letrozole has been researched along with Glial Cell Tumors in 3 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we investigated the pharmacokinetics of letrozole, a third-generation aromatase inhibitor, in the normal brain and in orthotopically implanted C6 glioma in Sprague-Dawley rats." | 7.79 | The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. ( Dave, N; Desai, PB; Gudelsky, GA, 2013) |
| "The aromatase inhibitor, letrozole, is being investigated in experimental animal models as a novel treatment for high-grade gliomas (HGGs)." | 3.91 | Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats. ( Adams, CH; Arora, P; DasGupta, B; Desai, PB; Gudelsky, G, 2019) |
| " Here, we investigated the pharmacokinetics of letrozole, a third-generation aromatase inhibitor, in the normal brain and in orthotopically implanted C6 glioma in Sprague-Dawley rats." | 3.79 | The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis. ( Dave, N; Desai, PB; Gudelsky, GA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arora, P | 1 |
| Adams, CH | 1 |
| Gudelsky, G | 1 |
| DasGupta, B | 1 |
| Desai, PB | 3 |
| Dave, N | 2 |
| Gudelsky, GA | 2 |
| Chow, LM | 1 |
| LaSance, K | 1 |
| Qi, X | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE III RANDOMIZED CONTROL CASE STUDY OF LETROZOLE IN WOMEN WITH HEAVILY PRETREATED OVARIAN CANCER (MITO 32)[NCT04421547] | Phase 3 | 236 participants (Anticipated) | Interventional | 2020-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for letrozole and Glial Cell Tumors
| Article | Year |
|---|---|
Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Brain; Brain Neoplasms; Drug Inte | 2019 |
The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.
Topics: Algorithms; Animals; Antineoplastic Agents; Area Under Curve; Brain; Brain Neoplasms; Chromatography | 2013 |
Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.
Topics: Animals; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Cell Line, Tumor; Cytochrome P-450 | 2015 |