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Body Weight; Female; Fructose; Glucose; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Leucine; Lysine; Male; Methionine; Microvilli; Mink; Monosaccharides; Proline

2000
Differential insulin sensitivities of glucose, amino acid, and albumin metabolism in elderly men and women.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Amino Acids; Blood Glucose; Body Mass Index; Carbon Isotopes; Female; Glucose; Glucose Clamp Technique; Homeostasis; Humans; Infusions, Intravenous; Insulin; Leucine; Male; Proteins; Serum Albumin

2001
Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis.
    American journal of medical genetics, 2000, Dec-11, Volume: 95, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acid Substitution; Arginine; Arteriosclerosis; Coronary Artery Disease; Cysteine; Finland; Gene Frequency; Genotype; Haplotypes; Humans; Infant, Newborn; Leucine; Longevity; Mexico; Middle Aged; Phenylalanine; Polymorphism, Genetic; Werner Syndrome

2000
Energetic cost of protein turnover in healthy elderly humans.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2001, Volume: 25, Issue:5

    Topics: Adipose Tissue; Adult; Aged; Aging; Basal Metabolism; Body Composition; Calorimetry, Indirect; Carbon Isotopes; Electric Impedance; Female; Humans; Indicator Dilution Techniques; Leucine; Male; Proteins

2001
Effects of insulin and amino acids on leucine metabolism in young and middle-aged humans.
    European journal of nutrition, 2001, Volume: 40, Issue:3

    Topics: Adult; Aging; Amino Acids; Carbon Isotopes; Fasting; Female; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Leucine; Male; Middle Aged; Oxidation-Reduction; Radioisotope Dilution Technique

2001
Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal.
    The Journal of nutrition, 2002, Volume: 132, Issue:1

    Topics: Aging; Alanine; Amino Acids; Animals; Carbon Isotopes; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Postprandial Period; Rats; Rats, Wistar; Time Factors

2002
Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant.
    Biology of the neonate, 2002, Volume: 81, Issue:1

    Topics: Aging; Birth Weight; Carbon Isotopes; Dietary Proteins; Energy Intake; Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Keto Acids; Leucine; Pre-Eclampsia; Pregnancy; Proteins

2002
In vitro synthesis of the myelin basic proteins in the developing mouse brain: properties of a homogenate system.
    Journal of neurochemistry, 1979, Volume: 33, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Brain; Kinetics; Leucine; Mice; Myelin Basic Protein; Protein Biosynthesis

1979
The effect of age on enolase turnover in the free-living nematode, Turbatrix aceti.
    Archives of biochemistry and biophysics, 1979, Apr-15, Volume: 194, Issue:1

    Topics: Aging; Animals; Immunodiffusion; Kinetics; Leucine; Nematoda; Phosphopyruvate Hydratase

1979
Transfer RNA in aging Drosophila: II. Isoacceptor patterns.
    Mechanisms of ageing and development, 1979, Volume: 10, Issue:1-2

    Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Asparagine; Drosophila melanogaster; Histidine; Leucine; Male; RNA, Transfer; Tyrosine

1979
Postnatal amino acid uptake by the rat small intestine. Changes in membrane transport systems for amino acids associated with maturation of jejunal morphology.
    Journal of developmental physiology, 1979, Volume: 1, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Arginine; Biological Transport, Active; gamma-Aminobutyric Acid; In Vitro Techniques; Intestinal Mucosa; Jejunum; Kinetics; Leucine; Lysine; Methionine; Phenylalanine; Rats; Valine

1979
Age-dependence of the x-ray-induced deficiency in DNA synthesis in HeLa S3 cells during Generation 1.
    Radiation research, 1975, Volume: 63, Issue:3

    Topics: Aging; Cell Division; DNA; DNA, Neoplasm; Dose-Response Relationship, Radiation; Floxuridine; HeLa Cells; Hydroxyurea; Leucine; Mitosis; Protein Biosynthesis; Radiation Effects; Thymidine; X-Rays

1975
Restoration of impaired immune functions of aged animals by chronic bestatin treatment.
    Immunology, 1979, Volume: 38, Issue:1

    Topics: Aging; Animals; Antibody Formation; Antibody-Dependent Cell Cytotoxicity; Hypersensitivity, Delayed; Immunity; Leucine; Life Expectancy; Lymphocyte Activation; Lymphoma, Non-Hodgkin; Macrophages; Mice; Spleen; T-Lymphocytes, Regulatory

1979
Amino acid analog incorporation into protein in dimethyl sulfoxide and mutagen-treated aging mice.
    Birth defects original article series, 1978, Volume: 14, Issue:1

    Topics: Aging; Aminoisobutyric Acids; Animals; Dimethyl Sulfoxide; Female; Genetic Code; Hemoglobins; Leucine; Ligases; Male; Mesylates; Methyl Methanesulfonate; Mice; Radiation Injuries, Experimental; RNA, Transfer, Amino Acyl

1978
Content, synthesis and degradation of acetyl-coenzyme A carboxylase in the liver of growing chicks.
    European journal of biochemistry, 1975, May-06, Volume: 53, Issue:2

    Topics: Acetyl-CoA Carboxylase; Aging; Animals; Antigen-Antibody Reactions; Chickens; Immunodiffusion; Leucine; Ligases; Liver; Time Factors

1975
On the clinical significance of the plasma alpha-amino-n-butyric acid:leucine ratio.
    The American journal of clinical nutrition, 1979, Volume: 32, Issue:2

    Topics: Adult; Aging; Aminobutyrates; Child; Child, Preschool; Humans; Infant; Leucine; Liver Diseases; Metabolism, Inborn Errors

1979
Incorporation of leucine metabolites into brain and sciatic nerve myelin.
    Journal of neurochemistry, 1979, Volume: 32, Issue:5

    Topics: Aging; Animals; Brain; Female; Leucine; Male; Myelin Proteins; Rats; Sciatic Nerve

1979
Developmental and methylmercury effects on brain protein synthesis.
    Archives of environmental contamination and toxicology, 1979, Volume: 8, Issue:4

    Topics: Aging; Animals; Brain; Leucine; Methylmercury Compounds; Nerve Tissue Proteins; Rats; Time Factors

1979
Derangement in cardiac protein metabolism in fetal alcohol syndrome.
    Research communications in chemical pathology and pharmacology, 1979, Volume: 25, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Diet; DNA; Female; Fetal Alcohol Spectrum Disorders; In Vitro Techniques; Leucine; Muscle Proteins; Myocardium; Pregnancy; Rats; Ribosomes; RNA

1979
Age-associated changes in activities of rat hepatocytes. I. Protein synthesis.
    Experimental aging research, 1979, Volume: 5, Issue:6

    Topics: Aging; Animals; Leucine; Liver; Male; Peptide Biosynthesis; Protein Biosynthesis; Rats; Subcellular Fractions

1979
[Activity of blood serum leucine aminopeptidase (LAP) and lactate dehydrogenase (LDH) in healthy non-pregnant women depending on their age].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1979, Dec-03, Volume: 34, Issue:49

    Topics: Adolescent; Adult; Aging; Female; Humans; L-Lactate Dehydrogenase; Lactates; Leucine; Leucyl Aminopeptidase; Menstruation

1979
The nucleosome repeat length increases during erythropoiesis in the chick.
    Nucleic acids research, 1978, Volume: 5, Issue:4

    Topics: Aging; Animals; Chick Embryo; Chickens; DNA; Erythroblasts; Erythrocytes; Erythropoiesis; Histones; Leucine; Lysine; Nucleoproteins

1978
Protein biosynthesis in aging mouse tissues.
    Experimental gerontology, 1977, Volume: 12, Issue:5-6

    Topics: Aging; Aminolevulinic Acid; Animals; Kinetics; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes; Microsomes, Liver; Muscle Proteins; Myocardium; Protein Biosynthesis; Subcellular Fractions

