letrozole has been researched along with Endometriosis in 49 studies
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a prospective randomised controlled trial to explore the efficacy of clomiphene citrate (CC) and Letrozole (LTZ) for improving fecundity in infertile women with minimal to mild endometriosis after operative laparoscopy." | 9.51 | Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. ( Chen, H; Fu, J; Huang, W; Liu, D; Wang, Q; Yang, S; Zhou, L, 2022) |
| "To compare the efficacy and the tolerability of letrozole combined with oral contraceptives versus oral contraceptives alone in treating endometriosis-related pain." | 9.41 | Letrozole combined with oral contraceptives versus oral contraceptives alone in the treatment of endometriosis-related pain symptoms: a pilot study. ( Luan, X; Wang, Y; Zhao, Y, 2021) |
| "To evaluate pregnancy rates with letrozole and clomiphene citrate (CC) alone for superovulation in an intrauterine insemination program for women with recently surgically treated minimal to mild endometriosis." | 9.16 | Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis. ( Abd Elaal, I; Abu Hashim, H; El Rakhawy, M, 2012) |
| "Women with pain symptoms caused by rectovaginal endometriosis were treated with letrozole (2." | 9.15 | Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial. ( Ferrero, S; Gillott, DJ; Remorgida, V; Venturini, PL, 2011) |
| "In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication." | 9.15 | A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis. ( Alborzi, M; Alborzi, S; Dehbashi, S; Hamedi, B; Omidvar, A, 2011) |
| "The combination drug regimen was more effective in reducing pain and deep dyspareunia than norethisterone acetate; however, letrozole caused a higher incidence of adverse effects, cost more and did not improve patients' satisfaction or influence recurrence of pain." | 9.14 | Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis. ( Camerini, G; Ferrero, S; Ragni, N; Remorgida, V; Seracchioli, R; Venturini, PL, 2009) |
| "To discuss the effects of dydrogesterone combined with letrozole on the effectiveness, sex hormone levels, and serological indicators in patients with endometriosis." | 9.12 | The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis. ( Sun, S; Xu, Z; Zhang, H; Zhong, P, 2021) |
| "The combination of letrozole and desogestrel induces a relief of pain symptoms in women with endometriosis but it causes the development of ovarian cysts." | 9.12 | Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis. ( Abbamonte, LH; Ferrero, S; Fulcheri, E; Ragni, N; Remorgida, V, 2007) |
| "The combination of letrozole and norethindrone acetate achieved marked reduction of laparoscopically visible and histologically confirmed endometriosis in all 10 patients and significant pain relief in nine out of 10 patients who had not responded previously to currently available treatments." | 9.11 | Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. ( Ailawadi, RK; Bulun, SE; Gurates, B; Jobanputra, S; Kataria, M, 2004) |
| " Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models." | 8.12 | Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. ( Coskun, G; Efendic, F; Erdem, E; Hayretdag, C; Irkorucu, O; Keles, P; Kuras, S; Pence, HH; Polat, S; Saker, D; Sapmaz, E; Sapmaz, T; Sevgin, K; Tekayev, M; Topkaraoglu, S, 2022) |
