letrozole has been researched along with Reproductive Sterility in 28 studies
Excerpt | Relevance | Reference |
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"To study the feasibility of a randomized controlled trial (RCT) comparing intrauterine insemination (IUI) with and without letrozole in couples with unexplained or mild male factor infertility STUDY DESIGN: We performed a randomized pilot study including 100 couples with unexplained or mild male factor infertility in the Reproductive Medicine Centre of Peking University Third Hospital in China." | 9.41 | Intrauterine insemination (IUI) with or without letrozole for unexplained or mild male factor infertility: A randomized pilot study. ( Huang, S; Li, N; Li, R; Luo, L; Mol, BWJ; Norman, RJ; Qiao, J; Wang, H; Wang, L; Wang, R; Yan, H, 2021) |
"We aimed to compare the cost effectiveness of letrozole versus purified urinary follicle stimulating hormone (FSH) in treating patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 9.24 | Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. ( Hassan, A; Shehata, N; Wahba, A, 2017) |
"To compare the efficacy of letrozole to recombinant FSH for ovarian stimulation combined with IUI in a group of patients that had failed to conceive after clomiphene citrate (CC) and IUI." | 6.73 | Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intraute ( Botsis, D; Creatsas, GK; Gregoriou, O; Konidaris, S; Papadias, K; Vlahos, NF, 2008) |
" EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT." | 5.69 | Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. ( Al-Hendy, A; Christman, GM; Flaminia, A; Flores, VA; González, F; Huang, H; Johnson, JJ; Segars, J; Siblini, H; Singh, B; Taylor, HS; Zhang, H, 2023) |
"To evaluate the effectiveness and safety of IVF versus expectant management, unstimulated intrauterine insemination (IUI), and IUI with ovarian stimulation using gonadotropins, clomiphene citrate (CC), or letrozole in improving pregnancy outcomes." | 5.41 | In vitro fertilisation for unexplained subfertility. ( Bhattacharya, S; Gibreel, A; Kamath, MS; Pandian, Z; Sunkara, SK, 2023) |
"To study the feasibility of a randomized controlled trial (RCT) comparing intrauterine insemination (IUI) with and without letrozole in couples with unexplained or mild male factor infertility STUDY DESIGN: We performed a randomized pilot study including 100 couples with unexplained or mild male factor infertility in the Reproductive Medicine Centre of Peking University Third Hospital in China." | 5.41 | Intrauterine insemination (IUI) with or without letrozole for unexplained or mild male factor infertility: A randomized pilot study. ( Huang, S; Li, N; Li, R; Luo, L; Mol, BWJ; Norman, RJ; Qiao, J; Wang, H; Wang, L; Wang, R; Yan, H, 2021) |
"We aimed to compare the cost effectiveness of letrozole versus purified urinary follicle stimulating hormone (FSH) in treating patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 5.24 | Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. ( Hassan, A; Shehata, N; Wahba, A, 2017) |
" We included randomized controlled trials (RCTs) comparing IUI-OS with gonadotrophins, letrozole and CC among couples with unexplained infertility." | 5.22 | Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis. ( Cohlen, BJ; D'Hooghe, TM; Danhof, NA; Dankert, T; Diamond, MP; Erdem, M; Legro, RS; Mochtar, MH; Mol, BWJ; Peeraer, K; Showell, M; Thyagaraju, C; van Eekelen, R; van Wely, M; Wang, R; Wessel, JA, 2022) |
"Letrozole produced a comparable pregnancy rate vs." | 5.12 | Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study. ( Jee, BC; Kim, KC; Kim, SH; Ku, SY; Lee, WD; Suh, CS, 2006) |
