leucine has been researched along with Ache in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (47.06) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 7 (20.59) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; Liu, Y; Su, T | 1 |
| Fukuda, I; Hasegawa, M; Higashino, K; Hinata, M; Horita, N; Ikeda, M; Imai, M; Imai, S; Kanemasa, T; Minami, M; Morioka, Y; Morita, A; Sakaguchi, G; Sanaki, T; Soga, M; Tsuchida, J; Yamamoto, M; Yamane, S; Yoshioka, T | 1 |
| Bannon, AW; Bespalov, A; Bitner, RS; Chu, KL; Cole, EE; Gauvin, D; Jarvis, MF; Joshi, SK; Lee, CH; Lewis, LG; McGaraughty, S; Mikusa, J; Milicic, I; Neelands, T; Niforatos, W; Pai, M; Roderwald, V; Scott, VE; Searle, XB; Swensen, AM; Vortherms, TA; Xu, J; Zhan, C; Zhang, M; Zhong, C; Zhu, CZ | 1 |
| Abogadie, FC; Bunnett, NW; Darby, B; Grace, MS; Lieu, T; McIntyre, P; Veldhuis, N | 1 |
| Gendron, L; Giddings, AM; Gilmour, BP; Longpre, JM; Olepu, S; Runyon, SP; Sarret, P; Thomas, JB; Warner, KR; Wiethe, RW; Zhang, Y | 1 |
| Azevedo, AO; Caliari, MV; Duarte, ID; Guzzo, LS; Perez, AC; Queiroz-Junior, CM; Romero, TR | 1 |
| Bakhle, YS; de Francischi, JN; Dos Reis, WG; Duarte, ID; Lima, PP; Rezende, RM | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Beck, TW; Conway-Klaassen, JM; Golding, LA; Kruskall, LJ; Stock, MS; Tandy, RD; Young, JC | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Blisnick, T; Desor, D; Dugave, C; Hermitte, V; Messaoudi, M; Rigault, AG; Rougeon, F; Rougeot, C | 1 |
| Balciuniene, I; Juskiene, I; Sabalaite, R | 1 |
| Fantini, L; Morselli-Labate, AM; Pezzilli, R | 1 |
| González, H; Lozano-Chourio, MA; Quero, M; Zambrano, O | 1 |
| Ikeda, T; Matsushima, O; Nakayama, T; Naono, R; Nishimori, T | 1 |
| Marcus, R; Seltzer, S; Stoch, R | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournié-Zaluski, MC; Gacel, G; Roques, BP | 1 |
| Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A | 1 |
| Jeffcoate, WJ | 1 |
| Benson, HA; Macfarlane, BV; Wright, A | 1 |
| Demuth, HU; Inoue, M; Kisara, K; Nylander, I; Ohshima, K; Sakurada, C; Sakurada, T; Silberring, J; Tadano, T; Taira, A; Tan-No, K; Terenius, L | 1 |
| Hassall, DC; Morrow, LA; Watts, DC; Wilson, NH | 1 |
| Havlicek, V; LaBella, FS; Leybin, L; Pinsky, C; Rezek, M | 1 |
| Jakoubek, B; Kraus, M; Pavlík, A; Rehulka, J | 1 |
| Bazian, AS; Brazovskaia, FA; Kruglikov, RI | 1 |
| Gonzalez, JP; Patel, A; Sewell, RD; Smith, HJ; Williams, PS; Yu, Z | 1 |
| Caline, H; Costentin, J; Dourmap, N; Michael-Titus, A; Schwartz, JC | 1 |
| Bourgoin, S; Cesselin, F; Dickenson, AH; Fournié-Zaluski, MC; Hamon, M; Le Bars, D; Roques, BP | 1 |
| Kubota, K; Matsuoka, Y; Satoh, S; Uruno, T | 1 |
| Hill, RG; Hughes, J; Pittaway, KM | 1 |
| Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H | 1 |
| Dickenson, AH; Fournie-Zaluski, MC; Roques, BP; Sullivan, AF | 1 |
| Izumi, R; Kaneto, H; Takahashi, M | 1 |
| Blumen, G; Castro, NM; Maia, JC; Merzel, J; Raw, I; Schmidt, BJ | 1 |
3 review(s) available for leucine and Ache
| Article | Year |
|---|---|
Clinical characteristics of Leucine-rich glioma-inactivated protein 1 antibody-mediated autoimmune encephalitis in a 6-year-old girl: case report and literature reviews.