| " Previous studies have shown that administration of letrozole, a non-steroidal aromatase inhibitor for cancer treatment, increased the clinical pregnancy rate in women with endometriosis, but the mechanisms remain to be determined." | 8.12 | Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis. ( Li, C; Li, M; Li, R; Wang, L; Zhang, H; Zhang, J, 2022) |
| "This study was to investigate the effects of cisplatin (CDDP) and letrozole on surgically induced endometriosis and comparison of the two drugs in a rat model." | 7.83 | Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model. ( He, Z; Lang, J; Li, Z; Liu, H; Zhang, G, 2016) |
| "To compare the estradiol production and P450 aromatase messenger RNA (mRNA) expression of cultured luteinized granulosa cells and the effect of letrozole on these parameters between women with and without endometriosis." | 7.78 | Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis. ( Gao, XH; Lu, X; Sun, XX; Wang, L; Wang, YW; Wu, Y, 2012) |
| "To determine the effects of letrozole and melatonin on surgically induced endometriosis in a rat endometriosis model." | 7.76 | The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. ( Attar, R; Ficicioglu, C; Kumbak, B; Ozkan, F; Yesildaglar, N; Yildirim, G, 2010) |
| "The administration of letrozole and norethisterone acetate reduces pain and gastrointestinal symptoms of women with colorectal endometriosis, particularly when patients suffer from symptoms mimicking diarrhoea-predominant irritable bowel syndrome." | 7.76 | Letrozole and norethisterone acetate in colorectal endometriosis. ( Biscaldi, E; Camerini, G; Ferrero, S; Ragni, N; Remorgida, V; Seracchioli, R; Venturini, PL, 2010) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 7.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "We conducted a prospective randomised controlled trial to explore the efficacy of clomiphene citrate (CC) and Letrozole (LTZ) for improving fecundity in infertile women with minimal to mild endometriosis after operative laparoscopy." | 5.51 | Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial. ( Chen, H; Fu, J; Huang, W; Liu, D; Wang, Q; Yang, S; Zhou, L, 2022) |
| "To compare the efficacy and the tolerability of letrozole combined with oral contraceptives versus oral contraceptives alone in treating endometriosis-related pain." | 5.41 | Letrozole combined with oral contraceptives versus oral contraceptives alone in the treatment of endometriosis-related pain symptoms: a pilot study. ( Luan, X; Wang, Y; Zhao, Y, 2021) |
| "To evaluate pregnancy rates with letrozole and clomiphene citrate (CC) alone for superovulation in an intrauterine insemination program for women with recently surgically treated minimal to mild endometriosis." | 5.16 | Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis. ( Abd Elaal, I; Abu Hashim, H; El Rakhawy, M, 2012) |
| "In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication." | 5.15 | A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis. ( Alborzi, M; Alborzi, S; Dehbashi, S; Hamedi, B; Omidvar, A, 2011) |
| "Women with pain symptoms caused by rectovaginal endometriosis were treated with letrozole (2." | 5.15 | Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial. ( Ferrero, S; Gillott, DJ; Remorgida, V; Venturini, PL, 2011) |
| "The combination drug regimen was more effective in reducing pain and deep dyspareunia than norethisterone acetate; however, letrozole caused a higher incidence of adverse effects, cost more and did not improve patients' satisfaction or influence recurrence of pain." | 5.14 | Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis. ( Camerini, G; Ferrero, S; Ragni, N; Remorgida, V; Seracchioli, R; Venturini, PL, 2009) |
