letrozole has been researched along with Leiomyoma in 12 studies
Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we report a case of lobular breast cancer metastasizing to a leiomyoma in a patient using letrozole." | 7.77 | Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment. ( Aydinli, K; Basgul, AY; Calay, Z; Dünder, I; Güdücü, N; Işçi, H, 2011) |
| "The objective was to determine the direct effect of letrozole on the proliferation and apoptosis of cultured leiomyoma cells co-treated with prostaglandin E(2) (PGE(2))." | 7.74 | Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2). ( Han, M; Kim, JM; Kim, JY; Lee, KS; Park, JE, 2008) |
| "Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy." | 6.73 | Treatment of symptomatic uterine leiomyoma with letrozole. ( Celik, H; Gurates, B; Kilic, G; Kumru, S; Parmaksiz, C; Simsek, M, 2008) |
| " EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT." | 5.69 | Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. ( Al-Hendy, A; Christman, GM; Flaminia, A; Flores, VA; González, F; Huang, H; Johnson, JJ; Segars, J; Siblini, H; Singh, B; Taylor, HS; Zhang, H, 2023) |
| "Condensation letrozole in combination with cabergoline in the management of uterine fibroids." | 5.24 | Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial. ( Gharabaghi, PM; Mobasseri, M; Ouladsahebmadarek, E; Rahmani, V; Sayyah-Melli, M, 2017) |
| "This was a preliminary study to determine the effect of aromatase inhibitors in preventing the flare induced by GnRH agonist (GnRH-a) in women with endometriosis (n = 9) or leiomyomata (n = 4) who were given letrozole on the first 5 days of the GnRH-a therapy." | 5.14 | Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. ( Bedaiwy, MA; Casper, RF; Mousa, NA, 2009) |
| " Here we report a case of lobular breast cancer metastasizing to a leiomyoma in a patient using letrozole." | 3.77 | Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment. ( Aydinli, K; Basgul, AY; Calay, Z; Dünder, I; Güdücü, N; Işçi, H, 2011) |
| "The objective was to determine the direct effect of letrozole on the proliferation and apoptosis of cultured leiomyoma cells co-treated with prostaglandin E(2) (PGE(2))." | 3.74 | Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2). ( Han, M; Kim, JM; Kim, JY; Lee, KS; Park, JE, 2008) |
| "The quality of the myometrial scar, defined by ultrasound evaluation, was similar in the two study groups both at one-week (p=0." | 2.79 | Preoperative treatment with letrozole in patients undergoing laparoscopic myomectomy of large uterine myomas: a prospective non-randomized study. ( Ferrero, S; Leone Roberti Maggiore, U; Scala, C; Venturini, PL, 2014) |
| "Uterine leiomyomas are the most common benign tumours of the female genital tract, often necessitating hysterectomy." | 2.73 | Treatment of symptomatic uterine leiomyoma with letrozole. ( Celik, H; Gurates, B; Kilic, G; Kumru, S; Parmaksiz, C; Simsek, M, 2008) |
| "Uterine fibroids, also called uterine leiomyomas or myomas, are the most common benign tumours in women of reproductive age." | 2.49 | Aromatase inhibitors for uterine fibroids. ( Lu, D; Navaratnam, K; Shi, G; Song, H, 2013) |
| "Intra- and postoperative complications, postoperative pain, and patient satisfaction were similar in the four study groups." | 1.42 | Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study. ( Bizzarri, N; Ferrero, S; Ghirardi, V; Remorgida, V; Venturini, PL, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Siblini, H | 1 |
| Al-Hendy, A | 1 |
| Segars, J | 1 |
| González, F | 1 |
| Taylor, HS | 1 |
| Singh, B | 1 |
| Flaminia, A | 1 |
| Flores, VA | 1 |
| Christman, GM | 1 |
| Huang, H | 1 |
| Johnson, JJ | 1 |
| Zhang, H | 1 |
| Duhan, N | 1 |
| Madaan, S | 1 |
| Sen, J | 1 |
| Song, H | 1 |
| Lu, D | 1 |