1977
Age-related changes in ribosomal profiles and in vitro protein synthesis in skeletal muscle during fasting and subsequent refeeding of rats.
    The Journal of nutrition, 1978, Volume: 108, Issue:3

    Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Centrifugation, Density Gradient; Fasting; Leucine; Male; Muscle Proteins; Muscles; Rats; Ribosomes; RNA; RNA, Ribosomal

1978
The metabolism of leucine by developing rat brain: effect of leucine and 2-oxo-4-methylvalerate on lipid synthesis from glucose and ketone bodies.
    Journal of neurochemistry, 1978, Volume: 30, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Brain; Cerebral Cortex; Female; Glucose; Keto Acids; Ketone Bodies; Leucine; Lipids; Male; Pregnancy; Rats; Valerates

1978
Enhanced cerebral protein synthesis in developing hypothyroid rats: evidence for delayed maturation.
    Journal of neurochemistry, 1978, Volume: 31, Issue:5

    Topics: Aging; Animals; Cerebral Cortex; Hypothyroidism; In Vitro Techniques; Kinetics; Leucine; Nerve Tissue Proteins; Rats

1978
[Regulation of the synthesis and secretion of prolactin (LTH) and growth hormone (STH) in rats].
    Jugoslavenska ginekologija i opstetricija, 1978, Volume: 18, Issue:5-6

    Topics: Aging; Animals; Chorionic Gonadotropin; Female; Growth Hormone; In Vitro Techniques; Leucine; Male; Organ Size; Ovary; Pituitary Gland; Progesterone; Prolactin; Rats

1978
Age-related changes of accuracy and efficiency of protein synthesis machinery in rat.
    Biochimica et biophysica acta, 1977, Mar-02, Volume: 475, Issue:1

    Topics: Aging; Animals; Carbon Radioisotopes; Isotope Labeling; Kinetics; Leucine; Liver; Phenylalanine; Poly U; Protein Biosynthesis; Rats; Ribosomes; Tritium

1977
Altered amounts of hemoglobin synthesis in livers of dystrophic hamsters.
    Canadian journal of biochemistry, 1977, Volume: 55, Issue:8

    Topics: Aging; Animals; Cricetinae; Hemoglobins; Leucine; Liver; Muscular Dystrophy, Animal

1977
Age-related changes in course of restitution of secretory material in rat submandibular gland stimulated with isoproterenol.
    Experimental gerontology, 1977, Volume: 12, Issue:3-4

    Topics: Aging; Animals; Histocytochemistry; Isoproterenol; Leucine; Male; Rats; Submandibular Gland

1977
[Molecular biology of aging. Part 9: Age-dependent effects of 2-mercapto-ethanol on protein synthesis in the cell-free system of the rat liver].
    Zeitschrift fur Alternsforschung, 1977, Volume: 32, Issue:2

    Topics: Aging; Animals; Cell-Free System; Female; Leucine; Mercaptoethanol; Microsomes, Liver; Protein Biosynthesis; Rats

1977
[Molecular biology of aging. 8. Aging of intermitotic cells--relationship to protein synthesis in the mucosa of the small intestine].
    Zeitschrift fur Alternsforschung, 1977, Volume: 32, Issue:2

    Topics: Aging; Animals; Cytosol; Female; Interphase; Intestinal Mucosa; Leucine; Microsomes; Protein Biosynthesis; Rats

1977
Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.
    The Journal of biological chemistry, 1976, Jun-25, Volume: 251, Issue:12

    Topics: Aging; Amino Acids; Biological Transport; Cell Division; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Kinetics; Leucine; Mathematics; Protein Biosynthesis; Proteins; Time Factors

1976
Aging of human bone and articular cartilage collagen: changes in the reducible cross-links and their precursors.
    Gerontology, 1976, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Aging; Bone and Bones; Cartilage, Articular; Child; Child, Preschool; Collagen; Humans; Leucine; Lysine; Middle Aged; Solubility

1976
[Biochemical basis of aging].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1976, Feb-15, Volume: 31, Issue:4

    Topics: Aging; Animals; Collagen; Connective Tissue; DNA; Free Radicals; Genes; Humans; Leucine; Protein Biosynthesis; Proteins; Rats; RNA

1976
Alterations in proline metabolic enzymes with mammalian development.
    Metabolism: clinical and experimental, 1976, Volume: 25, Issue:10

    Topics: Aging; Animals; Carboxylic Acids; Female; Kidney; Kinetics; Leucine; Liver; Mitochondria, Liver; Organ Specificity; Oxidoreductases; Oxygenases; Pregnancy; Proline; Pyrroles; Rats; Stereoisomerism; Valine

1976
[Influence of cytosolic fraction on incorporation of aminoacids into microsomal system of rat liver (author's transl)].
    Zeitschrift fur Alternsforschung, 1976, Volume: 31, Issue:5

    Topics: Age Factors; Aging; Animals; Cytosol; Leucine; Microsomes, Liver; Molecular Biology; Rats

1976
Altered regulation of protein synthesis during aging as determined by in vitro ribosomal assays.
    Experimental gerontology, 1975, Volume: 10, Issue:1

    Topics: Aging; Animals; Centrifugation, Density Gradient; Leucine; Male; Mice; Mice, Inbred C57BL; Muscles; Rats; Ribonucleases; Ribosomal Proteins; Ribosomes; RNA, Transfer; Tritium

1975
Leucine incorporation into proteins and cathepsin -D activity in human skeletal muscles. The influence of the age of the subject.
    Experimental gerontology, 1975, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Amino Acids; Biopsy; Carbon Radioisotopes; Cathepsins; Cell Fractionation; Cell Nucleus; Female; Humans; Leucine; Male; Microsomes; Middle Aged; Muscle Proteins; Muscles; Regression Analysis; Stimulation, Chemical

1975
Age-related changes in the incorporation of [14-C] leucine into myofibrillar and sarcoplasmic proteins of red and white muscles of chicks.
    The Australian journal of experimental biology and medical science, 1975, Volume: 53, Issue:1

    Topics: Aging; Animals; Carbon Radioisotopes; Chickens; Color; Cytoplasm; Leucine; Male; Muscle Proteins; Muscles; Myofibrils; Myosins

1975
Protein synthesis and amino acid accumulation during development in the rat: dissociation of diaphragm and heart muscle sensitivity to insulin.
    Hormone research, 1975, Volume: 6, Issue:1

    Topics: Aging; Aminoacylation; Animals; Animals, Newborn; Diaphragm; Female; Fetus; Heart; Insulin; Leucine; Muscle Development; Muscle Proteins; Myocardium; Pregnancy; Protein Biosynthesis; Rats

1975
The effect of ageing on in vitro fidelity of translation in mouse liver.
    Biochimica et biophysica acta, 1975, Nov-04, Volume: 407, Issue:4

    Topics: Aging; Animals; Leucine; Liver; Magnesium; Mice; Microsomes, Liver; Phenylalanine; Poly U; Protein Biosynthesis

1975
Lens growth in the Nakano mouse.
    Investigative ophthalmology, 1976, Volume: 15, Issue:5

    Topics: Aging; Animals; Cataract; Crystallins; Lens, Crystalline; Leucine; Mice

1976
[Variations in the in vivo incorporation of L-(3H)leucine into the proteins of the cerebellum of normal hypo- and hyperthyroid rats during the first ten days of postnatal life (author's transl)].
    Journal of neurochemistry, 1976, Volume: 26, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Brain; Cerebellum; Hyperthyroidism; Hypothyroidism; Leucine; Nerve Tissue Proteins; Protein Biosynthesis; Rats

1976
Development modulates the serum induced effect on the incorporation of [2-3H]mannose into chick optic lobe protein: the possible role of glia.
    Neurochemistry international, 1992, Volume: 21, Issue:2

