leucine has been researched along with Acute Confusional Senile Dementia in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (17.39) | 18.2507 |
| 2000's | 26 (37.68) | 29.6817 |
| 2010's | 26 (37.68) | 24.3611 |
| 2020's | 5 (7.25) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L; Li, Z; Liu, Y; Zetterberg, H; Zhang, H; Zhong, X | 1 |
| Bochicchio, D; Boutin, H; Christie, L; Herholz, K; Hinz, R; Lawrence, CB; Parker, CA | 1 |
| Fields, L; Li, L; Li, M; Liu, Y; Lu, H; Shi, X; Wang, B; Wang, D; Zetterberg, H; Zhang, H | 1 |
| Amaral, AP; Conde, R; Graça, G; Morais, E; Oliveira, N; Sousa, A; Verde, I | 1 |
| Frost, DC; Gu, TJ; Li, L; Li, M; Yu, Q; Zhong, X | 1 |
| An, SSA; Bagyinszky, E; Giau, VV; Kim, S; Park, J; Shim, K; Youn, YC | 1 |
| Aarabi, MH; Ghazi Sherbaf, F; Same, K | 1 |
| Anfossi, M; Bernardi, L; Bruni, AC; Clodomiro, A; Colao, R; Conidi, ME; Curcio, SA; Di Lorenzo, R; Frangipane, F; Gallo, M; Maletta, R; Mirabelli, M; Puccio, G; Smirne, N; Vasso, F | 1 |
| Berman, DE; Leibel, RL; Morabito, MV; Schneider, RT; Small, SA; Zhang, Y | 1 |
| Hook, G; Hook, V; Kindy, M; Toneff, T; Yu, J | 1 |
| An, SS; Bagyinszky, E; Choi, BO; Kim, H; Kim, S; Youn, YC | 1 |
| Acker, C; Azose, M; Buthorn, J; D'Abramo, C; Davies, P; Greenwald, BS; Jimenez, H; Koppel, J; Lesser, M; Lewis, J; Liu, Z | 1 |
| Diouf, E; Filali, S; Gabelle, A; Gabert, L; Gérard, C; Hirtz, C; Lehmann, S; Pirot, F; Pivot, C; Sauvinet, V; Tall, ML | 1 |
| Bauchet, L; Combe, GG; Gabelle, A; Girard, M; Hanon, O; Hirtz, C; Lehmann, S; Vialaret, J | 1 |
| Chen, S; He, S; Huang, Y; Shi, Y; Wu, Y; Xia, M; Xu, C; Xu, J; Zang, W; Zhang, J; Zhao, T | 1 |
| Gonzalez, J; Ramirez, J; Schwans, JP | 1 |
| Arancio, O; Fa', M; Hidalgo, A; Liu, S; Mathews, PM; Nixon, RA; Schmidt, SD; Trinchese, F; Yamaguchi, H; Yoshii, N; Zhang, H | 1 |
| de Bot, ST; Dooijes, D; Kremer, HP; Verbeek, MM | 1 |
| Bousquet, O; Lauzon, M; Leclerc, N; Paiement, J; Perreault, S | 1 |
| Ruchala, P; Teplow, DB; Yamin, G | 1 |
| Cano-Abad, MF; García, AG; Moreno-Ortega, AJ; Ruiz-Nuño, A | 1 |
| Cao, L; Chen, SD; Cheng, Q; Cui, PJ; Deng, YL; Ding, JQ; Ma, JF; Tang, HD; Wang, G; Wang, Y; Xu, W; Zhang, T; Zheng, L | 1 |
| Abbamondi, N; Anfossi, M; Bernardi, L; Bruni, AC; Bugiani, O; Clodomiro, A; Colao, R; Curcio, SA; Di Lorenzo, R; Foncin, JF; Forloni, G; Frangipane, F; Gallo, M; Geracitano, S; Giaccone, G; Leotta, A; Lio, SG; Maletta, R; Milan, G; Mirabelli, M; Muraca, MG; Nee, L; Pappatà, S; Pinessi, L; Postiglione, A; Puccio, G; Rainero, I; Rogaeva, E; Rubino, E; Smirne, N; Sorbi, S; Spillantini, MG; St George Hyslop, P; Terni, B; Tomaino, C | 1 |
| Alegret, M; Antúnez, C; Boada, M; Carrasco, JM; Galán, JJ; González-Pérez, A; Hernández, I; López-Arrieta, J; Marín, J; Martínez-Lage, P; Moreno, C; Morón, FJ; Real, LM; Ruiz, A; Tárraga, L | 1 |
