letrozole has been researched along with Polycystic Ovarian Syndrome in 300 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of combination treatment of letrozole and clomiphene citrate (CC) in comparison to that of letrozole alone to induce ovulation in infertile women with polycystic ovary syndrome (PCOS)." | 9.69 | A triple-blind, randomized controlled trial, comparing combined letrozole and clomiphene versus only letrozole for ovulation induction in women with polycystic ovarian syndrome. ( Hota, S; Kalidoss, VK; Panda, SR; Sharmila, V, 2023) |
| " In total, 1078 women with PCOS will be randomised (1:1) to the letrozole-stimulated or HRT group in their first FET cycle and their pregnancy and perinatal outcomes during this cycle will be followed up and analysed." | 9.69 | Live birth after letrozole-stimulated cycles versus hormone replacement treatment cycles for the first frozen embryo transfer in women with polycystic ovary syndrome: protocol for a multicentre randomised controlled trial. ( Deng, B; Feng, YR; Gong, F; Li, Y; Lin, G; Ma, Y; Wang, X; Wu, Y; Zhang, C; Zhang, S, 2023) |
| "We conducted a prospective randomised controlled trial to explore the efficacy of clomiphene citrate (CC) and Letrozole (LTZ) for improving fecundity in infertile women with minimal to mild endometriosis after operative laparoscopy." | 9.51 | Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. ( Chen, H; Fu, J; Huang, W; Liu, D; Wang, Q; Yang, S; Zhou, L, 2022) |
| "To estimate the effect of letrozole and clomiphene citrate in women with infertility and polycystic ovarian syndrome (PCOS)." | 9.41 | Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis. ( Geng, Y; Hu, R; Huang, Y; Li, F; Liu, Z; Song, Y; Zhang, M, 2023) |
| "To compare the efficacy of letrozole and clomiphene citrate (CC) for ovulation induction in infertile women with polycystic ovarian syndrome (PCOS)." | 9.41 | Letrozole versus clomiphene citrate for ovulation induction in anovulatory women with polycystic ovarian syndrome: A randomized controlled trial. ( Bansal, S; Goyal, M; Sharma, C; Shekhar, S, 2021) |
| "To compare the effects of letrozole and human menopausal gonadotropin (HMG) in the treatment of patients with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC)." | 9.34 | Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study. ( Chen, L; Hong, T; Huang, X; Jiang, F; Shi, S; Zhuang, Y, 2020) |
| " We have designed a multicenter randomized controlled trial (RCT) to evaluate whether personalized or fixed acupuncture increases the likelihood of live births in infertile women with polycystic ovary syndrome (PCOS) compared with letrozole or placebo letrozole." | 9.34 | A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome. ( Gao, X; Hu, M; Hu, R; Hu, Z; Huang, S; Lai, M; Li, J; Li, S; Liang, X; Liu, J; Ma, H; Ng, EHY; Qiao, J; Quan, K; Shang, H; Stener-Victorin, E; Wang, C; Wang, X; Wen, Q; Wen, X; Xia, T; Zheng, Y, 2020) |
| "Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin (HMG) for endometrial preparation compared with routine AC-FET." | 9.34 | The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial. ( Farid Mojtahedi, M; Hosseini-Najarkolaee, E; Hosseini-Najarkolaei, A; Kashani, L; Moini, A; Salehi, E, 2020) |
| "To evaluate whether a combination of letrozole and clomiphene citrate (CC) results in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)." | 9.30 | A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. ( Kresowik, JD; Mejia, RB; Summers, KM; Van Voorhis, BJ, 2019) |
| "The purpose is a comparison of effectiveness of myo-inositol and metformin in infertile women with polycystic ovary syndrome (PCOS) treated with letrozole." | 9.30 | The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. ( Bazarganipour, F; Kutenaee, MA; Pourghasem, S; Taghavi, SA, 2019) |
| "This is a randomized non-blinded controlled trial study that included 80 infertile females with polycystic ovarian syndrome receiving a standard dose of either clomiphene citrate or letrozole on day 2 of the cycle." | 9.30 | Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome. ( Al-Aubaidy, H; Al-Obaidi, MT; Al-Saadi, WI; Al-Wasiti, EAR; Ali, ZH, 2019) |
| "The aim of the study was to compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity for ovulation induction in women with polycystic ovary syndrome (PCOS)." | 9.30 | Comparison of endometrial receptivity of clomiphene citrate versus letrozole in women with polycystic ovary syndrome: a randomized controlled study. ( Lv, S; Wang, L; Wen, X; Yang, T; Yang, X; Zhao, J, 2019) |
| "A total of 202 patients with clomiphene citrate (CC) -resistant polycystic ovary syndrome (PCOS) were randomly allocated into two arms of induction of ovulation; the first group (n = 102) received CC 100 mg and metformin 500 mg while the second group (n = 100) received letrozole 2." | 9.27 | Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. ( Rezk, M; Saif El-Nasr, I; Shaheen, AE, 2018) |
| "To compare the therapeutic efficacy of clomiphene citrate (CC) and letrozole (LE) on ovulation, pregnancy, and live birth in women with polycystic ovary syndrome (PCOS); and to ensure if LE can replace CC as the first-line therapy for ovulation induction in these women." | 9.24 | Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial. ( Feng, G; Fu, J; Huang, W; Liu, C; Liu, D; Tan, J; Wang, Q; Yang, S, 2017) |
| "We aimed to compare the cost effectiveness of letrozole versus purified urinary follicle stimulating hormone (FSH) in treating patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 9.24 | Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. ( Hassan, A; Shehata, N; Wahba, A, 2017) |
| "Letrozole appears to improve live birth rates and pregnancy rates in infertile women with anovulatory PCOS, compared to SERMs, when used for ovulation induction, followed by intercourse." | 9.22 | Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome. ( Farquhar, C; Franik, S; Kiesel, L; Kremer, JA; Le, QK, 2022) |
| "To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE." | 9.22 | [Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.] ( Chen, Y; Zhang, D, 2016) |
| "To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate." | 9.22 | A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016) |
| "To study whether a combination of berberine and letrozole results in higher live births than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)." | 9.22 | Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. ( Liang, RN; Liu, JP; Ma, HX; Ng, EH; Shao, XG; Wang, YY; Wu, XK; Xue, HY, 2016) |
| "Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes." | 9.19 | Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. ( Alvero, R; Baker, V; Barnhart, KT; Bates, GW; Brzyski, RG; Casson, P; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Haisenleder, DJ; Huang, H; Krawetz, SA; Legro, RS; Lucidi, S; Ohl, D; Santoro, N; Schlaff, WD; Snyder, P; Trussell, JC; Usadi, R; Yan, Q; Zhang, H, 2014) |
| "The aim of the present study was to investigate the clinical value of low‑dose aspirin in combination with Tiao Jing Cu Yun pills in patients with polycystic ovary syndrome (PCOS) by measuring follicular peripheral blood flow parameters and the clinical efficacy." | 9.19 | Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome. ( Du, B; Jiang, X; Ma, M; Shi, L; Zhang, Q; Zhao, Y; Zhou, L, 2014) |
| " In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients." | 9.17 | Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome. ( Dehghan, M; Ghasemi-Rad, M; Hajishafiha, M; Kiarang, N; Sadegh-Asadi, N; Shayegh, SN, 2013) |
| "To compare the hormonal-metabolic profiles and reproductive outcomes between women receiving metformin plus letrozole and women undergoing bilateral ovarian drilling in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS)." | 9.17 | Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome. ( Abd Elgafor, I, 2013) |
| "The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin." | 9.16 | Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome. ( Banerjee Ray, P; Chakraborti, PS; Ray, A, 2012) |
| "To compare the clinical outcomes of letrozole and laparoscopic ovarian drilling (LOD) in patients with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS)." | 9.15 | Reproductive outcome after letrozole versus laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome. ( Abdellah, MS, 2011) |
| "To compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity in women with polycystic ovary syndrome (PCOS)." | 9.15 | Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome. ( Hines, R; Johnson, V; Sopelak, V; Wallace, KL, 2011) |
| "To evaluate the outcome of long letrozole therapy for induction of ovulation in patients with clomiphene-resistant polycystic ovary syndrome (PCOS)." | 9.14 | Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol. ( Badawy, A; Eid, M; Mosbah, A; Tharwat, A, 2009) |
| "To compare the effect of letrozole with laparoscopic ovarian diathermy (LOD) for ovulation induction in clomiphene citrate (CC) resistant women with polycystic ovary syndrome (PCOS)." | 9.14 | Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. ( Abu Hashim, H; Badawy, A; Mashaly, AM, 2010) |
| "Meta-analysis was used to evaluate the efficacy and safety of aspirin combined with letrozole in the treatment of polycystic ovary syndrome (PCOS)." | 9.12 | Effectiveness and safety of aspirin combined with letrozole in the treatment of polycystic ovary syndrome: a systematic review and meta-analysis. ( Su, F; Wang, M; Wang, Z; Yu, Q, 2021) |
| "The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 9.01 | Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. ( Cheng, G; Hu, S; Wang, Y; Xia, W; Yu, Q; Zhu, C, 2019) |
| "Letrozole appears to improve live birth and pregnancy rates in subfertile women with anovulatory polycystic ovary syndrome, compared to clomiphene citrate." | 8.98 | Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. ( Eltrop, SM; Farquhar, C; Franik, S; Kiesel, L; Kremer, JA, 2018) |
| "The objective of the present systematic review and meta-analysis was to examine the literature and to identify the results of randomized controlled trials (RCTs) comparing the use of letrozole to clomiphene citrate (CC) for ovulation induction in patients with polycystic ovary syndrome (PCOS)." | 8.91 | Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. ( Geber, S; Roque, M; Sampaio, M; Tostes, AC; Valle, M, 2015) |
| "Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women." | 8.90 | The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). ( Nathan, N; Sullivan, SD, 2014) |
| "The aim of this study was to systematically compare the clinical efficacy and safety of letrozole with clomiphene citrate for ovulation induction in women with polycystic ovary syndrome (PCOS)." | 8.87 | Meta-analysis of letrozole versus clomiphene citrate in polycystic ovary syndrome. ( He, D; Jiang, F, 2011) |
| "To evaluate whether extending letrozole (LE) treatment duration could induce ovulation in women with polycystic ovary syndrome (PCOS) who previously failed to ovulate after a 5-day regimen of 5 mg LE daily for at least 1 ovulation induction cycle, defined as "LE resistance"." | 8.31 | Extending letrozole treatment duration is effective in inducing ovulation in women with polycystic ovary syndrome and letrozole resistance. ( Fu, Y; Zhu, X, 2023) |
| "The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS)." | 8.31 | Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome. ( Han, YI; Jeong, HG; Kim, T; Lee, HJ; Nam, S; Park, H; Ryu, KJ, 2023) |
| "No studies have been conducted on the impact of different types of ovulatory dysfunction on the outcomes of frozen-thawed embryo transfers (FETs) in a letrozole-stimulated cycle in women with polycystic ovarian syndrome (PCOS)." | 8.31 | Comparison of pregnancy outcomes of letrozole-induced frozen-thawed embryo transfer cycles in PCOS women with two different abnormal ovulation patterns: A retrospective cohort study. ( Cao, JX; Hou, JW; Jiang, WJ; Song, JY; Sun, ZG; Wang, DD; Yan, MH, 2023) |
| "To assess efficacy of adjuvant dexamethasone during letrozole cycles for ovulation induction (OI) in women with letrozole-resistant polycystic ovary syndrome (PCOS)." | 8.31 | Ovulation induction with letrozole and dexamethasone in infertile patients with letrozole-resistant polycystic ovary syndrome. ( Babayev, SN; Baumgarten, SC; Neblett, MF; Shenoy, CC, 2023) |
| "This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS." | 8.31 | Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet. ( Gao, L; Jiang, M; Pan, L; Sun, C; Tan, Y; Wang, E; Yang, J; Yao, F; Yao, J, 2023) |
| " The aim of this study was to investigate the effect of LDS on dyslipidemia and hepatic inflammation in rats with letrozole (LET)-induced PCOS and to assess the possible involvement of PCSK9 in these effects." | 8.31 | Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome. ( Agbana, RD; Ajadi, IO; Areloegbe, SE; Areola, ED; Atuma, CL; Fafure, AA; Olaniyi, KS; Olatunji, LA; Sabinari, IW; Shah, MZUH, 2023) |
| "Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction." | 8.31 | Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023) |
| " The rats with polycystic ovary syndrome (PCOS) that were induced by Letrozole exhibited increased levels of urea and creatinine." | 8.31 | Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome. ( Boyina, R; Bukke, SPN; Hussaini, B; Karumanchi, SK; Manchikalapati, B; Marri, J; Odoma, S; Pathange, BBR; Rachamsetty, K, 2023) |
| "The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 8.12 | Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022) |
| " In this regard, studies have demonstrated that Aloe vera gel has the potential to modulate steroidogenic activity in letrozole induced polycystic ovary syndrome (PCOS) rat." | 8.12 | Partially purified non-polar phytocomponents from Aloe barbadensis Mill. gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary syndrome rodent model- an "in-vivo" study. ( Dey, A; Dhadhal, S; Maharjan, R; Nagar, PS; Nampoothiri, L, 2022) |
| " Interestingly, naringenin supplementation significantly reduced body weight, ameliorated hormone levels, improved insulin resistance, and mitigated pathological changes in ovarian tissue, up-regulated the expression of PGC-1ɑ, SIRT1, occludin and claudin-1 in colon." | 8.12 | Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome. ( An, T; Bao, XL; Gao, L; Han, BS; Hu, YY; Jiang, GJ; Lian, J; Lv, BH; Wang, TY; Wu, YX; Yang, XY, 2022) |
| "This study aims to investigate the effects of a high-fat, high-fructose (HF/HFr) diet on metabolic/endocrine dysregulations associated with letrozole (LET)-induced Polycystic Ovarian Syndrome (PCOS) in prepubertal female mice." | 8.12 | The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice. ( Bajerska, J; Kołodziejski, PA; Pieczyńska, JM; Pruszyńska-Oszmałek, E; Łukomska, A, 2022) |
| "The impact of low-dose spironolactone (LSPL) on polycystic ovarian syndrome (PCOS)-associated cardio-renal disorder is unknown." | 8.12 | Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model. ( Akintayo, CO; Areloegbe, SE; Aturamu, A; Olaniyi, KS; Oniyide, AA; Peter, MU, 2022) |
| "Altogether, the present study suggests that low-dose spironolactone confers protection against adipose dysfunction in experimental PCOS animals by attenuating inflammation, oxidative stress and cellular apoptosis." | 8.12 | Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model. ( Areloegbe, SE; Olaniyi, KS; Oyeleke, MB; Peter, MU, 2022) |
| "To investigate the efficacy of oral letrozole (LE) starting on day 3 or 5 of the menstrual cycle in patients with polycystic ovary syndrome (PCOS)." | 8.12 | Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome. ( Chen, Y; Gao, M; Jin, X; Shi, L; Ye, S; Zhang, Z, 2022) |
| "The beneficial effects of metformin, especially its capacity to ameliorate insulin resistance (IR) in polycystic ovary syndrome (PCOS), explains why it is widely prescribed." | 8.02 | Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance. ( Li, S; Xiao, L; Xie, Y, 2021) |
| " deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats." | 8.02 | Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats. ( Goh, YM; Hashim, N; Haslan, MA; Samsulrizal, N; Shirazi, FH; Zin, NSNM, 2021) |
| " Liraglutide has favourable neuroprotective effects that may protect against the possible cognitive dysfunction in PCOS." | 8.02 | Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome. ( Abdel Salam, RM; Ahmed, MAE; Eltarzy, MA; Saad, MA, 2021) |
| "This study aimed to investigate the impact of letrozole use during frozen embryo transfer cycles on obstetrical and perinatal outcomes of singleton and twin pregnancies compared with artificial frozen cycles among women with polycystic ovary syndrome." | 8.02 | Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome. ( Bian, X; Mao, X; Wang, B; Wei, M; Wu, L; Zhang, J; Zhang, S, 2021) |
| "This study investigated the effects of proanthocyanidins (PCs) on ovarian fibrosis in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 8.02 | Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole-induced polycystic ovary syndrome in rats. ( Cao, W; Dong, Z; Lan, H; Song, JL; Zeng, Z; Zhou, Y, 2021) |
| "We sought to compare the efficacy of the letrozole (LTZ) stair-step protocol with clomiphene citrate (CC) stair-step protocol in the management of 150 mg dose of CC-resistant polycystic ovary syndrome (PCOS) patients." | 8.02 | Comparison of the efficacy of letrozole stair-step protocol with clomiphene citrate stair-step protocol in the management of clomiphene citrate-resistant polycystic ovary syndrome patients. ( Oğlak, SC; Sakar, MN, 2021) |
| "The present study was conducted to investigate the therapeutic effects of a potent polyphenol, fisetin, on the letrozole-induced rat model of polycystic ovary syndrome (PCOS)." | 8.02 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021) |
| "The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate." | 7.96 | A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrateresistant polycystic ovary syndrome - a retrospective study. ( Bademkıran, MH; Ege, S; Hançer Çaça, FN; Özçelik, SM; Peker, N; Tahaoğlu, AE, 2020) |
| "Children of women with polycystic ovary syndrome who conceived with letrozole (LTZ) or clomiphene (CC) in the PPCOS II study or women with unexplained infertility (AMIGOS study) who conceived with LTZ, CC, or gonadotropin (GN)." | 7.96 | Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. ( Alvero, R; Baker, V; Barnhart, KT; Casson, P; Cedars, MI; Christman, GM; Coutifaris, C; Coward, RM; Diamond, MP; Dodson, WC; Eisenberg, E; Estes, SJ; Hansen, KR; Huang, H; Krawetz, SA; Kunselman, A; Legro, RS; Robinson, R; Rosen, RM; Santoro, N; Schlaff, WD; Stetter, C; Trussell, JC; Usadi, R; Zhang, H, 2020) |
| "BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model." | 7.96 | Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways. ( Dun, J; Huang, L; Huang, M; Ji, F; Lin, Q; Lin, Y; Xu, J; Yang, J; You, X; Zhang, J, 2020) |
| "To investigate whether live birth rate (LBR) following frozen-thawed embryo transfer in letrozole-stimulated cycles (L-FET) differs from LBR after artificial-cycle frozen-thawed embryos transfers (AC-FET) in women with polycystic ovary syndrome (PCOS)." | 7.91 | Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. ( Chen, Q; Fan, Y; Kuang, Y; Liu, H; Mao, X; Wang, Y; Xiao, Y; Zhang, J, 2019) |
| " The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women." | 7.88 | Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. ( Abid, A; Afsar, T; Almajwal, A; Jahan, S; Khalid, S; Razak, S; Shaheen, G, 2018) |
| "BACKGROUND Women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) are given letrozole before a trigger injection of human chorionic gonadotropin (hCG) to lower estrogen (E2) levels, but can experience ovarian hyperstimulation syndrome (OHSS)." | 7.88 | A Retrospective Study of Letrozole Treatment Prior to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization at Risk of Ovarian Hyperstimulation Syndrome. ( Chen, Y; Hao, C; Yang, T; Zhao, J, 2018) |
| "This retrospective study investigated the efficacy and safety of letrozole for patients with polycystic ovary syndrome (PCOS)." | 7.88 | Letrozole for patients with polycystic ovary syndrome: A retrospective study. ( Guang, HJ; Li, F; Shi, J, 2018) |