"A low-cost stimulation protocol that includes letrozole and hMG in normal responders for assisted reproductive technologies resulted in a satisfactory ongoing pregnancy rate." | 5.12 | Preliminary experience with a low-cost stimulation protocol that includes letrozole and human menopausal gonadotropins in normal responders for assisted reproductive technologies. ( Grabia, A; Kopelman, S; Mlayes, L; Papier, S; Pesce, R; Sueldo, C, 2006) |
" We included randomized controlled trials that compared a stimulation regimen with CC, Letrozole or gonadotrophins to each other or to natural cycle IUI among couples with unexplained infertility." | 5.05 | IUI for unexplained infertility-a network meta-analysis. ( Danhof, NA; Mochtar, MH; Mol, BWJ; van der Veen, F; van Wely, M; Wang, R, 2020) |
"To compare the effects of human menopausal gonadotropin (HMG) combined with letrozole (LE) to HMG only for ovarian stimulation on pregnancy outcome of infertile patients undergoing artificial insemination by husband (AIH) due to unexplained or mild male factors." | 4.12 | Retrospective analysis: The application of human menopausal gonadotropin combined with letrozole for IUI in patients undergoing artificial insemination by husband due to unexplained or mild male factors. ( Chen, JQ; Chen, XW; Li, HQ; Lu, XP; Pan, XL; Su, NJ, 2022) |
"We performed ovarian stimulation in 126 women with breast cancer by using letrozole and gonadotropins for the purpose of fertility preservation by embryo or oocyte cryopreservation." | 3.76 | Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks. ( Babayev, SN; Barad, D; Kim, JY; Oktay, K, 2010) |
"Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml." | 2.74 | Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial. ( Chakravarty, B; Chattopadhyay, R; Chaudhury, K; Ganesh, A; Goswami, SK, 2009) |
"To compare the efficacy of letrozole to recombinant FSH for ovarian stimulation combined with IUI in a group of patients that had failed to conceive after clomiphene citrate (CC) and IUI." | 2.73 | Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intraute ( Botsis, D; Creatsas, GK; Gregoriou, O; Konidaris, S; Papadias, K; Vlahos, NF, 2008) |
"Clinical pregnancy was higher in protocols with lax cancellation policies or higher gonadotropin doses, with subsequent increased relative risks of multiple gestations of 1." | 2.66 | Gonadotropins versus oral ovarian stimulation agents for unexplained infertility: a systematic review and meta-analysis. ( DeCherney, AH; Hill, MJ; Lindner, PG; Terry, N; Zolton, JR, 2020) |
"Acne is an off-label use of some COCs." | 1.72 | Female Pelvic Conditions: Polycystic Ovary Syndrome. ( Brady, PH; Gin, GT; Rosenblum, E; Wilkinson, LD, 2022) |
"Pregnancy was recorded as clinical pregnancy with fetal heart activity seen at 6- to 7-week transvaginal ultrasound." | 1.38 | What is the optimal follicular size before triggering ovulation in intrauterine insemination cycles with clomiphene citrate or letrozole? An analysis of 988 cycles. ( Palatnik, A; Robb, P; Strawn, E; Szabo, A, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (25.00) | 29.6817 |
2010's | 5 (17.86) | 24.3611 |
2020's | 16 (57.14) | 2.80 |
Authors | Studies |
---|---|
Wilkinson, LD | 1 |
Brady, PH | 1 |
Gin, GT | 1 |
Rosenblum, E | 1 |
Wessel, JA | 1 |
Danhof, NA | 2 |
van Eekelen, R | 1 |
Diamond, MP | 3 |
Legro, RS | 3 |
Peeraer, K | 1 |
D'Hooghe, TM | 1 |
Erdem, M | 1 |
Dankert, T | 1 |
Cohlen, BJ | 1 |
Thyagaraju, C | 1 |
Mol, BWJ | 3 |
Showell, M | 1 |
van Wely, M | 2 |
Mochtar, MH | 2 |