| Bagnoli, S; Bessi, V; Bracco, L; Cellini, E; Guarnieri, BM; Lucenteforte, E; Nacmias, B; Piaceri, I; Sorbi, S; Tedde, A | 1 |
| Beattie, BL; Butler, R; Dwosh, E; Feldman, HH; Guimond, C; Hsiung, GY; Rogaeva, E; Sadovnick, AD; St George-Hyslop, P; Thong, UP | 1 |
| Chen, YC; Chen, YR; Huang, HB; Lin, TH; Liu, HT; Lo, CJ; Shiao, MS; Su, CL; Wang, CC | 1 |
| Antonell, A; Balasa, M; Bosch, B; Fabregat, N; Fortea, J; Lladó, A; Molinuevo, JL; Oliva, R; Sánchez-Valle, R | 1 |
| Armstrong, AH; Chen, J; Hecht, MH; McKoy, AF | 1 |
| Hook, G; Hook, V; Kindy, M | 2 |
| Abdul, HM; Butterfield, DA; Cai, J; Di Domenico, F; Markesbery, WR; Pierce, WM; Robinson, RA; St Clair, DK; Sultana, R | 1 |
| Baker, A; Bredesen, DE; Butterfield, DA; Cai, J; Fiorini, A; Fombonne, J; Galvan, V; Gorostiza, O; Lange, MB; Pierce, WM; Robinson, RA; Sultana, R; Zhang, J | 1 |
| Cardoso, BR; Cominetti, C; Cozzolino, SM; Freitas, MI; Jacob-Filho, W; Jaluul, O; Ong, TP | 1 |
| Li, XC; Liu, B; Liu, GP; Luo, DJ; Wang, JZ; Wang, Q; Yao, XQ; Yin, YY; Zhang, XX | 1 |
| Baguet, A; Beher, D; Genoud, S; Hussain, I; Losberger, C; Ousson, S; Permanne, B; Saric, A; Vilbois, F | 1 |
| Berry, RW; Binder, LI; Gamblin, TC | 1 |
| Hashimoto, Y; Niikura, T; Nishimoto, I; Yamagishi, Y | 1 |
| Arancio, O; Battaglia, F; Liu, S; Nixon, RA; Trinchese, F; Walter, S | 1 |
| Hook, VY; Reisine, TD | 1 |
| Hashimoto, Y; Kitazume, S; Saido, TC; Suzuki, M | 1 |
| Asahara, H; Checler, F; Chui, DH; Furuya, H; Ikezoe, K; Iwaki, T; Kawarabayashi, T; Kikuchi, H; Kira, J; Makifuchi, T; Miyoshi, K; Murai, H; Ohyagi, Y; Sakae, N; Shoji, M; Tabira, T; Takeda, K; Taniwaki, T; Tsuruta, Y; Yamada, T | 1 |
| Brooks, WS; Gregory, G; Halliday, GM; Kersaitis, C; Kril, JJ; Kwok, JB; Lepar, G; Rahimi, F; Schofield, PR; Shepherd, CE; Song, YJ | 1 |
| Benaki, D; Evangelou, A; Livaniou, E; Mikros, E; Pelecanou, M; Vlassi, M; Zikos, C | 1 |
| Akatsu, H; Hata, M; Kosaka, K; Satoh, K; Shimizu, T; Yamada, T; Yamamoto, T; Yokota, H | 1 |
| Borghi, R; Cecconi, M; Dagna-Bricarelli, F; Pantieri, R; Pardini, M; Piccini, A; Russo, R; Tabaton, M; Vitali, A | 1 |
| Alvarez, V; Calatayud, MT; Corao, AI; Coto, E; García-Castro, M; González, P; Lahoz, CH; Martínez, C; Menéndez, M; Peña, J | 1 |
| Fioroni, G; Flex, A; Gaetani, E; Gerardino, L; Papaleo, P; Pola, P; Pola, R | 1 |
| Anfossi, M; Bernardi, L; Bruni, AC; Calignano, C; Colao, R; Costanzo, A; Curcio, SA; Ferrise, F; Frangipane, F; Gallo, M; Geracitano, S; Leotta, A; Maletta, R; Mirabelli, M; Muraca, MG; Paonessa, A; Puccio, G; Smirne, N; Tomaino, C | 1 |
| Hook, G; Hook, VY; Kindy, M | 1 |
| Axelman, K; Cowburn, RF; Dahlkild, A; Engvall, B; Forsell, C; Froelich, S; Ingelson, M; Johansson, K; Johnston, JA; Lannfelt, L; Lilius, L; St George-Hyslop, PH; Vestling, M | 1 |
| Collinge, J; Ellison, D; Fox, NC; Hardy, J; Harvey, RJ; Hutton, M; Roques, PK; Rossor, MN | 1 |