| "Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat." | 7.85 | Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome. ( Benrick, A; Carlström, M; Cushman, SW; Fornes, R; Hu, M; Ivarsson, N; Maciel, GAR; Maliqueo, M; Marcondes, RR; Stener-Victorin, E; Stenkula, KG, 2017) |
| " The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance." | 7.85 | Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017) |
| " Polycystic ovary syndrome was induced by letrozole administration, and animals presented with obesity, sex hormone disorder, no ovulation, large cystic follicles, and increasing fasting insulin (FINS) and leptin levels." | 7.85 | Effects of Exercise Intervention on Preventing Letrozole-Exposed Rats From Polycystic Ovary Syndrome. ( Cao, SF; Hu, WL; Jiang, LY; Wu, MM, 2017) |
| "The present study examines the effect of soy isoflavones on letrozole-induced polycystic ovary syndrome (PCOS) rat model." | 7.85 | Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism. ( Balaji, B; M, SS; Rajan, RK, 2017) |
| "To explore the effect of compound malt pills (CMP) on polycystic ovarian syndrome (PCOS) rat model induced by letrozole and the underlying mechanisms." | 7.83 | [Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome]. ( Chen, R; Lan, N; Wang, S; Yang, Y, 2016) |
| "The aims of the current study were to examine the effects of temporal changes in oxidative stress (OS) and low-grade inflammation in letrozole-treated rats and to correlate these changes with the development of polycystic ovary syndrome (PCOS)-like features." | 7.83 | Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat. ( Krishna, A; Pandey, U; Pandey, V; Singh, A; Tripathi, YB, 2016) |
| " First, letrozole was used to induce the PCOS model, 24 h food intake, 24 h body weight changes and the expression of p-STAT3 were determined following leptin or artificial cerebrospinal fluid (aCSF) icv injection in rats." | 7.83 | Central leptin resistance and hypothalamic inflammation are involved in letrozole-induced polycystic ovary syndrome rats. ( Lian, Y; Wang, W; Zhao, F, 2016) |
| "To study the efficiency of letrozole, an aromatase inhibitor, in endometrial preparation for cryopreserved-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS)." | 7.80 | Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study. ( Chen, YZ; Hu, YJ; Huang, HF; Zhu, YM, 2014) |
| "The objective was to evaluate ovarian functionality and oxidative response in hyperandrogenism-induced polycystic ovary (PCO) and the protective effects of immunomodulator drug (IMOD), an electromagnetically-treated, selenium-based, herbal medicine." | 7.78 | Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary. ( Abdollahi, M; Ahmadi, A; Baeeri, M; Rezvanfar, MA; Shojaei-Saadi, HA, 2012) |
| "To determine the effect of intravaginal micronized P on pregnancy rates in clomiphene citrate and letrozole ovulation induction cycles in women with polycystic ovary syndrome (PCOS)." | 7.76 | Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction. ( Aubuchon, M; Khabbaz, M; Montville, CP; Thomas, MA; Williams, DB, 2010) |
| "To investigate the effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome (PCOS)." | 7.74 | [Effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome]. ( Li, H; Quan, S; Song, YL; Xing, FQ; Yang, MQ, 2008) |
| "Letrozole induction of ovulation in clomiphene citrate-resistant women with polycystic ovary syndrome is associated with an ovulation rate of 54." | 7.73 | Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio. ( Eldosoky, M; Elnashar, A; Fouad, H; Saeid, N, 2006) |
| " The aim of the study was to evaluate the effectiveness and efficacy of letrozole and clomiphene citrate (CC) combined with human menopausal gonadotropin (HMG) in CC-resistant infertile women with PCOS." | 6.80 | Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study. ( Liu, S; Lu, X; Mao, H; Xi, W; Xue, X; Yang, Y, 2015) |
| "letrozole for 5 treatment cycles (or approximately up to 25 weeks)." | 6.77 | The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. ( Brzyski, RG; Casson, PR; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Kunselman, AR; Legro, RS; Santoro, N; Schlaff, WD; Taylor, HS; Zhang, H, 2012) |
| "Polycystic ovary syndrome is a common disease that is closely related to ovulation dysfunction and 7% of women of childbearing age are afflicted with it." | 6.77 | Comparison of the effects of letrozole and clomiphene citrate for ovulation induction in infertile women with polycystic ovary syndrome. ( Nahid, L; Sirous, K, 2012) |
| "PCOS patients with an increased LH/FSH ratio, AMH, FAI, and late menarche may need an increased dosage of LET for a treatment response, which could be helpful in designing a personalized treatment strategy." | 5.91 | Predictors of response to ovulation induction using letrozole in women with polycystic ovary syndrome. ( Chen, S; Chen, Z; Guo, Z; Hao, Y; Hu, P; Yu, Q, 2023) |
| "Icariin-treated rats had lower weight gain and reduced triglycerides, fasting insulin, HOMA-IR, TNF-α, and interleukin-6 with higher high-density lipoprotein cholesterol levels than PCOS rats." | 5.91 | Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. ( Hai, Y; Huang, X; Ke, X; Li, P; Li, X; Ren, L; Tian, J; Wang, J; Wang, M; Zhang, R; Zuo, B; Zuo, L, 2023) |
| "Quercetin treatment reversed the molecular, functional and morphological abnormalities brought on due to letrozole in pathological and physiological setting, particularly the issues of reproduction connected to PCOS." | 5.91 | Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome. ( Al-Jafary, MA; Al-Qhtani, MH; Al-Suhaimi, EA; Ansari, MA; Bashir, SM; Ganie, MA; Homeida, AM; Mir, MA; Rather, GA; Shafi, M; Shah, MZUH; Sheikh, WM; Shrivastva, VK, 2023) |
| "8." | 5.91 | Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study. ( Cai, S; Gong, F; Guo, H; Li, X; Li, Y; Lin, G; Ma, S; Peng, Y; Tan, H; Tang, Y; Wang, X; Zhang, S, 2023) |
| " This study aimed to investigate the effect of letrozole and metformin combined with targeted nursing on ovarian function, LH, and FSH in infertile patients with PCOS." | 5.72 | The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome. ( Jiang, S; Li, R; Sheng, Y; Tang, T; Xu, H, 2022) |
| " These isoflavones generally have low solubility resulting in low bioavailability and bioactivity." | 5.72 | Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats. ( Acharya, S; Bulsara, J; Desai, S; Halpati, K; Patil, P; Soni, A, 2022) |
| "Letrozole (1 mg/kg/day) was administered to female Sprague-Dawley (SD) rats for 21 days to induce PCOS." | 5.72 | Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats. ( Ibrahim, SF; Kamal, DAM; Mokhtar, MH; Ugusman, A; Zaid, SSM, 2022) |
| "To evaluate the efficacy of combination treatment of letrozole and clomiphene citrate (CC) in comparison to that of letrozole alone to induce ovulation in infertile women with polycystic ovary syndrome (PCOS)." | 5.69 | A triple-blind, randomized controlled trial, comparing combined letrozole and clomiphene versus only letrozole for ovulation induction in women with polycystic ovarian syndrome. ( Hota, S; Kalidoss, VK; Panda, SR; Sharmila, V, 2023) |
| " In total, 1078 women with PCOS will be randomised (1:1) to the letrozole-stimulated or HRT group in their first FET cycle and their pregnancy and perinatal outcomes during this cycle will be followed up and analysed." | 5.69 | Live birth after letrozole-stimulated cycles versus hormone replacement treatment cycles for the first frozen embryo transfer in women with polycystic ovary syndrome: protocol for a multicentre randomised controlled trial. ( Deng, B; Feng, YR; Gong, F; Li, Y; Lin, G; Ma, Y; Wang, X; Wu, Y; Zhang, C; Zhang, S, 2023) |
| "The letrozole-treated mice showed a disrupted estrous cycle and were arrested in the diestrus phase." | 5.62 | Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice. ( Chen, CW; Chen, KH; Chen, LK; Ho, CH; Hwang, JL; Juan, CC; Liu, PS; Seow, KM; Wang, PH, 2021) |
| "The effective treatment of polycystic ovary syndrome (PCOS)-related hormonal disorders necessitates the development of novel treatment strategies." | 5.62 | Beneficial phytoestrogenic effects of resveratrol on polycystic ovary syndromein rat model. ( Chen, L; Gai, S; Li, F; Liu, X; Shan, Y; Wang, S; Zhang, N; Zhao, D; Zhuang, L, 2021) |
| "A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)." | 5.62 | Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021) |
| "Letrozole was associated with significantly higher clinical pregnancy (38." | 5.62 | Letrozole as first-line drug for ovulation induction in treatment-naïve infertile polycystic ovarian syndrome women. ( Joseph, T; Kamath, MS; Kunjummen, AT; Rebekah, G; Waanbah, BD, 2021) |
| "Spironolactone (SPL) is a mineralocorticoid receptor (MR) blocker that has been in wide clinical use for some decades." | 5.56 | Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe. ( Adeyanju, OA; Agbana, RD; Falodun, TO; Michael, OS; Oyewole, AL; Soetan, OA, 2020) |
| " The methods for establishing PCOS-IR animal model include using dehydroepiandrosterone (DHEA) and sodium prasterone sulfate subcutaneous injection, testosterone propionate combined with high-fat diet, and so on." | 5.56 | A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet. ( Wang, MX; Xu, X; Yin, Q, 2020) |
| "Letrozole (1 mg/kg) was administered orally for a period of 28 days to induce PCOS." | 5.56 | The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. ( Ekramzadeh, M; Golmakani, MT; Koohpeyma, F; Sherafatmanesh, S; Tanideh, N, 2020) |
| "Considering the presence of sexual dysfunction in patients with polycystic ovary syndrome, our aim was to provide scientific evidence studying effect of oral probiotic on sexual function in patients with PCOS treated with letrozole in an Iranian population." | 5.51 | Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial. ( Azizi-Kutenaee, M; Bazarganipour, F; Heidari, S; Taghavi, SA, 2022) |
| "We conducted a prospective randomised controlled trial to explore the efficacy of clomiphene citrate (CC) and Letrozole (LTZ) for improving fecundity in infertile women with minimal to mild endometriosis after operative laparoscopy." | 5.51 | Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. ( Chen, H; Fu, J; Huang, W; Liu, D; Wang, Q; Yang, S; Zhou, L, 2022) |
| "Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population." | 5.51 | Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin. ( AbdelMaksoud, S; El-Bahy, AA; Handoussa, H; Khaled, N; Radwan, R, 2019) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 5.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| "Letrozole was administered orally (1 mg kg-1) to induce PCOS condition in Wistar female rats for a period of 2-3 weeks followed by a dose of melatonin (200 µg/100 g b." | 5.48 | Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat. ( Ahmad Hajam, Y; Basheer, M; Ghosh, H; Rai, S, 2018) |
| "Letrozole is a nonsteroidal aromatase inhibitor that is used in experimental research to induce PCOS." | 5.46 | Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats. ( Akbari, M; Aliabadi, E; Keshtgar, S; Mirkhani, H; Mortezaee, K; Namavar, MR; Rastegar, T; Solhjoo, S; Toolee, H, 2017) |
| "Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness." | 5.43 | The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. ( Kelley, ST; Rivera, AJ; Skarra, DV; Thackray, VG, 2016) |
| "Metformin was also given as a standard control to one of the rat groups." | 5.43 | Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. ( Afsar, T; Ain, QU; Almajwal, A; Jahan, S; Mehboob, A; Munir, F; Razak, S; Shaheen, G; Ullah, H, 2016) |
| "To estimate the effect of letrozole and clomiphene citrate in women with infertility and polycystic ovarian syndrome (PCOS)." | 5.41 | Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis. ( Geng, Y; Hu, R; Huang, Y; Li, F; Liu, Z; Song, Y; Zhang, M, 2023) |
| "To compare the efficacy of letrozole and clomiphene citrate (CC) for ovulation induction in infertile women with polycystic ovarian syndrome (PCOS)." | 5.41 | Letrozole versus clomiphene citrate for ovulation induction in anovulatory women with polycystic ovarian syndrome: A randomized controlled trial. ( Bansal, S; Goyal, M; Sharma, C; Shekhar, S, 2021) |
| "The letrozole model group is a good animal model for the study of AMH in PCOS patients with obesity or insulin resistance." | 5.40 | Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome. ( Du, DF; Du, MR; Fang, F; Li, XL, 2014) |
| "Letrozole is a potent, nonsteroidal, aromatase inhibitor, originally used for postmenopausal breast cancer therapy, at present its only registered indication." | 5.37 | Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. ( Casper, RF; Mitwally, MF, 2011) |
| "To compare the effects of letrozole and human menopausal gonadotropin (HMG) in the treatment of patients with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC)." | 5.34 | Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study. ( Chen, L; Hong, T; Huang, X; Jiang, F; Shi, S; Zhuang, Y, 2020) |
| " We have designed a multicenter randomized controlled trial (RCT) to evaluate whether personalized or fixed acupuncture increases the likelihood of live births in infertile women with polycystic ovary syndrome (PCOS) compared with letrozole or placebo letrozole." | 5.34 | A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome. ( Gao, X; Hu, M; Hu, R; Hu, Z; Huang, S; Lai, M; Li, J; Li, S; Liang, X; Liu, J; Ma, H; Ng, EHY; Qiao, J; Quan, K; Shang, H; Stener-Victorin, E; Wang, C; Wang, X; Wen, Q; Wen, X; Xia, T; Zheng, Y, 2020) |
| "Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin (HMG) for endometrial preparation compared with routine AC-FET." | 5.34 | The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial. ( Farid Mojtahedi, M; Hosseini-Najarkolaee, E; Hosseini-Najarkolaei, A; Kashani, L; Moini, A; Salehi, E, 2020) |
| "To evaluate whether a combination of letrozole and clomiphene citrate (CC) results in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)." | 5.30 | A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome. ( Kresowik, JD; Mejia, RB; Summers, KM; Van Voorhis, BJ, 2019) |
| "The purpose is a comparison of effectiveness of myo-inositol and metformin in infertile women with polycystic ovary syndrome (PCOS) treated with letrozole." | 5.30 | The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole. ( Bazarganipour, F; Kutenaee, MA; Pourghasem, S; Taghavi, SA, 2019) |
| "This is a randomized non-blinded controlled trial study that included 80 infertile females with polycystic ovarian syndrome receiving a standard dose of either clomiphene citrate or letrozole on day 2 of the cycle." | 5.30 | Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome. ( Al-Aubaidy, H; Al-Obaidi, MT; Al-Saadi, WI; Al-Wasiti, EAR; Ali, ZH, 2019) |
| "The aim of the study was to compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity for ovulation induction in women with polycystic ovary syndrome (PCOS)." | 5.30 | Comparison of endometrial receptivity of clomiphene citrate versus letrozole in women with polycystic ovary syndrome: a randomized controlled study. ( Lv, S; Wang, L; Wen, X; Yang, T; Yang, X; Zhao, J, 2019) |
| "A total of 202 patients with clomiphene citrate (CC) -resistant polycystic ovary syndrome (PCOS) were randomly allocated into two arms of induction of ovulation; the first group (n = 102) received CC 100 mg and metformin 500 mg while the second group (n = 100) received letrozole 2." | 5.27 | Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. ( Rezk, M; Saif El-Nasr, I; Shaheen, AE, 2018) |
| "To compare the therapeutic efficacy of clomiphene citrate (CC) and letrozole (LE) on ovulation, pregnancy, and live birth in women with polycystic ovary syndrome (PCOS); and to ensure if LE can replace CC as the first-line therapy for ovulation induction in these women." | 5.24 | Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial. ( Feng, G; Fu, J; Huang, W; Liu, C; Liu, D; Tan, J; Wang, Q; Yang, S, 2017) |
| "We aimed to compare the cost effectiveness of letrozole versus purified urinary follicle stimulating hormone (FSH) in treating patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 5.24 | Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial. ( Hassan, A; Shehata, N; Wahba, A, 2017) |
| " Additionally, novel cosmetic techniques like electrolysis, laser and use of topically applied eflornithine to tackle the most distressing feature of facial hirsutism associated with PCOS, non-pharmacological therapy like acupuncture and the role of herbal medicine in PCOS management have also been discussed." | 5.22 | Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. ( Ali, T; Amin, F; Ara, R; Bader, GN; Kareem, O; Malik, A; Mir, SA; Rashid, R, 2022) |
| "Letrozole appears to improve live birth rates and pregnancy rates in infertile women with anovulatory PCOS, compared to SERMs, when used for ovulation induction, followed by intercourse." | 5.22 | Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome. ( Farquhar, C; Franik, S; Kiesel, L; Kremer, JA; Le, QK, 2022) |
| "To investigate the optimal ovulation induction with the combination of combining letrozole(LE),clomiphene citrate (CC),and human menopausal gonadotropin (HMG) in polycystic ovary syndrome(PCOS) patients resistant to CC or LE." | 5.22 | [Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.] ( Chen, Y; Zhang, D, 2016) |
| "To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate." | 5.22 | A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016) |
| "To study whether a combination of berberine and letrozole results in higher live births than letrozole alone in infertile women with polycystic ovary syndrome (PCOS)." | 5.22 | Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome. ( Liang, RN; Liu, JP; Ma, HX; Ng, EH; Shao, XG; Wang, YY; Wu, XK; Xue, HY, 2016) |
| " A total of 750 infertile women with polycystic ovary syndrome (PCOS) were randomly assigned to up to receive five cycles of letrozole or clomiphene citrate." | 5.20 | Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome. ( Allshouse, AA; Alvero, R; Casson, PR; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Krawetz, SA; Legro, RS; Polotsky, AJ; Santoro, N; Schlaff, WD; Trussell, JC; Zhang, H, 2015) |
| "Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes." | 5.19 | Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. ( Alvero, R; Baker, V; Barnhart, KT; Bates, GW; Brzyski, RG; Casson, P; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Haisenleder, DJ; Huang, H; Krawetz, SA; Legro, RS; Lucidi, S; Ohl, D; Santoro, N; Schlaff, WD; Snyder, P; Trussell, JC; Usadi, R; Yan, Q; Zhang, H, 2014) |
| "The aim of the present study was to investigate the clinical value of low‑dose aspirin in combination with Tiao Jing Cu Yun pills in patients with polycystic ovary syndrome (PCOS) by measuring follicular peripheral blood flow parameters and the clinical efficacy." | 5.19 | Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome. ( Du, B; Jiang, X; Ma, M; Shi, L; Zhang, Q; Zhao, Y; Zhou, L, 2014) |
| " In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients." | 5.17 | Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome. ( Dehghan, M; Ghasemi-Rad, M; Hajishafiha, M; Kiarang, N; Sadegh-Asadi, N; Shayegh, SN, 2013) |
| "To compare the hormonal-metabolic profiles and reproductive outcomes between women receiving metformin plus letrozole and women undergoing bilateral ovarian drilling in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS)." | 5.17 | Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome. ( Abd Elgafor, I, 2013) |
| "The objective of this study was to compare the efficacy of letrozole versus clomiphene citrate as an ovulation induction drug in polycystic ovarian syndrome (PCOS) patients of Indian origin." | 5.16 | Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome. ( Banerjee Ray, P; Chakraborti, PS; Ray, A, 2012) |
| "To compare the clinical outcomes of letrozole and laparoscopic ovarian drilling (LOD) in patients with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS)." | 5.15 | Reproductive outcome after letrozole versus laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome. ( Abdellah, MS, 2011) |
