Page last updated: 2024-10-30

letrozole and Leiomyoma

letrozole has been researched along with Leiomyoma in 12 studies

Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.

Research Excerpts

ExcerptRelevanceReference
" Here we report a case of lobular breast cancer metastasizing to a leiomyoma in a patient using letrozole."7.77Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment. ( Aydinli, K; Basgul, AY; Calay, Z; Dünder, I; Güdücü, N; Işçi, H, 2011)
"The objective was to determine the direct effect of letrozole on the proliferation and apoptosis of cultured leiomyoma cells co-treated with prostaglandin E(2) (PGE(2))."7.74Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2). ( Han, M; Kim, JM; Kim, JY; Lee, KS; Park, JE, 2008)
"Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy."6.73Treatment of symptomatic uterine leiomyoma with letrozole. ( Celik, H; Gurates, B; Kilic, G; Kumru, S; Parmaksiz, C; Simsek, M, 2008)
" EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT."5.69Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. ( Al-Hendy, A; Christman, GM; Flaminia, A; Flores, VA; González, F; Huang, H; Johnson, JJ; Segars, J; Siblini, H; Singh, B; Taylor, HS; Zhang, H, 2023)
"Condensation letrozole in combination with cabergoline in the management of uterine fibroids."5.24Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial. ( Gharabaghi, PM; Mobasseri, M; Ouladsahebmadarek, E; Rahmani, V; Sayyah-Melli, M, 2017)
"This was a preliminary study to determine the effect of aromatase inhibitors in preventing the flare induced by GnRH agonist (GnRH-a) in women with endometriosis (n = 9) or leiomyomata (n = 4) who were given letrozole on the first 5 days of the GnRH-a therapy."5.14Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. ( Bedaiwy, MA; Casper, RF; Mousa, NA, 2009)
" Here we report a case of lobular breast cancer metastasizing to a leiomyoma in a patient using letrozole."3.77Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment. ( Aydinli, K; Basgul, AY; Calay, Z; Dünder, I; Güdücü, N; Işçi, H, 2011)
"The objective was to determine the direct effect of letrozole on the proliferation and apoptosis of cultured leiomyoma cells co-treated with prostaglandin E(2) (PGE(2))."3.74Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2). ( Han, M; Kim, JM; Kim, JY; Lee, KS; Park, JE, 2008)
"The quality of the myometrial scar, defined by ultrasound evaluation, was similar in the two study groups both at one-week (p=0."2.79Preoperative treatment with letrozole in patients undergoing laparoscopic myomectomy of large uterine myomas: a prospective non-randomized study. ( Ferrero, S; Leone Roberti Maggiore, U; Scala, C; Venturini, PL, 2014)
"Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy."2.73Treatment of symptomatic uterine leiomyoma with letrozole. ( Celik, H; Gurates, B; Kilic, G; Kumru, S; Parmaksiz, C; Simsek, M, 2008)
"Uterine fibroids, also called uterine leiomyomas or myomas, are the most common benign tumours in women of reproductive age."2.49Aromatase inhibitors for uterine fibroids. ( Lu, D; Navaratnam, K; Shi, G; Song, H, 2013)
"Intra- and postoperative complications, postoperative pain, and patient satisfaction were similar in the four study groups."1.42Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study. ( Bizzarri, N; Ferrero, S; Ghirardi, V; Remorgida, V; Venturini, PL, 2015)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (25.00)29.6817
2010's8 (66.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Siblini, H1
Al-Hendy, A1
Segars, J1
González, F1
Taylor, HS1
Singh, B1
Flaminia, A1
Flores, VA1
Christman, GM1
Huang, H1
Johnson, JJ1
Zhang, H1
Duhan, N1
Madaan, S1
Sen, J1
Song, H1
Lu, D1
Navaratnam, K1
Shi, G1
Leone Roberti Maggiore, U1
Scala, C1
Venturini, PL3
Ferrero, S3
Bizzarri, N1
Ghirardi, V1
Remorgida, V2
Sayyah-Melli, M1
Mobasseri, M1
Gharabaghi, PM1
Ouladsahebmadarek, E1
Rahmani, V1
Gurates, B1
Parmaksiz, C1
Kilic, G1
Celik, H1
Kumru, S1
Simsek, M1
Bedaiwy, MA1
Mousa, NA1
Casper, RF1
Parsanezhad, ME1
Azmoon, M1
Alborzi, S1
Rajaeefard, A1
Zarei, A1
Kazerooni, T1
Frank, V1
Schmidt, EH1
Işçi, H1
Güdücü, N1
Basgul, AY1
Aydinli, K1
Calay, Z1
Dünder, I1
Han, M1
Kim, JY1
Park, JE1
Kim, JM1
Lee, KS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Influence of the Aromatase Inhibitor Anastrozole and GnRH Analog Goserelin Acetate as Preoperative Treatment of Vaginal Surgical Treatment of Uterine Leiomyoma: Analysis of Intra and Immediate/Late Postoperative Patterns[NCT01280045]5 participants (Actual)Interventional2011-01-31Terminated (stopped due to No grant was received then we stopped the recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for letrozole and Leiomyoma

