leucine and Ache

leucine has been researched along with Ache in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199016 (47.06)18.7374
1990's2 (5.88)18.2507
2000's8 (23.53)29.6817
2010's7 (20.59)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Chen, L; Liu, Y; Su, T1
Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T1
Bannon, AW; Bespalov, A; Bitner, RS; Chu, KL; Cole, EE; Gauvin, D; Jarvis, MF; Joshi, SK; Lee, CH; Lewis, LG; McGaraughty, S; Mikusa, J; Milicic, I; Neelands, T; Niforatos, W; Pai, M; Roderwald, V; Scott, VE; Searle, XB; Swensen, AM; Vortherms, TA; Xu, J; Zhan, C; Zhang, M; Zhong, C; Zhu, CZ1
Abogadie, FC; Bunnett, NW; Darby, B; Grace, MS; Lieu, T; McIntyre, P; Veldhuis, N1
Gendron, L; Giddings, AM; Gilmour, BP; Longpre, JM; Olepu, S; Runyon, SP; Sarret, P; Thomas, JB; Warner, KR; Wiethe, RW; Zhang, Y1
Azevedo, AO; Caliari, MV; Duarte, ID; Guzzo, LS; Perez, AC; Queiroz-Junior, CM; Romero, TR1
Bakhle, YS; de Francischi, JN; Dos Reis, WG; Duarte, ID; Lima, PP; Rezende, RM1
de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR1
Beck, TW; Conway-Klaassen, JM; Golding, LA; Kruskall, LJ; Stock, MS; Tandy, RD; Young, JC1
Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C1
Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C1
Balciuniene, I; Juskiene, I; Sabalaite, R1
Fantini, L; Morselli-Labate, AM; Pezzilli, R1
González, H; Lozano-Chourio, MA; Quero, M; Zambrano, O1
Ikeda, T; Matsushima, O; Nakayama, T; Naono, R; Nishimori, T1
Marcus, R; Seltzer, S; Stoch, R1
Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP1
Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A1
Jeffcoate, WJ1
Benson, HA; Macfarlane, BV; Wright, A1
Demuth, HU; Inoue, M; Kisara, K; Nylander, I; Ohshima, K; Sakurada, C; Sakurada, T; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L1
Hassall, DC; Morrow, LA; Watts, DC; Wilson, NH1
Havlicek, V; LaBella, FS; Leybin, L; Pinsky, C; Rezek, M1
Jakoubek, B; Kraus, M; Pavlík, A; Rehulka, J1
Bazian, AS; Brazovskaia, FA; Kruglikov, RI1
Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z1
Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC1
Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP1
Kubota, K; Matsuoka, Y; Satoh, S; Uruno, T1
Hill, RG; Hughes, J; Pittaway, KM1
Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H1
Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF1
Izumi, R; Kaneto, H; Takahashi, M1
Blumen, G; Castro, NM; Maia, JC; Merzel, J; Raw, I; Schmidt, BJ1

Reviews

3 review(s) available for leucine and Ache

ArticleYear
Clinical characteristics of Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 6-year-old girl: case report and literature reviews.
    BMC neurology, 2023, Jun-30, Volume: 23, Issue:1

    Topics: Autoimmune Diseases of the Nervous System; Child; Encephalitis; Female; Glioma; Humans; Hyponatremia; Leucine; Pain

2023
Perspectives in the control of chronic pain by nutritional manipulation.
    Pain, 1981, Volume: 11, Issue:2

    Topics: Animals; Antidepressive Agents; Brain; Chronic Disease; Humans; Leucine; Migraine Disorders; Neurotransmitter Agents; Pain; Phenylalanine; Rats; Sensory Thresholds; Serotonin; Tryptophan

1981
Brain peptides and pain sensation.
    American heart journal, 1980, Volume: 99, Issue:1

    Topics: Animals; beta-Lipotropin; Brain Chemistry; Endorphins; Enkephalins; Fluorescent Antibody Technique; Guinea Pigs; Humans; Leucine; Methionine; Mice; Morphine; Narcotics; Pain; Peptides; Radioimmunoassay; Rats

1980

Trials

3 trial(s) available for leucine and Ache

ArticleYear
The effects of adding leucine to pre and postexercise carbohydrate beverages on acute muscle recovery from resistance training.
    Journal of strength and conditioning research, 2010, Volume: 24, Issue:8

    Topics: Beverages; Creatine Kinase; Dietary Carbohydrates; Double-Blind Method; Female; Humans; L-Lactate Dehydrogenase; Leucine; Male; Muscle Fatigue; Muscle, Skeletal; Pain; Resistance Training; Time Factors; Young Adult

2010
Chemomechanical caries removal for children.
    Stomatologija, 2005, Volume: 7, Issue:2

    Topics: Anesthesia, Dental; Child; Child, Preschool; Dental Care for Children; Dental Caries; Dental Cavity Preparation; Dental Instruments; Dental Restoration, Permanent; Dentition, Permanent; DMF Index; Glutamic Acid; Humans; Leucine; Lysine; Pain; Tooth, Deciduous; Treatment Outcome

2005
Clinical randomized controlled trial of chemomechanical caries removal (Carisolv).
    International journal of paediatric dentistry, 2006, Volume: 16, Issue:3

    Topics: Anesthesia, Local; Child; Child Behavior; Cross-Over Studies; Dental Caries; Dental Cavity Preparation; Dental High-Speed Equipment; Female; Glutamic Acid; Humans; Leucine; Lysine; Male; Molar; Pain; Patient Satisfaction; Time Factors; Tooth, Deciduous; Treatment Outcome

2006

Other Studies

28 other study(ies) available for leucine and Ache

ArticleYear
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
    Pain, 2018, Volume: 159, Issue:5

    Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels

2018
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
    The journal of pain, 2014, Volume: 15, Issue:4

    Topics: Analgesics; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Disease Models, Animal; Immunohistochemistry; Leucine; Male; Neurons; Nociception; Pain; Patch-Clamp Techniques; Rats, Sprague-Dawley; Spinal Cord

2014
The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo.
    British journal of pharmacology, 2014, Volume: 171, Issue:16

    Topics: Animals; HEK293 Cells; Humans; Hyperalgesia; Leucine; Male; Mice, Inbred C57BL; Morpholines; Oligopeptides; Pain; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, PAR-2; Sulfonamides; TRPV Cation Channels; Trypsin

2014
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
    Journal of medicinal chemistry, 2014, Sep-11, Volume: 57, Issue:17

    Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Kinetics; Leucine; Models, Chemical; Molecular Structure; Pain; Rats; Receptors, Neurotensin; Sulfonamides

2014
Involvement of endogenous opioid peptides in the peripheral antinociceptive effect induced by the coffee specific diterpene kahweol.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:5

    Topics: Analgesics; Animals; beta-Endorphin; Coffee; Dinoprostone; Diterpenes; Hyperalgesia; Leucine; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Peptides; Pressure; Rats; Rats, Wistar; Skin

2015
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
    Pain, 2009, Volume: 142, Issue:1-2

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunologic Factors; Inflammation; Injections, Intraventricular; Leucine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Reaction Time; Sulfonamides; Time Factors

2009
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine

2009
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012, Volume: 26, Issue:12

    Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan

2012
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Jul-08, Volume: 100, Issue:14

    Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries

2003
New approaches for the treatment of acute pancreatitis.
    JOP : Journal of the pancreas, 2006, Jan-11, Volume: 7, Issue:1

    Topics: Acute Disease; Amylases; Animals; Antibodies, Monoclonal; Cholangiopancreatography, Endoscopic Retrograde; Clinical Trials as Topic; Drug Evaluation, Preclinical; Gabexate; Humans; Imidazoles; Infliximab; Interleukin-10; Leucine; Nutrition Therapy; Pain; Pancreatitis; Pancreatitis, Acute Necrotizing; Practice Guidelines as Topic; Probiotics; Treatment Outcome

2006
Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing.
    Brain research, 2007, Aug-24, Volume: 1165

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hexokinase; Hyperalgesia; Leucine; Male; Pain; Pain Measurement; Peptides; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Tachykinins

2007
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin

1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
    Neuropharmacology, 1983, Volume: 22, Issue:11

    Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin

1983
Reversible blockade of retrograde axonal transport in the rat sciatic nerve by vincristine.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Axonal Transport; Leucine; Male; Pain; Rats; Rats, Wistar; Sciatic Nerve; Vincristine

1997
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
    Neuropeptides, 1998, Volume: 32, Issue:5

    Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors

1998
A chemomechanical method for caries removal.
    Dental update, 2000, Volume: 27, Issue:8

    Topics: Dental Caries; Dental Cavity Preparation; Dental Pulp; Dental Restoration, Permanent; Dentin; Glutamic Acid; Humans; Leucine; Lysine; Pain; Patient Satisfaction

2000
Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats.
    Nature, 1976, Dec-02, Volume: 264, Issue:5585

    Topics: Animals; Humans; Injections, Intraventricular; Leucine; Male; Methionine; Morphine; Nerve Tissue Proteins; Oligopeptides; Pain; Rats; Receptors, Opioid; Structure-Activity Relationship; Substance Withdrawal Syndrome

1976
Uptake of 3H-leucine into the brain and other organs during the conditioned reaction to painful stimulation; effect of diazepam.
    Activitas nervosa superior, 1976, Volume: 18, Issue:1-2

    Topics: Animals; Brain; Conditioning, Classical; Diazepam; Humans; Leucine; Male; Nerve Tissue Proteins; Organ Specificity; Pain; Rats; Stress, Psychological

1976
[H3-leucine incorporation in neurons of different murine brain structures upon elaboration of a defensive conditioned reflex].
    Nauchnye doklady vysshei shkoly. Biologicheskie nauki, 1976, Issue:12

    Topics: Animals; Conditioning, Classical; Hippocampus; Leucine; Light; Male; Mice; Nerve Tissue Proteins; Neural Analyzers; Pain; Telencephalon; Visual Cortex

1976
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan

1989
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
    Neuropharmacology, 1989, Volume: 28, Issue:2

    Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan

1989
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin

1986
2S,3R 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
    Japanese journal of pharmacology, 1988, Volume: 46, Issue:3

    Topics: Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Leucine; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylbutyrates; Sensory Thresholds

1988
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin

1987
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
    Neuropharmacology, 1986, Volume: 25, Issue:5

    Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin

1986
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin

1987
Comparative studies on morphine- and stress-induced analgesia and the development of tolerance to the effects: implication of protein synthesis mechanism in the process.
    Japanese journal of pharmacology, 1985, Volume: 37, Issue:2

    Topics: Animals; Brain Chemistry; Cycloheximide; Drug Tolerance; Leucine; Male; Mice; Mice, Inbred Strains; Morphine; Nerve Tissue Proteins; Pain; Solubility; Stress, Physiological

1985
In vitro uptake of labelled amino acids by the skin of children with generalized congenital analgesia.
    Nuclear-Medizin, 1969, Apr-15, Volume: 8, Issue:1

    Topics: Autoradiography; Biopsy; Black People; Brazil; Carbon Isotopes; Child, Preschool; Humans; In Vitro Techniques; Leucine; Pain; Pain Insensitivity, Congenital; Skin; Tryptophan; Tyrosine; White People

1969