| "To compare the effect of clomiphene citrate (CC) and letrozole on endometrial receptivity in women with polycystic ovary syndrome (PCOS)." | 5.15 | Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome. ( Hines, R; Johnson, V; Sopelak, V; Wallace, KL, 2011) |
| "To evaluate the outcome of long letrozole therapy for induction of ovulation in patients with clomiphene-resistant polycystic ovary syndrome (PCOS)." | 5.14 | Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol. ( Badawy, A; Eid, M; Mosbah, A; Tharwat, A, 2009) |
| "To compare the effect of letrozole with laparoscopic ovarian diathermy (LOD) for ovulation induction in clomiphene citrate (CC) resistant women with polycystic ovary syndrome (PCOS)." | 5.14 | Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. ( Abu Hashim, H; Badawy, A; Mashaly, AM, 2010) |
| "To compare the effectiveness of letrozole and clomiphene citrate (CC) in induction of ovulation in polycystic ovary syndrome (PCOS)." | 5.14 | Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome. ( Begum, A; Begum, MR; Ferdous, J; Quadir, E, 2009) |
| "The efficacy of Kuntai capsule combined with letrozole (LE) in improving ovarian function of polycystic ovary syndrome (PCOS) has been evaluated before, but there is still a lack of evidence-based support for the regulation of sex hormone levels." | 5.12 | Kuntai Capsule Combined With Letrozole on Gonadal Hormone Levels and Ovarian Function in Patients With PCOS: A Systematic Review and Meta-Analysis. ( Dong, S; Huang, Q; Tang, X; Wang, C; Yu, C; Zhang, D, 2021) |
| "The aim of this study was to determine the risks of congenital malformations and pregnancy loss with letrozole compared with clomiphene primarily, and with other fertility drugs and natural conception." | 5.12 | Risk of foetal harm with letrozole use in fertility treatment: a systematic review and meta-analysis. ( Achilli, C; Bhide, P; Coomarasamy, A; Legro, RS; Pundir, J; Rombauts, L; Sabatini, L; Teede, H; Thangaratinam, S; Zamora, J, 2021) |
| "Meta-analysis was used to evaluate the efficacy and safety of aspirin combined with letrozole in the treatment of polycystic ovary syndrome (PCOS)." | 5.12 | Effectiveness and safety of aspirin combined with letrozole in the treatment of polycystic ovary syndrome: a systematic review and meta-analysis. ( Su, F; Wang, M; Wang, Z; Yu, Q, 2021) |
| "Adding metformin to clomiphene citrate in clomiphene-resistant polycystic ovary syndrome (PCOS) patients increases ovulatory response." | 5.12 | Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease. ( Ansari, Sh; Bagheri, M; Sohrabvand, F, 2006) |
| "To compare the use of the aromatase inhibitor, letrozole, in conjunction with follicle-stimulating hormone (FSH) injection, and FSH alone for controlled ovarian hyperstimulation (COH) in patients with polycystic ovarian syndrome (PCOS) or ovulatory infertility." | 5.11 | Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation. ( Casper, RF; Mitwally, MF, 2004) |
| " With letrozole treatment in the same patients with PCOS, ovulation occurred in 9 of 12 cycles (75%) and pregnancy was achieved in 3 patients (25%)." | 5.09 | Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate. ( Casper, RF; Mitwally, MF, 2001) |
| "In women with PCOS, letrozole improves live birth and clinical pregnancy rates and reduces time-to-pregnancy compared to CC and therefore can be recommended as the preferred first-line treatment for women with PCOS and infertility." | 5.01 | First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. ( Amer, SA; Bhattacharya, S; Bordewijk, EM; Falbo, A; Federica, G; Gao, J; Homburg, R; Huang, W; Johnson, NP; Kar, S; König, TE; Legro, RS; Li, W; Lord, J; Mol, BW; Moll, E; Morin-Papunen, L; Nazik, H; Norman, RJ; Özmen, Ü; Palomba, S; Sahin, Y; van Wely, M; Vegetti, W; Wang, R; Williams, CD; Wu, X; Zhang, H, 2019) |
| "The objective of this systematic review was to examine the literature and to compare the effectiveness of letrozole (LE) versus laparoscopic ovarian drilling (LOD) for the induction of ovulation in women with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS)." | 5.01 | Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. ( Cheng, G; Hu, S; Wang, Y; Xia, W; Yu, Q; Zhu, C, 2019) |
| "Letrozole appears to improve live birth and pregnancy rates in subfertile women with anovulatory polycystic ovary syndrome, compared to clomiphene citrate." | 4.98 | Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome. ( Eltrop, SM; Farquhar, C; Franik, S; Kiesel, L; Kremer, JA, 2018) |
| "The objective of the present systematic review and meta-analysis was to examine the literature and to identify the results of randomized controlled trials (RCTs) comparing the use of letrozole to clomiphene citrate (CC) for ovulation induction in patients with polycystic ovary syndrome (PCOS)." | 4.91 | Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. ( Geber, S; Roque, M; Sampaio, M; Tostes, AC; Valle, M, 2015) |
| "Letrozole appears to improve live birth and pregnancy rates in subfertile women with anovulatory PCOS, compared to clomiphene citrate." | 4.90 | Aromatase inhibitors for subfertile women with polycystic ovary syndrome. ( Farquhar, C; Franik, S; Kremer, JA; Nelen, WL, 2014) |
| "Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women." | 4.90 | The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). ( Nathan, N; Sullivan, SD, 2014) |
| " The Pregnancy in PCOS trial II will determine the safety and efficacy of clomiphene citrate compared to letrozole, in achieving live birth in infertile women with PCOS." | 4.88 | Reproductive impact of polycystic ovary syndrome. ( Legro, RS; Usadi, RS, 2012) |
| "The aim of this study was to systematically compare the clinical efficacy and safety of letrozole with clomiphene citrate for ovulation induction in women with polycystic ovary syndrome (PCOS)." | 4.87 | Meta-analysis of letrozole versus clomiphene citrate in polycystic ovary syndrome. ( He, D; Jiang, F, 2011) |
| "To evaluate whether extending letrozole (LE) treatment duration could induce ovulation in women with polycystic ovary syndrome (PCOS) who previously failed to ovulate after a 5-day regimen of 5 mg LE daily for at least 1 ovulation induction cycle, defined as "LE resistance"." | 4.31 | Extending letrozole treatment duration is effective in inducing ovulation in women with polycystic ovary syndrome and letrozole resistance. ( Fu, Y; Zhu, X, 2023) |
| "The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in a letrozole-induced mouse model of polycystic ovary syndrome (PCOS)." | 4.31 | Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome. ( Han, YI; Jeong, HG; Kim, T; Lee, HJ; Nam, S; Park, H; Ryu, KJ, 2023) |
| "No studies have been conducted on the impact of different types of ovulatory dysfunction on the outcomes of frozen-thawed embryo transfers (FETs) in a letrozole-stimulated cycle in women with polycystic ovarian syndrome (PCOS)." | 4.31 | Comparison of pregnancy outcomes of letrozole-induced frozen-thawed embryo transfer cycles in PCOS women with two different abnormal ovulation patterns: A retrospective cohort study. ( Cao, JX; Hou, JW; Jiang, WJ; Song, JY; Sun, ZG; Wang, DD; Yan, MH, 2023) |
| "To assess efficacy of adjuvant dexamethasone during letrozole cycles for ovulation induction (OI) in women with letrozole-resistant polycystic ovary syndrome (PCOS)." | 4.31 | Ovulation induction with letrozole and dexamethasone in infertile patients with letrozole-resistant polycystic ovary syndrome. ( Babayev, SN; Baumgarten, SC; Neblett, MF; Shenoy, CC, 2023) |
| "This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS." | 4.31 | Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet. ( Gao, L; Jiang, M; Pan, L; Sun, C; Tan, Y; Wang, E; Yang, J; Yao, F; Yao, J, 2023) |
| " The aim of this study was to investigate the effect of LDS on dyslipidemia and hepatic inflammation in rats with letrozole (LET)-induced PCOS and to assess the possible involvement of PCSK9 in these effects." | 4.31 | Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome. ( Agbana, RD; Ajadi, IO; Areloegbe, SE; Areola, ED; Atuma, CL; Fafure, AA; Olaniyi, KS; Olatunji, LA; Sabinari, IW; Shah, MZUH, 2023) |
| "Both Dehydroepiandrosterone (DHEA) and letrozole (LET) treatments induced a PCOS phenotype and liver dysfunction." | 4.31 | Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid. ( Chen, S; Fan, Y; Gao, H; Li, T; Li, Y; Liu, R; Yin, C; Zhang, T, 2023) |
| " The rats with polycystic ovary syndrome (PCOS) that were induced by Letrozole exhibited increased levels of urea and creatinine." | 4.31 | Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome. ( Boyina, R; Bukke, SPN; Hussaini, B; Karumanchi, SK; Manchikalapati, B; Marri, J; Odoma, S; Pathange, BBR; Rachamsetty, K, 2023) |
| "The objective of the present study was to investigate the effect of melatonin and L-thyroxine (T4) on the expression of various receptors, and some metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 4.12 | Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome. ( Brown, GM; Cardinali, DP; Ghosh, H; Manzar, MD; Pandi-Perumal, SR; Rai, S; Reiter, RJ, 2022) |
| "The risks of pregnancy, livebirth, multiple gestation, preterm birth, neonatal intensive care unit (NICU) admission and congenital malformations were higher for letrozole compared with clomiphene in participants with polycystic ovarian syndrome (PCOS), though no treatment differences were observed in those with unexplained infertility." | 4.12 | Emulating a target trial of the comparative effectiveness of clomiphene citrate and letrozole for ovulation induction. ( Chiu, YH; Hernán, MA; Hernández-Díaz, S; Hsu, J; Rinaudo, P; Yland, JJ, 2022) |
| " In this regard, studies have demonstrated that Aloe vera gel has the potential to modulate steroidogenic activity in letrozole induced polycystic ovary syndrome (PCOS) rat." | 4.12 | Partially purified non-polar phytocomponents from Aloe barbadensis Mill. gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary syndrome rodent model- an "in-vivo" study. ( Dey, A; Dhadhal, S; Maharjan, R; Nagar, PS; Nampoothiri, L, 2022) |
| " Interestingly, naringenin supplementation significantly reduced body weight, ameliorated hormone levels, improved insulin resistance, and mitigated pathological changes in ovarian tissue, up-regulated the expression of PGC-1ɑ, SIRT1, occludin and claudin-1 in colon." | 4.12 | Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome. ( An, T; Bao, XL; Gao, L; Han, BS; Hu, YY; Jiang, GJ; Lian, J; Lv, BH; Wang, TY; Wu, YX; Yang, XY, 2022) |
| "This study aims to investigate the effects of a high-fat, high-fructose (HF/HFr) diet on metabolic/endocrine dysregulations associated with letrozole (LET)-induced Polycystic Ovarian Syndrome (PCOS) in prepubertal female mice." | 4.12 | The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice. ( Bajerska, J; Kołodziejski, PA; Pieczyńska, JM; Pruszyńska-Oszmałek, E; Łukomska, A, 2022) |
| "The impact of low-dose spironolactone (LSPL) on polycystic ovarian syndrome (PCOS)-associated cardio-renal disorder is unknown." | 4.12 | Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model. ( Akintayo, CO; Areloegbe, SE; Aturamu, A; Olaniyi, KS; Oniyide, AA; Peter, MU, 2022) |
| " To that end, we have established a Swiss albino mouse model of PCOS based on 3 weeks of daily treatment with letrozole (50 μg/day; intraperitoneal) and dehydroepiandrosterone (DHEA, 6 mg/100 g body weight; subcutaneous) in 5-week-old female mice fed on normal or high-fat diet (HFD)." | 4.12 | Distinctions in PCOS Induced by Letrozole Vs Dehydroepiandrosterone With High-fat Diet in Mouse Model. ( Adiga, SK; Bakkum-Gamez, J; Chang, AY; DeStephano, C; Kalthur, G; Kalthur, SG; Kannan, N; Kundapur, SD; Mutalik, S; Nayak, G; Panchanan, G; Poojary, PS; Rao, A; Sherman, M; Zhao, Y, 2022) |
| " We retrospectively compared the pregnancy and neonatal outcomes after frozen single-blastocyst transfer with endometrial preparation by HRT regimen (n = 3540), ovulation induction by human menopausal gonadotropin (hMG) regimen (n = 226), and ovulation induction by letrozole regimen (n = 175)." | 4.12 | Ovulation induction regimens are associated with a higher rate of livebirth after frozen single-blastocyst transfer among women with polycystic ovary syndrome. ( Niu, Y; Suo, L; Wang, Y; Wei, D; Zhao, D; Zou, J, 2022) |
| "Altogether, the present study suggests that low-dose spironolactone confers protection against adipose dysfunction in experimental PCOS animals by attenuating inflammation, oxidative stress and cellular apoptosis." | 4.12 | Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model. ( Areloegbe, SE; Olaniyi, KS; Oyeleke, MB; Peter, MU, 2022) |
| "To assess the protective effect of dark chocolate (DC) on the letrozole-induced rat model of polycystic ovary syndrome (PCOS)." | 4.12 | Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats: hormonal, biochemical, and histopathological investigation. ( Hesami, S; Hosseini, A; Mirazi, N; Nourian, A, 2022) |
| "Letrozole-treated rats showed successful induction of PCOS, confirmed by histopathology and significantly increased body weight, testosterone, insulin, AMH, and MDA, and decreased SOD." | 4.12 | Fenofibrate ameliorates letrozole-induced polycystic ovary in rats via modulation of PPARα and TNFα/CD95 pathway. ( El-Hussieny, M; Morsy, MA; Nair, AB; Refaie, MMM; Venugopala, KN; Zenhom, NM, 2022) |
| "To investigate the efficacy of oral letrozole (LE) starting on day 3 or 5 of the menstrual cycle in patients with polycystic ovary syndrome (PCOS)." | 4.12 | Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome. ( Chen, Y; Gao, M; Jin, X; Shi, L; Ye, S; Zhang, Z, 2022) |
| "The beneficial effects of metformin, especially its capacity to ameliorate insulin resistance (IR) in polycystic ovary syndrome (PCOS), explains why it is widely prescribed." | 4.02 | Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance. ( Li, S; Xiao, L; Xie, Y, 2021) |
| " deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats." | 4.02 | Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats. ( Goh, YM; Hashim, N; Haslan, MA; Samsulrizal, N; Shirazi, FH; Zin, NSNM, 2021) |
| " Liraglutide has favourable neuroprotective effects that may protect against the possible cognitive dysfunction in PCOS." | 4.02 | Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome. ( Abdel Salam, RM; Ahmed, MAE; Eltarzy, MA; Saad, MA, 2021) |
| " Twenty-four female Wistar rats were allocated into three groups: control; polycystic ovary syndrome (PCOS) in which PCOS was induced by letrozole, orally in a dose of 1 mg/kg once daily for 3 weeks; and ADM group in which ADM was injected intraperitonally in a dose of 3." | 4.02 | Potential effect of adrenomedullin on metabolic and endocrinal dysfunctions in the experimentally induced polycystic ovary: Targeting implication of endoplasmic reticulum stress. ( Alghazaly, GM; Barhoma, RA; El-Saka, MH; Elsaadany, A; Elshwaikh, S; Ibrahim, RR; Madi, NM; Marea, KE, 2021) |
| "This study aimed to investigate the impact of letrozole use during frozen embryo transfer cycles on obstetrical and perinatal outcomes of singleton and twin pregnancies compared with artificial frozen cycles among women with polycystic ovary syndrome." | 4.02 | Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome. ( Bian, X; Mao, X; Wang, B; Wei, M; Wu, L; Zhang, J; Zhang, S, 2021) |
| "This study investigated the effects of proanthocyanidins (PCs) on ovarian fibrosis in letrozole-induced polycystic ovary syndrome (PCOS) in rats." | 4.02 | Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole-induced polycystic ovary syndrome in rats. ( Cao, W; Dong, Z; Lan, H; Song, JL; Zeng, Z; Zhou, Y, 2021) |
| "To assess whether anti-Müllerian hormone (AMH) can predict response to ovulation induction (OI) with clomiphene citrate (CC), letrozole (LET), or follicle-stimulating hormone (FSH) in women with polycystic ovary syndrome (PCOS) undergoing OI/intrauterine inseminations (IUI)." | 4.02 | Response to ovulation induction treatments in women with polycystic ovary syndrome as a function of serum anti-Müllerian hormone levels. ( Bormann, CL; Dimitriadis, I; Hammer, KC; James, KE; Sacha, CR; Souter, I; Vagios, S, 2021) |
| "To assess the characteristics of intestinal flora in PCOS and explore whether abnormal intestinal flora can affect insulin resistance and promote PCOS and whether chenodeoxycholic acid (CDCA) can activate intestinal farnesoid X receptor (FXR), improving glucose metabolism in PCOS." | 4.02 | Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome. ( He, Y; Huang, QF; Li, ZW; Tang, WL; Wang, ZW; Wu, S; Yang, YL; Zhou, HW; Zhou, WW; Zhou, ZY, 2021) |
| "We sought to compare the efficacy of the letrozole (LTZ) stair-step protocol with clomiphene citrate (CC) stair-step protocol in the management of 150 mg dose of CC-resistant polycystic ovary syndrome (PCOS) patients." | 4.02 | Comparison of the efficacy of letrozole stair-step protocol with clomiphene citrate stair-step protocol in the management of clomiphene citrate-resistant polycystic ovary syndrome patients. ( Oğlak, SC; Sakar, MN, 2021) |
| "The present study was conducted to investigate the therapeutic effects of a potent polyphenol, fisetin, on the letrozole-induced rat model of polycystic ovary syndrome (PCOS)." | 4.02 | Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021) |
| "The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate." | 3.96 | A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrateresistant polycystic ovary syndrome - a retrospective study. ( Bademkıran, MH; Ege, S; Hançer Çaça, FN; Özçelik, SM; Peker, N; Tahaoğlu, AE, 2020) |
| "Children of women with polycystic ovary syndrome who conceived with letrozole (LTZ) or clomiphene (CC) in the PPCOS II study or women with unexplained infertility (AMIGOS study) who conceived with LTZ, CC, or gonadotropin (GN)." | 3.96 | Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. ( Alvero, R; Baker, V; Barnhart, KT; Casson, P; Cedars, MI; Christman, GM; Coutifaris, C; Coward, RM; Diamond, MP; Dodson, WC; Eisenberg, E; Estes, SJ; Hansen, KR; Huang, H; Krawetz, SA; Kunselman, A; Legro, RS; Robinson, R; Rosen, RM; Santoro, N; Schlaff, WD; Stetter, C; Trussell, JC; Usadi, R; Zhang, H, 2020) |
| "BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model." | 3.96 | Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways. ( Dun, J; Huang, L; Huang, M; Ji, F; Lin, Q; Lin, Y; Xu, J; Yang, J; You, X; Zhang, J, 2020) |
| "A PCOS with insulin resistance rat model was created by administering letrozole and a high-fat diet." | 3.96 | MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance. ( Li, K; Lin, Z; Ma, H; Pan, H; Yu, C; Zhang, C, 2020) |
| " In addition, the minimal weight gain and lack of insulin resistance in adult female mice after letrozole treatment indicates that this model may be useful for investigating the effects of hyperandrogenemia on the hypothalamic-pituitary-gonadal axis and the periphery without the influence of substantial metabolic dysregulation." | 3.91 | Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice. ( Anvar, AR; Ho, BS; Kelley, ST; Sau, L; Skarra, DV; Thackray, VG; Torres, PJ, 2019) |
| "To investigate whether live birth rate (LBR) following frozen-thawed embryo transfer in letrozole-stimulated cycles (L-FET) differs from LBR after artificial-cycle frozen-thawed embryos transfers (AC-FET) in women with polycystic ovary syndrome (PCOS)." | 3.91 | Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. ( Chen, Q; Fan, Y; Kuang, Y; Liu, H; Mao, X; Wang, Y; Xiao, Y; Zhang, J, 2019) |
| " The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women." | 3.88 | Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study. ( Abid, A; Afsar, T; Almajwal, A; Jahan, S; Khalid, S; Razak, S; Shaheen, G, 2018) |
| "BACKGROUND Women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) are given letrozole before a trigger injection of human chorionic gonadotropin (hCG) to lower estrogen (E2) levels, but can experience ovarian hyperstimulation syndrome (OHSS)." | 3.88 | A Retrospective Study of Letrozole Treatment Prior to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization at Risk of Ovarian Hyperstimulation Syndrome. ( Chen, Y; Hao, C; Yang, T; Zhao, J, 2018) |