| Aldudo, J; Arbizu, T; Bullido, MJ; Oliva, R; Valdivieso, F | 1 |
| Castaño, EM; Levy, E; Mangone, CA; Morelli, L; Prat, MI | 1 |
| Badmajew, E; Dowjat, WK; Kuchna, I; Kulczycki, J; Popovitch, E; Tarnawski, M; Wegiel, J; Wisniewski, HM; Wisniewski, T | 1 |
| Citron, M; Corcoran, C; Diehl, TS; Eckman, CB; Levesque, G; Ostaszewski, BL; Selkoe, DJ; St George Hyslop, P; Xia, W; Younkin, SG | 1 |
| Cantu, JM; Hernandez-Romo, JA; Leal, CA; Lin, C; Ramirez-Casillas, GA; Ramirez-Dueñas, MG; Rogaeva, EA; St George-Hyslop, PH | 1 |
| Aston, CE; DeKosky, ST; Ferrell, RE; Hardy, J; Kamboh, MI; Kokmen, E; Perez-Tur, J | 1 |
| Campion, D; Davoust, D; Dumanchin, C; Frébourg, T; Gantier, R; Gilbert, D; Toma, F | 1 |
| Helisalmi, S; Hiltunen, M; Karvonen, MK; Koulu, M; Mannermaa, A; Pesonen, U; Pirskanen, M; Soininen, H; Uusitupa, M; Valve, R | 1 |
| Brice, A; Campion, D; Frebourg, T; Gantier, R; Martin, C; Pothin, Y; Raux, G | 1 |
| Bugiani, O; Crain, BJ; Farlow, MR; Ghetti, B; Giaccone, G; Heyman, A; Hulette, CM; Murrell, JR; Piccardo, P; Tagliavini, F; Takao, M; Unverzagt, FW | 1 |
| Brice, A; Campion, D; Durr, A; Frebourg, T; Hahn, V; Jacquemont, ML; Tallaksen, C | 1 |
| Kuliev, A; Lederer, K; Masciangelo, C; Rechitsky, S; Verlinsky, O; Verlinsky, Y | 1 |
| Capell, A; Edbauer, D; Ghetti, B; Haass, C; Kaether, C; Moehlmann, T; Murrell, J; Steiner, H; Winkler, E; Xia, X; Zheng, H | 1 |
| Ivy, GO | 1 |
| Anderson, JP; Chen, Y; Kim, KS; Robakis, NK | 1 |
| Hsiao, K; Prusiner, SB | 1 |
| Gibson, AM; McDermott, JR | 1 |
2 review(s) available for leucine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Involvement of proteases in glycosyltransferase secretion: Alzheimer's beta-secretase-dependent cleavage and a following processing by an aminopeptidase.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Aminopeptidases; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; beta-D-Galactoside alpha 2-6-Sialyltransferase; Cell Membrane; COS Cells; Detergents; Endopeptidases; Glutamine; Golgi Apparatus; Humans; Leucine; Models, Biological; Molecular Sequence Data; Mutation; Peptide Hydrolases; Protein Structure, Tertiary; Sialyltransferases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Molecular genetics and transgenic model of Gertsmann-Sträussler-Scheinker disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Codon; Genetic Markers; Gerstmann-Straussler-Scheinker Disease; Humans; Leucine; Mice; Mice, Transgenic; Models, Genetic; Prions; Proline; PrPSc Proteins | 1991 |
67 other study(ies) available for leucine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Isotopic N,N-dimethyl leucine tags for absolute quantification of clusterin and apolipoprotein E in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Clusterin; Female; Humans; Leucine; Male | 2022 |