| "This was a preliminary study to determine the effect of aromatase inhibitors in preventing the flare induced by GnRH agonist (GnRH-a) in women with endometriosis (n = 9) or leiomyomata (n = 4) who were given letrozole on the first 5 days of the GnRH-a therapy." | 5.14 | Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists. ( Bedaiwy, MA; Casper, RF; Mousa, NA, 2009) |
| "To discuss the effects of dydrogesterone combined with letrozole on the effectiveness, sex hormone levels, and serological indicators in patients with endometriosis." | 5.12 | The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis. ( Sun, S; Xu, Z; Zhang, H; Zhong, P, 2021) |
| "To compare the effectiveness of letrozole and clomiphene citrate (CC) in ovulatory patients with borderline male factor infertility, early stage endometriosis, and unexplained infertility." | 5.12 | Letrozole vs. clomiphene citrate in patients with ovulatory infertility. ( Ayoğlu, F; Barut, A; Bayar, U; Kaya, E; Ozcan, O; Tanriverdi, HA, 2006) |
| "The combination of letrozole and desogestrel induces a relief of pain symptoms in women with endometriosis but it causes the development of ovarian cysts." | 5.12 | Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis. ( Abbamonte, LH; Ferrero, S; Fulcheri, E; Ragni, N; Remorgida, V, 2007) |
| "The combination of letrozole and norethindrone acetate achieved marked reduction of laparoscopically visible and histologically confirmed endometriosis in all 10 patients and significant pain relief in nine out of 10 patients who had not responded previously to currently available treatments." | 5.11 | Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study. ( Ailawadi, RK; Bulun, SE; Gurates, B; Jobanputra, S; Kataria, M, 2004) |
| " After a 6-month washout of endometriosis hormone therapies, women took letrozole (2." | 4.87 | Aromatase inhibitors in recurrent ovarian endometriomas: report of five cases with literature review. ( De, A; Ghosh, D; Kamilya, G; Lall Seal, S; Majhi, AK; Mukherji, J, 2011) |
| " Previous studies have shown that administration of letrozole, a non-steroidal aromatase inhibitor for cancer treatment, increased the clinical pregnancy rate in women with endometriosis, but the mechanisms remain to be determined." | 4.12 | Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis. ( Li, C; Li, M; Li, R; Wang, L; Zhang, H; Zhang, J, 2022) |
| " Consequently, we aimed to investigate the effects of metformin, letrozole, and atorvastatin on inflammation and apoptosis in experimentally induced ovarian and peritoneal endometriosis in rat models." | 4.12 | Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. ( Coskun, G; Efendic, F; Erdem, E; Hayretdag, C; Irkorucu, O; Keles, P; Kuras, S; Pence, HH; Polat, S; Saker, D; Sapmaz, E; Sapmaz, T; Sevgin, K; Tekayev, M; Topkaraoglu, S, 2022) |
| "To assess the effect of letrozole in combination with low dose gonadotropins for ovulation induction in anovulatory infertility from polycystic ovary syndrome (PCOS) and controlled ovarian stimulation for endometriosis, and unexplained infertility patients." | 3.85 | Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study. ( Arya, S; Crisp, Z; Dwivedi, AK; Jose, J; Kupesic-Plavsic, S; Mulla, ZD; Noble, LS, 2017) |
| "This study was to investigate the effects of cisplatin (CDDP) and letrozole on surgically induced endometriosis and comparison of the two drugs in a rat model." | 3.83 | Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model. ( He, Z; Lang, J; Li, Z; Liu, H; Zhang, G, 2016) |