| "We conducted a secondary analysis of a multicenter, randomized clinical trial (Pregnancy in Polycystic Ovary Syndrome II, NCT00719186) comparing clomiphene citrate vs letrozole in the treatment of infertility." | 3.88 | Association among depression, symptom experience, and quality of life in polycystic ovary syndrome. ( Cedars, MI; Greenwood, EA; Huddleston, HG; Legro, RS; Pasch, LA, 2018) |
| "To evaluate the effect of metformin and pioglitazone on leutinizing hormone and follicle stimulating hormone receptor mRNA expression, hyperandrogenism and insulin resistance in high fat diet induced and letrozole induced PCOS in rats." | 3.88 | Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats. ( Patel, R; Shah, G, 2018) |
| "This retrospective study investigated the efficacy and safety of letrozole for patients with polycystic ovary syndrome (PCOS)." | 3.88 | Letrozole for patients with polycystic ovary syndrome: A retrospective study. ( Guang, HJ; Li, F; Shi, J, 2018) |
| "Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat." | 3.85 | Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome. ( Benrick, A; Carlström, M; Cushman, SW; Fornes, R; Hu, M; Ivarsson, N; Maciel, GAR; Maliqueo, M; Marcondes, RR; Stener-Victorin, E; Stenkula, KG, 2017) |
| " The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance." | 3.85 | Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017) |
| "To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients." | 3.85 | Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study. ( Arya, S; Crisp, Z; Dwivedi, AK; Jose, J; Kupesic-Plavsic, S; Mulla, ZD; Noble, LS, 2017) |
| " Polycystic ovary syndrome was induced by letrozole administration, and animals presented with obesity, sex hormone disorder, no ovulation, large cystic follicles, and increasing fasting insulin (FINS) and leptin levels." | 3.85 | Effects of Exercise Intervention on Preventing Letrozole-Exposed Rats From Polycystic Ovary Syndrome. ( Cao, SF; Hu, WL; Jiang, LY; Wu, MM, 2017) |
| "The present study examines the effect of soy isoflavones on letrozole-induced polycystic ovary syndrome (PCOS) rat model." | 3.85 | Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism. ( Balaji, B; M, SS; Rajan, RK, 2017) |
| "The objective of our study was to investigate glycemic, oxidative/antioxidative and inflammatory status in letrozole and estradiol valerate induced polycystic ovarian syndrome (PCOS) models." | 3.83 | Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment. ( Cucolaş, C; Dăneasă, A; Filip, GA; Lenghel, LM; Olteanu, D; Orăsan, R, 2016) |
| "To explore the effect of compound malt pills (CMP) on polycystic ovarian syndrome (PCOS) rat model induced by letrozole and the underlying mechanisms." | 3.83 | [Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome]. ( Chen, R; Lan, N; Wang, S; Yang, Y, 2016) |
| "The aims of the current study were to examine the effects of temporal changes in oxidative stress (OS) and low-grade inflammation in letrozole-treated rats and to correlate these changes with the development of polycystic ovary syndrome (PCOS)-like features." | 3.83 | Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat. ( Krishna, A; Pandey, U; Pandey, V; Singh, A; Tripathi, YB, 2016) |
| " First, letrozole was used to induce the PCOS model, 24 h food intake, 24 h body weight changes and the expression of p-STAT3 were determined following leptin or artificial cerebrospinal fluid (aCSF) icv injection in rats." | 3.83 | Central leptin resistance and hypothalamic inflammation are involved in letrozole-induced polycystic ovary syndrome rats. ( Lian, Y; Wang, W; Zhao, F, 2016) |
| "To study the efficiency of letrozole, an aromatase inhibitor, in endometrial preparation for cryopreserved-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS)." | 3.80 | Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study. ( Chen, YZ; Hu, YJ; Huang, HF; Zhu, YM, 2014) |
| "The objective was to evaluate ovarian functionality and oxidative response in hyperandrogenism-induced polycystic ovary (PCO) and the protective effects of immunomodulator drug (IMOD), an electromagnetically-treated, selenium-based, herbal medicine." | 3.78 | Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary. ( Abdollahi, M; Ahmadi, A; Baeeri, M; Rezvanfar, MA; Shojaei-Saadi, HA, 2012) |
| "We explored the effects of combination of acupuncture and Chinese medicinal herbs in treating model rats with polycystic ovarian syndrome (PCOS) and to explore whether acupuncture has positive effects on the absorption of salvianolic acid B in the extracts of a Chinese medicine formula when treating the model rats." | 3.77 | Combination of acupuncture and chinese medicinal herbs in treating model rats with polycystic ovary syndrome. ( Fang, JQ; Ma, RJ; Qu, F; Yang, DH; Zhou, J, 2011) |
| "To determine the effect of intravaginal micronized P on pregnancy rates in clomiphene citrate and letrozole ovulation induction cycles in women with polycystic ovary syndrome (PCOS)." | 3.76 | Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction. ( Aubuchon, M; Khabbaz, M; Montville, CP; Thomas, MA; Williams, DB, 2010) |
| "Letrozole is at least as effective as clomiphene for inducing ovulation and achieving pregnancy in patients with polycystic ovarian syndrome." | 3.75 | Letrozole versus clomiphene citrate: which is better for ovulation induction? ( Casper, RF, 2009) |
| "To investigate the effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome (PCOS)." | 3.74 | [Effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome]. ( Li, H; Quan, S; Song, YL; Xing, FQ; Yang, MQ, 2008) |
| "Letrozole induction of ovulation in clomiphene citrate-resistant women with polycystic ovary syndrome is associated with an ovulation rate of 54." | 3.73 | Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio. ( Eldosoky, M; Elnashar, A; Fouad, H; Saeid, N, 2006) |
| "Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator." | 2.87 | Insulin resistance is associated with depression risk in polycystic ovary syndrome. ( Cedars, MI; Eisenberg, E; Greenwood, EA; Huddleston, HG; Legro, RS; Pasch, LA, 2018) |
| " The aim of the study was to evaluate the effectiveness and efficacy of letrozole and clomiphene citrate (CC) combined with human menopausal gonadotropin (HMG) in CC-resistant infertile women with PCOS." | 2.80 | Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study. ( Liu, S; Lu, X; Mao, H; Xi, W; Xue, X; Yang, Y, 2015) |
| "letrozole for 5 treatment cycles (or approximately up to 25 weeks)." | 2.77 | The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. ( Brzyski, RG; Casson, PR; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Kunselman, AR; Legro, RS; Santoro, N; Schlaff, WD; Taylor, HS; Zhang, H, 2012) |
| "Polycystic ovary syndrome is a common disease that is closely related to ovulation dysfunction and 7% of women of childbearing age are afflicted with it." | 2.77 | Comparison of the effects of letrozole and clomiphene citrate for ovulation induction in infertile women with polycystic ovary syndrome. ( Nahid, L; Sirous, K, 2012) |
| "Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml." | 2.74 | Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial. ( Chakravarty, B; Chattopadhyay, R; Chaudhury, K; Ganesh, A; Goswami, SK, 2009) |
| "Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities." | 2.48 | Polycystic ovarian syndrome management options. ( Bates, GW; Propst, AM, 2012) |
| "Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity." | 2.48 | Evaluation and treatment of anovulatory and unexplained infertility. ( Bates, GW; Propst, AM, 2012) |
| "Letrozole is an attractive option with its oral route of administration, cost, safety profile and effectiveness in ovulation induction and ovarian stimulation." | 2.47 | Aromatase inhibitors for ovulation induction and ovarian stimulation. ( Ledger, W; Lee, VC, 2011) |
| "Treatment with letrozole caused hyperandrogenism, hypoestrogenism, hyperinsulinemia and multiple ovarian cysts/degenerated follicles." | 1.91 | Protective Role of Acetate Against Depressive-Like Behaviour Associated with Letrozole-Induced PCOS Rat Model: Involvement of HDAC2 and DNA Methylation. ( Areloegbe, SE; Olaniyi, KS; Wolugbom, JA, 2023) |
| "PCOS patients with an increased LH/FSH ratio, AMH, FAI, and late menarche may need an increased dosage of LET for a treatment response, which could be helpful in designing a personalized treatment strategy." | 1.91 | Predictors of response to ovulation induction using letrozole in women with polycystic ovary syndrome. ( Chen, S; Chen, Z; Guo, Z; Hao, Y; Hu, P; Yu, Q, 2023) |
| "Icariin-treated rats had lower weight gain and reduced triglycerides, fasting insulin, HOMA-IR, TNF-α, and interleukin-6 with higher high-density lipoprotein cholesterol levels than PCOS rats." | 1.91 | Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. ( Hai, Y; Huang, X; Ke, X; Li, P; Li, X; Ren, L; Tian, J; Wang, J; Wang, M; Zhang, R; Zuo, B; Zuo, L, 2023) |
| "Quercetin treatment reversed the molecular, functional and morphological abnormalities brought on due to letrozole in pathological and physiological setting, particularly the issues of reproduction connected to PCOS." | 1.91 | Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome. ( Al-Jafary, MA; Al-Qhtani, MH; Al-Suhaimi, EA; Ansari, MA; Bashir, SM; Ganie, MA; Homeida, AM; Mir, MA; Rather, GA; Shafi, M; Shah, MZUH; Sheikh, WM; Shrivastva, VK, 2023) |
| "8." | 1.91 | Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study. ( Cai, S; Gong, F; Guo, H; Li, X; Li, Y; Lin, G; Ma, S; Peng, Y; Tan, H; Tang, Y; Wang, X; Zhang, S, 2023) |
| " This study aimed to investigate the effect of letrozole and metformin combined with targeted nursing on ovarian function, LH, and FSH in infertile patients with PCOS." | 1.72 | The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome. ( Jiang, S; Li, R; Sheng, Y; Tang, T; Xu, H, 2022) |
| " These isoflavones generally have low solubility resulting in low bioavailability and bioactivity." | 1.72 | Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats. ( Acharya, S; Bulsara, J; Desai, S; Halpati, K; Patil, P; Soni, A, 2022) |
| "Acne is an off-label use of some COCs." | 1.72 | Female Pelvic Conditions: Polycystic Ovary Syndrome. ( Brady, PH; Gin, GT; Rosenblum, E; Wilkinson, LD, 2022) |
| "Letrozole-treated animals had impaired glucose homeostasis, elevated testosterone, leptin and LH/FSH ratio and decreased GnRH and adiponectin with ovarian tissues revealing degenerated follicles and disrupted morphology." | 1.72 | Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3 immunoreactivity. ( Areloegbe, SE; Olaniyi, KS; Oyeleke, MB, 2022) |
| "Letrozole (1 mg/kg/day) was administered to female Sprague-Dawley (SD) rats for 21 days to induce PCOS." | 1.72 | Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats. ( Ibrahim, SF; Kamal, DAM; Mokhtar, MH; Ugusman, A; Zaid, SSM, 2022) |
| "Polycystic ovary syndrome affects 7% of women of reproductive ages." | 1.62 | Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis. ( Dehghan, Z; Mirmotalebisohi, SA; Mohammadi-Yeganeh, S; Salehi, M; Sameni, M; Zali, H, 2021) |
| " The animals received resveratrol at a dosage of 20 mg/kg and 30 mg/kg for the next 30 days." | 1.62 | The effectiveness of resveratrol in treatment of PCOS on the basis of experimental model in rats. ( Abashova, E; Borodina, V; Bulgakova, O; Tral, T; Yarmolinskaya, M, 2021) |
| "The letrozole-treated mice showed a disrupted estrous cycle and were arrested in the diestrus phase." | 1.62 | Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice. ( Chen, CW; Chen, KH; Chen, LK; Ho, CH; Hwang, JL; Juan, CC; Liu, PS; Seow, KM; Wang, PH, 2021) |
| "The effective treatment of polycystic ovary syndrome (PCOS)-related hormonal disorders necessitates the development of novel treatment strategies." | 1.62 | Beneficial phytoestrogenic effects of resveratrol on polycystic ovary syndromein rat model. ( Chen, L; Gai, S; Li, F; Liu, X; Shan, Y; Wang, S; Zhang, N; Zhao, D; Zhuang, L, 2021) |
| " FTZ was administrated to mice by oral gavage daily at dosage of 2." | 1.62 | Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice. ( Guo, J; Guo, Q; Rong, X; Tang, J; Wu, L; Xie, K; Xu, Y; Yan, K; Ye, D; Zhu, A, 2021) |
| "A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)." | 1.62 | Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021) |
| "Polycystic ovary syndrome is a common reproductive disorder in the female of reproductive age, which is characterized by hyperandrogenism, insulin resistance, cystic ovary and infertility." | 1.62 | Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice. ( Annie, L; Gurusubramanian, G; Roy, VK, 2021) |
| "Treatment with quercetin improved the PCOS related disturbances in estrous cycle, lipid profile, serum levels of testosterone, estradiol and progesterone, and IR." | 1.62 | Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021) |
| "Letrozole was associated with significantly higher clinical pregnancy (38." | 1.62 | Letrozole as first-line drug for ovulation induction in treatment-naïve infertile polycystic ovarian syndrome women. ( Joseph, T; Kamath, MS; Kunjummen, AT; Rebekah, G; Waanbah, BD, 2021) |
| "Spironolactone (SPL) is a mineralocorticoid receptor (MR) blocker that has been in wide clinical use for some decades." | 1.56 | Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe. ( Adeyanju, OA; Agbana, RD; Falodun, TO; Michael, OS; Oyewole, AL; Soetan, OA, 2020) |
| "Letrozole-treated females demonstrate multiple PCOS-like phenotypes, including polycystic ovaries, anovulation, and elevated circulating testosterone and LH, assayed in "one-off" measures." | 1.56 | Hyperactive LH Pulses and Elevated Kisspeptin and NKB Gene Expression in the Arcuate Nucleus of a PCOS Mouse Model. ( Esparza, LA; Ho, BS; Kauffman, AS; Schafer, D; Thackray, VG, 2020) |
| "Hyperandrogenism is one of the major characteristics of polycystic ovary syndrome (PCOS)." | 1.56 | Decreased microRNA-125b-5p disrupts follicle steroidogenesis through targeting PAK3/ERK1/2 signalling in mouse preantral follicles. ( Cherrington, BD; E, Q; Gong, X; Han, Y; Li, T; Liu, X; Xiao, H; Xu, B; Ying, X; Zhang, X, 2020) |
| "Letrozole was used to produce a PCOS rat model and a 4-week-strain-intervention was performed." | 1.56 | Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota. ( Chen, W; He, Y; Li, X; Wang, G; Wang, Q; Zhang, H; Zhao, J, 2020) |
| " The methods for establishing PCOS-IR animal model include using dehydroepiandrosterone (DHEA) and sodium prasterone sulfate subcutaneous injection, testosterone propionate combined with high-fat diet, and so on." | 1.56 | A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet. ( Wang, MX; Xu, X; Yin, Q, 2020) |
| "Letrozole (1 mg/kg) was administered orally for a period of 28 days to induce PCOS." | 1.56 | The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats. ( Ekramzadeh, M; Golmakani, MT; Koohpeyma, F; Sherafatmanesh, S; Tanideh, N, 2020) |
| "The prevalence of nonalcoholic fatty liver disease (NAFLD) is higher in women with polycystic ovarian syndrome (PCOS) than that in healthy women." | 1.56 | Involvement of endogenous testosterone in hepatic steatosis in women with polycystic ovarian syndrome. ( Chen, Y; Cui, T; Li, T; Liu, R; Yang, Y; Yin, C; Zhang, T, 2020) |
| "Polycystic ovary syndrome is one of the most common causes of female infertility, affecting 5-10% of the population." | 1.51 | Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin. ( AbdelMaksoud, S; El-Bahy, AA; Handoussa, H; Khaled, N; Radwan, R, 2019) |
| "Flutamide treatment in LET females reversed elevated T levels and restored ovarian expression of Cyp17a1 (critical for androgen synthesis) to normal levels." | 1.48 | Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. ( Malik, S; Mellon, PL; Ryan, GE, 2018) |
| "Letrozole-treated patients required a significantly lower amount of gonadotropins units (p < 0." | 1.48 | Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study. ( Cantatore, C; Caringella, AM; Caroppo, E; D'Amato, G; Palini, S; Stanziano, A, 2018) |
| "Letrozole was administered orally (1 mg kg-1) to induce PCOS condition in Wistar female rats for a period of 2-3 weeks followed by a dose of melatonin (200 µg/100 g b." | 1.48 | Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat. ( Ahmad Hajam, Y; Basheer, M; Ghosh, H; Rai, S, 2018) |
| "Letrozole is a nonsteroidal aromatase inhibitor that is used in experimental research to induce PCOS." | 1.46 | Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats. ( Akbari, M; Aliabadi, E; Keshtgar, S; Mirkhani, H; Mortezaee, K; Namavar, MR; Rastegar, T; Solhjoo, S; Toolee, H, 2017) |
| "Letrozole treatment was associated with a time-dependent shift in the gut microbiome and a substantial reduction in overall species and phylogenetic richness." | 1.43 | The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. ( Kelley, ST; Rivera, AJ; Skarra, DV; Thackray, VG, 2016) |
| "Polycystic ovary syndrome is the most common endocrinopathy among reproductive-aged women in the United States, affecting approximately 7% of female patients." | 1.43 | Diagnosis and Treatment of Polycystic Ovary Syndrome. ( Mortada, R; Porter, S; Williams, T, 2016) |
| "Metformin was also given as a standard control to one of the rat groups." | 1.43 | Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. ( Afsar, T; Ain, QU; Almajwal, A; Jahan, S; Mehboob, A; Munir, F; Razak, S; Shaheen, G; Ullah, H, 2016) |
| "The letrozole-induced PCOs were characterized by irregular cycles, high incidence of subcapsular ovarian cysts with diminished or scant granulosa cell layers, increased number of atretic preantral and antral follicles, and absence of CL." | 1.42 | Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary. ( Abdollahi, M; Baeeri, M; Gooshe, M; Mansoori, P; Rezvanfar, MA; Saadat, S; Saeedi, S; Shojaei Saadi, HA, 2015) |
| "The letrozole model group is a good animal model for the study of AMH in PCOS patients with obesity or insulin resistance." | 1.40 | Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome. ( Du, DF; Du, MR; Fang, F; Li, XL, 2014) |
| " To test the hypothesis that continuous administration of lower doses of letrozole starting before puberty would result in both metabolic and reproductive phenotypes of PCOS, we performed a 12-wk dose-response study." | 1.39 | Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. ( Benrick, A; Duleba, AJ; Johansson, J; Labrie, F; Lönn, M; Maliqueo, M; Stener-Victorin, E; Sun, M; Svensson, H, 2013) |
| "Letrozole is a potent, nonsteroidal, aromatase inhibitor, originally used for postmenopausal breast cancer therapy, at present its only registered indication." | 1.37 | Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome. ( Casper, RF; Mitwally, MF, 2011) |
| "Letrozole treatment induced an increase in the expression of AR, StAR and 3beta-HSD and a decrease in ERbeta." | 1.35 | Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. ( Alfaro, NS; Mason, JI; Ortega, HH; Salvetti, NR; Velazquez, MM; Zurvarra, FM, 2009) |
| "All letrozole rats were anovulatory and developed polycystic ovaries with structural changes strikingly similar to those in human PCOS." | 1.34 | A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. ( Cajander, S; Holmäng, A; Lönn, M; Lystig, T; Mannerås, L; Seleskovic, Z; Stener-Victorin, E, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 20 (6.67) | 29.6817 |
| 2010's | 129 (43.00) | 24.3611 |
| 2020's | 151 (50.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dehghan, Z | 1 |
| Mohammadi-Yeganeh, S | 1 |
| Sameni, M | 1 |
| Mirmotalebisohi, SA | 1 |
| Zali, H | 1 |
| Salehi, M | 1 |
| Xie, Y | 1 |
| Xiao, L | 1 |
| Li, S | 3 |
| Upadhyay, S | 1 |
| Krishna, A | 2 |
| Singh, A | 4 |
| Ma, X | 2 |
| Li, X | 7 |
| Ma, L | 1 |
| Chen, Y | 9 |
| He, S | 1 |
| Ghosh, H | 2 |
| Rai, S | 2 |
| Manzar, MD | 1 |
| Pandi-Perumal, SR | 1 |
| Brown, GM | 1 |
| Reiter, RJ | 1 |
| Cardinali, DP | 1 |
| Liyanage, GSG | 1 |
| Inoue, R | 1 |
| Fujitani, M | 1 |
| Ishijima, T | 1 |
| Shibutani, T | 1 |
| Abe, K | 1 |
| Kishida, T | 1 |
| Okada, S | 1 |
| Haslan, MA | 1 |
| Samsulrizal, N | 1 |
| Hashim, N | 1 |
| Zin, NSNM | 1 |