Measurement of Protein Synthesis Rate in Rat by [
Topics: Alzheimer Disease; Animals; Anisomycin; Cross-Sectional Studies; Disease Models, Animal; Leucine; Longitudinal Studies; Positron-Emission Tomography; Rats; Rats, Inbred F344; Rats, Wistar | 2023 |
DiLeu Isobaric Labeling Coupled with Limited Proteolysis Mass Spectrometry for High-Throughput Profiling of Protein Structural Changes in Alzheimer's Disease.
Topics: Alzheimer Disease; Apolipoprotein A-I; Humans; Leucine; Mass Spectrometry; Proteolysis; Proteomics | 2023 |
NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.
Topics: Acetone; Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Glutamates; Histidine; Humans; Isobutyrates; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Tyrosine; Valine | 2024 |
Mass Defect-Based DiLeu Tagging for Multiplexed Data-Independent Acquisition.
Topics: Alzheimer Disease; Amino Acid Sequence; Biomarkers; Cerebrospinal Fluid Proteins; Humans; Leucine; Middle Aged; Proof of Concept Study; Proteome; Proteomics; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tandem Mass Spectrometry | 2020 |
Identification of a novel PSEN1 mutation (Leu232Pro) in a Korean patient with early-onset Alzheimer's disease and a family history of dementia.
Topics: Adult; Alzheimer Disease; Asian People; Atrophy; Codon; Dementia; Exons; Genetic Association Studies; Genetic Predisposition to Disease; Helix-Loop-Helix Motifs; Humans; Leucine; Magnetic Resonance Imaging; Mutation, Missense; Neuroimaging; Parietal Lobe; Presenilin-1; Proline | 2017 |
New link between Parkinson's and Alzheimer's: Research uncovers the role of mutant leucine rich repeat kinase 2 and amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Humans; Leucine; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Parkinson Disease; Phosphorylation | 2017 |
Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation.
Topics: Adult; Age of Onset; Alzheimer Disease; Female; Genetic Predisposition to Disease; Genotype; Humans; Leucine; Male; Membrane Transport Proteins; Memory Disorders; Methionine; Middle Aged; Mitochondrial Precursor Protein Import Complex Proteins; Mutation; Neuropsychological Tests; Polymorphism, Genetic; Presenilin-1 | 2013 |
Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Progression; Enzyme-Linked Immunosorbent Assay; Glucose Tolerance Test; Hippocampus; Humans; Leptin; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroblastoma; Vesicular Transport Proteins | 2014 |
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cattle; Cells, Cultured; Chromaffin Cells; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Leucine; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Pyrrolidonecarboxylic Acid | 2014 |
Probable novel PSEN2 Val214Leu mutation in Alzheimer's disease supported by structural prediction.