    Topics: Aging; Animals; Blood; Cells, Cultured; Chick Embryo; Chickens; Culture Media; Glucose-6-Phosphate; Glucosephosphates; Glycoproteins; Leucine; Mannose; Nerve Tissue Proteins; Neuroglia; Neurons; Superior Colliculi; Tritium

1992
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
    Annals of the New York Academy of Sciences, 1992, Dec-31, Volume: 674

    Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins

1992
Effects of aging on gene expression of acetyl-CoA carboxylase and fatty acid synthase in rat liver.
    Journal of biochemistry, 1992, Volume: 112, Issue:2

    Topics: Acetyl-CoA Carboxylase; Aging; Animals; Autoradiography; Enzyme Induction; Fatty Acid Synthases; Gene Expression; Leucine; Liver; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger; Transcription, Genetic

1992
Research note: age-dependent changes in 3-oxy-methyl-D-glucose and leucine intestinal absorption in chickens.
    Poultry science, 1992, Volume: 71, Issue:9

    Topics: 3-O-Methylglucose; Aging; Animals; Chickens; Intestinal Absorption; Leucine; Male; Methylglucosides

1992
Intestinal amino acid and monosaccharide transport in suckling pigs fed milk replacers with different sources of carbohydrate.
    The Journal of nutrition, 1992, Volume: 122, Issue:12

    Topics: Aging; Amino Acids; Animals; Animals, Suckling; Biological Transport; Dietary Carbohydrates; Female; Food, Formulated; Fructose; Galactose; Glucose; Intestinal Absorption; Intestinal Mucosa; Lactose; Leucine; Male; Milk; Monosaccharides; Polysaccharides; Proline; Sucrose; Swine; Weight Gain

1992
Mechanism of maturational decline of rat intestinal lactase-phlorizin hydrolase.
    The Biochemical journal, 1992, Feb-15, Volume: 282 ( Pt 1)

    Topics: Aging; alpha-Glucosidases; Animals; Carbohydrate Metabolism; Carbon Radioisotopes; Intestine, Small; Kinetics; Lactase-Phlorizin Hydrolase; Leucine; Protein Biosynthesis; Proteins; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Sucrase-Isomaltase Complex; Tritium

1992
Age-related modifications of leucine uptake in brush-border membrane vesicles from rat jejunum.
    Mechanisms of ageing and development, 1992, Volume: 63, Issue:3

    Topics: Aging; Animals; Biological Transport, Active; In Vitro Techniques; Jejunum; Kinetics; Leucine; Male; Membrane Potentials; Microvilli; Potassium; Rats; Rats, Inbred Strains; Sodium

1992
[The comparative characteristics of the age-related changes in the rate of fast axonal transport in the vagus and hypoglossal nerves and in the ventral spinal cord roots of rats].
    Neirofiziologiia = Neurophysiology, 1990, Volume: 22, Issue:5

    Topics: Aging; Animals; Axonal Transport; Hypoglossal Nerve; Leucine; Male; Rats; Spinal Nerve Roots; Time Factors; Tritium; Vagus Nerve

1990
Fetal dexamethasone exposure sensitizes neonatal rat brain to hypoxia: effects on protein and DNA synthesis.
    Brain research. Developmental brain research, 1991, Dec-17, Volume: 64, Issue:1-2

    Topics: Aging; Animals; Animals, Newborn; Brain; Dexamethasone; DNA; Dose-Response Relationship, Drug; Female; Fetus; Hypoxia; Leucine; Nerve Tissue Proteins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Thymidine

1991
Enhanced protein breakdown after eccentric exercise in young and older men.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:2

    Topics: Adult; Aging; Calorimetry; Carbon Dioxide; Creatine Kinase; Exercise; Humans; Kinetics; Leucine; Male; Methylhistidines; Middle Aged; Nitrogen; Oxygen Consumption; Proteins

1991
Effect of aging on GHRF-induced growth hormone release from anterior pituitary cells in primary culture.
    Journal of gerontology, 1991, Volume: 46, Issue:2

    Topics: Aging; Animals; Cell Count; Cells, Cultured; Endopeptidases; Growth Hormone; Growth Hormone-Releasing Hormone; Leucine; Male; Pituitary Gland, Anterior; Proteins; Rats; Rats, Inbred F344; Tritium; Trypsin

1991
Cocaine acutely inhibits DNA synthesis in developing rat brain regions: evidence for direct actions.
    Brain research, 1990, Dec-24, Volume: 537, Issue:1-2

    Topics: Aging; Animals; Brain; Cell Division; Cocaine; DNA; Female; Leucine; Lidocaine; Methoxamine; Nerve Tissue Proteins; Phenoxybenzamine; Pregnancy; Rats; Rats, Inbred Strains; Thymidine

1990
A critical crosslink region in human-bone-derived collagen type I. Specific cleavage site at residue Leu95.
    European journal of biochemistry, 1990, Aug-28, Volume: 192, Issue:1

    Topics: Adult; Aging; Amino Acid Sequence; Bone and Bones; Bony Callus; Collagen; Cross-Linking Reagents; Electrophoresis; Hot Temperature; Humans; Leucine; Microbial Collagenase; Molecular Sequence Data; Osteogenesis Imperfecta; Pepsin A; Peptides; Skin

1990
Effects of ageing on transcriptional and post-transcriptional regulation of malic enzyme and glucose-6-phosphate dehydrogenase in rat liver.
    European journal of biochemistry, 1990, Mar-30, Volume: 188, Issue:3

    Topics: Aging; Animals; Blotting, Northern; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Insulin; Leucine; Liver; Malate Dehydrogenase; Male; Nucleic Acid Hybridization; Polyribosomes; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic; Triiodothyronine

1990
Aging affects cellular zinc and protein synthesis in the femoral diaphysis of rats.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1990, Volume: 190, Issue:4

    Topics: Aging; Animals; Cycloheximide; Femur; Leucine; Male; Picolinic Acids; Protein Biosynthesis; Rats; Rats, Inbred Strains; Tritium; Zinc

1990
Protein synthesis in the neuropil of the rat dentate gyrus during synapse development.
    Journal of neuroscience research, 1990, Volume: 26, Issue:4

    Topics: Aging; Amino Acids; Animals; Electrophoresis, Polyacrylamide Gel; Female; Hippocampus; In Vitro Techniques; Leucine; Male; Molecular Weight; Nerve Tissue Proteins; Neurons; Peptide Biosynthesis; Polyribosomes; Rats; Synapses

1990
Effects of aging and xerosis on the amino acid composition of human skin.
    The Journal of investigative dermatology, 1990, Volume: 95, Issue:3

    Topics: Aging; Amino Acids; Female; Filaggrin Proteins; Glycine; Humans; Ichthyosis; Leucine; Phenylalanine; Skin; Tyrosine

1990
Regional differences in in vivo myocardial protein synthesis in the neonatal rabbit heart.
    Journal of molecular and cellular cardiology, 1990, Volume: 22, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Female; Hemodynamics; Leucine; Myocardium; Myosins; Pregnancy; Protein Biosynthesis; Rabbits; RNA, Transfer, Leu

1990
The synthesis of amylase in parotid glands of young and old rats.
    Mechanisms of ageing and development, 1985, Volume: 31, Issue:3

    Topics: Aging; Amylases; Animals; Leucine; Male; Parotid Gland; Rats; Rats, Inbred Strains; Tritium

1985
Metabolism of phosphate and sulfate groups modifying the P0 protein of peripheral nervous system myelin.
    Journal of neurochemistry, 1987, Volume: 48, Issue:3