ArticleYear
Aromatase inhibitors for uterine fibroids.
    The Cochrane database of systematic reviews, 2013, Oct-23, Issue:10

    Topics: Antineoplastic Agents; Aromatase Inhibitors; Female; Hot Flashes; Humans; Leiomyoma; Letrozole; Nitr

2013

Trials

6 trials available for letrozole and Leiomyoma

ArticleYear
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
    Nutrients, 2023, Jan-09, Volume: 15, Issue:2

    Topics: Adult; Catechin; Clomiphene; Female; Folic Acid; Humans; Infertility; Leiomyoma; Letrozole; Liver; P

2023
Preoperative treatment with letrozole in patients undergoing laparoscopic myomectomy of large uterine myomas: a prospective non-randomized study.
    European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 181

    Topics: Adult; Antineoplastic Agents; Blood Loss, Surgical; Chemotherapy, Adjuvant; Cicatrix; Contraceptives

2014
Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial.
    European journal of obstetrics, gynecology, and reproductive biology, 2017, Volume: 210

    Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Cabergoline; Drug Therapy, Combination; Ergoline

2017
Treatment of symptomatic uterine leiomyoma with letrozole.
    Reproductive biomedicine online, 2008, Volume: 17, Issue:4

    Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Bone and Bones; Bone Density; Female; Follicle S

2008
Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists.
    Fertility and sterility, 2009, Volume: 91, Issue:4 Suppl

    Topics: Adult; Aromatase Inhibitors; Endometriosis; Estrogens; Female; Follicle Stimulating Hormone; Gonadot

2009
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status.
    Fertility and sterility, 2010, Volume: 93, Issue:1

    Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Estradiol; Female; Follicle Stimulatin

2010

Other Studies

5 other studies available for letrozole and Leiomyoma

ArticleYear
Role of the aromatase inhibitor letrozole in the management of uterine leiomyomas in premenopausal women.
    European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 171, Issue:2

    Topics: Adult; Aromatase Inhibitors; Female; Humans; Leiomyoma; Letrozole; Middle Aged; Nitriles; Premenopau

2013
Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study.
    European journal of obstetrics, gynecology, and reproductive biology, 2015, Volume: 192

    Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Attitude of Health Personnel; Contrace

2015
Letrozole monotherapy in the treatment of uterine myomas.
    Fertility and sterility, 2010, May-01, Volume: 93, Issue:7

    Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema

2010
Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment.
    European journal of gynaecological oncology, 2011, Volume: 32, Issue:5

    Topics: Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Leiomyoma; Letrozole; Mi

2011
Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2).
    European journal of obstetrics, gynecology, and reproductive biology, 2008, Volume: 138, Issue:1

    Topics: Apoptosis; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Dinoprostone; Enzyme Activator

2008