Topics: Aged; Alzheimer Disease; Amino Acid Substitution; DNA Mutational Analysis; Exons; Female; Humans; Leucine; Models, Molecular; Mutation; Presenilin-2; Protein Structure, Tertiary; Valine | 2014 |
Pathogenic tau species drive a psychosis-like phenotype in a mouse model of Alzheimer's disease.
Topics: Acoustic Stimulation; Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; Humans; Inhibition, Psychological; Leucine; Mice; Mice, Transgenic; Mutation; Phenotype; Proline; Psychotic Disorders; Reflex, Startle; tau Proteins | 2014 |
[Injectable preparation of labeled leucine with the carbon 13 for a clinical research program on the Alzheimer disease: pharmaceutical control of raw materials and the finished product and stability study].
Topics: Alzheimer Disease; Carbon Isotopes; Drug Stability; Drug Storage; Humans; Isotope Labeling; Leucine; Pharmaceutical Solutions; Radiopharmaceuticals | 2015 |
Stable Isotope Labeling by Amino acid in Vivo (SILAV): a new method to explore protein metabolism.
Topics: Alzheimer Disease; Carbon Isotopes; Cerebrospinal Fluid Proteins; Humans; Isotope Labeling; Leucine; Mass Spectrometry; Proteomics | 2015 |
Probable novel PSEN2 Pro123Leu mutation in a Chinese Han family of Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Asian People; Codon; Diagnostic Imaging; Exons; Genetic Association Studies; Humans; Leucine; Mutation, Missense; Presenilin-2; Proline | 2015 |
Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acids; Butyrylcholinesterase; Cholinesterase Inhibitors; Fluorenes; Humans; Leucine; Lysine; Protein Binding; Tryptophan | 2016 |
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Calpain; Cells, Cultured; Disease Models, Animal; Glycoproteins; Hippocampus; Homozygote; Immunohistochemistry; Leucine; Memory; Mice; Mice, Transgenic; Models, Neurological; Synaptic Transmission | 2008 |
CSF studies facilitate DNA diagnosis in familial Alzheimer's disease due to a presenilin-1 mutation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Arginine; Creutzfeldt-Jakob Syndrome; Dementia; Female; Humans; Leucine; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Presenilin-1; Reference Values; tau Proteins; Young Adult | 2009 |
Increased association between rough endoplasmic reticulum membranes and mitochondria in transgenic mice that express P301L tau.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Antibodies, Monoclonal; Brain; Endoplasmic Reticulum, Rough; Female; Humans; Leucine; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Microtubule-Associated Proteins; Mitochondria; Mutation; Proline; Qa-SNARE Proteins; Receptors, Peptide; Spinal Cord; Subcellular Fractions; tau Proteins | 2009 |
A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Binding Sites; Dipeptides; Disulfides; Endopeptidases; Leucine; Molecular Sequence Data; Peptides; Protein Binding | 2009 |
Mitochondria sense with different kinetics the calcium entering into HeLa cells through calcium channels CALHM1 and mutated P86L-CALHM1.
Topics: Alzheimer Disease; Amino Acid Substitution; Apoptosis; Calcium; Calcium Channels; Endoplasmic Reticulum; HeLa Cells; Humans; Kinetics; Leucine; Membrane Glycoproteins; Mitochondria; Mutation; Proline | 2010 |
CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Calcium Channels; Case-Control Studies; China; Female; Humans; Leucine; Male; Membrane Glycoproteins; Polymorphism, Genetic; Proline; Risk Factors | 2010 |
Worldwide distribution of PSEN1 Met146Leu mutation: a large variability for a founder mutation.
Topics: Adult; Alzheimer Disease; Brain; Cognition Disorders; Family Health; Female; Fluorodeoxyglucose F18; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Global Health; History, 17th Century; History, 21st Century; Humans; International Cooperation; Italy; Leucine; Male; Memory Disorders; Methionine; Middle Aged; Mutation; Phenotype; Positron-Emission Tomography; Presenilin-1 | 2010 |
CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Calcium Channels; Female; Gene Frequency; Genes, Recessive; Genotype; Humans; Leucine; Male; Membrane Glycoproteins; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; Proline; Spain | 2010 |
Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.
