Page last updated: 2024-10-30

letrozole and Seizures

letrozole has been researched along with Seizures in 4 studies

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with letrozole, an aromatase inhibitor that blocks the conversion of testosterone to 17beta-estradiol, significantly inhibited testosterone-induced exacerbation of seizures."1.32Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol. ( Reddy, DS, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Ledesma-Corvi, S1
García-Fuster, MJ1
Ishihara, Y1
Itoh, K1
Tanaka, M1
Tsuji, M1
Kawamoto, T1
Kawato, S1
Vogel, CFA1
Yamazaki, T1
Iqbal, R1
Jain, GK1
Siraj, F1
Vohora, D1
Reddy, DS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals)[NCT00146146]Phase 315 participants (Actual)Interventional2005-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

4 other studies available for letrozole and Seizures

ArticleYear
Aromatase Inhibition and Electroconvulsive Seizures in Adolescent Rats: Antidepressant and Long-Term Cognitive Sex Differences.
    The international journal of neuropsychopharmacology, 2023, 09-25, Volume: 26, Issue:9

    Topics: Animals; Antidepressive Agents; Aromatase; Cognition; Estrogens; Female; Letrozole; Male; Rats; Rats

2023
Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
    Scientific reports, 2017, 07-24, Volume: 7, Issue:1

    Topics: Animals; Aromatase Inhibitors; Brain; Cerebral Cortex; Dietary Supplements; Docosahexaenoic Acids; E

2017
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.
    Epilepsy research, 2018, Volume: 143

    Topics: Animals; Anticonvulsants; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippoc

2018
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
    Neuroscience, 2004, Volume: 129, Issue:1

    Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Rela

2004