| "To compare the efficacy of norethisterone acetate (NETA; group N) or letrozole combined with NETA (group L) in treating endometriotic ovarian cysts." | 3.80 | Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study. ( Ferrero, S; Leone Roberti Maggiore, U; Remorgida, V; Venturini, PL, 2014) |
| "To compare the estradiol production and P450 aromatase messenger RNA (mRNA) expression of cultured luteinized granulosa cells and the effect of letrozole on these parameters between women with and without endometriosis." | 3.78 | Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis. ( Gao, XH; Lu, X; Sun, XX; Wang, L; Wang, YW; Wu, Y, 2012) |
| "Two premenopausal patients with bladder endometriosis were treated with letrozole (2." | 3.77 | Aromatase inhibitors in the treatment of bladder endometriosis. ( Biscaldi, E; Ferrero, S; Luigi Venturini, P; Remorgida, V, 2011) |
| "Letrozole and ETA caused a regression on the implant size in experimental endometriosis." | 3.77 | Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model. ( Baser, I; Ceyhan, ST; Fidan, U; Ide, T; Kilic, S; Onguru, O; Yaman, H, 2011) |
| "The administration of letrozole and norethisterone acetate reduces pain and gastrointestinal symptoms of women with colorectal endometriosis, particularly when patients suffer from symptoms mimicking diarrhoea-predominant irritable bowel syndrome." | 3.76 | Letrozole and norethisterone acetate in colorectal endometriosis. ( Biscaldi, E; Camerini, G; Ferrero, S; Ragni, N; Remorgida, V; Seracchioli, R; Venturini, PL, 2010) |
| "Our aim was to investigate the effects of metformin and letrozole on experimentally induced endometriosis in a rat model." | 3.76 | The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. ( Basbug, M; Oner, G; Ozcelik, B; Ozgun, MT; Ozturk, F; Serin, IS, 2010) |
| "To determine the effects of letrozole and melatonin on surgically induced endometriosis in a rat endometriosis model." | 3.76 | The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. ( Attar, R; Ficicioglu, C; Kumbak, B; Ozkan, F; Yesildaglar, N; Yildirim, G, 2010) |
| "Four premenopausal patients with documented refractory endometriosis and chronic pelvic pain were treated with aromatase inhibitors, either anastrazole (3) or letrozole (1), for 6 months." | 3.75 | Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients. ( Konje, JC; Verma, A, 2009) |
| "In contrast to our expectations, letrozole stimulated growth of normal human endometrium in an in vitro model of endometriosis." | 3.75 | Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix. ( Casper, RF; Khazaei, M; Montaseri, A, 2009) |
| "Pregnancy rates were comparable between the letrozole-FSH co-treatment group and the FSH alone group." | 3.75 | Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination. ( Bedaiwy, MA; Casper, R; Claessens, A; Esfandiari, N; Gotleib, L; Mousa, N; Shokry, M, 2009) |
| "Letrozole was superior to exemestane in relieving the endometriosis-associated pain in this postmenopausal woman." | 3.74 | Aromatase inhibitors in the treatment of severe endometriosis. ( Bedaiwy, MA; Casper, RF; Mousa, NA, 2007) |
| "The use of aromatase inhibitor treatment of endometriosis in postmenopausal women makes sense, is safe and is well tolerated." | 2.82 | Use of aromatase inhibitors in menopausal deep endometriosis: a case report and literature review. ( Goldberg, GL; Kuo, DYS; Rotenberg, O, 2022) |