Topics: Age of Onset; Aged; Alzheimer Disease; Calcium Channels; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Italy; Leucine; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Proline | 2010 |
A novel PS1 gene mutation in a large Aboriginal kindred.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Canada; Family Health; Female; Genome-Wide Association Study; Humans; Leucine; Male; Middle Aged; Mutation; Neuropsychological Tests; Phenylalanine; Presenilin-1 | 2010 |
Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cell Survival; Humans; Leucine; Mutation; Neurons; Nuclear Magnetic Resonance, Biomolecular; PC12 Cells; Peptide Fragments; Phenylalanine; Protein Conformation; Rats; Urea | 2011 |
A novel PSEN1 gene mutation (L235R) associated with familial early-onset Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Arginine; Family Health; Female; Humans; Imaging, Three-Dimensional; Leucine; Magnetic Resonance Imaging; Middle Aged; Mutation; Parietal Lobe; Presenilin-1; Temporal Lobe | 2011 |
Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.
Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Amino Acids, Aromatic; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Leucine; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Phenylalanine; Protein Processing, Post-Translational | 2011 |
The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cathepsin B; Cysteine Proteinase Inhibitors; Disease Models, Animal; Guinea Pigs; Leucine; Memory; Mice; Mice, Transgenic | 2011 |
Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Topics: Age Factors; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Brain Chemistry; Disease Models, Animal; Gene Knock-In Techniques; Humans; Leucine; Male; Mice; Mice, Transgenic; Nerve Tissue Proteins; Presenilin-1; Proline; Protein Carbonylation; Protein Structure, Tertiary; Proteomics | 2011 |
Do proteomics analyses provide insights into reduced oxidative stress in the brain of an Alzheimer disease transgenic mouse model with an M631L amyloid precursor protein substitution and thereby the importance of amyloid-beta-resident methionine 35 in Alz
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation; Humans; Leucine; Methionine; Mice; Mice, Transgenic; Molecular Sequence Data; Oxidative Stress; Proteins; Proteomics | 2012 |
Glutathione peroxidase 1 Pro198Leu polymorphism in Brazilian Alzheimer's disease patients: relations to the enzyme activity and to selenium status.
Topics: Aged; Alzheimer Disease; Base Sequence; Brazil; Case-Control Studies; DNA Primers; Female; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Leucine; Male; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Proline; Selenium | 2012 |
Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
Topics: Alzheimer Disease; Carboxylic Ester Hydrolases; Catalysis; Cell Line, Tumor; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HEK293 Cells; Humans; Lentivirus; Leucine; Methylation; Protein O-Methyltransferase; Protein Phosphatase 2 | 2012 |
Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Binding Sites; Enzyme Activation; HEK293 Cells; Humans; Leucine; Lysine; Membrane Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity | 2013 |
Tau polymerization: role of the amino terminus.
Topics: Alzheimer Disease; Amino Acid Sequence; Arachidonic Acid; Arginine; Humans; Lasers; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Polymers; Recombinant Proteins; Scattering, Radiation; tau Proteins | 2003 |
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults.