    Topics: Aging; Animals; Kinetics; Leucine; Myelin P0 Protein; Myelin Proteins; Myelin Sheath; Peripheral Nerves; Phosphates; Rats; Rats, Inbred Strains; Sciatic Nerve; Sulfates

1987
Studies on myelin-basic-protein methylation during mouse brain development.
    The Biochemical journal, 1986, Dec-01, Volume: 240, Issue:2

    Topics: Aging; Amino Acids; Animals; Brain; Electrophoresis, Polyacrylamide Gel; Leucine; Methionine; Methylation; Mice; Mice, Inbred Strains; Myelin Basic Protein

1986
Age-related changes in the proliferative kinetics of phytohemagglutinin-stimulated lymphocytes. Analysis by uptake of tritiated precursors of DNA, RNA and proteins, and by flow cytometry.
    Mechanisms of ageing and development, 1988, Volume: 43, Issue:3

    Topics: Adult; Aged; Aging; Biological Transport; DNA; Female; Fetal Blood; Flow Cytometry; Humans; Infant, Newborn; Kinetics; Leucine; Lymphocyte Activation; Lymphocytes; Phytohemagglutinins; Pregnancy; Protein Biosynthesis; Reference Values; RNA; Thymidine; Tritium; Uridine

1988
Morphological, physiological and biochemical alterations in livers of rodents induced by protease inhibitors: a comparison with old livers.
    Advances in experimental medicine and biology, 1989, Volume: 266

    Topics: Aging; Animals; Biological Transport; Dolichols; Leucine; Leupeptins; Liver; Male; Mice; Mice, Inbred C57BL; Ouabain; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Inbred Strains; Sulfobromophthalein

1989
Monoclonal antibodies against rat saliva and salivary gland antigens.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1985, Volume: 33, Issue:3

    Topics: Aging; Animals; Antibodies, Monoclonal; Cell Differentiation; Chemical Precipitation; Chromatography, Affinity; Collodion; Electrophoresis, Polyacrylamide Gel; Female; Histocytochemistry; Immunochemistry; Immunoenzyme Techniques; Leucine; Rats; Rats, Inbred Strains; Saliva; Salivary Glands; Staining and Labeling; Submandibular Gland

1985
Immunity, infection, malignancy and aging: possible immunity restoration and tumor prevention.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1989, Volume: 43, Issue:8

    Topics: Adult; Aged; Aging; Animals; Antibiotics, Antineoplastic; Humans; Immunity; Infections; Leucine; Mice; Middle Aged; Neoplasms

1989
Leucine metabolism in aging humans: effect of insulin and substrate availability.
    The American journal of physiology, 1989, Volume: 256, Issue:2 Pt 1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Amino Acids; Carbon Isotopes; Humans; Insulin; Isotope Labeling; Leucine; Male; Reference Values

1989
Mechanism of action of thyroxine (T4) on the biogenesis of mitochondria using antibiotic-free system: a gerontological survey.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:6

    Topics: Aging; Animals; Carbon Radioisotopes; DNA; DNA, Mitochondrial; Germ-Free Life; Leucine; Male; Mitochondria, Liver; Organelle Biogenesis; Protein Biosynthesis; Rats; Rats, Inbred Strains; Thyroxine

1989
Lysosome instability in aged rat brain.
    Neuroscience letters, 1989, Feb-13, Volume: 97, Issue:1-2

    Topics: Aging; Animals; Brain; Cathepsin D; Cytosol; Glucuronidase; Leucine; Lysosomes; Rats; Rats, Inbred Strains

1989
[Aging of the pancreas. Its implication in malnutrition states in elderly persons].
    Presse medicale (Paris, France : 1983), 1988, Nov-05, Volume: 17, Issue:39

    Topics: Adult; Aged; Aging; Animals; Humans; Leucine; Male; Nutrition Disorders; Pancreas; Protein Biosynthesis; Rats; Rats, Inbred Strains

1988
Effects of hydrocortisone on carbohydrase concentrations, de novo synthesis and turnover patterns in immature rat intestine.
    Cell biochemistry and function, 1986, Volume: 4, Issue:2

    Topics: Aging; alpha-Glucosidases; Animal Population Groups; Animals; Animals, Suckling; Antibodies; Antigens; beta-Galactosidase; Glucan 1,4-alpha-Glucosidase; Glycoside Hydrolases; Humans; Hydrocortisone; Infant, Newborn; Injections, Subcutaneous; Intestine, Small; Leucine; Microvilli; Oligo-1,6-Glucosidase; Proteins; Radioimmunoassay; Rats; Rats, Inbred Strains; Sucrase; Trehalase

1986
Enhancement of graft-versus-host reaction and delayed cutaneous hypersensitivity in mice by ubenimex.
    The Journal of antibiotics, 1986, Volume: 39, Issue:8

    Topics: Adjuvants, Immunologic; Aging; Animals; Dose-Response Relationship, Drug; Graft vs Host Reaction; Hypersensitivity, Delayed; Leucine; Mice; Mice, Inbred Strains; Mitomycin; Mitomycins

1986
Further studies on the nutritional factors affecting the urinary excretion of acid-soluble peptides in rats.
    The British journal of nutrition, 1988, Volume: 60, Issue:2

    Topics: Aging; Amino Acids; Animals; Caseins; Dietary Proteins; Leucine; Lysine; Male; Methylhistidines; Nitrogen; Peptides; Proline; Rats; Rats, Inbred Strains; Tryptophan; Valine

1988
Leucine degradation in sheep.
    The British journal of nutrition, 1988, Volume: 59, Issue:2

    Topics: Adipose Tissue; Aging; Animals; Deamination; Decarboxylation; Dietary Proteins; Kidney; Leucine; Liver; Male; Muscles; Sheep

1988
Bilateral pericruciate cortical innervation of the red nucleus in cats with adult or neonatal cerebral hemispherectomy.
    Brain research, 1988, Jun-21, Volume: 453, Issue:1-2

    Topics: Aging; Animals; Autoradiography; Cats; Cerebral Cortex; Cerebral Decortication; Female; Leucine; Male; Neural Pathways; Neuronal Plasticity; Proline; Red Nucleus

1988
Late effects of early feeding of a low cholesterol diet on the intestinal active and passive transport properties in the rabbit.
    Mechanisms of ageing and development, 1987, Sep-30, Volume: 40, Issue:2

    Topics: Aging; Animals; Bile Acids and Salts; Body Weight; Cholesterol, Dietary; Colon; Fatty Acids, Nonesterified; Female; Galactose; Glucose; Ileum; Intestinal Absorption; Jejunum; Kinetics; Leucine; Rabbits

1987
The effect of electroconvulsive shock on brain tubulin during development and aging.
    Life sciences, 1986, Mar-31, Volume: 38, Issue:13

    Topics: Aging; Animals; Brain; Colchicine; Electroshock; Leucine; Male; Microtubules; Polyribosomes; Rats; Rats, Inbred Lew; Synaptosomes; Tubulin

1986
Acceleration of age-associated immune decline and mortality by early repeated administration of bestatin to C57BL/6 mice.
    Journal of biological response modifiers, 1986, Volume: 5, Issue:2

    Topics: Adjuvants, Immunologic; Aging; Animals; Cytotoxicity Tests, Immunologic; Female; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Injections, Intraperitoneal; Interleukin-1; Interleukin-2; Killer Cells, Natural; Leucine; Life Expectancy; Lymphoma; Macrophages; Mice; Mice, Inbred C57BL; Rodent Diseases; T-Lymphocytes

1986
[Effect of different fixation methods and partial chemical sympathetic denervation on cell size and 3H-leucine incorporation by rat sympathetic neurocytes].
    Tsitologiia, 1987, Volume: 29, Issue:1

    Topics: Aging; Animals; Autoradiography; Cell Nucleus; Cytological Techniques; Leucine; Neurons; Rats; Sympathectomy, Chemical; Sympathetic Nervous System; Tritium