Wang, R | 3 |
Aramesh, S | 1 |
Azizi Kutenaee, M | 1 |
Najafi, F | 1 |
Ghaffari, P | 1 |
Taghavi, SA | 1 |
Chen, L | 3 |
Jiang, S | 3 |
Xi, Q | 3 |
Li, W | 3 |
Lyu, Q | 3 |
Kuang, Y | 3 |
Li, HQ | 1 |
Pan, XL | 1 |
Su, NJ | 1 |
Lu, XP | 1 |
Chen, JQ | 1 |
Chen, XW | 1 |
Siblini, H | 1 |
Al-Hendy, A | 1 |
Segars, J | 1 |
González, F | 1 |
Taylor, HS | 1 |
Singh, B | 1 |
Flaminia, A | 1 |
Flores, VA | 1 |
Christman, GM | 2 |
Huang, H | 1 |
Johnson, JJ | 1 |
Zhang, H | 3 |
Speer, L | 1 |
Sunkara, SK | 1 |
Kamath, MS | 1 |
Pandian, Z | 1 |
Gibreel, A | 1 |
Bhattacharya, S | 1 |
van der Veen, F | 1 |
Zolton, JR | 1 |
Lindner, PG | 1 |
Terry, N | 1 |
DeCherney, AH | 1 |
Hill, MJ | 1 |
Quaas, AM | 1 |
Gavrizi, SZ | 1 |
Peck, JD | 1 |
Robinson, RD | 1 |
Casson, P | 2 |
Hansen, KR | 1 |
Moustafa, SM | 1 |
Garneau, AS | 1 |
Goodman, LR | 1 |
Amrane, S | 1 |
Vitez, SF | 1 |
Palmerola, KL | 1 |
Lobo, RA | 1 |
Liang, Y | 1 |
Guo, Q | 1 |
Wu, XH | 1 |
Zhang, LN | 1 |
Ge, J | 1 |
Xu, ML | 1 |
Feng, ZL | 1 |
Wu, XQ | 1 |
Huang, S | 1 |
Yan, H | 1 |
Li, N | 1 |
Wang, H | 1 |
Luo, L | 1 |
Wang, L | 1 |
Norman, RJ | 1 |
Li, R | 1 |
Qiao, J | 1 |
Hassan, A | 1 |
Shehata, N | 1 |
Wahba, A | 1 |
Ganesh, A | 1 |
Goswami, SK | 1 |
Chattopadhyay, R | 1 |
Chaudhury, K | 1 |
Chakravarty, B | 1 |
Oktay, K | 1 |
Kim, JY | 1 |
Barad, D | 1 |
Babayev, SN | 1 |
Mitwally, M | 1 |
Casper, R | 1 |
Ager, J | 1 |
Brzyski, R | 1 |
Eisenberg, E | 1 |
Palatnik, A | 1 |
Strawn, E | 1 |
Szabo, A | 1 |
Robb, P | 1 |
Pourmatroud, E | 1 |
Zargar, M | 1 |
Nikbakht, R | 1 |
Moramazi, F | 1 |
Ryan, GL | 1 |
Moss, V | 1 |
Davis, WA | 1 |
Sparks, AE | 1 |
Dokras, A | 1 |
Van Voorhis, BJ | 1 |
Jee, BC | 1 |
Ku, SY | 1 |
Suh, CS | 1 |
Kim, KC | 1 |
Lee, WD | 1 |
Kim, SH | 1 |
Grabia, A | 1 |
Papier, S | 1 |
Pesce, R | 1 |
Mlayes, L | 1 |
Kopelman, S | 1 |
Sueldo, C | 1 |
Gregoriou, O | 1 |
Vlahos, NF | 1 |
Konidaris, S | 1 |
Papadias, K | 1 |
Botsis, D | 1 |
Creatsas, GK | 1 |
Lee, TH | 1 |
Lin, YH | 1 |
Seow, KM | 1 |
Hwang, JL | 1 |
Tzeng, CR | 1 |
Yang, YS | 1 |
Noriega-Portella, L | 1 |
Noriega-Hoces, L | 1 |
Delgado, A | 1 |
Rubio, J | 1 |
Gonzales-Castañeda, C | 1 |
Gonzales, GF | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation[NCT01044862] | Phase 3 | 900 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
Comparison Between Letrozole and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome: A Randomised Controlled Trial[NCT02304107] | Phase 3 | 140 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
"Supplementation of the Luteal Phase With Vaginal Progesterone (Crinone 8%) in Women With Polycystic Ovary Syndrome Undergoing Ovulation Induction With Letrozole: A Prospective and Randomized Controlled Trial"[NCT03440359] | Phase 2/Phase 3 | 52 participants (Actual) | Interventional | 2012-07-06 | Completed | ||
Comparison of Tamoxifen and Clomiphene Citrate in Mild Stimulation IVF: a Prospective Cohort Study[NCT02690870] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | ||
A Scientific & Clinical Review of Minimal Stimulation Protocol Using AROMEK (Letrozole) and Follitrope (Recombinant FSH)Combined With INVOCell(Intravaginal Culturing) - Effectiveness as Low Cost IVF[NCT01058252] | 30 participants (Anticipated) | Observational | 2021-05-31 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT01044862)
Timeframe: Participants were followed for the duration of their treatment and, if pregnant through 6 weeks post-delivery, up to 66 weeks
Intervention | participants (Number) |
---|---|
Aromatase Inhibitors (AI) | 56 |
Clomiphene Citrate (CC) | 70 |
Follicle Stimulating Hormone (FSH) | 97 |
