letrozole has been researched along with Glioma in 3 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated the pharmacokinetics of letrozole, a third-generation aromatase inhibitor, in the normal brain and in orthotopically implanted C6 glioma in Sprague-Dawley rats." | 7.79 | The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. ( Dave, N; Desai, PB; Gudelsky, GA, 2013) |
| "The aromatase inhibitor, letrozole, is being investigated in experimental animal models as a novel treatment for high-grade gliomas (HGGs)." | 3.91 | Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. ( Adams, CH; Arora, P; DasGupta, B; Desai, PB; Gudelsky, G, 2019) |
| " Here, we investigated the pharmacokinetics of letrozole, a third-generation aromatase inhibitor, in the normal brain and in orthotopically implanted C6 glioma in Sprague-Dawley rats." | 3.79 | The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. ( Dave, N; Desai, PB; Gudelsky, GA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arora, P | 1 |
| Adams, CH | 1 |
| Gudelsky, G | 1 |
| DasGupta, B | 1 |
| Desai, PB | 3 |
| Dave, N | 2 |
| Gudelsky, GA | 2 |
| Chow, LM | 1 |
| LaSance, K | 1 |
| Qi, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE III RANDOMIZED CONTROL CASE STUDY OF LETROZOLE IN WOMEN WITH HEAVILY PRETREATED OVARIAN CANCER (MITO 32)[NCT04421547] | Phase 3 | 236 participants (Anticipated) | Interventional | 2020-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for letrozole and Glioma
| Article | Year |
|---|---|
Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Drug Inte | 2019 |
The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.
Topics: Algorithms; Animals; Antineoplastic Agents; Area Under Curve; Brain; Brain Neoplasms; Chromatography | 2013 |
Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cytochrome P-450 | 2015 |