1987
Rate of protein glycosylation in rat cerebral cortex.
    Journal of neurochemistry, 1986, Volume: 47, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Diffusion; Glucose; Glycoproteins; Kinetics; Leucine; Mannose; Nerve Tissue Proteins; Rats; Rats, Inbred Strains; Tritium

1986
Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes.
    Experimental eye research, 1985, Volume: 41, Issue:6

    Topics: Aging; Animals; Cell Count; Heterozygote; Leucine; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Microscopy, Electron; Phagosomes; Photoreceptor Cells; Pigment Epithelium of Eye; Retina; Retinal Degeneration; Rod Cell Outer Segment; Time Factors; Vision Disorders

1985
The effects of mild congenital methylmercury intoxication on the metabolism of 3-hydroxybutyrate and glucose in the brains of suckling rats.
    Neurotoxicology, 1985,Spring, Volume: 6, Issue:1

    Topics: 3-Hydroxybutyric Acid; Aging; Animals; Animals, Suckling; Body Weight; Brain; Female; Glucose; Hydroxybutyrates; Leucine; Lipid Metabolism; Methylmercury Compounds; Nerve Tissue Proteins; Organ Size; Oxidation-Reduction; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains

1985
The nature of maturational decline of intestinal lactase activity.
    Biochimica et biophysica acta, 1985, May-29, Volume: 840, Issue:1

    Topics: Aging; Animals; Antigen-Antibody Complex; beta-Galactosidase; Galactosidases; Immune Sera; Intestine, Small; Kinetics; Leucine; Molecular Weight; Rats; Rats, Inbred Strains; Sucrase-Isomaltase Complex

1985
Early nutrition and intestinal transport function: effect of low-cholesterol diet.
    The Journal of laboratory and clinical medicine, 1986, Volume: 107, Issue:4

    Topics: Aging; Animals; Bile Acids and Salts; Cholesterol, Dietary; Colon; Fatty Acids; Galactose; Glucose; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Kinetics; Leucine; Nutritional Physiological Phenomena; Rabbits; Weaning

1986
Decreased protein synthesis of transforming lymphocytes from aged humans: relationship to impaired mitogenesis with age.
    Mechanisms of ageing and development, 1985, Volume: 30, Issue:1

    Topics: Adult; Aged; Aging; Cycloheximide; Glycolysis; Humans; Leucine; Lymphocyte Activation; Lymphocytes; Mitosis; Models, Biological; Phytohemagglutinins; Protein Biosynthesis; Time Factors

1985
Transient tectogeniculate projections in neonatal kittens: an autoradiographic study.
    The Journal of comparative neurology, 1985, Sep-22, Volume: 239, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cats; Geniculate Bodies; Histocytochemistry; Leucine; Superior Colliculi; Visual Pathways

1985
Regulation of tubulin by triiodothyronine in hypothyroid rat brain.
    Bioscience reports, 1985, Volume: 5, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Colchicine; Female; Fetus; Hypothyroidism; Kinetics; Leucine; Organ Culture Techniques; Pregnancy; Rats; Triiodothyronine; Tubulin

1985
Rat serum protein changes with age.
    Experimental gerontology, 1971, Feb-01, Volume: 6, Issue:1

    Topics: Adult; Aged; Aging; Alpha-Globulins; Animals; Blood Protein Electrophoresis; Blood Proteins; Carbon Isotopes; Female; gamma-Globulins; Humans; Leucine; Liver; Male; Rats; Serum Albumin; Serum Globulins; Tritium

1971
Effect of maturation and aging on the rate of fast axoplasmic transport in mammalian nerve.
    Progress in brain research, 1973, Volume: 40, Issue:0

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Axonal Transport; Cats; Dogs; Ganglia, Spinal; Leucine; Neurons; Sciatic Nerve; Tritium

1973
Effect of age on thyroxine-induced cardiac hypertrophy in mice.
    Journal of gerontology, 1973, Volume: 28, Issue:3

    Topics: Aging; Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Leucine; Male; Mice; Mice, Inbred C57BL; Myocardium; Organ Size; Protein Biosynthesis; Thyroxine; Time Factors; Tritium

1973
The effect of acute exercise on amino acid incorporation into mitochondria of rabbit tissues.
    Biochimica et biophysica acta, 1969, Aug-20, Volume: 186, Issue:2

    Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Aging; Amino Acids; Animals; Brain; Buffers; Carbon Isotopes; Centrifugation, Density Gradient; Hypoxia; Leucine; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Oxygen; Physical Exertion; Proline; Protein Biosynthesis; Quaternary Ammonium Compounds; Rabbits; Swimming; Testosterone

1969
Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala.
    Journal of cell science, 1972, Volume: 10, Issue:2

    Topics: Aging; Animals; Cytochromes; Diptera; Flight, Animal; Glycerophosphates; Leucine; Malates; Microscopy, Electron; Mitochondria, Muscle; Muscle Proteins; Myofibrils; NAD; Oxidative Phosphorylation; Pyruvates; Tritium

1972
Cellular differentiation and isozymes of branched-chain amino acid transaminase.
    Enzyme, 1973, Volume: 15, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Aging; Animals; Brain; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Chromatography, DEAE-Cellulose; Diabetes Mellitus; Female; Hydrocortisone; Hypophysectomy; Isoenzymes; Kidney; Lactation; Leucine; Liver; Liver Neoplasms; Liver Regeneration; Mammary Glands, Animal; Molecular Weight; Organ Specificity; Pituitary Gland; Pregnancy; Rats; Transaminases

1973
Chemical and immunological studies of liver microsomes from mouse mutants with ultrastructurally abnormal hepatic endoplasmic reticulum.
    Biochemical genetics, 1974, Volume: 12, Issue:1

    Topics: Aging; Alleles; Animals; Animals, Newborn; Carbon Radioisotopes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Female; Fetus; Genes, Lethal; Glucose-6-Phosphatase; Immunodiffusion; Immunoelectrophoresis; Isotope Labeling; Leucine; Liver; Membranes; Mice; Microsomes, Liver; Mutation; Pregnancy; Proteins; Rabbits; Tritium

1974
Heterogeneity of rough-surfaced liver microsomal membranes of adult, phenobarbital-treated, and newborn rats.
    The Journal of cell biology, 1968, Volume: 38, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Centrifugation, Density Gradient; Electron Transport Complex IV; Fasting; Glucose-6-Phosphatase; Glycerol; Leucine; Liver; Membranes; Microscopy, Electron; Microsomes; NAD; NADP; Osmosis; Phenobarbital; Proteins; Rats; Tritium

1968
Measurements of rates of protein synthesis in rat brain slices.
    Journal of neurochemistry, 1974, Volume: 22, Issue:5

    Topics: Aging; Amino Acids; Animals; Brain; Carbon Radioisotopes; Histidine; In Vitro Techniques; Kinetics; Leucine; Lysine; Male; Nerve Tissue Proteins; Phenylalanine; Time Factors; Tritium; Valine

1974
[The incorporation in vivo of l-(3H)leucine into cerebellar proteins, in the young normal, underfed, hyperthyroid and hypothyroid rat (author's transl)].
    Journal of neurochemistry, 1974, Volume: 23, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cerebellum; Fasting; Hyperthyroidism; Hypothyroidism; Leucine; Nerve Tissue Proteins; Propylthiouracil; Rats; Thyroxine; Time Factors; Tritium

1974
Muscle protein synthesis during development of the normal and dystrophic chicken. Activity of supernatant elongation factors.
    Biochimica et biophysica acta, 1974, Dec-06, Volume: 374, Issue:2