(NCT01044862)
Timeframe: Participants were followed for the duration of their treatment and, if pregnant through 6 weeks post-delivery, up to 66 weeks
Intervention | number of multiples (Number) |
---|---|
Aromatase Inhibitors (AI) | 9 |
Clomiphene Citrate (CC) | 8 |
Follicle Stimulating Hormone (FSH) | 34 |
(NCT01044862)
Timeframe: Participants were followed for the duration of their treatment and, if pregnant through 6 weeks post-delivery, up to 66 weeks
Intervention | participants (Number) |
---|---|
Aromatase Inhibitors (AI) | 85 |
Clomiphene Citrate (CC) | 106 |
Follicle Stimulating Hormone (FSH) | 140 |
(NCT01044862)
Timeframe: Participants were followed for the duration of their treatment and, if pregnant through 6 weeks post-delivery, up to 66 weeks
Intervention | days (Mean) |
---|---|
Aromatase Inhibitors (AI) | 67.2 |
Clomiphene Citrate (CC) | 67.4 |
Follicle Stimulating Hormone (FSH) | 62.3 |
4 reviews available for letrozole and Reproductive Sterility
Article | Year |
---|---|
Ovarian stimulation strategies for intrauterine insemination in couples with unexplained infertility: a systematic review and individual participant data meta-analysis.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility; Infertility, Femal | 2022 |
In vitro fertilisation for unexplained subfertility.
Topics: Abortion, Spontaneous; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vitro; Gonadot | 2023 |
IUI for unexplained infertility-a network meta-analysis.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility; Insemination, Arti | 2020 |
Gonadotropins versus oral ovarian stimulation agents for unexplained infertility: a systematic review and meta-analysis.
Topics: Administration, Oral; Adolescent; Adult; Clomiphene; Female; Fertility; Fertility Agents, Female; Go | 2020 |
13 trials available for letrozole and Reproductive Sterility
Article | Year |
---|---|
Granulocyte colony stimulating factor (GCSF) did not affect the fertility outcomes in women with unexplained infertility after intrauterine insemination: a randomised clinical trial.
Topics: Abortion, Spontaneous; Clomiphene; Cytokines; Female; Fertility; Granulocyte Colony-Stimulating Fact | 2022 |
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
Topics: Adult; Catechin; Clomiphene; Female; Folic Acid; Humans; Infertility; Leiomyoma; Letrozole; Liver; P | 2023 |
Re: Randomized controlled trial of three doses of letrozole for ovulation induction in patients with unexplained infertility. Badawy A, Metwally M, Fawzy M. Reprod Biomed Online. 2007;14(5):559-62.
Topics: Female; Humans; Infertility; Letrozole; Ovulation Induction; Patients | 2023 |
Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes.
Topics: Adolescent; Adult; Clomiphene; Endometrium; Family Characteristics; Female; Fertility Agents, Female | 2021 |
Intrauterine insemination (IUI) with or without letrozole for unexplained or mild male factor infertility: A randomized pilot study.
Topics: China; Female; Humans; Infertility; Infertility, Male; Insemination; Insemination, Artificial; Letro | 2021 |
Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cost-Benefit Analysis; Drug Therapy, Combination; Female; F | 2017 |
Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estradiol; Female; Fertility Age | 2009 |
Estimating rates of multiple gestation pregnancies: sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial.
Topics: Adolescent; Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Double-Blind | 2011 |
A new look at tamoxifen: co-administration with letrozole in intrauterine insemination cycles.