Topics: Autoimmune Diseases of the Nervous System; Child; Encephalitis; Female; Glioma; Humans; Hyponatremia; Leucine; Pain | 2023 |
Perspectives in the control of chronic pain by nutritional manipulation.
Topics: Animals; Antidepressive Agents; Brain; Chronic Disease; Humans; Leucine; Migraine Disorders; Neurotransmitter Agents; Pain; Phenylalanine; Rats; Sensory Thresholds; Serotonin; Tryptophan | 1981 |
Brain peptides and pain sensation.
Topics: Animals; beta-Lipotropin; Brain Chemistry; Endorphins; Enkephalins; Fluorescent Antibody Technique; Guinea Pigs; Humans; Leucine; Methionine; Mice; Morphine; Narcotics; Pain; Peptides; Radioimmunoassay; Rats | 1980 |
3 trial(s) available for leucine and Ache
| Article | Year |
|---|---|
The effects of adding leucine to pre and postexercise carbohydrate beverages on acute muscle recovery from resistance training.
Topics: Beverages; Creatine Kinase; Dietary Carbohydrates; Double-Blind Method; Female; Humans; L-Lactate Dehydrogenase; Leucine; Male; Muscle Fatigue; Muscle, Skeletal; Pain; Resistance Training; Time Factors; Young Adult | 2010 |
Chemomechanical caries removal for children.
Topics: Anesthesia, Dental; Child; Child, Preschool; Dental Care for Children; Dental Caries; Dental Cavity Preparation; Dental Instruments; Dental Restoration, Permanent; Dentition, Permanent; DMF Index; Glutamic Acid; Humans; Leucine; Lysine; Pain; Tooth, Deciduous; Treatment Outcome | 2005 |
Clinical randomized controlled trial of chemomechanical caries removal (Carisolv).
Topics: Anesthesia, Local; Child; Child Behavior; Cross-Over Studies; Dental Caries; Dental Cavity Preparation; Dental High-Speed Equipment; Female; Glutamic Acid; Humans; Leucine; Lysine; Male; Molar; Pain; Patient Satisfaction; Time Factors; Tooth, Deciduous; Treatment Outcome | 2006 |
28 other study(ies) available for leucine and Ache
| Article | Year |
|---|---|
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic Acid; Leucine; Male; Morpholines; Neurons; Osteoarthritis; Pain; Pain Measurement; Phosphorylation; Pyrroles; Rats; Rats, Sprague-Dawley; Sulfonamides; TRPV Cation Channels | 2018 |
Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models.
Topics: Analgesics; Animals; Azabicyclo Compounds; Calcium Channel Blockers; Disease Models, Animal; Immunohistochemistry; Leucine; Male; Neurons; Nociception; Pain; Patch-Clamp Techniques; Rats, Sprague-Dawley; Spinal Cord | 2014 |
The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo.
Topics: Animals; HEK293 Cells; Humans; Hyperalgesia; Leucine; Male; Mice, Inbred C57BL; Morpholines; Oligopeptides; Pain; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, PAR-2; Sulfonamides; TRPV Cation Channels; Trypsin | 2014 |
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.
Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Kinetics; Leucine; Models, Chemical; Molecular Structure; Pain; Rats; Receptors, Neurotensin; Sulfonamides | 2014 |
Involvement of endogenous opioid peptides in the peripheral antinociceptive effect induced by the coffee specific diterpene kahweol.
Topics: Analgesics; Animals; beta-Endorphin; Coffee; Dinoprostone; Diterpenes; Hyperalgesia; Leucine; Male; Naloxone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Peptides; Pressure; Rats; Rats, Wistar; Skin | 2015 |
The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Immunologic Factors; Inflammation; Injections, Intraventricular; Leucine; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Reaction Time; Sulfonamides; Time Factors | 2009 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidney; Leucine; Male; Membrane Proteins; Molecular Sequence Data; Naltrexone; Neprilysin; Pain; Pain Measurement; Prostate; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Salivary Proteins and Peptides; Spinal Cord; Submandibular Gland; Substance P; Thiorphan; Wounds and Injuries | 2003 |
New approaches for the treatment of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Antibodies, Monoclonal; Cholangiopancreatography, Endoscopic Retrograde; Clinical Trials as Topic; Drug Evaluation, Preclinical; Gabexate; Humans; Imidazoles; Infliximab; Interleukin-10; Leucine; Nutrition Therapy; Pain; Pancreatitis; Pancreatitis, Acute Necrotizing; Practice Guidelines as Topic; Probiotics; Treatment Outcome | 2006 |
Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hexokinase; Hyperalgesia; Leucine; Male; Pain; Pain Measurement; Peptides; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Tachykinins | 2007 |
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; Pain; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1983 |
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Sensory Thresholds; Species Specificity; Thiorphan; Tiopronin | 1983 |
Reversible blockade of retrograde axonal transport in the rat sciatic nerve by vincristine.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axonal Transport; Leucine; Male; Pain; Rats; Rats, Wistar; Sciatic Nerve; Vincristine | 1997 |
Intrathecal administration of p-hydroxymercuribenzoate or phosphoramidon/bestatin-combined induces antinociceptive effects through different opioid mechanisms.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Combinations; Glycopeptides; Hindlimb; Hydroxymercuribenzoates; Injections, Spinal; Leucine; Male; Mice; Mice, Inbred Strains; Naltrexone; Narcotic Antagonists; Pain; Protease Inhibitors; Receptors, Opioid; Time Factors | 1998 |
A chemomechanical method for caries removal.