Topics: Alanine; Alzheimer Disease; Amino Acids; Amyloid beta-Protein Precursor; Animals; Arginine; Culture Media, Conditioned; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Hybrid Cells; Intracellular Signaling Peptides and Proteins; Leucine; Luminescent Proteins; Mice; Mutation; Neurons; Neuroprotective Agents; Peptides; Protein Structure, Tertiary; Proteins; Rats; Structure-Activity Relationship; Time Factors; Transfection | 2003 |
Calpain inhibitors, a treatment for Alzheimer's disease: position paper.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calpain; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hippocampus; Leucine; Long-Term Potentiation; Maze Learning; Membrane Proteins; Memory Disorders; Mice; Mice, Transgenic; Organ Culture Techniques; Presenilin-1; Treatment Outcome; Up-Regulation | 2003 |
Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Chromaffin Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dithiothreitol; Endopeptidases; Extracellular Space; Glutathione; Leucine; Mice; Mice, Knockout; Mutation; Neurons; Nicotine; Nicotinic Agonists; Peptide Fragments; Potassium Chloride; Secretory Vesicles; Substrate Specificity; Time Factors | 2003 |
Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Brain Chemistry; Cells, Cultured; Cytosol; DNA; Female; Fetus; Genes, p53; Guinea Pigs; Heat-Shock Response; Humans; Hydrogen Peroxide; Intracellular Space; Leucine; Male; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neuroblastoma; Neurons; Peptide Fragments; Presenilin-1; Promoter Regions, Genetic; Protein Binding; Response Elements; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Valine | 2005 |
Pick bodies in a family with presenilin-1 Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blotting, Western; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Disease; Humans; Immunohistochemistry; Leucine; Male; Membrane Proteins; Methionine; Middle Aged; Mutation; Neurofibrillary Tangles; Pick Disease of the Brain; Plaque, Amyloid; Postmortem Changes; Presenilin-1; tau Proteins | 2005 |
Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity.
Topics: Alzheimer Disease; Circular Dichroism; Glutamic Acid; Glycine; Humans; Intracellular Signaling Peptides and Proteins; Leucine; Magnetic Resonance Spectroscopy; Models, Molecular; Peptides; Protein Conformation; Protein Structure, Secondary; Proteins; Temperature; Trifluoroethanol; Water | 2005 |
Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Blotting, Western; Brain; Case-Control Studies; Cell Adhesion; Cell Line, Tumor; Cell Movement; Extracellular Matrix; Female; Humans; In Situ Hybridization; Leucine; Male; Membrane Proteins; Middle Aged; Neuroglia; Neurons; Plaque, Amyloid; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transfection | 2005 |
A novel presenilin 1 L166H mutation in a pseudo-sporadic case of early-onset Alzheimer's disease.
Topics: Adult; Alzheimer Disease; DNA Mutational Analysis; Female; Histidine; Humans; Leucine; Membrane Proteins; Mutation; Presenilin-1 | 2005 |
Myocyte enhancing factor-2A in Alzheimer's disease: genetic analysis and association with MEF2A-polymorphisms.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leucine; MADS Domain Proteins; Male; MEF2 Transcription Factors; Middle Aged; Myogenic Regulatory Factors; Odds Ratio; Peptides; Polymorphism, Genetic; Proline | 2007 |
Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cathepsin B; Cysteine Endopeptidases; Dipeptides; Guinea Pigs; Leucine; Molecular Weight; Protease Inhibitors; Synaptosomes | 2007 |
Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Chi-Square Distribution; DNA Mutational Analysis; Factor XIII; Female; Humans; Leucine; Logistic Models; Male; Polymorphism, Genetic; Valine | 2006 |
Presenilin 2 Ser130Leu mutation in a case of late-onset "sporadic" Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Humans; Leucine; Male; Mutation; Pedigree; Presenilin-2; Serine | 2007 |
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression; Humans; Leucine; Maze Learning; Memory; Mice; Mice, Transgenic | 2008 |
A novel pathogenic mutation (Leu262Phe) found in the presenilin 1 gene in early-onset Alzheimer's disease.
Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Genetic Testing; Humans; Leucine; Membrane Proteins; Phenylalanine; Point Mutation; Polymorphism, Single-Stranded Conformational; Presenilin-1; Presenilin-2; Sequence Analysis, DNA | 1997 |
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 14; Female; Genes, Dominant; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Mutation; Pedigree; Presenilin-1; Retrospective Studies; Serine; Surveys and Questionnaires | 1998 |
Identification of a novel mutation (Leu282Arg) of the human presenilin 1 gene in Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Arginine; Electrophoresis, Polyacrylamide Gel; Female; Genetic Testing; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Pedigree; Point Mutation; Polymorphism, Genetic; Presenilin-1; Risk Factors | 1998 |
Presenilin 1 Met146Leu variant due to an A --> T transversion in an early-onset familial Alzheimer's disease pedigree from Argentina.