| Navaratnam, K | 1 |
| Shi, G | 1 |
| Leone Roberti Maggiore, U | 1 |
| Scala, C | 1 |
| Venturini, PL | 3 |
| Ferrero, S | 3 |
| Bizzarri, N | 1 |
| Ghirardi, V | 1 |
| Remorgida, V | 2 |
| Sayyah-Melli, M | 1 |
| Mobasseri, M | 1 |
| Gharabaghi, PM | 1 |
| Ouladsahebmadarek, E | 1 |
| Rahmani, V | 1 |
| Gurates, B | 1 |
| Parmaksiz, C | 1 |
| Kilic, G | 1 |
| Celik, H | 1 |
| Kumru, S | 1 |
| Simsek, M | 1 |
| Bedaiwy, MA | 1 |
| Mousa, NA | 1 |
| Casper, RF | 1 |
| Parsanezhad, ME | 1 |
| Azmoon, M | 1 |
| Alborzi, S | 1 |
| Rajaeefard, A | 1 |
| Zarei, A | 1 |
| Kazerooni, T | 1 |
| Frank, V | 1 |
| Schmidt, EH | 1 |
| Işçi, H | 1 |
| Güdücü, N | 1 |
| Basgul, AY | 1 |
| Aydinli, K | 1 |
| Calay, Z | 1 |
| Dünder, I | 1 |
| Han, M | 1 |
| Kim, JY | 1 |
| Park, JE | 1 |
| Kim, JM | 1 |
| Lee, KS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of the Aromatase Inhibitor Anastrozole and GnRH Analog Goserelin Acetate as Preoperative Treatment of Vaginal Surgical Treatment of Uterine Leiomyoma: Analysis of Intra and Immediate/Late Postoperative Patterns[NCT01280045] | 5 participants (Actual) | Interventional | 2011-01-31 | Terminated (stopped due to No grant was received then we stopped the recruitment) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for letrozole and Leiomyoma
| Article | Year |
|---|---|
Aromatase inhibitors for uterine fibroids.
Topics: Antineoplastic Agents; Aromatase Inhibitors; Female; Hot Flashes; Humans; Leiomyoma; Letrozole; Nitr | 2013 |
6 trials available for letrozole and Leiomyoma
| Article | Year |
|---|---|
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women.
Topics: Adult; Catechin; Clomiphene; Female; Folic Acid; Humans; Infertility; Leiomyoma; Letrozole; Liver; P | 2023 |
Preoperative treatment with letrozole in patients undergoing laparoscopic myomectomy of large uterine myomas: a prospective non-randomized study.
Topics: Adult; Antineoplastic Agents; Blood Loss, Surgical; Chemotherapy, Adjuvant; Cicatrix; Contraceptives | 2014 |
Comparing the effect of aromatase inhibitor (letrozole) + cabergoline (Dostinex) and letrozole alone on uterine myoma regression,a randomized clinical trial.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Cabergoline; Drug Therapy, Combination; Ergoline | 2017 |
Treatment of symptomatic uterine leiomyoma with letrozole.
Topics: Adult; Antineoplastic Agents; Aromatase Inhibitors; Bone and Bones; Bone Density; Female; Follicle S | 2008 |
Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Estrogens; Female; Follicle Stimulating Hormone; Gonadot | 2009 |
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status.
Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Estradiol; Female; Follicle Stimulatin | 2010 |
5 other studies available for letrozole and Leiomyoma
| Article | Year |
|---|---|
Role of the aromatase inhibitor letrozole in the management of uterine leiomyomas in premenopausal women.
Topics: Adult; Aromatase Inhibitors; Female; Humans; Leiomyoma; Letrozole; Middle Aged; Nitriles; Premenopau | 2013 |
Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study.
Topics: Adult; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Attitude of Health Personnel; Contrace | 2015 |
Letrozole monotherapy in the treatment of uterine myomas.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema | 2010 |
Lobular carcinoma of the breast metastasizing to leiomyoma in a patient under letrozole treatment.
Topics: Aromatase Inhibitors; Breast Neoplasms; Carcinoma, Lobular; Female; Humans; Leiomyoma; Letrozole; Mi | 2011 |
Effects of letrozole on proliferation and apoptosis in cultured leiomyoma cells treated with prostaglandin E(2).
Topics: Apoptosis; Aromatase Inhibitors; Cell Proliferation; Cells, Cultured; Dinoprostone; Enzyme Activator | 2008 |