Topics: Dental Caries; Dental Cavity Preparation; Dental Pulp; Dental Restoration, Permanent; Dentin; Glutamic Acid; Humans; Leucine; Lysine; Pain; Patient Satisfaction | 2000 |
Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats.
Topics: Animals; Humans; Injections, Intraventricular; Leucine; Male; Methionine; Morphine; Nerve Tissue Proteins; Oligopeptides; Pain; Rats; Receptors, Opioid; Structure-Activity Relationship; Substance Withdrawal Syndrome | 1976 |
Uptake of 3H-leucine into the brain and other organs during the conditioned reaction to painful stimulation; effect of diazepam.
Topics: Animals; Brain; Conditioning, Classical; Diazepam; Humans; Leucine; Male; Nerve Tissue Proteins; Organ Specificity; Pain; Rats; Stress, Psychological | 1976 |
[H3-leucine incorporation in neurons of different murine brain structures upon elaboration of a defensive conditioned reflex].
Topics: Animals; Conditioning, Classical; Hippocampus; Leucine; Light; Male; Mice; Nerve Tissue Proteins; Neural Analyzers; Pain; Telencephalon; Visual Cortex | 1976 |
Novel inhibitors of enkephalin-degrading enzymes. II: N5'-substituted-4-thioxohydantoic acids as aminopeptidase inhibitors.
Topics: Aminopeptidases; Analgesics; Animals; Glycine; Indicators and Reagents; Leucine; Mice; Naloxone; Neprilysin; Pain; Proline; Protease Inhibitors; Thiohydantoins; Thiorphan | 1989 |
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J and DBA/2J).
Topics: Analgesics; Animals; Cerebral Ventricles; Enkephalins; Injections, Intraventricular; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Naloxone; Pain; Protease Inhibitors; Reference Values; Species Specificity; Thiorphan | 1989 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain; Rats; Spinal Cord; Thiorphan; Tiopronin | 1986 |
2S,3R 3-amino-2-hydroxy-4-phenylbutanoic acid derivatives, enkephalinase inhibitors, augment met5-enkephalin-induced antinociception.
Topics: Analgesics; Animals; Drug Synergism; Enkephalin, Methionine; Leucine; Male; Metalloendopeptidases; Mice; Mice, Inbred Strains; Neprilysin; Pain; Phenylbutyrates; Sensory Thresholds | 1988 |
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Reaction Time; Sincalide; Tetragastrin; Thiorphan; Tiopronin | 1987 |
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; Norepinephrine; Pain; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Time Factors; Tiopronin | 1986 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural Inhibition; Neurons, Afferent; Pain; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Thiorphan; Tiopronin | 1987 |
Comparative studies on morphine- and stress-induced analgesia and the development of tolerance to the effects: implication of protein synthesis mechanism in the process.
Topics: Animals; Brain Chemistry; Cycloheximide; Drug Tolerance; Leucine; Male; Mice; Mice, Inbred Strains; Morphine; Nerve Tissue Proteins; Pain; Solubility; Stress, Physiological | 1985 |
In vitro uptake of labelled amino acids by the skin of children with generalized congenital analgesia.
Topics: Autoradiography; Biopsy; Black People; Brazil; Carbon Isotopes; Child, Preschool; Humans; In Vitro Techniques; Leucine; Pain; Pain Insensitivity, Congenital; Skin; Tryptophan; Tyrosine; White People | 1969 |