    Topics: Acyltransferases; Aging; Animals; Carbon Radioisotopes; Chick Embryo; Chickens; Chromatography, Ion Exchange; Cytosol; Ethylmaleimide; Hydroxyapatites; Leucine; Muscle Development; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; Peptide Elongation Factors; Phenylalanine; Ribosomes; RNA, Transfer; Spectrophotometry, Ultraviolet; Time Factors; Transfer RNA Aminoacylation

1974
Postnatal changes in the temperature dependence of synaptosomal amino acid uptake.
    FEBS letters, 1974, Nov-15, Volume: 48, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Calorimetry; Cerebral Cortex; Glycine; Kinetics; Leucine; Rats; Synaptosomes; Temperature; Thermodynamics; Threonine; Time Factors

1974
Intestinal absorption of glycine, L-alanine and L-leucine in the old rat.
    Experimental gerontology, 1974, Volume: 9, Issue:5-6

    Topics: Aging; Alanine; Animals; Biological Transport; Carbon Radioisotopes; Female; Glycine; Intestinal Absorption; Intestines; Kinetics; Leucine; Liver; Organ Size; Rats

1974
An electrophoretic study of protein synthesis in brain regions of senescent male mice.
    Experimental gerontology, 1974, Volume: 9, Issue:5-6

    Topics: Aging; Animals; Brain; Brain Stem; Carbon Radioisotopes; Corpus Striatum; Electrophoresis, Polyacrylamide Gel; Hippocampus; Hydrolysis; Hypothalamus; Leucine; Liver; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Sodium Dodecyl Sulfate; Superior Colliculi; Tritium

1974
Leucyl-transfer ribonucleic acid synthetase in senescing tobacco leaves.
    The Biochemical journal, 1974, Volume: 140, Issue:2

    Topics: Aging; Amino Acyl-tRNA Synthetases; Centrifugation; Chromatography; Chromatography, DEAE-Cellulose; Dialysis; Leucine; Nicotiana; Plants; Plants, Toxic; Tritium

1974
A comparative study on age-related changes in protein synthesis by cardiac, red & white muscles of developing chicks.
    Indian journal of experimental biology, 1974, Volume: 12, Issue:4

    Topics: Aging; Animals; Chickens; Leucine; Male; Muscle Proteins; Muscles; Myocardium

1974
Basic mechanisms of aging.
    Scandinavian journal of clinical and laboratory investigation. Supplementum, 1974, Volume: 141

    Topics: Acetylglucosaminidase; Aging; Animals; Brain; Cathepsins; Cytoplasm; Diaphragm; DNA; Glucuronidase; Humans; Immunologic Memory; Leucine; Liver; Lysosomes; Mice; Muscles; Piracetam; Rats; RNA; Thymus Gland

1974
[Measurements of lysosomal enzyme activities and leucine incorporation rates in the brains of young and old rats after application of piracetam].
    Arzneimittel-Forschung, 1974, Volume: 24, Issue:10

    Topics: Acetamides; Aging; Animals; Brain; Carbon Radioisotopes; Cathepsins; Glucuronidase; Hexosaminidases; Leucine; Lysosomes; Male; Nerve Tissue Proteins; Protein Binding; Pyrrolidinones; Rats

1974
Age-dependent changes in the structure and function of mammalian chromatin. I. Variations in chromatin template activity.
    Experimental gerontology, 1973, Volume: 8, Issue:3

    Topics: Adenosine Monophosphate; Aging; Animals; Carbon Isotopes; Chromatin; Deoxycholic Acid; DNA; DNA-Directed RNA Polymerases; Escherichia coli; Histones; Leucine; Liver; Male; Protein Binding; Proteins; Rats; Ribonucleases; RNA; Submandibular Gland; Templates, Genetic; Trichloroacetic Acid; Tritium

1973
Changes in transfer RNAs and aminoacyl-tRNA synthetases during sea urchin development.
    Biochimica et biophysica acta, 1973, Jul-27, Volume: 312, Issue:4

    Topics: Aging; Amino Acyl-tRNA Synthetases; Animals; Arginine; Carbon Isotopes; Chromatography, DEAE-Cellulose; Electrophoresis, Disc; Embryo, Nonmammalian; Female; Fertilization; Leucine; Lysine; Ovum; RNA, Transfer; Saccharomyces cerevisiae; Sea Urchins; Serine; Spectrophotometry, Ultraviolet; Time Factors; Tritium

1973
Effects of glucose on insulin biosynthesis in foetal and newborn rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Cattle; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Female; Fetus; Gestational Age; Glucose; Insulin; Iodine Radioisotopes; Islets of Langerhans; Leucine; Molecular Weight; Pregnancy; Proinsulin; Rats; Time Factors; Tritium

1973
Chromatin modification of chick embryo cells during in vitro senescence.
    Mechanisms of ageing and development, 1974, Volume: 3, Issue:1

    Topics: Aging; Animals; Carbon Radioisotopes; Cells, Cultured; Chick Embryo; Chromatin; Electrophoresis, Disc; Fibroblasts; Histones; In Vitro Techniques; Isotope Labeling; Leucine; Microscopy, Electron; Microscopy, Phase-Contrast; RNA; Tritium

1974
Functional regeneration in liver of old rats after partial hepatectomy.
    Experimental gerontology, 1974, Volume: 9, Issue:4

    Topics: Aging; Animals; Carbon Radioisotopes; Female; Ferritins; Germ-Free Life; Half-Life; Hepatectomy; Histological Techniques; In Vitro Techniques; Leucine; Liver; Liver Regeneration; Microsomes, Liver; Protein Biosynthesis; Rats; RNA, Transfer; Serum Albumin; Serum Globulins; Thymidine; Time Factors; Tritium

1974
The relationship between DNA synthesis and the synthesis of nuclear proteins in rat brain. Effect of hydrocortisone acetate.
    Biochimica et biophysica acta, 1973, Mar-19, Volume: 299, Issue:2

    Topics: Aging; Animals; Brain; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Centrifugation, Density Gradient; DNA; Female; Hydrocortisone; Leucine; Liver; Male; Nerve Tissue Proteins; Nucleoproteins; Organ Specificity; Rats; Rats, Inbred Strains; Subcellular Fractions; Thymidine; Time Factors; Tritium

1973
Problems in the use of (Me- 3H) thymidine for the measurement of DNA synthesis.
    Biochimica et biophysica acta, 1973, Apr-11, Volume: 299, Issue:4

    Topics: Aging; Animals; Brain; Carbon Isotopes; Cycloheximide; Cytarabine; Dactinomycin; Diaphragm; DNA; Fasting; Kidney; Kinetics; Leucine; Lipids; Liver; Liver Regeneration; Male; Methods; Protein Biosynthesis; Rats; RNA; Thymidine; Tritium

1973
Biosynthesis of rat serum albumin. VII. Effects observed in liver slices.
    The American journal of physiology, 1973, Volume: 224, Issue:6

    Topics: Aging; Albumins; Amino Acids; Animals; Carbon Isotopes; Carbon Tetrachloride; Fasting; Female; Globulins; In Vitro Techniques; Incubators; Leucine; Liver; Male; Nephrosis; Proteins; Rats; Serum Albumin

1973
Relationship of protein metabolism to senescence of corn (Zea mays L.) stalk parenchyma, cob parenchyma and first developed leaf tissues.
    Mechanisms of ageing and development, 1973, Volume: 1, Issue:5

    Topics: Aging; Alanine; Amino Acids; Aspartic Acid; Carbon Isotopes; Cell Count; Chromatography; Dactinomycin; Glutamine; Leucine; Models, Biological; Ornithine; Phenylalanine; Plant Proteins; Plants; Ribonucleases; Ribosomes; RNA; RNA, Messenger; Threonine; Time Factors; Tyrosine

1973
Changes in leucyl-tRNA species of pea leaves during senescence and after zeatin treatment.
    Mechanisms of ageing and development, 1973, Volume: 1, Issue:5