| Shirazi, FH | 1 |
| Goh, YM | 1 |
| Yarmolinskaya, M | 1 |
| Bulgakova, O | 1 |
| Abashova, E | 1 |
| Borodina, V | 1 |
| Tral, T | 1 |
| Refaie, MMM | 2 |
| El-Hussieny, M | 2 |
| Abdelraheem, WM | 1 |
| Seow, KM | 1 |
| Liu, PS | 1 |
| Chen, KH | 1 |
| Chen, CW | 1 |
| Chen, LK | 1 |
| Ho, CH | 1 |
| Hwang, JL | 1 |
| Wang, PH | 1 |
| Juan, CC | 1 |
| Tang, X | 1 |
| Huang, Q | 1 |
| Wang, C | 2 |
| Zhang, D | 3 |
| Dong, S | 1 |
| Yu, C | 2 |
| He, Y | 4 |
| Mei, L | 1 |
| Wang, L | 5 |
| Zhao, J | 5 |
| Zhang, H | 9 |
| Chen, W | 4 |
| Wang, G | 2 |
| Yland, JJ | 1 |
| Chiu, YH | 1 |
| Rinaudo, P | 1 |
| Hsu, J | 1 |
| Hernán, MA | 1 |
| Hernández-Díaz, S | 1 |
| Wu, YY | 2 |
| Li, SY | 1 |
| Zhu, HQ | 1 |
| Zhuang, ZM | 1 |
| Shao, M | 1 |
| Chen, FL | 1 |
| Liu, CS | 1 |
| Tang, QF | 1 |
| Rashid, R | 2 |
| Mir, SA | 1 |
| Kareem, O | 1 |
| Ali, T | 1 |
| Ara, R | 1 |
| Malik, A | 1 |
| Amin, F | 1 |
| Bader, GN | 2 |
| Dey, A | 1 |
| Dhadhal, S | 1 |
| Maharjan, R | 1 |
| Nagar, PS | 1 |
| Nampoothiri, L | 2 |
| Zhang, Y | 7 |
| Xu, L | 2 |
| Ibrahim, YF | 1 |
| Alorabi, M | 1 |
| Abdelzaher, WY | 1 |
| Toni, ND | 1 |
| Thabet, K | 1 |
| Hegazy, A | 1 |
| Bahaa, HA | 1 |
| Batiha, GE | 1 |
| Welson, NN | 1 |
| Morsy, MA | 2 |
| Venugopala, KN | 2 |
| Abdel-Aziz, AM | 1 |
| Jiang, S | 1 |
| Tang, T | 1 |
| Sheng, Y | 2 |
| Li, R | 2 |
| Xu, H | 1 |
| Bulsara, J | 1 |
| Soni, A | 1 |
| Patil, P | 1 |
| Halpati, K | 1 |
| Desai, S | 1 |
| Acharya, S | 2 |
| Huang, L | 2 |
| Liang, A | 1 |
| Li, T | 4 |
| Lei, X | 1 |
| Chen, X | 3 |
| Liao, B | 1 |
| Tang, J | 2 |
| Cao, X | 1 |
| Chen, G | 1 |
| Chen, F | 1 |
| Wang, Y | 9 |
| Hu, L | 1 |
| He, W | 1 |
| Li, M | 2 |
| Wilkinson, LD | 1 |
| Brady, PH | 1 |
| Gin, GT | 1 |
| Rosenblum, E | 1 |
| Olaniyi, KS | 14 |
| Areloegbe, SE | 11 |
| Wu, YX | 1 |
| Yang, XY | 1 |
| Han, BS | 1 |
| Hu, YY | 1 |
| An, T | 1 |
| Lv, BH | 1 |
| Lian, J | 1 |
| Wang, TY | 1 |
| Bao, XL | 1 |
| Gao, L | 3 |
| Jiang, GJ | 1 |
| Pieczyńska, JM | 1 |
| Pruszyńska-Oszmałek, E | 1 |
| Kołodziejski, PA | 1 |
| Łukomska, A | 1 |
| Bajerska, J | 1 |
| Peter, MU | 2 |
| Akintayo, CO | 2 |
| Oniyide, AA | 4 |
| Aturamu, A | 3 |
| Poojary, PS | 1 |
| Nayak, G | 1 |
| Panchanan, G | 1 |
| Rao, A | 1 |
| Kundapur, SD | 1 |
| Kalthur, SG | 1 |
| Mutalik, S | 1 |
| Adiga, SK | 1 |
| Zhao, Y | 5 |
| Bakkum-Gamez, J | 1 |
| Chang, AY | 1 |
| DeStephano, C | 1 |
| Sherman, M | 1 |
| Kannan, N | 1 |
| Kalthur, G | 1 |
| Tian, J | 2 |
| Xu, Y | 6 |
| Xiong, Y | 1 |
| Zuo, L | 3 |
| Zhou, M | 1 |
| Cao, C | 1 |
| Huang, X | 4 |
| Wang, J | 4 |
| Bashir, AM | 3 |
| Sabinari, IW | 2 |
| Wang, F | 2 |
| Han, J | 1 |
| Wang, X | 6 |
| Liu, Y | 7 |
| Zhang, Z | 3 |
| Xiao, H | 2 |
| Tong, Q | 1 |
| Yu, Y | 1 |
| Qi, B | 1 |
| Bu, X | 1 |
| Pan, T | 1 |
| Xing, Y | 1 |
| Niu, Y | 1 |
| Zhao, D | 2 |
| Suo, L | 1 |
| Zou, J | 1 |
| Wei, D | 1 |
| Respekta, N | 1 |
| Maślanka, A | 1 |
| Mlyczyńska, E | 1 |
| Billert, M | 1 |
| Szlaga, A | 2 |
| Sambak, P | 1 |
| Pawlicki, P | 1 |
| Płachno, B | 1 |
| Skrzypski, M | 1 |
| Kotula-Balak, M | 1 |
| Błasiak, A | 1 |
| Rak, A | 2 |
| Oyeleke, MB | 2 |
| Mirazi, N | 1 |
| Hesami, S | 1 |
| Nourian, A | 1 |
| Hosseini, A | 1 |
| Azizi-Kutenaee, M | 1 |
| Heidari, S | 1 |
| Taghavi, SA | 2 |
| Bazarganipour, F | 2 |
| Panda, SR | 1 |
| Sharmila, V | 1 |
| Kalidoss, VK | 1 |
| Hota, S | 1 |
| Chen, J | 3 |
| Dong, H | 1 |
| Ma, R | 1 |
| Zou, Y | 1 |
| Wang, W | 2 |
| Zheng, Q | 1 |
| Feng, Y | 1 |
| Tan, Z | 1 |
| Zeng, X | 1 |
| Deng, Y | 1 |
| Gu, B | 1 |
| Sun, A | 1 |
| Franik, S | 3 |
| Le, QK | 1 |
| Kremer, JA | 3 |
| Kiesel, L | 2 |
| Farquhar, C | 3 |
| Wolugbom, JA | 1 |
| Zhu, X | 2 |
| Fu, Y | 1 |
| Kamal, DAM | 3 |
| Ibrahim, SF | 3 |
| Ugusman, A | 3 |
| Zaid, SSM | 1 |
| Mokhtar, MH | 3 |
| Zenhom, NM | 1 |
| Nair, AB | 1 |
| Ataabadi, MS | 1 |
| Bahmanpour, S | 1 |
| Yousefinejad, S | 1 |
| Alaee, S | 1 |
| Shi, L | 3 |
| Ye, S | 2 |
| Gao, M | 2 |
| Jin, X | 2 |
| Kirici, P | 2 |
| Kaplan, S | 2 |
| Annac, E | 2 |
| Tanriverdi, ES | 2 |
| Cagiran, FT | 2 |
| Kali, Z | 2 |
| Mavral, N | 2 |
| Taskapan, MC | 2 |
| Ahmed, AF | 2 |
| Sharkawi, SS | 2 |
| AbdelHameed, SS | 2 |
| Bayoumi, AM | 2 |
| Moussa, RS | 2 |
| Alhakamy, NA | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Administration of Single High Dose Letrozole for Ovulation Induction - A Randomized Controlled Trial[NCT02703649] | Phase 4 | 36 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| Laparoscopic Ovarian Drilling Versus Letrozole In Clomiphene Citrate Resistant Polycystic Ovary: A Randomized Controlled Trial[NCT03664050] | Phase 3 | 90 participants (Anticipated) | Interventional | 2018-01-01 | Recruiting | ||
| Efficacy of Combined Letrozole-metformin in Comparison With Letrozole Only in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome[NCT03135301] | Phase 3 | 80 participants (Anticipated) | Interventional | 2017-06-20 | Recruiting | ||
| Dosage Optimization for Letrozole Treatment in Clomiphene Resistant Patients With Polycystic Ovary Syndrome: A Prospective Interventional Study[NCT01315912] | Phase 4 | 44 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531] | Phase 3 | 1,100 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | ||
| Intrauterine Insemination With Letrozole Versus Intrauterine Insemination in Natural Cycle. A Randomised Controlled Trial[NCT03455426] | 100 participants (Actual) | Interventional | 2018-03-15 | Completed | |||
| Letrozole Versus Laparoscopic Ovarian Drilling for Clomiphene-resistant Women With Polycystic Ovary Syndrome[NCT03009838] | Phase 3 | 150 participants (Anticipated) | Interventional | 2017-01-02 | Recruiting | ||
| Double Blind Cross-over Randomized Controlled Trial Comparing Letrozole Versus Clomifene Citrate for Ovulation Induction in Women With Polycystic Ovarian Syndrome[NCT00478504] | Phase 4 | 159 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Follicular Synchronization in Polycystic Ovarian Syndrome Patients Undergoing Intracytoplasmatic Sperm Injection With Letrozole /Antagonist Protocol: A Randomized Controlled Trial[NCT04069117] | Phase 4 | 200 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| A 20 Week Double-Blind Randomized Trial of Clomiphene Citrate and Letrozole for the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT00719186] | Phase 3 | 750 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| Graceful Lifestyle Changes Intervention Study for Women With PCOS and Infertility[NCT02630485] | 240 participants (Anticipated) | Interventional | 2015-12-31 | Not yet recruiting | |||
| Combined Letrozole and Clomid in Polycystic Ovary Syndrome: a Randomized Control Trial of Combination of Letrozole and Clomiphene Citrate or Letrozole Alone for the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT02802865] | Phase 4 | 70 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
| Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome[NCT04867252] | Phase 2 | 88 participants (Actual) | Interventional | 2021-05-03 | Completed | ||
| Hormonal Replacement Therapy Plus Letrozole Incorporation Versus Letrozole Mild Ovarian Stimulation in Endometrial Preparation for Frozen Embryo Transfer: A Randomised Controlled Trial[NCT06181305] | Phase 4 | 210 participants (Anticipated) | Interventional | 2023-12-12 | Not yet recruiting | ||
| COmbining Oral Letrozole and Clomiphene for Ovarian Stimulation (COOL-COS) Associated With Corifollitropin Alfa: a Pilot Study[NCT02448459] | Phase 1 | 40 participants (Actual) | Interventional | 2015-05-31 | Completed | ||
| Evaluation of a Simplified Low-cost and Friendly Controlled Ovarian Stimulation Combining Oral Letrozole and Clomiphene Citrate: a Pilot Study[NCT02288143] | Phase 4 | 28 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer in Polycystic Ovary Syndrome (PCOS) Patients[NCT02775877] | 100 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| Effect of Acupuncture Pre-treatment Combined With Letrozole on Live Birth in Infertile Women With Polycystic Ovary Syndrome[NCT02491320] | Phase 3 | 384 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| Combined Letrozole-metformin-pioglitazone Versus Combined Clomiphene Citrate-metformin-pioglitazone in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome[NCT01909141] | Early Phase 1 | 100 participants (Actual) | Interventional | 2013-08-31 | Completed | ||
| The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of Polycystic Ovary Syndrome.[NCT03843736] | Phase 3 | 200 participants (Anticipated) | Interventional | 2019-02-21 | Recruiting | ||
| The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment[NCT05298657] | 200 participants (Anticipated) | Observational [Patient Registry] | 2022-09-01 | Not yet recruiting | |||
| Comparison Between Letrozole and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome: A Randomised Controlled Trial[NCT02304107] | Phase 3 | 140 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH[NCT02389088] | 9 participants (Actual) | Interventional | 2006-04-30 | Completed | |||
| Extended Letrozole Regimen Co-treatment With Gonadotropin Releasing Hormone Antagonist Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in Poor Responders Undergoing IVF-ET. A Randomized Controlled Trial[NCT04268927] | Phase 2 | 106 participants (Anticipated) | Interventional | 2018-04-01 | Recruiting | ||
| Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Patients With Poor Ovarian Response Undergoing IVF-ET, a Randomized Controlled Trial[NCT01219153] | Phase 2 | 136 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination[NCT01232075] | Phase 2 | 214 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| "Supplementation of the Luteal Phase With Vaginal Progesterone (Crinone 8%) in Women With Polycystic Ovary Syndrome Undergoing Ovulation Induction With Letrozole: A Prospective and Randomized Controlled Trial"[NCT03440359] | Phase 2/Phase 3 | 52 participants (Actual) | Interventional | 2012-07-06 | Completed | ||
| The Randomized Clinical Trials of Letrozole Administration During Luteal Phase in Patients Who Have the Risk of Ovarian Hyperstimulation Syndrome[NCT02686151] | Phase 3 | 50 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| Phase II Randomized Study of Neoadjuvant Metformin Plus Letrozole vs Placebo Plus Letrozole for ER-positive Postmenopausal Breast Cancer[NCT01589367] | Phase 2 | 208 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Clomiphene Citrate Plus HPuFSH Versus Letrozole Plus HPuFSH in Clomid Resistant Infertile PCOS Women[NCT01793038] | 160 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | |||
| Comparison Between the Role of Follicular Output Rate and Preovulatory Count in the Prediction of Pregnancy in Women With Polycystic Ovarian Syndrome Undergoing Intra Cytoplasmic Sperm Injection (ICSI)[NCT02190006] | 300 participants (Anticipated) | Observational | 2014-07-31 | Recruiting | |||
| The Role of Estrogen in Luteinizing Hormone Surge and Ovulation[NCT01999569] | Phase 4 | 10 participants (Actual) | Interventional | 2007-04-30 | Completed | ||
| Use of High Cost Monitoring During Letrozole Ovulation Induction and Effect on Pregnancy Rates - A Pilot Study[NCT01279200] | Phase 4 | 21 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome measure is the occurrence of a live birth during the study period. Safety measures will be the number and type of reported adverse events in subjects and offspring. (NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Arm A: Clomiphene Citrate | 72 |
| Arm B: Letrozole | 103 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | ovulations (Number) |
|---|---|
| Arm A: Clomiphene Citrate | 331 |
| Arm B: Letrozole | 388 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Arm A: Clomiphene Citrate | 103 |
| Arm B: Letrozole | 154 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | events (Number) |
|---|---|
| Arm A: Clomiphene Citrate | 13 |
| Arm B: Letrozole | 22 |
(NCT00719186)
Timeframe: September 2008 - December 2011
| Intervention | participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Neonatal jaundice | Neonatal respiratory distress syndrome | Neonatal hospitalization >3 days | Intrauterine growth restriction | Neonatal infectin | Minor birth defect | Other complication | Congenital anomaly | Neonatal death | |
| Arm A: Clomiphene Citrate | 17 | 2 | 4 | 1 | 2 | 0 | 4 | 1 | 2 |
| Arm B: Letrozole | 27 | 7 | 4 | 5 | 2 | 1 | 5 | 4 | 1 |
Clinical Pregnancy: an intrauterine pregnancy with fetal heart motion determined by ultrasonography; No Clinical Pregnancy: no intrauterine pregnancy with fetal heart motion determined by ultrasonography (NCT02802865)
Timeframe: 6-7 weeks after treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 1 |
| Letrozole + Clomiphene | 3 |
Conception: a positive serum or urinary test of hCG; No conception: Neither a positive serum or urinary test of hCG (NCT02802865)
Timeframe: 5 weeks after treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 3 |
| Letrozole + Clomiphene | 4 |
Thickness of endometrial lining assessed by ultrasound (NCT02802865)
Timeframe: Cycle day 12-14
| Intervention | mm (Mean) |
|---|---|
| Letrozole | 6.2 |
| Letrozole + Clomiphene | 8.3 |
Live Birth: delivery of a live infant; No Live Birth: no delivery of a live infant (NCT02802865)
Timeframe: 9-10 months after treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 1 |
| Letrozole + Clomiphene | 3 |
Multiple Gestation: an intrauterine pregnancy with multiple fetal heart rates determined by ultrasonography; No Multiple Gestation: either no intrauterine pregnancy, or an intrauterine pregnancy with a single fetal heart rate determined by ultrasonography (NCT02802865)
Timeframe: 9-10 months after treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 0 |
| Letrozole + Clomiphene | 0 |
Number of follicles measuring > 10mm on ultrasound (NCT02802865)
Timeframe: Cycle day 12-14
| Intervention | follicles (Median) |
|---|---|
| Letrozole | 0 |
| Letrozole + Clomiphene | 1 |
Ovulation: mid-luteal progesterone > /=3 ng/mL. No ovulation: mid-luteal progesterone <3ng/mL. (NCT02802865)
Timeframe: 7 days following LH surge or at cycle day 21 if no LH surge was detected
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 15 |
| Letrozole + Clomiphene | 27 |
Pregnancy Loss: any pregnancy loss including biochemical pregnancy, ectopic pregnancy, and miscarriage; No Pregnancy Loss: no pregnancy loss including biochemical pregnancy, ectopic pregnancy, or miscarriage. (NCT02802865)
Timeframe: 9-10 months after treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Letrozole | 2 |
| Letrozole + Clomiphene | 1 |
Size of largest follicle on ultrasound (NCT02802865)
Timeframe: Cycle day 12-14
| Intervention | mm (Median) |
|---|---|
| Letrozole | 10 |
| Letrozole + Clomiphene | 16 |
(NCT01909141)
Timeframe: 3 months
| Intervention | mm (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 10.56 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 9.68 |
(NCT01909141)
Timeframe: 3 months
| Intervention | follicles (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 1.44 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 1.5 |
(NCT01909141)
Timeframe: 3 months
| Intervention | percentage of all cycles (Number) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 93 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 108 |
(NCT01909141)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 28 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 24 |
serum creatinine was measured at the end of the study period (after 3 months) in both groups. (NCT01909141)
Timeframe: 3 months
| Intervention | mg/dL (Mean) |
|---|---|
| Arm 1:Letrozole-pioglitazone -Metformin Group | 0.62 |
| Arm 2: Clomiphene Citrate-pioglitazone-metformin | 0.57 |
Estradiol (pmol/L) measured during Phase I (without Letrozole) and during Phase II (with Letrozole) at time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation. (NCT02389088)
Timeframe: At time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation for both Phase I and Phase II
| Intervention | pmol/L (Mean) |
|---|---|
| Phase I - Week 0 - 24 Hours | 451.7 |
| Phase I - Week 5 - 0 Hour | 116 |
| Phase I - Week 5 - 24 Hour | 247.2 |
| Phase I - Week 6 - 0 Hour | 131.4 |
| Phase I - Week 6 - 24 Hour | 347.5 |
| Phase II - Week 0 - 24 Hours | 401.4 |
| Phase II - Week 5 - 0 Hours | 57.9 |
| Phase II - Week 5 - 24 Hours | 91.3 |
| Phase II - Week 6 - 0 Hours | 66.5 |
| Phase II - Week 6 - 24 Hours | 126.6 |
Inhibin B (ng/L) measured during Phase I (without Letrozole) and during Phase II (with Letrozole) at time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation. (NCT02389088)
Timeframe: At time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation for both Phase I and Phase II
| Intervention | ng/L (Mean) |
|---|---|
| Phase I - Week 0 - 24 Hours | 420.6 |
| Phase I - Week 5 - 0 Hour | 87.9 |
| Phase I - Week 5 - 24 Hour | 395.1 |
| Phase I - Week 6 - 0 Hour | 85.2 |
| Phase I - Week 6 - 24 Hour | 445.5 |
| Phase II - Week 0 - 24 Hours | 390 |
| Phase II - Week 5 - 0 Hours | 165.2 |
| Phase II - Week 5 - 24 Hours | 340 |
| Phase II - Week 6 - 0 Hours | 184.3 |
| Phase II - Week 6 - 24 Hours | 427.3 |
LH and FSH (IU/L) measured during Phase I (without Letrozole) and during Phase II (with Letrozole) at time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation. (NCT02389088)
Timeframe: At time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation for both Phase I and Phase II
| Intervention | IU/L (Mean) | |
|---|---|---|
| LH | FSH | |
| Phase I - Week 0 - 24 Hours | NA | NA |
| Phase I - Week 5 - 0 Hour | 0.6 | 3.5 |
| Phase I - Week 5 - 24 Hour | NA | NA |
| Phase I - Week 6 - 0 Hour | 2.0 | 4.3 |
| Phase I - Week 6 - 24 Hour | NA | NA |
| Phase II - Week 0 - 24 Hours | NA | NA |
| Phase II - Week 5 - 0 Hours | 1.22 | 8.0 |
| Phase II - Week 5 - 24 Hours | NA | NA |
| Phase II - Week 6 - 0 Hours | 3.6 | 9.3 |
| Phase II - Week 6 - 24 Hours | NA | NA |
Testosterone, Androstenedione and 17-OH Progesterone (nmol/L) measured during Phase I (without Letrozole) and during Phase II (with Letrozole) at time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation. (NCT02389088)
Timeframe: At time 24 hours during Week 0 and times 0 and 24 hours during Weeks 5 and 6 after FSH stimulation for both Phase I and Phase II
| Intervention | nmol/L (Mean) | ||
|---|---|---|---|
| Testosterone | Androstenedione | 17OH-Progesterone | |
| Phase I - Week 0 - 24 Hours | NA | NA | NA |
| Phase I - Week 5 - 0 Hour | 0.6 | 2.8 | 32.1 |
| Phase I - Week 5 - 24 Hour | NA | NA | NA |
| Phase I - Week 6 - 0 Hour | 0.8 | 3.6 | 31.1 |
| Phase I - Week 6 - 24 Hour | NA | NA | NA |
| Phase II - Week 0 - 24 Hours | NA | NA | NA |
| Phase II - Week 5 - 0 Hours | 0.6 | 2.9 | 24.0 |
| Phase II - Week 5 - 24 Hours | NA | NA | NA |
| Phase II - Week 6 - 0 Hours | 0.01 | 4.3 | 37.4 |
| Phase II - Week 6 - 24 Hours | NA | NA | NA |
Urine ovulation tests assessed (NCT01999569)
Timeframe: Cycle days 10-18
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 9 |
| Letrozole Treatment Cycle | 10 |
Ovulation; elevated progesterone (NCT01999569)
Timeframe: Cycle day 12
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 10 |
| Letrozole Treatment Cycle | 10 |
Serum progesterone ng/mL drawn during cycle days twelve through 22 (NCT01999569)
Timeframe: Cycle days 12-22
| Intervention | Participants (Count of Participants) |
|---|---|
| Control | 9 |
| Letrozole Treatment Cycle | 10 |
Percentage of women in each arm who became pregnant within the study time frame. (NCT01279200)
Timeframe: 3 menstrual/treatment cycles (approximately 28-33 days each)
| Intervention | percentage of participants (Number) |
|---|---|
| Urinary LH Kits | 75 |
| Midcycle Ultrasound + hCG Injection | 25 |
Cycles means treatment/menstrual cycles, approximately 28-33 days. (NCT01279200)
Timeframe: 3 menstrual/treatment cycles, or upon conception, whichever comes first
| Intervention | menstrual cycles (Mean) |
|---|---|
| Urinary LH Kits | 1.83 |
| Midcycle Ultrasound + hCG Injection | 1 |
37 reviews available for letrozole and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Kuntai Capsule Combined With Letrozole on Gonadal Hormone Levels and Ovarian Function in Patients With PCOS: A Systematic Review and Meta-Analysis.