| "Everolimus was administered orally at 10 mg daily and letrozole was administered orally at 2." | 2.80 | Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma. ( Coleman, RL; Gershenson, DM; Jiang, Y; Johnston, T; Levenback, C; Lu, KH; Munsell, MF; Nowakowski, M; Ring, K; Slomovitz, BM; Soliman, PT; Yates, MS; Zhang, Q, 2015) |
| "Endometriosis is defined as the growth of endometrial tissue outside of the uterine cavity." | 2.47 | The emerging use of aromatase inhibitors for endometriosis treatment. ( Nothnick, WB, 2011) |
| " Since endometriosis is a chronic disease, future investigations should clarify whether the long-term administration of AIs is superior to currently available endocrine therapies in terms of improvement of pain, adverse effects and patient satisfaction." | 2.47 | Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review. ( Ferrero, S; Gillott, DJ; Remorgida, V; Venturini, PL, 2011) |
| "Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility." | 2.46 | Endometriosis: in search of optimal treatment. ( Nothnick, WB, 2010) |
| "Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility." | 2.45 | Future targets in endometriosis treatment: targeting the endometriotic implant. ( Nothnick, WB; Zhang, X, 2009) |
| "Endometriosis was induced by autotransplanting pieces of uterus onto the peritoneum in rats." | 1.39 | [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. ( Fang, X; Guo, L; Su, J; Xia, X, 2013) |
| "Treatment with anastrozole or letrozole was started on either postoperative day 1 or 28 and continued for 4 weeks." | 1.36 | Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis. ( Barañao, RI; Bilotas, M; Meresman, G; Stella, I; Sueldo, C, 2010) |
| "Endometriosis was induced surgically in the following groups of mice: 1) untreated transgenic mice with disrupted P450arom gene (ArKO); 2) ArKO mice treated with systemic estrogen; 3) untreated wild-type (WT) mice; 4) WT mice treated with estrogen; 5) WT mice treated with the aromatase inhibitor, letrozole; and 6) WT mice treated with letrozole and estrogen." | 1.31 | Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue. ( Bulun, SE; Evans, D; Fang, Z; Gurates, B; Simpson, E; Tamura, M; Yang, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 29 (59.18) | 24.3611 |
| 2020's | 6 (12.24) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, MP | 1 |
| Potter, BV | 1 |
| Rotenberg, O | 1 |
| Kuo, DYS | 1 |
| Goldberg, GL | 1 |
| Sun, S | 1 |
| Zhang, H | 2 |
| Zhong, P | 1 |
| Xu, Z | 1 |
| Zhang, J | 1 |
| Wang, L | 2 |
| Li, C | 1 |
| Li, R | 1 |
| Li, M | 1 |
| Sapmaz, T | 1 |
| Coskun, G | 1 |
| Saker, D | 1 |
| Pence, HH | 1 |
| Keles, P | 1 |
| Hayretdag, C | 1 |
| Kuras, S | 1 |
| Topkaraoglu, S | 1 |
| Erdem, E | 1 |
| Efendic, F | 1 |
| Sevgin, K | 1 |
| Tekayev, M | 1 |
| Polat, S | 1 |
| Sapmaz, E | 1 |
| Irkorucu, O | 1 |
| Zhao, Y | 2 |
| Luan, X | 1 |
| Wang, Y | 1 |
| Zhou, L | 1 |
| Fu, J | 1 |
| Liu, D | 1 |
| Wang, Q | 1 |
| Chen, H | 1 |
| Yang, S | 2 |
| Huang, W | 1 |
| Arya, S | 1 |
| Kupesic-Plavsic, S | 1 |
| Mulla, ZD | 1 |
| Dwivedi, AK | 1 |
| Crisp, Z | 1 |
| Jose, J | 1 |
| Noble, LS | 1 |
| Jouhari, S | 1 |
| Mohammadzadeh, A | 1 |
| Soltanghoraee, H | 1 |
| Mohammadi, Z | 1 |
| Khazali, S | 1 |
| Mirzadegan, E | 1 |
| Lakpour, N | 1 |
| Fatemi, F | 1 |
| Zafardoust, S | 1 |
| Mohazzab, A | 1 |
| Naderi, MM | 1 |
| Siddiqa, AJ | 1 |
| Shrivastava, NK | 1 |
| Ali Mohsin, ME | 1 |
| Abidi, MH | 1 |