    Topics: Acylation; Aging; Amino Alcohols; Carbon Isotopes; Chlorophyll; Chloroplasts; Glycine max; Leucine; Models, Biological; Nucleic Acid Conformation; Plant Growth Regulators; Plant Physiological Phenomena; Plant Proteins; Purines; RNA, Transfer; Tritium

1973
Nuclear proteins in brain of 7-day-old and adult rats.
    Journal of neurochemistry, 1973, Volume: 21, Issue:5

    Topics: Aging; Animals; Brain; Cell Nucleus; Chromatin; DNA; Electrophoresis, Polyacrylamide Gel; Histones; Leucine; Microsomes; Mitochondria; Nerve Tissue Proteins; Nucleoproteins; Rats; Subcellular Fractions; Time Factors; Tritium

1973
Decreased protein synthesis by microsomes isolated from senescent rat liver.
    Experimental gerontology, 1973, Volume: 8, Issue:5

    Topics: Age Factors; Aging; Amino Acids; Animals; Carbon Radioisotopes; Cell Fractionation; Cell-Free System; Cytosol; Female; In Vitro Techniques; Leucine; Microsomes, Liver; Protein Biosynthesis; Proteins; Rats; RNA

1973
Albumin and transferrin synthesis in the liver of rats in the immediate postnatal period.
    Biochimica et biophysica acta, 1973, Dec-21, Volume: 331, Issue:3

    Topics: Aging; Albumins; Animals; Animals, Newborn; Blood Proteins; Carbon Radioisotopes; Female; Fetus; Leucine; Liver; Pregnancy; Protein Biosynthesis; Rats; Time Factors; Transferrin

1973
Polyamine effects on 14C-leucine transfer to microsomal protein in a rat liver cell free system during ageing.
    Experimental gerontology, 1973, Volume: 8, Issue:6

    Topics: Aging; Animals; Carbon Radioisotopes; Cell-Free System; Centrifugation; Cytoplasm; Isotope Labeling; Leucine; Microsomes, Liver; Polyamines; Protein Biosynthesis; Rats; Ribonucleases; RNA, Transfer; Spermidine; Spermine

1973
A method for the isolation of rat submandibular salivary gland polysomes on linear sucrose density gradients.
    Analytical biochemistry, 1974, Volume: 57, Issue:2

    Topics: Aging; Aminoacylation; Animals; Carbon Radioisotopes; Cattle; Cell Fractionation; Centrifugation, Density Gradient; Evaluation Studies as Topic; Female; Leucine; Methods; Microscopy, Electron; Pancreas; Polyribosomes; Pregnancy; Protein Biosynthesis; Rats; Ribonucleases; Submandibular Gland; Ultracentrifugation

1974
Effect of undernutrition on amino acid compartimentation in the developing rat brain.
    Journal of neurochemistry, 1974, Volume: 22, Issue:4

    Topics: Aging; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Body Weight; Brain; Carbon Radioisotopes; Chromatography, Ion Exchange; Citric Acid Cycle; Glutamates; Glutamine; Leucine; Organ Size; Protein Deficiency; Rats; Statistics as Topic

1974
Isolation of microvilli fraction from jejunal mucosa and in vivo incorporation of 14C-leucine into microvilli and total homogenate protein of suckling rats.
    Biology of the neonate, 1974, Volume: 24, Issue:3

    Topics: Aging; Animals; Carbon Radioisotopes; DNA; Female; Galactosidases; Glucosidases; Intestinal Mucosa; Isotope Labeling; Jejunum; Lactation; Leucine; Milk; Pregnancy; Protein Biosynthesis; Proteinuria; Rats; RNA; Succinate Dehydrogenase; Sucrase; Time Factors

1974
Amino acid incorporation and aminoacyl transfer in an insect pupal system.
    The Journal of biological chemistry, 1968, Nov-25, Volume: 243, Issue:22

    Topics: Adenosine Triphosphate; Aging; Amino Acids; Animals; Carbon Isotopes; Coleoptera; Escherichia coli; Guanine Nucleotides; Leucine; Liver; Magnesium; Metamorphosis, Biological; Microsomes; Potassium; Puromycin; Rabbits; Ribonucleases; Ribosomes; RNA, Transfer; Tyrosine; Ultracentrifugation

1968
Protein turnover and protein synthesis following actinomycin-D injection as a function of age in Drosophila melanogaster.
    Gerontologia, 1971, Volume: 17, Issue:5

    Topics: Aging; Dactinomycin; Drosophila melanogaster; Female; Leucine; Ovary; Protein Biosynthesis; Proteins; RNA; RNA, Messenger; Thorax; Tritium

1971
The apparent turnover of mitochondria, ribosomes and sRNA of the brain in young adult and aged rats.
    Journal of neurochemistry, 1972, Volume: 19, Issue:7

    Topics: Aging; Animals; Brain; Carbon Isotopes; Cell Fractionation; Half-Life; Kinetics; Leucine; Male; Mitochondria; Nerve Tissue Proteins; Orotic Acid; Rats; Ribosomes; RNA; RNA, Ribosomal; RNA, Transfer; Tritium

1972
Inhibition of rat brain protein and nucleic acid synthesis by cannabinoids in vitro.
    Canadian journal of biochemistry, 1972, Volume: 50, Issue:6

    Topics: Aging; Animals; Animals, Newborn; Cannabis; Carbon Dioxide; Carbon Isotopes; Cerebral Cortex; Depression, Chemical; Dronabinol; In Vitro Techniques; Kinetics; Leucine; Male; Nerve Tissue Proteins; Nucleic Acids; Oxygen Consumption; Potassium; Protoveratrines; Rats; Stimulation, Chemical; Uracil; Uracil Nucleotides; Uridine

1972
Effect of age on rate of protein synthesis in isolated perfused mouse hearts.
    Journal of gerontology, 1972, Volume: 27, Issue:3

    Topics: Aging; Animals; Body Water; Extracellular Space; Leucine; Mice; Myocardium; Perfusion; Protein Biosynthesis; Radioisotopes

1972
Synthesis and degradation of liver proteins in young and old rats.
    Biochimica et biophysica acta, 1972, Aug-16, Volume: 277, Issue:1

    Topics: Aging; Animals; Bloodletting; Carbon Isotopes; Cycloheximide; Ferritins; Iron; Kinetics; Leucine; Liver; Protein Biosynthesis; Proteins; Rats; Serum Albumin; Tritium

1972
[Age-dependent changes of protein synthesis in small intestine rings].
    Zeitschrift fur Alternsforschung, 1971, Volume: 24, Issue:3

    Topics: Aging; Amino Acids; Animals; Carbon Isotopes; Culture Techniques; Female; Intestinal Mucosa; Intestine, Small; Leucine; Protein Biosynthesis; Rats

1971
Rapid mitochondrial enlargement in muscle as a response to triamcinolone acetonide and its relationship to the ribosomal defect.
    Biochemical pharmacology, 1971, Volume: 20, Issue:5

    Topics: Aging; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Drug Antagonism; Leucine; Male; Methandrostenolone; Microscopy, Electron; Mitochondria, Muscle; Muscle Proteins; Muscles; Muscular Diseases; Rats; Ribosomes; Time Factors; Triamcinolone Acetonide

1971
Studies on human platelets. IV. Protein synthesis in maturing human platelets.
    Thrombosis et diathesis haemorrhagica, 1971, Aug-31, Volume: 26, Issue:1

    Topics: Aging; Amino Acids; Autoradiography; Blood Platelets; Blood Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chronic Disease; Humans; Leucine; Purpura, Thrombocytopenic; Splenectomy; Tritium

1971
Solubilization of a reticulocyte ribosomal fraction responsible for the decline in ribosomal activity with cell maturation.
    Archives of biochemistry and biophysics, 1971, Volume: 145, Issue:1