Topics: Aromatase Inhibitors; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Gonadal Hormones; Hu | 2021 |
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications.
Topics: Acupuncture; Anovulation; Eflornithine; Female; Herbal Medicine; Hirsutism; Humans; Hydroxymethylglu | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2022 |
Letrozole Compared With Clomiphene Citrate for Polycystic Ovarian Syndrome: A Systematic Review and Meta-analysis.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; Ov | 2023 |
First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis.
Topics: Birth Rate; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, Female | 2019 |
Controversial association between polycystic ovary syndrome and breast cancer.
Topics: Androgens; Anovulation; Aromatase Inhibitors; Breast Neoplasms; Clomiphene; Contraceptives, Oral, Co | 2019 |
Risk of foetal harm with letrozole use in fertility treatment: a systematic review and meta-analysis.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infant, Newborn; Infertility, Female; Letrozol | 2021 |
Stimulated cycle versus artificial cycle for frozen embryo transfer in patients with polycystic ovary syndrome: a Meta-analysis.
Topics: Abortion, Spontaneous; Aromatase Inhibitors; Cryopreservation; Embryo Implantation; Embryo Transfer; | 2021 |
Effectiveness and safety of aspirin combined with letrozole in the treatment of polycystic ovary syndrome: a systematic review and meta-analysis.
Topics: Aspirin; China; Female; Humans; Letrozole; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy | 2021 |
Higher ovulation rate with letrozole as compared with clomiphene citrate in infertile women with polycystic ovary syndrome: a systematic review and meta-analysis.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Ovulation Indu | 2021 |
Polycystic ovarian syndrome and infertility: overview and insights of the putative treatments.
Topics: Anti-Mullerian Hormone; Bariatric Surgery; Clomiphene; Female; Gonadotropins; Humans; Infertility, F | 2021 |
Ovarian surgery for symptom relief in women with polycystic ovary syndrome.
Topics: Acne Vulgaris; Clomiphene; Female; Gonadotropins; Hirsutism; Humans; Laparoscopy; Letrozole; Menstru | 2017 |
Letrozole versus clomiphene citrate in polycystic ovary syndrome: a meta-analysis of randomized controlled trials.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; Ov | 2018 |
Aromatase inhibitors (letrozole) for subfertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anastrozole; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Fe | 2018 |
Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L-arginine.
Topics: Animals; Arginine; Aromatase Inhibitors; Body Weight; Female; Gasotransmitters; Hemin; Humans; Letro | 2019 |
Pharmacology of medications used for ovarian stimulation.
Topics: Clomiphene; Female; Fertility Agents, Female; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; | 2019 |
Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Topics: Aromatase Inhibitors; Birth Rate; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Hum | 2019 |
Contemporary Management of Polycystic Ovarian Syndrome.
Topics: Androgen Antagonists; Aromatase Inhibitors; Biomarkers; Clomiphene; Contraceptives, Oral, Combined; | 2019 |
Recent advances in the understanding and management of polycystic ovary syndrome.
Topics: Aromatase Inhibitors; Clomiphene; Female; Humans; Insulin Resistance; Letrozole; Obesity; Polycystic | 2019 |
Aromatase inhibitors for subfertile women with polycystic ovary syndrome.
Topics: Anastrozole; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Fertility Agents, Female; | 2014 |
The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS).
Topics: Animals; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Letrozole; Metfo | 2014 |
Endocrine and reproductive effects of polycystic ovarian syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Infertility, Fe | 2015 |
The use of aromatase inhibitors for ovulation induction.
Topics: Adult; Aromatase Inhibitors; Birth Rate; Clomiphene; Coitus; Female; Humans; Infertility, Female; Le | 2015 |
Novel strategies in the management of polycystic ovary syndrome.
Topics: Adult; Clomiphene; Contraceptives, Oral, Combined; Female; Fertility Agents, Female; Fertilization i | 2015 |
Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Let | 2015 |
Treatment strategies for the infertile polycystic ovary syndrome patient.
Topics: Anovulation; Antineoplastic Agents; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, | 2015 |
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction.
Topics: Adult; Anovulation; Body Weight; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans | 2016 |
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertiliz | 2016 |
Ovulation induction in polycystic ovary syndrome: Current options.
Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy; | 2016 |
Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome: a meta-analysis.
Topics: Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Medicine, Chinese Trad | 2017 |
Aromatase inhibitors for female infertility: a systematic review of the literature.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Female; Fertilization in Vitro; Gonadotropins; | 2009 |
Aromatase inhibitors for ovulation induction and ovarian stimulation.
Topics: Aromatase Inhibitors; Female; Humans; Letrozole; Nitriles; Ovarian Diseases; Ovulation Induction; Po | 2011 |
Meta-analysis of letrozole versus clomiphene citrate in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovulation Induction; Poly | 2011 |
Reproductive impact of polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Clomiphene; Female; Fertilization in Vitro; Humans; Infant, Newborn; Infertil | 2012 |
Polycystic ovarian syndrome management options.
Topics: Clomiphene; Contraceptives, Oral, Hormonal; Estrogen Antagonists; Exercise; Female; Humans; Infertil | 2012 |
Evaluation and treatment of anovulatory and unexplained infertility.
Topics: Anovulation; Clomiphene; Diet; Evidence-Based Medicine; Exercise; Female; Fertility Agents, Female; | 2012 |
Ovulation induction in polycystic ovary syndrome.
Topics: Adult; Anovulation; Aromatase Inhibitors; Body Mass Index; Clomiphene; Diathermy; Female; Fertility | 2008 |
57 trials available for letrozole and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Probiotic effects on sexual function in women with polycystic ovary syndrome: a double blinded randomized controlled trial.
Topics: Female; Fertility Agents, Female; Humans; Iran; Letrozole; Polycystic Ovary Syndrome; Pregnancy; Pro | 2022 |
A triple-blind, randomized controlled trial, comparing combined letrozole and clomiphene versus only letrozole for ovulation induction in women with polycystic ovarian syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Ovulation Indu | 2023 |
Ovulation induction using sequential letrozole/gonadotrophin in infertile women with PCOS: a randomized controlled trial.
Topics: Adolescent; Adult; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans; Infertility, | 2023 |
Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and Infertility.
Topics: Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Menotropins; Ovulation Ind | 2023 |
Comparing efficacy and safety of stair step protocols for clomiphene citrate and letrozole in ovulation induction for women with polycystic ovary syndrome (PCOS): a randomized controlled clinical trial.
Topics: Child; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitrile | 2023 |
Live birth after letrozole-stimulated cycles versus hormone replacement treatment cycles for the first frozen embryo transfer in women with polycystic ovary syndrome: protocol for a multicentre randomised controlled trial.
Topics: Embryo Transfer; Estrogens; Female; Humans; Infant, Newborn; Letrozole; Live Birth; Multicenter Stud | 2023 |
Clomiphene citrate plus letrozole versus clomiphene citrate alone for ovulation induction in infertile women with ovulatory dysfunction: a randomized controlled trial.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Live Birth; Ov | 2023 |
The role of Letrozole (LE) in controlled ovarian stimulation (COS) in patients at high risk to develop ovarian hyper stimulation syndrome (OHSS). A prospective randomized controlled pilot study.
Topics: Adult; Anti-Mullerian Hormone; Aromatase Inhibitors; Female; Fertilization in Vitro; Gonadotropin-Re | 2020 |
Letrozole and human menopausal gonadotropin for ovulation induction in clomiphene resistance polycystic ovary syndrome patients: A randomized controlled study.
Topics: Abortion, Spontaneous; Adult; Clomiphene; Endometrium; Estradiol; Female; Humans; Infertility, Femal | 2020 |
Comparing the effect of clomiphene citrate and letrozole on ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Double-Blind Method; Endometrium; Female; Fertility Agents, | 2020 |
A multicenter randomized trial of personalized acupuncture, fixed acupuncture, letrozole, and placebo letrozole on live birth in infertile women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Acupuncture Therapy; Aromatase Inhibitors; Female; Humans; Infertility, Femal | 2020 |
Letrozole versus clomiphene citrate for ovulation induction in anovulatory women with polycystic ovarian syndrome: A randomized controlled trial.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Ovulati | 2021 |
Evaluation of the effect of trans-vaginal ovarian needle punctures on women with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Drug Resistance; Estrogen Ant | 2021 |
The effect of letrozole versus artificial hormonal endometrial preparation on pregnancy outcome after frozen-thawed embryos transfer cycles: a randomized clinical trial.
Topics: Adult; Cryopreservation; Embryo Implantation; Embryo Transfer; Endometrium; Female; Humans; Letrozol | 2020 |
Letrozole Versus Clomiphene Citrate and Natural Cycle: Endometrial Receptivity During Implantation Window in Women With Polycystic Ovary Syndrome.
Topics: Clomiphene; Embryo Implantation; Endometrium; Female; Fertility Agents, Female; Humans; Letrozole; O | 2020 |
Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial.
Topics: Clomiphene; Endometriosis; Female; Fertility Agents, Female; Humans; Infertility, Female; Laparoscop | 2022 |
Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial.
Topics: Adult; Clomiphene; Female; Hormone Antagonists; Humans; Infertility, Female; Letrozole; Nitriles; Ov | 2017 |
[Optimal Ovulation Induction in Polycystic Ovary Syndrome Resistant to Clomiphene Citrate or Letrozole.]
Topics: Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility, Female | 2016 |
Double-blind randomized controlled trial of letrozole versus clomiphene citrate in subfertile women with polycystic ovarian syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2017 |
Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Metformin; Nitriles; Ovulati | 2018 |
The effects of letrozole and clomiphene citrate on ligands expression of Wnt3, Wnt7a, and Wnt8b in proliferative endometrium of women with Polycystic ovarian syndrome.
Topics: Adult; Anti-Mullerian Hormone; Clomiphene; Endometrium; Estradiol; Female; Fertility Agents, Female; | 2018 |
Insulin resistance is associated with depression risk in polycystic ovary syndrome.
Topics: Adult; Clomiphene; Depression; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; P | 2018 |
Effects of letrozole and clomiphene citrate on Wnt signaling pathway in endometrium of polycystic ovarian syndrome and healthy women†.
Topics: Adult; Aromatase Inhibitors; beta Catenin; Clomiphene; Endometrium; Estradiol; Estrogen Receptor alp | 2019 |
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
A randomized controlled trial comparing lifestyle intervention to letrozole for ovulation in women with polycystic ovary syndrome: a study protocol.
Topics: Administration, Oral; Adolescent; Adult; Diet, Healthy; Exercise; Female; Fertility Agents, Female; | 2018 |
A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Age Factors; Biomarkers; Body Mass Index; Clomiphene; Female; Fertility; Fertilit | 2019 |
The effectiveness of inositol and metformin on infertile polycystic ovary syndrome women with resistant to letrozole.
Topics: Adult; Female; Folic Acid; Humans; Infertility, Female; Inositol; Letrozole; Metformin; Ovulation In | 2019 |
Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Endometrium; Female; Humans; Infertility, Female; Letrozole | 2019 |
Comparison of endometrial receptivity of clomiphene citrate versus letrozole in women with polycystic ovary syndrome: a randomized controlled study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Endometrium; Female; Fertility Agents, Female; Humans; Letr | 2019 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female | 2013 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Female; Fertility Agents, Female; Humans; Infertility, Femal | 2014 |
Effects of combining low‑dose aspirin with a Chinese patent medicine on follicular blood flow and pregnancy outcome.
Topics: Adult; Aspirin; Drug Therapy, Combination; Drugs, Chinese Herbal; Endometrium; Female; Fertility Age | 2014 |
Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Clomiphene; Coitus; Female; Fertility Agents, Femal | 2015 |
Comparison of letrazole and clomiphene citrate in women with polycystic ovaries undergoing ovarian stimulation.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Fema | 2015 |
A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome.
Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Egypt; Female; F | 2016 |
Use of letrozole and clomiphene citrate combined with gonadotropins in clomiphene-resistant infertile women with polycystic ovary syndrome: a prospective study.
Topics: Adult; Clomiphene; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fertility Ag | 2015 |
Randomized controlled trial of letrozole, berberine, or a combination for infertility in the polycystic ovary syndrome.
Topics: Administration, Oral; Adult; Berberine; China; Double-Blind Method; Drug Administration Schedule; Dr | 2016 |
Cost effectiveness of letrozole and purified urinary FSH in treating women with clomiphene citrate-resistant polycystic ovarian syndrome: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cost-Benefit Analysis; Drug Therapy, Combination; Female; F | 2017 |
Comparison of acupuncture pretreatment followed by letrozole versus letrozole alone on live birth in anovulatory infertile women with polycystic ovary syndrome: a study protocol for a randomised controlled trial.
Topics: Acupuncture Therapy; Adult; Aromatase Inhibitors; Birth Rate; Clinical Protocols; Electroacupuncture | 2016 |
The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Cohort Studies; Estradiol; Female; Follicle Stimulating Hormone; Granul | 2017 |
Endometrial effects of letrozole and clomiphene citrate in women with polycystic ovary syndrome using spiral artery Doppler.
Topics: Adult; Clomiphene; Endometrium; Female; Fertility Agents, Female; Humans; Letrozole; Nitriles; Ovari | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Extended letrozole therapy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a novel protocol.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Estrogen Antagonists; Female; | 2009 |
Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estradiol; Female; Fertility Age | 2009 |
RETRACTED: Letrozole versus combined metformin and clomiphene citrate for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Algorithms; Clomiphene; Drug Combinations; Drug Resistance; Female; Fertility Agents, Female; | 2010 |
Letrozole versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Diathermy; Female; Humans; Letrozole; Nitriles; Ovulation Induction; Po | 2010 |
Reproductive outcome after letrozole versus laparoscopic ovarian drilling for clomiphene-resistant polycystic ovary syndrome.
Topics: Adult; Anovulation; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Drug Resistance; | 2011 |
Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Endometrium; Female; Fertility Agents, Female; Gene Expression Regulation; Humans | 2011 |
Comparison of efficacy of letrozole and clomiphene citrate in ovulation induction in Indian women with polycystic ovarian syndrome.
Topics: Adult; Chorionic Gonadotropin; Clomiphene; Endometrium; Estradiol; Female; Fertility Agents, Female; | 2012 |
The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Antineoplastic Agents; Chi-Square Distribution; Clomiphene; Double-Blind Method; | 2012 |
Comparison of the effects of letrozole and clomiphene citrate for ovulation induction in infertile women with polycystic ovary syndrome.
Topics: Adult; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitrile | 2012 |
Efficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Blood Glucose; Clomiphene; Drug Therapy, Combination; Female; Fertility | 2013 |
Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation.
Topics: Adult; Aromatase Inhibitors; Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letr | 2004 |
Efficacy of combined metformin-letrozole in comparison with metformin-clomiphene citrate in clomiphene-resistant infertile women with polycystic ovarian disease.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Resistance; Drug Therapy, Combination; Endometrium; Fe | 2006 |
RETRACTED: Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial.
Topics: Abortion, Spontaneous; Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; En | 2009 |
RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial.
Topics: Abortion, Spontaneous; Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Drug Resistance; Endome | 2008 |
Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Endometrium; Female; Fert | 2009 |
Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate.
Topics: Anovulation; Aromatase Inhibitors; Chorionic Gonadotropin; Endometrium; Enzyme Inhibitors; Estradiol | 2001 |
206 other studies available for letrozole and Polycystic Ovarian Syndrome
| Article | Year |
|---|---|
Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis.
Topics: Computational Biology; Databases, Protein; Drug Repositioning; Female; Gene Expression Regulation; H | 2021 |
Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; Female; Hyperinsulinism; Hypoglycemic Agents; Insu | 2021 |
Role of 14-3-3β protein on ovarian folliculogenesis, steroidogenesis and its correlation in the pathogenesis of PCOS in mice.
Topics: 14-3-3 Proteins; Animals; Female; Letrozole; Mice; Polycystic Ovary Syndrome; Testosterone | 2021 |
Soy isoflavones alleviate polycystic ovary syndrome in rats by regulating NF- κB signaling pathway.
Topics: Animals; Estrus; Female; Glycine max; Isoflavones; Letrozole; NF-kappa B; Ovary; Polycystic Ovary Sy | 2021 |
Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Estrogen Receptor alpha; Female; Gene Expression; Gene Expression R | 2022 |
Effects of Soy Isoflavones, Resistant Starch and Antibiotics on Polycystic Ovary Syndrome (PCOS)-Like Features in Letrozole-Treated Rats.
Topics: Animals; Anti-Bacterial Agents; Biomarkers; Butyric Acid; Disease Models, Animal; Equol; Female; Gas | 2021 |
Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats.
Topics: Animals; Antioxidants; Blood Glucose; Corpus Luteum; Disease Models, Animal; Endometrium; Female; Fi | 2021 |
The effectiveness of resveratrol in treatment of PCOS on the basis of experimental model in rats.
Topics: Animals; Antioxidants; Disease Models, Animal; Estrous Cycle; Female; Letrozole; Ovary; Polycystic O | 2021 |
Diacerein ameliorates induced polycystic ovary in female rats via modulation of inflammasome/caspase1/IL1β and Bax/Bcl2 pathways.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Disease Models, Anima | 2022 |
Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice.
Topics: Animals; Cysteine; Diabetes Mellitus, Type 2; Diestrus; Disease Models, Animal; Estrous Cycle; Femal | 2021 |
Topics: Animals; Butyrates; Disease Models, Animal; Female; Humans; Lactobacillus plantarum; Letrozole; Ovar | 2022 |
Emulating a target trial of the comparative effectiveness of clomiphene citrate and letrozole for ovulation induction.
Topics: Adolescent; Adult; Child; Clomiphene; Female; Fertility Agents, Female; Humans; Infant, Newborn; Inf | 2022 |
Network pharmacology integrated with experimental validation reveals the regulatory mechanism of action of Hehuan Yin decoction in polycystic ovary syndrome with insulin resistance.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Female; Insulin Resistance; | 2022 |
Partially purified non-polar phytocomponents from Aloe barbadensis Mill. gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary syndrome rodent model- an "in-vivo" study.
Topics: Aloe; Animals; Disease Models, Animal; Female; Letrozole; Mice; Plant Preparations; Polycystic Ovary | 2022 |
Comparative study of DHEA and letrozole induced polycystic ovary syndrome in post-pubertal rats.
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Female; Follicle Stimulating Hormone; Human | 2022 |
Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats.
Topics: Animals; Anthraquinones; Disease Models, Animal; Female; Humans; Letrozole; Polycystic Ovary Syndrom | 2022 |
The Effects of Letrozole and Metformin Combined with Targeted Nursing Care on Ovarian Function, LH, and FSH in Infertile Patients with Polycystic Ovary Syndrome.