Topics: Adenine; Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Argentina; Female; Genetic Variation; Humans; Leucine; Male; Membrane Proteins; Methionine; Middle Aged; Pedigree; Presenilin-1; Thymine | 1998 |
Cell-type-specific enhancement of amyloid-beta deposition in a novel presenilin-1 mutation (P117L).
Topics: Adult; Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cerebellum; Dentate Gyrus; Down Syndrome; Entorhinal Cortex; Female; Hippocampus; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Point Mutation; Poland; Presenilin-1; Proline | 1998 |
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Gene Expression Regulation; Humans; Leucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Valine | 1998 |
A novel Leu171Pro mutation in presenilin-1 gene in a Mexican family with early onset Alzheimer disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Humans; Leucine; Membrane Proteins; Mexico; Mutation, Missense; Pedigree; Polymerase Chain Reaction; Presenilin-1; Proline | 1998 |
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apolipoproteins E; Exons; Female; Humans; Leucine; Male; Middle Aged; Mutation, Missense; Polymorphism, Single-Stranded Conformational; Proline; Reference Values; Registries; Risk Factors; United States | 1999 |
The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta.
Topics: Alzheimer Disease; Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Leucine; Membrane Proteins; Mutation; Presenilin-1; Protein Binding; Recombinant Proteins; Surface Plasmon Resonance; Valine | 2000 |
The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer's disease or the link apolipoprotein E.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoproteins E; Female; Genotype; Humans; Leucine; Male; Neuropeptide Y; Polymorphism, Single Nucleotide; Proline; Protein Sorting Signals | 2000 |
A novel presenilin 1 missense mutation (L153V) segregating with early-onset autosomal dominant Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Female; France; Genes, Dominant; Humans; Leucine; Male; Membrane Proteins; Mutation, Missense; Presenilin-1; Valine | 2000 |
Ectopic white matter neurons, a developmental abnormality that may be caused by the PSEN1 S169L mutation in a case of familial AD with myoclonus and seizures.
Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Protein Precursor; Brain; Choristoma; Fatal Outcome; Female; Humans; Leucine; Male; Membrane Proteins; Mutation; Myoclonus; Neurons; Pedigree; Presenilin-1; Seizures; Serine | 2001 |
Spastic paraparesis and atypical dementia caused by PSEN1 mutation (P264L), responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Substitution; Dementia; Genetic Predisposition to Disease; Humans; Leucine; Male; Membrane Proteins; Middle Aged; Mutation; Paraparesis, Spastic; Presenilin-1; Proline | 2002 |
Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; DNA Mutational Analysis; Female; Genes, Dominant; Genetic Testing; Humans; Leucine; Mutation; Pedigree; Pregnancy; Pregnancy Outcome; Preimplantation Diagnosis; Valine | 2002 |
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Fibroblasts; Humans; Kidney; Leucine; Membrane Proteins; Mutation; Peptide Fragments; Presenilin-1; Receptors, Notch; Recombinant Proteins; Transfection | 2002 |
Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain.
Topics: Aging; Alzheimer Disease; Animals; Brain; Dolichols; Endopeptidases; Humans; Immunologic Techniques; Intermediate Filaments; Leucine; Leupeptins; Lipofuscin; Macaca fascicularis; Male; Protease Inhibitors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Ubiquitins | 1992 |
An alternative secretase cleavage produces soluble Alzheimer amyloid precursor protein containing a potentially amyloidogenic sequence.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Humans; Immunoblotting; Kidney; Leucine; Lysine; Molecular Sequence Data; PC12 Cells; Rats; Transfection | 1992 |
The processing of Alzheimer A4/beta-amyloid protein precursor: identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Brain; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Kinetics; Leucine; Lysine; Metalloendopeptidases; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Substrate Specificity | 1991 |