letrozole has been researched along with Seizures in 4 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with letrozole, an aromatase inhibitor that blocks the conversion of testosterone to 17beta-estradiol, significantly inhibited testosterone-induced exacerbation of seizures." | 1.32 | Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol. ( Reddy, DS, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ledesma-Corvi, S | 1 |
| García-Fuster, MJ | 1 |
| Ishihara, Y | 1 |
| Itoh, K | 1 |
| Tanaka, M | 1 |
| Tsuji, M | 1 |
| Kawamoto, T | 1 |
| Kawato, S | 1 |
| Vogel, CFA | 1 |
| Yamazaki, T | 1 |
| Iqbal, R | 1 |
| Jain, GK | 1 |
| Siraj, F | 1 |
| Vohora, D | 1 |
| Reddy, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals)[NCT00146146] | Phase 3 | 15 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for letrozole and Seizures
| Article | Year |
|---|---|
Aromatase Inhibition and Electroconvulsive Seizures in Adolescent Rats: Antidepressant and Long-Term Cognitive Sex Differences.
Topics: Animals; Antidepressive Agents; Aromatase; Cognition; Estrogens; Female; Letrozole; Male; Rats; Rats | 2023 |
Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
Topics: Animals; Aromatase Inhibitors; Brain; Cerebral Cortex; Dietary Supplements; Docosahexaenoic Acids; E | 2017 |
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.
Topics: Animals; Anticonvulsants; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippoc | 2018 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Rela | 2004 |