leucamide-a and Stomach-Neoplasms

leucamide-a has been researched along with Stomach-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for leucamide-a and Stomach-Neoplasms

Article	Year
Leucamide A: a new cytotoxic heptapeptide from the Australian sponge Leucetta microraphis. The Journal of organic chemistry, 2002, Jul-12, Volume: 67, Issue:14 Leucamide A (1), a bioactive cyclic heptapeptide containing a unique mixed 4,2-bisheterocycle tandem pair consisting of a methyloxazole and thiazole subunit was isolated together with the known compound BRS1 (2), from the dichloromethane extract of the Australian marine sponge Leucetta microraphis. The planar structure of leucamide A (1) was elucidated by employing spectroscopic techniques (NMR, MS, UV, and IR). Its absolute stereochemistry was established by chemical degradation, derivatization, and chiral GC[bond]MS analysis. A conformational analysis of 1 was made using MMFF. Leucamide A (1) was found to be moderately cytotoxic toward several tumor cell lines. Topics: Amino Acids; Amino Alcohols; Animals; Antineoplastic Agents; Australia; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fatty Alcohols; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Models, Molecular; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Porifera; Stereoisomerism; Stomach Neoplasms	2002

Article

Year

Leucamide A: a new cytotoxic heptapeptide from the Australian sponge Leucetta microraphis.

The Journal of organic chemistry, 2002, Jul-12, Volume: 67, Issue:14

Leucamide A (1), a bioactive cyclic heptapeptide containing a unique mixed 4,2-bisheterocycle tandem pair consisting of a methyloxazole and thiazole subunit was isolated together with the known compound BRS1 (2), from the dichloromethane extract of the Australian marine sponge Leucetta microraphis. The planar structure of leucamide A (1) was elucidated by employing spectroscopic techniques (NMR, MS, UV, and IR). Its absolute stereochemistry was established by chemical degradation, derivatization, and chiral GC[bond]MS analysis. A conformational analysis of 1 was made using MMFF. Leucamide A (1) was found to be moderately cytotoxic toward several tumor cell lines.

Topics: Amino Acids; Amino Alcohols; Animals; Antineoplastic Agents; Australia; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fatty Alcohols; Gas Chromatography-Mass Spectrometry; Humans; Liver Neoplasms; Models, Molecular; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Porifera; Stereoisomerism; Stomach Neoplasms

2002