Topics: Female; Follicle Stimulating Hormone; Humans; Infertility, Female; Letrozole; Metformin; Polycystic | 2022 |
Bio-enhancement of Soy Isoflavones (Genistein & Daidzein) Using Bacillus coagulans in Letrozole Induced Polycystic Ovarian Syndrome by Regulating Endocrine Hormones in Rats.
Topics: Animals; Bacillus coagulans; Female; Genistein; Hormones; Humans; Isoflavones; Letrozole; Polycystic | 2022 |
Mogroside V Improves Follicular Development and Ovulation in Young-Adult PCOS Rats Induced by Letrozole and High-Fat Diet Through Promoting Glycolysis.
Topics: Animals; Diet, High-Fat; Female; Glycolysis; Hexokinase; Humans; Lactate Dehydrogenase 5; Lactic Aci | 2022 |
Female Pelvic Conditions: Polycystic Ovary Syndrome.
Topics: Acne Vulgaris; Anovulation; Female; Finasteride; Gonadotropin-Releasing Hormone; Hirsutism; Humans; | 2022 |
Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome.
Topics: Acetates; Animals; Cardiovascular Diseases; Disease Models, Animal; Female; Humans; Inflammation; Le | 2022 |
Naringenin regulates gut microbiota and SIRT1/ PGC-1ɑ signaling pathway in rats with letrozole-induced polycystic ovary syndrome.
Topics: Animals; Body Weight; Claudin-1; Female; Flavanones; Gastrointestinal Microbiome; Hormones; Humans; | 2022 |
The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice.
Topics: Animals; Diet, High-Fat; Female; Fructose; Insulin Resistance; Letrozole; Mice; Mice, Inbred C57BL; | 2022 |
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model.
Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Female; Humans; Inflammasomes; Letrozol | 2022 |
Distinctions in PCOS Induced by Letrozole Vs Dehydroepiandrosterone With High-fat Diet in Mouse Model.
Topics: Animals; Body Weight; Dehydroepiandrosterone; Diet, High-Fat; Disease Models, Animal; Female; Humans | 2022 |
Metabolomics combined with network pharmacology to explore the mechanisms of modified Guishen pill to ameliorate polycystic ovary syndrome.
Topics: Animals; Female; Humans; Letrozole; Metabolomics; Network Pharmacology; Polycystic Ovary Syndrome; R | 2022 |
Short chain fatty acid, acetate restores ovarian function in experimentally induced PCOS rat model.
Topics: Acetates; Animals; Estradiol; Fatty Acids, Volatile; Female; Letrozole; Polycystic Ovary Syndrome; R | 2022 |
Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
Topics: Animals; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Letrozole; Membrane Proteins; Mi | 2022 |
Effects of Bu Shen Hua Zhuo formula on the LPS/TLR4 pathway and gut microbiota in rats with letrozole-induced polycystic ovary syndrome.
Topics: Animals; Blood Glucose; Female; Gastrointestinal Microbiome; Insulin; Letrozole; Lipopolysaccharides | 2022 |
Ovulation induction regimens are associated with a higher rate of livebirth after frozen single-blastocyst transfer among women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Embryo Transfer; Female; Humans; Infant, Newborn; Letrozole; Menotropins; Ovu | 2022 |
Levels of spexin and its receptors GALR2 and GALR3 in the hypothalamus and ovary of letrozole-induced polycystic ovary syndrome in rats.
Topics: Animals; Female; Humans; Hypothalamus; Letrozole; Peptide Hormones; Polycystic Ovary Syndrome; Rats; | 2022 |
Low-dose spironolactone ameliorates adipose tissue inflammation and apoptosis in letrozole-induced PCOS rat model.
Topics: Adipose Tissue; Animals; Apoptosis; Female; Humans; Inflammation; Letrozole; Polycystic Ovary Syndro | 2022 |
Protective efficacy of dark chocolate in letrozole-induced ovary toxicity model rats: hormonal, biochemical, and histopathological investigation.
Topics: Animals; Antioxidants; Chocolate; Disease Models, Animal; Female; Letrozole; Polycystic Ovary Syndro | 2022 |
Acetate restores hypothalamic-adipose kisspeptin status in a rat model of PCOS by suppression of NLRP3 immunoreactivity.
Topics: Acetates; Animals; Female; Kisspeptins; Letrozole; NLR Family, Pyrin Domain-Containing 3 Protein; Po | 2022 |
Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome.
Topics: Animals; Disease Models, Animal; Female; Insulin Resistance; Kidney Diseases; Letrozole; NF-kappa B; | 2023 |
The Disparity in the Management of Polycystic Ovary Syndrome between Obstetrician-Gynecologists in Different-Level Hospitals under the Hierarchical Medical System.
Topics: Androgens; Blood Glucose; Female; Hospitals; Humans; Insulin Resistance; Letrozole; Lipids; Metformi | 2022 |
Protective Role of Acetate Against Depressive-Like Behaviour Associated with Letrozole-Induced PCOS Rat Model: Involvement of HDAC2 and DNA Methylation.
Topics: Acetates; Animals; Disease Models, Animal; DNA; DNA Methylation; Female; Histone Deacetylase 2; Huma | 2023 |
Extending letrozole treatment duration is effective in inducing ovulation in women with polycystic ovary syndrome and letrozole resistance.
Topics: Clomiphene; Duration of Therapy; Female; Fertility Agents, Female; Humans; Infertility, Female; Letr | 2023 |
Kelulut Honey Improves Folliculogenesis, Steroidogenic, and Aromatase Enzyme Profiles and Ovarian Histomorphology in Letrozole-Induced Polycystic Ovary Syndrome Rats.
Topics: Animals; Aromatase; Clomiphene; Female; Honey; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats | 2022 |
Fenofibrate ameliorates letrozole-induced polycystic ovary in rats via modulation of PPARα and TNFα/CD95 pathway.
Topics: Animals; Anti-Mullerian Hormone; Body Weight; Disease Models, Animal; Female; Fenofibrate; Humans; I | 2022 |
Blood volatile organic compounds as potential biomarkers for poly cystic ovarian syndrome (PCOS): An animal study in the PCOS rat model.
Topics: Animals; Biomarkers; Female; Humans; Letrozole; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Volat | 2023 |
Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model.
Topics: Animals; Clomiphene; Female; Gonadal Steroid Hormones; Honey; Humans; Letrozole; Metformin; Polycyst | 2022 |
Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model.
Topics: Animals; Clomiphene; Female; Gonadal Steroid Hormones; Honey; Humans; Letrozole; Metformin; Polycyst | 2022 |
Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model.
Topics: Animals; Clomiphene; Female; Gonadal Steroid Hormones; Honey; Humans; Letrozole; Metformin; Polycyst | 2022 |
Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model.
Topics: Animals; Clomiphene; Female; Gonadal Steroid Hormones; Honey; Humans; Letrozole; Metformin; Polycyst | 2022 |
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Poly | 2022 |
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Poly | 2022 |
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Poly | 2022 |
Effect of different timing of letrozole initiation on pregnancy outcome in polycystic ovary syndrome.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Nitriles; Poly | 2022 |
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk | 2023 |
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk | 2023 |
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk | 2023 |
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk | 2023 |
The effect of Nateglinide and Octreotide on follicular morphology and free radical scavenging system in letrazole-induced rat model of PCOS.
Topics: Animals; Disease Models, Animal; Female; Follicle Stimulating Hormone; Free Radicals; Insulin-Like G | 2022 |
The effect of Nateglinide and Octreotide on follicular morphology and free radical scavenging system in letrazole-induced rat model of PCOS.
Topics: Animals; Disease Models, Animal; Female; Follicle Stimulating Hormone; Free Radicals; Insulin-Like G | 2022 |
The effect of Nateglinide and Octreotide on follicular morphology and free radical scavenging system in letrazole-induced rat model of PCOS.
Topics: Animals; Disease Models, Animal; Female; Follicle Stimulating Hormone; Free Radicals; Insulin-Like G | 2022 |
The effect of Nateglinide and Octreotide on follicular morphology and free radical scavenging system in letrazole-induced rat model of PCOS.
Topics: Animals; Disease Models, Animal; Female; Follicle Stimulating Hormone; Free Radicals; Insulin-Like G | 2022 |
Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.
Topics: Animals; Diet, Ketogenic; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats | 2023 |
Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.
Topics: Animals; Diet, Ketogenic; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats | 2023 |
Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.
Topics: Animals; Diet, Ketogenic; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats | 2023 |
Ketogenic diet restores hormonal, apoptotic/proliferative balance and enhances the effect of metformin on a letrozole-induced polycystic ovary model in rats.
Topics: Animals; Diet, Ketogenic; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats | 2023 |
Topics: Animals; Aromatase; Female; Humans; Hyperandrogenism; Letrozole; Moraceae; Overweight; Polycystic Ov | 2023 |
Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.
Topics: Animals; Female; Humans; Insulin Resistance; Letrozole; Lipids; Metformin; Mitochondria; Nanoparticl | 2023 |
Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation.
Topics: Animals; Diet, High-Fat; Fatty Acids; Female; Follicle Stimulating Hormone; Humans; Letrozole; Lipid | 2023 |
Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats.
Topics: Animals; Disease Models, Animal; Female; Humans; Interleukin-1; Letrozole; Polycystic Ovary Syndrome | 2023 |
Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model.
Topics: Animals; Anovulation; Female; Gonadotropin-Releasing Hormone; Humans; Letrozole; Mice; Neurons; Neur | 2022 |
Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Female; Humans; Letrozole; Luteinizing Hormone; Mice; Mice, Inbred | 2023 |
Ovarian Response can be Predicted in Women with PCOS who have Ovulation Induction with Letrozole.
Topics: Cohort Studies; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Infertility, | 2023 |
Comparison of pregnancy outcomes of letrozole-induced frozen-thawed embryo transfer cycles in PCOS women with two different abnormal ovulation patterns: A retrospective cohort study.
Topics: Abortion, Spontaneous; Embryo Transfer; Female; Humans; Letrozole; Ovulation; Ovulation Induction; P | 2023 |
Ameliorative effect of sesame oil on experimentally induced polycystic ovary syndrome: A cross-link between XBP-1/PPAR-1, regulatory proteins for lipogenesis/steroids.
Topics: Animals; Disease Models, Animal; Female; Humans; Letrozole; Lipogenesis; Metformin; Peroxisome Proli | 2023 |
Development and evaluation of novel krill oil-based clomiphene microemulsion as a therapeutic strategy for PCOS treatment.
Topics: Animals; Clomiphene; Euphausiacea; Female; Humans; Infertility, Female; Insulin Resistance; Letrozol | 2023 |
Letrozole cotreatment improves the follicular output rate in high-body-mass-index women with polycystic ovary syndrome undergoing IVF treatment.
Topics: Body Mass Index; Female; Fertilization in Vitro; Humans; Infertility, Female; Letrozole; Polycystic | 2023 |
Role of diacerein on steroidogenesis and folliculogenesis related genes in ovary of letrozole-induced PCOS mice.
Topics: Animals; Disease Models, Animal; Estrogens; Female; Humans; Letrozole; Mice; Polycystic Ovary Syndro | 2023 |
LINC00092 derived from follicular fluid alleviated the symptoms of PCOS through inactivation of phosphatase and tensin homolog by recruiting KDM5A.
Topics: Animals; Female; Follicular Fluid; Letrozole; Polycystic Ovary Syndrome; Rats; Retinoblastoma-Bindin | 2023 |
Predictors of response to ovulation induction using letrozole in women with polycystic ovary syndrome.
Topics: Female; Fertility Agents, Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormo | 2023 |
Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway.
Topics: Acetylcholine; Animals; Carvedilol; Catalase; Clomiphene; Esterases; Female; Fertility Agents, Femal | 2023 |
Ovulation induction with letrozole and dexamethasone in infertile patients with letrozole-resistant polycystic ovary syndrome.
Topics: Clomiphene; Dexamethasone; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; | 2023 |
Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole-induced polycystic ovary syndrome in the Sprague Dawley rats.
Topics: Androgens; Animals; Disease Models, Animal; Female; Follicular Cyst; Humans; Letrozole; Metformin; P | 2023 |
Effect of Parquetina nigrescens (Afzel.) Leaves on Letrozole-Induced PCOS in Rats: a Molecular Insight into Its Phytoconstituents.
Topics: Animals; Blood Glucose; Cholesterol; Female; Follicle Stimulating Hormone; Humans; Letrozole; Lutein | 2023 |
Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
Topics: Androgens; Animals; Disease Models, Animal; Female; Hyperandrogenism; Kisspeptins; Letrozole; Mice; | 2023 |
Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome.
Topics: Animals; Cytokine Receptor gp130; Diet, High-Fat; Female; Gonadal Steroid Hormones; Humans; Insulin | 2023 |
Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet.
Topics: Animals; Diet, High-Fat; Female; Gonadal Steroid Hormones; Humans; Letrozole; Metabolomics; Microbio | 2023 |
Efficiency of Chinese medicine Bushen Huatan formula for treatment of polycystic ovary syndrome in mice via regulating gut microbiota and PPARγ pathway.
Topics: Animals; Butyrates; Female; Gastrointestinal Microbiome; Gonadal Steroid Hormones; Humans; Letrozole | 2023 |
Low-dose spironolactone combats dyslipidemia and hepatic inflammation by modulating PCSK9 in rat model of polycystic ovarian syndrome.
Topics: Animals; Dyslipidemias; Female; Humans; Inflammation; Letrozole; NLR Family, Pyrin Domain-Containing | 2023 |
Need to redefine letrozole resistance in polycystic ovary syndrome: understanding the concept of follicle-stimulating hormone threshold and window.
Topics: Female; Follicle Stimulating Hormone; Humans; Letrozole; Luteinizing Hormone; Polycystic Ovary Syndr | 2023 |
Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid.
Topics: Animals; Dehydroepiandrosterone; Female; Gastrointestinal Microbiome; Humans; Letrozole; Liver Disea | 2023 |
Effect of the ketogenic diet on gut microbiome composition and metabolomics in polycystic ovarian syndrome rats induced by letrozole and a high-fat diet.
Topics: Androgens; Animals; Diet, High-Fat; Diet, Ketogenic; Female; Gastrointestinal Microbiome; Gonadal St | 2023 |
Alleviative Effects of Adipose Tissue-derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS.
Topics: Adipokines; Adipose Tissue; Animals; Female; Humans; Letrozole; Polycystic Ovary Syndrome; Rats; Rat | 2023 |
Single-cell sequencing provides insights into the landscape of ovary in PCOS and alterations induced by CUMS.
Topics: Animals; Endothelial Cells; Female; Granulosa Cells; Humans; Inflammation; Interferons; Letrozole; P | 2023 |
Letrozole More Effective Than Clomiphene for Infertility Treatment Among Individuals With Polycystic Ovary Syndrome.
Topics: Clomiphene; Female; Humans; Infertility; Letrozole; Polycystic Ovary Syndrome | 2023 |
Alleviation of adipose-hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression.
Topics: Animals; Female; Glycogen; Humans; Letrozole; Lipids; NF-kappa B; NF-kappa B p50 Subunit; NLR Family | 2023 |
The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome.
Topics: AMP-Activated Protein Kinases; Angelica sinensis; Animals; DNA, Ribosomal; Eosine Yellowish-(YS); Fe | 2023 |
The effects of AdipoRon on cytochrome P450-related gene expression, acute steroidogenic regulatory protein, and structure of ovary in polycystic ovary syndrome model.
Topics: Adiponectin; Animals; Female; Gene Expression; Humans; Letrozole; Mice; Polycystic Ovary Syndrome; T | 2023 |
Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome.
Topics: Animals; Female; Follicle Stimulating Hormone; Humans; Letrozole; Mice; Polycystic Ovary Syndrome; Q | 2023 |
Butyrate alleviates renal inflammation and fibrosis in a rat model of polycystic ovarian syndrome by suppression of SDF-1.
Topics: Animals; Butyrates; Female; Fibrosis; Humans; Inflammation; Letrozole; Polycystic Ovary Syndrome; Ra | 2023 |
Letrozole use in vitrified single-blastocyst transfer cycles is associated with lower risk of large for gestational age infants in patients with polycystic ovary syndrome.
Topics: Cryopreservation; Embryo Transfer; Female; Humans; Infant, Large for Gestational Age; Infant, Newbor | 2023 |
Comprehensive Analysis of Gut Microbiota Alteration in the Patients and Animal Models with Polycystic Ovary Syndrome.
Topics: Animals; Disease Models, Animal; Female; Gastrointestinal Microbiome; Humans; Letrozole; Polycystic | 2023 |
Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin.
Topics: Animals; Female; Humans; Letrozole; Metformin; Polycystic Ovary Syndrome; Rats; Rats, Wistar | 2023 |
Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study.
Topics: Abortion, Spontaneous; Adult; Cohort Studies; Cryopreservation; Diabetes, Gestational; Embryo Transf | 2023 |
Depletion of gut microbiota influents glucose metabolism and hyperandrogenism traits of mice with PCOS induced by letrozole.
Topics: Animals; Anti-Bacterial Agents; Blood Glucose; Female; Gastrointestinal Microbiome; Humans; Hyperand | 2023 |
Agaricus Subrufescens ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with Letrozole induced polycystic ovarian syndrome.
Topics: Animals; Blood Glucose; Cholesterol; Creatinine; Estrogens; Female; Humans; Letrozole; Menstruation | 2023 |
Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS.
Topics: Animals; Butyric Acid; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Letrozole; M | 2023 |
The regulation of the follicular synchronization and sensitivity of rats with PCOS by AMH during prolonged pituitary downregulation.
Topics: Animals; Anti-Mullerian Hormone; Down-Regulation; Female; Follicle Stimulating Hormone; Gonadotropin | 2019 |
Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome.
Topics: Adult; Age Factors; Androgens; Animals; Aromatase Inhibitors; Bacterial Typing Techniques; Blood Glu | 2019 |
Traditional Medicine (Mahuang-Tang) Improves Ovarian Dysfunction and the Regulation of Steroidogenic Genes in Letrozole-Induced PCOS Rats.
Topics: Animals; Drugs, Chinese Herbal; Female; Hormones; Letrozole; Medicine, Korean Traditional; Medicine, | 2020 |
Spironolactone reversed hepato-ovarian triglyceride accumulation caused by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a familiar foe.
Topics: Animals; Female; Letrozole; Liver; Ovary; Polycystic Ovary Syndrome; Rats; Rats, Wistar; Spironolact | 2020 |
Hyperactive LH Pulses and Elevated Kisspeptin and NKB Gene Expression in the Arcuate Nucleus of a PCOS Mouse Model.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aromatase Inhibitors; Disease Models, Animal; Dynorphins; | 2020 |
Study of the effect of metformin on expression levels of TNF-α and IL-18 in animal models of polycystic ovary syndrome.
Topics: Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Down-Regulation; Estradiol; Estrous | 2021 |
A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrateresistant polycystic ovary syndrome - a retrospective study.
Topics: Adult; Clomiphene; Dose-Response Relationship, Drug; Female; Fertility Agents, Female; Gonadotropins | 2020 |
Decreased microRNA-125b-5p disrupts follicle steroidogenesis through targeting PAK3/ERK1/2 signalling in mouse preantral follicles.
Topics: Androgens; Animals; Estradiol; Estrogens; Female; Gene Expression Regulation; Hyperandrogenism; Letr | 2020 |
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins.
Topics: Adult; Age Factors; Child Behavior; Child Development; Child, Preschool; Clomiphene; Cognition; Fema | 2020 |
Lactic acid bacteria alleviate polycystic ovarian syndrome by regulating sex hormone related gut microbiota.
Topics: Animals; Bacteria; Bifidobacterium; Disease Models, Animal; Estrous Cycle; Fatty Acids, Volatile; Fe | 2020 |
A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Female; Follicle Stimulating Hormone; Insulin; Insu | 2020 |
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways.
Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Estrous Cycle; Female; Insulin; Insuli | 2020 |
MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance.
Topics: Animals; Biomarkers; Down-Regulation; Female; Gene Expression Profiling; Gene Ontology; High-Through | 2020 |
The effects of thylakoid-rich spinach extract and aqueous extract of caraway (Carum carvi L.) in letrozole-induced polycystic ovarian syndrome rats.
Topics: Animals; Biomarkers; Carum; Disease Models, Animal; Female; Hypoglycemic Agents; Iran; Letrozole; Me | 2020 |
Beneficial phytoestrogenic effects of resveratrol on polycystic ovary syndromein rat model.
Topics: Adiponectin; Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Estradiol; Female; Le | 2021 |
The leaf aqueous extract of Myrianthus arboreus P. Beauv. (Cecropiaceae) improved letrozole-induced polycystic ovarian syndrome associated conditions and infertility in female Wistar rats.
