letrozole has been researched along with Seizures in 4 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Excerpt | Relevance | Reference |
---|---|---|
"Pretreatment with letrozole, an aromatase inhibitor that blocks the conversion of testosterone to 17beta-estradiol, significantly inhibited testosterone-induced exacerbation of seizures." | 1.32 | Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol. ( Reddy, DS, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 2 (50.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Ledesma-Corvi, S | 1 |
García-Fuster, MJ | 1 |
Ishihara, Y | 1 |
Itoh, K | 1 |
Tanaka, M | 1 |
Tsuji, M | 1 |
Kawamoto, T | 1 |
Kawato, S | 1 |
Vogel, CFA | 1 |
Yamazaki, T | 1 |
Iqbal, R | 1 |
Jain, GK | 1 |
Siraj, F | 1 |
Vohora, D | 1 |
Reddy, DS | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals)[NCT00146146] | Phase 3 | 15 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 other studies available for letrozole and Seizures
Article | Year |
---|---|
Aromatase Inhibition and Electroconvulsive Seizures in Adolescent Rats: Antidepressant and Long-Term Cognitive Sex Differences.
Topics: Animals; Antidepressive Agents; Aromatase; Cognition; Estrogens; Female; Letrozole; Male; Rats; Rats | 2023 |
Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid.
Topics: Animals; Aromatase Inhibitors; Brain; Cerebral Cortex; Dietary Supplements; Docosahexaenoic Acids; E | 2017 |
Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice.
Topics: Animals; Anticonvulsants; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Hippoc | 2018 |
Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol.
Topics: Androstane-3,17-diol; Animals; Aromatase Inhibitors; Chromatography; Convulsants; Dose-Response Rela | 2004 |