letrozole has been researched along with Primary Ovarian Insufficiency in 5 studies
Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the randomised phase II LEO trial, we investigated the effect of adding everolimus (EVE) to letrozole (LET) in ovarian-suppressed premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) recurrent/metastatic breast cancer." | 9.41 | Leuprorelin combined with letrozole with/without everolimus in ovarian-suppressed premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer: The LEO study. ( Ahn, JH; Cheon, J; Jeong, JH; Jung, KH; Kim, GM; Kim, JE; Kim, SB; Koh, SJ; Lee, KS; Park, IH; Sim, SH; Sohn, J, 2021) |
| "In the randomised phase II LEO trial, we investigated the effect of adding everolimus (EVE) to letrozole (LET) in ovarian-suppressed premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) recurrent/metastatic breast cancer." | 5.41 | Leuprorelin combined with letrozole with/without everolimus in ovarian-suppressed premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer: The LEO study. ( Ahn, JH; Cheon, J; Jeong, JH; Jung, KH; Kim, GM; Kim, JE; Kim, SB; Koh, SJ; Lee, KS; Park, IH; Sim, SH; Sohn, J, 2021) |
| " This article reports a case of successful ovulation induction and pregnancy with letrozole combined with HMG." | 3.96 | Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report. ( Mu, Z; Song, J; Sun, Z; Yu, Y, 2020) |
| "Breast cancer is the most frequent cancer in reproductive age women." | 2.44 | Assisted reproduction and breast cancer. ( Atabekoglu, C; Sonmezer, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, Z | 1 |
| Song, J | 1 |
| Yu, Y | 1 |
| Sun, Z | 1 |
| Jeong, JH | 1 |
| Kim, JE | 1 |
| Ahn, JH | 1 |
| Jung, KH | 1 |
| Koh, SJ | 1 |
| Cheon, J | 1 |
| Sohn, J | 1 |
| Kim, GM | 1 |
| Lee, KS | 1 |
| Sim, SH | 1 |
| Park, IH | 1 |
| Kim, SB | 1 |
| Chen, B | 1 |
| Li, L | 1 |
| Wang, J | 1 |
| Zhou, Y | 1 |
| Zhu, J | 1 |
| Li, T | 1 |
| Pan, H | 1 |
| Liu, B | 1 |
| Cao, Y | 1 |
| Wang, B | 1 |
| Olgan, S | 1 |
| Humaidan, P | 1 |
| Sonmezer, M | 1 |
| Atabekoglu, C | 1 |
1 review available for letrozole and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Assisted reproduction and breast cancer.
Topics: Algorithms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cryopreservation; Embr | 2007 |
1 trial available for letrozole and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Leuprorelin combined with letrozole with/without everolimus in ovarian-suppressed premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer: The LEO study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Everolimus; Female; Follow- | 2021 |
3 other studies available for letrozole and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Female; Gonadotropins; Humans; Infertility, | 2020 |
Identification of the first homozygous POLG mutation causing non-syndromic ovarian dysfunction.
Topics: Adult; DNA Polymerase gamma; DNA-Directed DNA Polymerase; Exome Sequencing; Female; Homozygote; Huma | 2018 |
GnRH antagonist and letrozole co-treatment in diminished ovarian reserve patients: a proof-of-concept study.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Estradiol; Female; Fertility Agents, Female; | 2017 |