| Shaikh, TA | 1 |
| El-Meligy, MA | 1 |
| Xia, X | 1 |
| Guo, L | 1 |
| Su, J | 1 |
| Fang, X | 1 |
| Ferrero, S | 8 |
| Remorgida, V | 8 |
| Venturini, PL | 6 |
| Leone Roberti Maggiore, U | 2 |
| Gong, P | 1 |
| Chen, Y | 1 |
| Nwachukwu, JC | 1 |
| Srinivasan, S | 1 |
| Ko, C | 1 |
| Bagchi, MK | 1 |
| Taylor, RN | 1 |
| Korach, KS | 1 |
| Nettles, KW | 1 |
| Katzenellenbogen, JA | 1 |
| Katzenellenbogen, BS | 1 |
| Slomovitz, BM | 1 |
| Jiang, Y | 1 |
| Yates, MS | 1 |
| Soliman, PT | 1 |
| Johnston, T | 1 |
| Nowakowski, M | 1 |
| Levenback, C | 1 |
| Zhang, Q | 1 |
| Ring, K | 1 |
| Munsell, MF | 1 |
| Gershenson, DM | 1 |
| Lu, KH | 1 |
| Coleman, RL | 1 |
| Agarwal, SK | 1 |
| Foster, WG | 1 |
| Leung, AS | 1 |
| Dahan, MH | 1 |
| Cho, S | 1 |
| Mutlu, L | 1 |
| Zhou, Y | 1 |
| Taylor, HS | 2 |
| Li, Z | 1 |
| Liu, H | 1 |
| He, Z | 1 |
| Zhang, G | 1 |
| Lang, J | 1 |
| Bedaiwy, MA | 3 |
| Mousa, NA | 2 |
| Casper, RF | 3 |
| Verma, A | 1 |
| Konje, JC | 1 |
| Nothnick, WB | 3 |
| Zhang, X | 1 |
| Sasson, IE | 1 |
| Camerini, G | 2 |
| Seracchioli, R | 2 |
| Ragni, N | 3 |
| Bilotas, M | 1 |
| Meresman, G | 1 |
| Stella, I | 1 |
| Sueldo, C | 1 |
| Barañao, RI | 1 |
| Yildirim, G | 1 |
| Attar, R | 1 |
| Ozkan, F | 1 |
| Kumbak, B | 1 |
| Ficicioglu, C | 1 |
| Yesildaglar, N | 1 |
| Oner, G | 1 |
| Ozcelik, B | 1 |
| Ozgun, MT | 1 |
| Serin, IS | 1 |
| Ozturk, F | 1 |
| Basbug, M | 1 |
| Biscaldi, E | 2 |
| Lall Seal, S | 1 |
| Kamilya, G | 1 |
| Mukherji, J | 1 |
| De, A | 1 |
| Ghosh, D | 1 |
| Majhi, AK | 1 |
| Luigi Venturini, P | 1 |
| Alborzi, S | 2 |
| Hamedi, B | 1 |
| Omidvar, A | 1 |
| Dehbashi, S | 1 |
| Alborzi, M | 1 |
| Ceyhan, ST | 1 |
| Onguru, O | 1 |
| Fidan, U | 1 |
| Ide, T | 1 |
| Yaman, H | 1 |
| Kilic, S | 1 |
| Baser, I | 1 |
| Gillott, DJ | 2 |
| Abu Hashim, H | 1 |
| El Rakhawy, M | 1 |
| Abd Elaal, I | 1 |
| Badawy, AM | 1 |
| Elnashar, AM | 1 |
| Mosbah, AA | 1 |
| Lu, X | 1 |
| Wu, Y | 1 |
| Gao, XH | 1 |
| Wang, YW | 1 |
| Sun, XX | 1 |
| Scala, C | 1 |
| Di Luca, M | 1 |
| Langoi, D | 1 |
| Pavone, ME | 1 |
| Gurates, B | 3 |
| Chai, D | 1 |
| Fazleabas, A | 1 |
| Bulun, SE | 3 |
| Razzi, S | 1 |
| Fava, A | 1 |
| Sartini, A | 1 |
| De Simone, S | 1 |
| Cobellis, L | 1 |
| Petraglia, F | 1 |
| Ailawadi, RK | 1 |
| Jobanputra, S | 1 |
| Kataria, M | 1 |
| Fatemi, HM | 1 |
| Al-Turki, HA | 1 |
| Papanikolaou, EG | 1 |
| Kosmas, L | 1 |
| De Sutter, P | 1 |
| Devroey, P | 1 |
| Bayar, U | 1 |
| Tanriverdi, HA | 1 |
| Barut, A | 1 |
| Ayoğlu, F | 1 |
| Ozcan, O | 1 |
| Kaya, E | 1 |
| Abbamonte, LH | 1 |
| Fulcheri, E | 1 |
| Khazaei, M | 1 |
| Montaseri, A | 1 |
| Shokry, M | 1 |
| Mousa, N | 1 |
| Claessens, A | 1 |
| Esfandiari, N | 1 |
| Gotleib, L | 1 |
| Casper, R | 1 |
| Fang, Z | 1 |
| Tamura, M | 1 |
| Simpson, E | 1 |
| Evans, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicentric, Randomized, Non Comparative, Open-label Phase I/II Evaluating AZD2014 (Dual Mammalian Target of Rapamycin Complex 1/2 (mTORC1/mTORC2) Inhibitor) in Combination With Anastrozole Versus Anastrozole Alone in the Treatment of Metastatic Hormon[NCT02730923] | Phase 1/Phase 2 | 72 participants (Anticipated) | Interventional | 2016-04-30 | Active, not recruiting | ||
| A Phase II Study of Letrozole and RAD001 (Everolimus) in Patients With Advanced or Recurrent Endometrial Cancer[NCT01068249] | Phase 2 | 42 participants (Actual) | Interventional | 2010-04-30 | Active, not recruiting | ||