Topics: Animals; Cameroon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Infertility, Fe | 2020 |
Involvement of endogenous testosterone in hepatic steatosis in women with polycystic ovarian syndrome.
Topics: Adult; AMP-Activated Protein Kinases; Androgens; Animals; Aromatase Inhibitors; Dihydrotestosterone; | 2020 |
Altered vitamin D
Topics: Adipose Tissue; Administration, Oral; Animals; Calcitriol; Cholecalciferol; Female; Letrozole; Ovary | 2021 |
Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome.
Topics: Animals; Blood Glucose; Cognitive Dysfunction; Disease Models, Animal; Estradiol; Female; Gene Expre | 2021 |
Traditional Chinese Medicine formula FTZ protects against polycystic ovary syndrome through modulating adiponectin-mediated fat-ovary crosstalk in mice.
Topics: Adiponectin; Animals; Antineoplastic Agents; Diet, High-Fat; Drugs, Chinese Herbal; Female; Letrozol | 2021 |
Low dose spironolactone-mediated androgen-adiponectin modulation alleviates endocrine-metabolic disturbances in letrozole-induced PCOS.
Topics: Adiponectin; Animals; Biomarkers; Disease Models, Animal; Female; Inflammation Mediators; Letrozole; | 2021 |
Do lipid parameters change during clomiphene citrate or letrozole therapy in women being treated for infertility? A pilot study.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility; Infertility | 2021 |
Potential effect of adrenomedullin on metabolic and endocrinal dysfunctions in the experimentally induced polycystic ovary: Targeting implication of endoplasmic reticulum stress.
Topics: Adrenomedullin; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Gene Expressi | 2021 |
Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome.
Topics: Adult; Cesarean Section; Cryopreservation; Embryo Transfer; Female; Humans; Hypertension, Pregnancy- | 2021 |
Beneficial effects of minocycline on the ovary of polycystic ovary syndrome mouse model: Molecular docking analysis and evaluation of TNF-α, TNFR2, TLR-4 gene expression.
Topics: Animals; Disease Models, Animal; Estradiol; Female; Humans; Letrozole; Mice; Minocycline; Molecular | 2021 |
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Eucommiaceae; Female; Flavonoids; Gona | 2021 |
Letrozole-Induced Polycystic Ovary Syndrome Attenuates Cystathionine-β Synthase mRNA and Protein Abundance in the Ovaries of Female Sprague Dawley Rats.
Topics: Animals; Cystathionine beta-Synthase; Disease Models, Animal; Female; Letrozole; Ovary; Polycystic O | 2021 |
Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice.
Topics: Acrylamides; Androgens; Animals; Blood Glucose; Cytokines; Disease Models, Animal; Female; Hyperandr | 2021 |
Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis.
Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Estrous Cycle; Female; Hormones; Insulin Resist | 2021 |
Dietary proanthocyanidins alleviated ovarian fibrosis in letrozole-induced polycystic ovary syndrome in rats.
Topics: Animals; Female; Fibrosis; Humans; Letrozole; Polycystic Ovary Syndrome; Proanthocyanidins; Rats; Ra | 2021 |
Effect of vitamin D on experimental model of polycystic ovary syndrome in female rats.
Topics: Animals; Caspase 3; Disease Models, Animal; Female; Letrozole; Ovary; Oxidative Stress; Polycystic O | 2021 |
Response to ovulation induction treatments in women with polycystic ovary syndrome as a function of serum anti-Müllerian hormone levels.
Topics: Adult; Anti-Mullerian Hormone; Clomiphene; Female; Fertility Agents, Female; Follicle Stimulating Ho | 2021 |
Ameliorative effects of
Topics: Animals; Cuscuta; Disease Models, Animal; Female; Letrozole; Polycystic Ovary Syndrome; Rats; Rats, | 2021 |
Application of Pulsed Rhythmic Drug Administration to Ovulation Induction Therapy in PCOS Patients with Clomiphene-Resistance: a Retrospective Research.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Administration Routes; Drug Resistance; Female; Fertil | 2021 |
Linum usitatissimum seeds oil down-regulates mRNA expression for the steroidogenic acute regulatory protein and Cyp11A1 genes, ameliorating letrezole-induced polycystic ovarian syndrome in a rat model.
Topics: Animals; Antioxidants; Cholesterol Side-Chain Cleavage Enzyme; Chromatography, High Pressure Liquid; | 2021 |
Novel promising reproductive and metabolic effects of Cicer arietinum L. extract on letrozole induced polycystic ovary syndrome in rat model.
Topics: Animals; Aromatase Inhibitors; Cholesterol Side-Chain Cleavage Enzyme; Cicer; Clomiphene; Dose-Respo | 2021 |
Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome.
Topics: Animals; Bacteroides; Biomarkers; Case-Control Studies; Chenodeoxycholic Acid; Female; Fibroblast Gr | 2021 |
Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
Topics: Animals; Aromatase Inhibitors; Blood Glucose; Cell Proliferation; Cricetinae; Disease Models, Animal | 2021 |
Comparison of the efficacy of letrozole stair-step protocol with clomiphene citrate stair-step protocol in the management of clomiphene citrate-resistant polycystic ovary syndrome patients.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Ovulation Indu | 2021 |
Ameliorative effects of fisetin in letrozole-induced rat model of polycystic ovary syndrome.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Phytogenic; Blood Glucose; Carboxymet | 2021 |
Letrozole as first-line drug for ovulation induction in treatment-naïve infertile polycystic ovarian syndrome women.
Topics: Cohort Studies; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; Ovulation; | 2021 |
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
Topics: Adipocytes; Adipogenesis; Adipose Tissue, White; Animals; Body Composition; Body Weight; Cell Size; | 2017 |
The promising effect of linagliptin and/or indole-3-carbinol on experimentally-induced polycystic ovarian syndrome.
Topics: Administration, Oral; Animals; Female; Indoles; Letrozole; Linagliptin; Nitriles; Polycystic Ovary S | 2017 |
Kisspeptin expression features in the arcuate and anteroventral periventricular nuclei of hypothalamus of letrozole-induced polycystic ovarian syndrome in rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Female; Gonadal Steroid Hormones; Humans; Hypothalamus; Hy | 2017 |
Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
Topics: Androgen Antagonists; Animals; Blood Glucose; Body Weight; Catalase; Estradiol; Female; gamma-Aminob | 2017 |
Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study.
Topics: Adult; Drug Therapy, Combination; Endometriosis; Female; Fertility Agents, Female; Follicle Stimulat | 2017 |
High-fat diet exposure from pre-pubertal age induces polycystic ovary syndrome (PCOS) in rats.
Topics: Animals; Aromatase Inhibitors; Biomarkers; Diet, High-Fat; Female; Gene Expression Profiling; Letroz | 2018 |
Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS.
Topics: Adipocytes; Androgen Antagonists; Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal | 2018 |
Expression profiles of mRNA and long noncoding RNA in the ovaries of letrozole-induced polycystic ovary syndrome rat model through deep sequencing.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene | 2018 |
Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study.
Topics: Animals; Antioxidants; Biomarkers; Biopsy; Body Weight; Disease Management; Disease Models, Animal; | 2018 |
GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile.
Topics: Acetylcholine; Animals; Dopamine; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Gona | 2018 |
Influence of the conclusion of a recent large cooperative study in changing standard protocol of inducing menses in anovulatory women with oligomenorrhea prior to initiating ovulation induction with anti-estrogens and outcome.
Topics: Adult; Anovulation; Clomiphene; Endometrium; Estrogen Antagonists; Estrogens; Female; Fertility Agen | 2017 |
Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model.
Topics: Aizoaceae; Androgens; Animals; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein | 2018 |
A Retrospective Study of Letrozole Treatment Prior to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome Undergoing In Vitro Fertilization at Risk of Ovarian Hyperstimulation Syndrome.
Topics: Adult; China; Chorionic Gonadotropin; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infer | 2018 |
Association among depression, symptom experience, and quality of life in polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Clomiphene; Depression; Female; Fertility Agents, | 2018 |
MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome.
Topics: 3' Untranslated Regions; Adult; Animals; Antagomirs; Antineoplastic Agents; Apoptosis; Apoptosis Reg | 2018 |
Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats.
Topics: Animals; Body Weight; Carboxymethylcellulose Sodium; Diet, High-Fat; Female; Glucose Tolerance Test; | 2018 |
Mild ovarian stimulation with letrozole plus fixed dose human menopausal gonadotropin prior to IVF/ICSI for infertile non-obese women with polycystic ovarian syndrome being pre-treated with metformin: a pilot study.
Topics: Adult; Female; Gonadotropins; Humans; Infertility, Female; Letrozole; Metformin; Nitriles; Oocyte Re | 2018 |
Welsh Onion Root (
Topics: Allium; Animals; Aromatase; Aromatase Inhibitors; Asia; Diet; Disease Models, Animal; Estrogens; Fem | 2018 |
Luteal support with vaginal dydrogesterone increases pregnancy rate in patients with clomifene resistant polycystic ovary syndrome receiving letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Clomiphene; Dydrogesterone; Female; Fertility Agents, Female; H | 2019 |
Ovulation induction and intrauterine insemination in infertile women with polycystic ovary syndrome: A comparison of drugs.
Topics: Adult; Birth Rate; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemi | 2018 |
Letrozole for patients with polycystic ovary syndrome: A retrospective study.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Fema | 2018 |
Therapeutic Efficacy of Melatonin Against Polycystic Ovary Syndrome (PCOS) Induced by Letrozole in Wistar Rat.
Topics: Administration, Oral; Animals; Disease Models, Animal; Estrogens; Female; Letrozole; Melatonin; Poly | 2018 |
Translation and implementation of the Australian-led PCOS guideline: clinical summary and translation resources from the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Topics: Adolescent; Adult; Clomiphene; Disease Management; Evidence-Based Medicine; Female; Humans; Infertil | 2018 |
Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation.
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Gene Expression Regulation; Humans; | 2019 |
The Flavanone, Naringenin, Modifies Antioxidant and Steroidogenic Enzyme Activity in a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Estradiol; Female; Flavanones; Glutathione | 2019 |
Letrozole versus clomiphene in polycystic ovary syndrome-more than one way to crack an egg.
Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Ovulation Induction; Polycystic Ova | 2019 |
Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice.
Topics: Age Factors; Animals; Aromatase Inhibitors; Disease Models, Animal; Female; Gastrointestinal Microbi | 2019 |
Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model.
Topics: Animals; Anovulation; Aromatase Inhibitors; Disease Models, Animal; Dysbiosis; Female; Gastrointesti | 2019 |
Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome.
Topics: Adult; Blastocyst; Cryopreservation; Embryo Transfer; Female; Fertilization in Vitro; Freezing; Horm | 2019 |
ETA-mediated anti-TNF-α therapy ameliorates the phenotype of PCOS model induced by letrozole.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Etanercept; Female; Letrozole; Mice; NF-kappa B; Po | 2019 |
Therapeutic potential of sodium selenite in letrozole induced polycystic ovary syndrome rat model: Targeting mitochondrial approach (selenium in PCOS).
Topics: Animals; Blood Glucose; Citrate (si)-Synthase; Estradiol; Female; Insulin; Letrozole; Lipid Metaboli | 2019 |
Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone.
Topics: Androgen Antagonists; Animals; Female; Insulin Resistance; Letrozole; Luteinizing Hormone; Mineraloc | 2019 |
Ocimum kilimandscharicum L. restores ovarian functions in letrozole - induced Polycystic Ovary Syndrome (PCOS) in rats: Comparison with metformin.
Topics: Aged; Animals; Antioxidants; Aromatase Inhibitors; Blood Glucose; Body Weight; Chromatography, High | 2019 |
Letrozole stimulation in endometrial preparation for cryopreserved-thawed embryo transfer in women with polycystic ovarian syndrome: a pilot study.
Topics: Adult; Aromatase Inhibitors; Cryopreservation; Embryo Transfer; Endometrium; Female; Fertilization i | 2014 |
Effects of electro-acupuncture on ovarian P450arom, P450c17α and mRNA expression induced by letrozole in PCOS rats.
Topics: Acupuncture Therapy; Animals; Aromatase; Female; Immunohistochemistry; Letrozole; Microscopy, Electr | 2013 |
Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome.
Topics: Animals; Anti-Mullerian Hormone; Aromatase Inhibitors; Disease Models, Animal; Female; Letrozole; Ni | 2014 |
Reproductive endocrinology: revisiting ovulation induction in PCOS.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility | 2014 |
GC-MS analysis of Cocus nucifera flower extract and its effects on heterogeneous symptoms of polycystic ovarian disease in female Wistar rats.
Topics: Animals; Antioxidants; Blood Glucose; Cocos; Estrus; Female; Flowers; Gas Chromatography-Mass Spectr | 2014 |
Functional investigation on aromatase in endometrial hyperplasia in polycystic ovary syndrome cases.
Topics: Androgens; Aromatase; Aromatase Inhibitors; Blotting, Western; Case-Control Studies; Cells, Cultured | 2014 |
First reported case of sextuplets conceived via letrozole for ovulation induction.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Infertility, Female; Letrozole; Multiple Birth Offsprin | 2015 |
Cellular and molecular mechanisms of pentoxifylline's beneficial effects in experimental polycystic ovary.
Topics: Animals; Aromatase Inhibitors; Biomarkers; Female; Letrozole; Nitriles; Oxidative Stress; Pentoxifyl | 2015 |
Thuja occidentalis L. and its active compound, α-thujone: Promising effects in the treatment of polycystic ovary syndrome without inducing osteoporosis.
Topics: Animals; Bicyclic Monoterpenes; Blood Glucose; Catalase; Estradiol; Female; Glutathione Peroxidase; | 2015 |
[Study on the oxidative stress in the ovaries of a rat model of polycystic ovary].
Topics: Animals; Antioxidants; Disease Models, Animal; Estrogens; Female; Follicle Stimulating Hormone; Letr | 2015 |
Dual targeting of TNF-α and free radical toxic stress as a promising strategy to manage experimental polycystic ovary.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Disease Models, Animal; Drug Therapy, C | 2016 |
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.
Topics: Animals; Corpus Luteum; Diestrus; Enzyme Inhibitors; Estrous Cycle; Female; Hyperandrogenism; Hypoth | 2015 |
The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome.
Topics: Animals; Diet; Disease Models, Animal; Female; Gastrointestinal Microbiome; Letrozole; Mice; Nitrile | 2016 |
Differential Expression of microRNAs in the Ovaries from Letrozole-Induced Rat Model of Polycystic Ovary Syndrome.
Topics: Animals; Biomarkers; Female; Gene Expression; Letrozole; MicroRNAs; Nitriles; Ovary; Polycystic Ovar | 2016 |
Letrozole vs estradiol valerate induced PCOS in rats: glycemic, oxidative and inflammatory status assessment.
Topics: Animals; Antioxidants; Blood Glucose; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Estradio | 2016 |
[Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome].
Topics: Animals; Corpus Luteum; Disease Models, Animal; Drugs, Chinese Herbal; Estrogen Receptor alpha; Estr | 2016 |
Role of oxidative stress and low-grade inflammation in letrozole-induced polycystic ovary syndrome in the rat.
Topics: Animals; Aromatase Inhibitors; C-Reactive Protein; Female; Gene Expression Regulation; Inflammation; | 2016 |
Association between Polycystic Ovary Syndrome and Gut Microbiota.
Topics: Animals; Aromatase Inhibitors; Estrous Cycle; Female; Gastrointestinal Microbiome; Letrozole; Microb | 2016 |
Central leptin resistance and hypothalamic inflammation are involved in letrozole-induced polycystic ovary syndrome rats.
Topics: Animals; Body Weight; Eating; Female; Hypothalamus; Inflammation; Leptin; Letrozole; Nitriles; Ovary | 2016 |
Effects of Exercise Intervention on Preventing Letrozole-Exposed Rats From Polycystic Ovary Syndrome.
Topics: Animals; Aromatase Inhibitors; Body Weight; Disease Models, Animal; Female; Follicle Stimulating Hor | 2017 |
Diagnosis and Treatment of Polycystic Ovary Syndrome.
Topics: Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Humans; Hyperandrogenism; Hypogl | 2016 |
Kisspeptin mRNA expression is increased in the posterior hypothalamus in the rat model of polycystic ovary syndrome.
Topics: Animals; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hypothalamus, Posterior | 2017 |
Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model.
Topics: Animals; Disease Models, Animal; Estrus; Female; Gene Expression; Humans; Letrozole; MicroRNAs; Nitr | 2017 |
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
Topics: Acupuncture Therapy; Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Cytochrome P-450 Enzy | 2017 |
Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Biomarkers; Blood Glucose; Body Weights and Measures; C | 2016 |
Soy isoflavones exert beneficial effects on letrozole-induced rat polycystic ovary syndrome (PCOS) model through anti-androgenic mechanism.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Androgen Antagonists; Animals; An | 2017 |
The role of nesfatin-1 expression in letrozole-induced polycystic ovaries in the rat.
Topics: Animals; Calcium-Binding Proteins; Disease Models, Animal; DNA-Binding Proteins; Female; Letrozole; | 2017 |
[Effect of two different doses of letrozole in promoting ovulation in infertile women with polycystic ovarian syndrome].
Topics: Adult; Aromatase Inhibitors; Female; Fertility Agents, Female; Humans; Infertility, Female; Insemina | 2008 |
[Clinical analysis of assistant treatment proposals for infertile women with polycystic ovary syndrome].
Topics: Adult; Clomiphene; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infertility, Female; Let | 2008 |
Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, | 2010 |
Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, | 2010 |
Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, | 2010 |
Luteal support with intravaginal progesterone increases clinical pregnancy rates in women with polycystic ovary syndrome using letrozole for ovulation induction.
Topics: Administration, Intravaginal; Adult; Aromatase Inhibitors; Clomiphene; Female; Humans; Infertility, | 2010 |
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Aromatase; Blotting, Western; Diestrus; Disease Models, An | 2009 |
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Hu | 2011 |
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Hu | 2011 |
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Hu | 2011 |
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Hu | 2011 |
Use of the aromatase inhibitor letrozole for ovulation induction in women with polycystic ovarian syndrome.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Congenital Abnormalities; Female; Fertility Agents, F | 2011 |
Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological evidences for beneficial effect of pioglitazone.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aromatase Inhibitors; Estradiol; Female; Hypoglycem | 2012 |
Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Cohort Studies; Female; Fertility Agents, Female; Gonadotro | 2012 |
Outcome of metformin treatment in polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Therapy, Combination; Estrogen Antagonists; Female; Hu | 2012 |
Molecular mechanisms of a novel selenium-based complementary medicine which confers protection against hyperandrogenism-induced polycystic ovary.
Topics: Animals; Antioxidants; Biomarkers; Estradiol; Female; Hyperandrogenism; Letrozole; Lipid Peroxidatio | 2012 |
Combination of acupuncture and chinese medicinal herbs in treating model rats with polycystic ovary syndrome.
Topics: Acupuncture Therapy; Administration, Oral; Animals; Benzofurans; Chromatography, High Pressure Liqui | 2011 |
Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age.
Topics: Animals; Aromatase Inhibitors; Female; Letrozole; Nitriles; Polycystic Ovary Syndrome; Rats; Rats, W | 2013 |
Comparison of two aromatase inhibitors in women with clomiphene-resistant polycystic ovary syndrome.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Clomiphene; Estrogen Antagonists; Female; Humans; Letrozol | 2004 |
Letrozole induction of ovulation in women with clomiphene citrate-resistant polycystic ovary syndrome may not depend on the period of infertility, the body mass index, or the luteinizing hormone/follicle-stimulating hormone ratio.
Topics: Adult; Aromatase Inhibitors; Body Mass Index; Clomiphene; Drug Resistance; Female; Fertility Agents, | 2006 |
Microscopic characterization of follicular structures in letrozole-induced polycystic ovarian syndrome in the rat.
Topics: Animals; Cadherins; Desmin; Female; Hormones; Immunohistochemistry; Keratins; Letrozole; Nitriles; O | 2006 |
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.
Topics: Adipocytes; Androgens; Animals; Aromatase Inhibitors; Body Composition; Body Weight; Dihydrotestoste | 2007 |
Letrozole versus clomiphene citrate: which is better for ovulation induction?
Topics: Adult; Aromatase Inhibitors; Clomiphene; Dose-Response Relationship, Drug; Female; Fertility Agents, | 2009 |
Clomiphene citrate: an old favourite lives on.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Letrozole; N | 2007 |