    Topics: Aging; Animals; Blood Proteins; Carbon Isotopes; Cattle; Centrifugation, Density Gradient; Chlorides; Deuterium; Electrophoresis; Hemoglobins; Leucine; Magnesium; Phenylalanine; Polynucleotides; Potassium Chloride; Reticulocytes; Ribonucleases; Ribosomes; RNA, Messenger; RNA, Viral; Serum Albumin, Bovine; Solubility; Spectrophotometry; Time Factors; Tritium; Ultraviolet Rays; Uracil Nucleotides

1971
[The amino acid composition of human lens proteins in the course of lens alterations and cataract transformation. I. The amino acid composition of unclouded human lenses of various age groups].
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1966, Dec-15, Volume: 171, Issue:3

    Topics: Adult; Age Factors; Aged; Aging; Alanine; Amino Acids; Arginine; Asparagine; Cataract; Crystallins; Glutamates; Glycine; Humans; Isoleucine; Lens, Crystalline; Leucine; Lysine; Middle Aged; Nitrogen; Peptide Hydrolases; Phenylalanine; Tyrosine

1966
Haemoglobin synthesis in vitro by erythrocytes from Xenopus laevis.
    Comparative biochemistry and physiology, 1969, Sep-01, Volume: 30, Issue:5

    Topics: Aging; Animals; Anura; Autoradiography; Chromatography, Ion Exchange; Erythrocytes; Female; Hemoglobins; Hydrogen-Ion Concentration; Leucine; Male; Tritium

1969
Absence of a life-shortening effect of amino-acid analogues on adult Drosophila.
    Experimental gerontology, 1969, Sep-03, Volume: 4, Issue:3

    Topics: Aging; Amino Acids; Animals; Antimetabolites; Dietary Proteins; Drosophila; Hydrocarbons, Halogenated; Leucine; Longevity; Male; Phenylalanine; Protein Biosynthesis; Tritium

1969
Composition and formation of the insoluble protein fraction in the ocular lens.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1970, Volume: 5, Issue:2

    Topics: Aging; Albumins; Animals; Aspartic Acid; Carbon Isotopes; Cattle; Crystallins; Electrophoresis; Humans; Immunoelectrophoresis; Leucine; Rats; Sharks; Species Specificity; Spectrophotometry

1970
Cerebral amino acid transport in vitro during development: a kinetic analysis.
    Archives of biochemistry and biophysics, 1970, Volume: 138, Issue:1

    Topics: Aging; Amino Acids; Aminobutyrates; Animals; Biological Transport; Brain; Brain Chemistry; Chick Embryo; Chickens; Glutamates; In Vitro Techniques; Kinetics; Leucine; Lysine

1970
[Hormonal regulation at the level of transfer RNA. I. Comparative study of transfer RNA from the liver of immature hens and laying hens].
    Biochimica et biophysica acta, 1970, Jul-16, Volume: 213, Issue:1

    Topics: Aging; Alanine; Animals; Carbon Isotopes; Chickens; Chromatography, Ion Exchange; Estradiol; Female; Isoleucine; Kinetics; Leucine; Ligases; Liver; Phenols; RNA, Transfer; Serine; Tritium; Valine

1970
The turnover of mitochondria in a variety of tissues of young adult and aged rats.
    The Journal of biological chemistry, 1971, Apr-25, Volume: 246, Issue:8

    Topics: Aging; Animals; Brain; Half-Life; Intestinal Mucosa; Intestine, Small; Kidney; Leucine; Lung; Macromolecular Substances; Male; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; Myocardium; Proteins; Rats; Testis; Tritium

1971
Cerebral protein synthesis. 3. Developmental alteratons in the stability of cerebral messenger ribonucleic acid-ribosome complexes.
    The Journal of biological chemistry, 1971, Apr-10, Volume: 246, Issue:7

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Bile Acids and Salts; Cerebral Cortex; Detergents; Kinetics; Leucine; Magnesium; Male; Nerve Tissue Proteins; Rats; Ribonucleases; Ribosomes; RNA, Messenger; Tritium; Ultracentrifugation

1971
Effect of the administration of xanthine on the appearance of xanthine oxidase activity in the liver of growing rats.
    Experientia, 1968, Sep-15, Volume: 24, Issue:9

    Topics: Aging; Animals; Carbon Isotopes; Cortisone; Cycloheximide; Dactinomycin; Leucine; Liver; Orotic Acid; Phenylalanine; Rats; RNA; Xanthine Oxidase; Xanthines

1968
Protein synthesis in the core of calf lens.
    Experimental eye research, 1968, Volume: 7, Issue:4

    Topics: Aging; Albumins; Animals; Carbon Isotopes; Cattle; Crystallins; Lens, Crystalline; Leucine

1968
Transaminases of branched-chain amino acids. V. Activity change in developing and regenerating rat liver.
    Biochimica et biophysica acta, 1968, Oct-08, Volume: 167, Issue:2

    Topics: Adrenalectomy; Aging; Animals; Chromatography, Ion Exchange; Female; Fetus; Hepatectomy; Isoleucine; Leucine; Liver; Liver Regeneration; Male; Rats; Transaminases; Valine

1968
Evidence for long-lived components in developing mouse tissues labeled with leucine.
    Experimental gerontology, 1969, Volume: 4, Issue:1

    Topics: Adipose Tissue; Aging; Animals; Brain Chemistry; Carbon Isotopes; Growth; Intestine, Small; Kidney; Leucine; Lipids; Liver; Lung; Mice; Muscles; Myocardium; Protein Biosynthesis; Proteins; Skin; Spleen; Tendons; Time Factors; Tritium

1969
Effect of age on protein and ribonucleic acid metabolism in mouse skeletal muscle.
    Canadian journal of biochemistry, 1969, Volume: 47, Issue:3

    Topics: Aging; Animals; Carbon Isotopes; Cell Nucleus; DNA; Leucine; Mice; Mitochondria, Muscle; Muscle Proteins; Muscles; Myofibrils; RNA; Uridine

1969
Nucleic acid and protein synthesis in cardiac muscle of growing and adult mice.
    Experimental cell research, 1965, Volume: 40, Issue:2

    Topics: Aging; Animals; DNA; In Vitro Techniques; Leucine; Mice; Myocardium; Nucleosides; Protein Biosynthesis; RNA; Tritium

1965
Observations on reticulocyte maturation.
    Israel journal of medical sciences, 1965, Volume: 1, Issue:4

    Topics: Aging; Animals; Blood Proteins; Cell Aggregation; Chelating Agents; Dactinomycin; In Vitro Techniques; Leucine; Magnesium; Nucleotides; Rabbits; Reticulocytes; RNA

1965
Determination of optimal dietary protein requirements of young and old dogs.
    The Journal of nutrition, 1966, Volume: 88, Issue:1

    Topics: Aging; Animals; Dietary Proteins; DNA; Dogs; Kinetics; Leucine; Liver; Muscles; Nitrogen; Proteins; RNA

1966
Increase in the rate of protein synthesis with age in Drosophila subobscura.
    Nature, 1966, Feb-05, Volume: 209, Issue:5023

    Topics: Aging; Animals; Drosophila; Leucine; Male; Protein Biosynthesis

1966
[Enzyme histochemical and autoradiographic studies on bradytrophic tissues].
    Klinische Wochenschrift, 1966, Jul-15, Volume: 44, Issue:14

    Topics: Aging; Alcohol Oxidoreductases; Animals; Aorta; Autoradiography; Histocytochemistry; Intestinal Mucosa; Kidney; Leucine; Liver; Male; N-Glycosyl Hydrolases; Pancreas; Rats; Succinate Dehydrogenase; Tendons; Tritium

1966