Topics: Adult; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Fertili | 2013 |
Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Combinations; Female; Fertility Agents, Female; Gonado | 2006 |
Preliminary experience with a low-cost stimulation protocol that includes letrozole and human menopausal gonadotropins in normal responders for assisted reproductive technologies.
Topics: Adult; Chemotherapy, Adjuvant; Drug Combinations; Female; Humans; Infertility; Letrozole; Menotropin | 2006 |
Randomized controlled trial comparing superovulation with letrozole versus recombinant follicle-stimulating hormone combined with intrauterine insemination for couples with unexplained infertility who had failed clomiphene citrate stimulation and intraute
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Follicle Stimulating Horm | 2008 |
Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial.
Topics: Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Drug Therapy, Combination; Female; Fertility Ag | 2008 |
11 other studies available for letrozole and Reproductive Sterility
Article | Year |
---|---|
Female Pelvic Conditions: Polycystic Ovary Syndrome.
Topics: Acne Vulgaris; Anovulation; Female; Finasteride; Gonadotropin-Releasing Hormone; Hirsutism; Humans; | 2022 |
Optimal lead follicle size in letrozole human menopausal gonadotrophin intrauterine insemination cycles with and without spontaneous LH surge.
Topics: Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menopause; Menotropins; Ovulation | 2023 |
Optimal lead follicle size in letrozole human menopausal gonadotrophin intrauterine insemination cycles with and without spontaneous LH surge.
Topics: Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menopause; Menotropins; Ovulation | 2023 |
Optimal lead follicle size in letrozole human menopausal gonadotrophin intrauterine insemination cycles with and without spontaneous LH surge.
Topics: Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menopause; Menotropins; Ovulation | 2023 |
Optimal lead follicle size in letrozole human menopausal gonadotrophin intrauterine insemination cycles with and without spontaneous LH surge.
Topics: Female; Humans; Infertility; Insemination, Artificial; Letrozole; Menopause; Menotropins; Ovulation | 2023 |
Retrospective analysis: The application of human menopausal gonadotropin combined with letrozole for IUI in patients undergoing artificial insemination by husband due to unexplained or mild male factors.
Topics: Female; Humans; Infertility; Insemination, Artificial; Letrozole; Male; Menotropins; Pregnancy; Retr | 2022 |
Letrozole More Effective Than Clomiphene for Infertility Treatment Among Individuals With Polycystic Ovary Syndrome.
Topics: Clomiphene; Female; Humans; Infertility; Letrozole; Polycystic Ovary Syndrome | 2023 |
Elusive effect of endometrial thickness: through thick and thin.
Topics: Clomiphene; Gonadotropins; Humans; Infertility; Letrozole; Ovulation Induction; Treatment Outcome | 2021 |
Do lipid parameters change during clomiphene citrate or letrozole therapy in women being treated for infertility? A pilot study.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility; Infertility | 2021 |
Does the additional use of clomiphene citrate or letrozole for in vitro fertilization deserve more attention?
Topics: Administration, Oral; Adult; Clomiphene; Dose-Response Relationship, Drug; Embryo Transfer; Feasibil | 2021 |
Association of BRCA1 mutations with occult primary ovarian insufficiency: a possible explanation for the link between infertility and breast/ovarian cancer risks.
Topics: Adult; Breast Neoplasms; Female; Genes, BRCA1; Humans; Infertility; Letrozole; Mutation; Nitriles; O | 2010 |
What is the optimal follicular size before triggering ovulation in intrauterine insemination cycles with clomiphene citrate or letrozole? An analysis of 988 cycles.
Topics: Adult; Chi-Square Distribution; Chorionic Gonadotropin; Clomiphene; Drug Administration Schedule; Dr | 2012 |
Oral ovulation induction agents combined with low-dose gonadotropin injections and intrauterine insemination: cost- and clinical effectiveness.
Topics: Administration, Oral; Adult; Analysis of Variance; Clomiphene; Cost-Benefit Analysis; Female; Fertil | 2005 |
Effect of letrozole at 2.5 mg or 5.0 mg/day on ovarian stimulation with gonadotropins in women undergoing intrauterine insemination.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Chorionic Gonadotropin; Cost-Benefit Analysis; D | 2008 |