| Letrozole and CC Alone in an IUI Program in Women With Surgically Treated Minimal to Mild Endometriosis[NCT01334762] | 136 participants (Actual) | Interventional | 2007-05-31 | Completed | |||
| Induction of Ovulation With Raloxifene or Clomiphene Citrate in Polycystic Ovarian Syndrome[NCT00427700] | Phase 3 | 82 participants (Actual) | Interventional | 2008-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
OS is defined as the interval from first dose of study treatment to the date of death, irrespective of the cause of death; subjects still alive will be censored at the date of the last contact (NCT01068249)
Timeframe: from (1st treatment) to death or, for living patients, date of last contact, up to 24.4 months
| Intervention | months (Median) |
|---|---|
| RAD001 + Letrozole | 14 |
PFS is the time from first dose of study treatment until the first date of either objective disease progression or death due to any cause. Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), as a 30% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions. Median PFS was estimated using the Kaplan-Meier method. (NCT01068249)
Timeframe: from study entry (1st treatment) to date of tumor progression, date of death, or, for patients alive without tumor progression, date of last follow-up, assessed up to 2 years
| Intervention | months (Median) |
|---|---|
| RAD001 + Letrozole | 3 |
Toxicity was assessed using the National Cancer Institute Common Terminology Criteria for Adverse Events (version 3.0). (NCT01068249)
Timeframe: Adverse events were reported from first dose of study treatment until end of study treatment plus 30 days post treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| RAD001 + Letrozole | 28 |
(NCT01068249)
Timeframe: from study entry (1st treatment) to date of tumor progression, date of death, or, for patients alive without tumor progression, date of last follow-up, up to 2 years
| Intervention | Participants (Count of Participants) |
|---|---|
| RAD001 + Letrozole | 31 |
Objective response or stable disease rate monitored as patients accrue and are evaluated following the example of Thall and Simon. Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR (NCT01068249)
Timeframe: at 8 weeks of treatment, then every 12 weeks, up to 2 years
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Complete Response (CR) | Partial Response (PR) | |
| RAD001 + Letrozole | 9 | 2 |
Ovulation detected by ultrasound was defined as the percentage of a participants with ovulation detected by ultrasound, defined as the dominant follicle and its subsequent collapse. If a dominant follicle was not observed by day 21 after menses, the ovulation induction was considered to be a failure. (NCT00427700)
Timeframe: cycle day 14-20
| Intervention | percentage of participants (Number) |
|---|---|
| Clomiphene | 52.5 |
| Raloxifene | 40.4 |
The level of serum progesterone that indicated ovulation was considered to be 3 ng/mL or greater, on days 8 to 10 after ovulation. (NCT00427700)
Timeframe: 8-10 days after ovulation
| Intervention | ng/mL (Mean) |
|---|---|
| Clomiphene | 26.1 |
| Raloxiphene | 40 |
8 reviews available for letrozole and Endometriosis
| Article | Year |
|---|---|
Use of aromatase inhibitors in menopausal deep endometriosis: a case report and literature review.
Topics: Aromatase; Aromatase Inhibitors; Endometriosis; Female; Humans; Letrozole; Menopause; Rectum | 2022 |
The Effect of Letrozole Combined with Dydrogesterone for Endometriosis in China: A Meta-Analysis.
Topics: Animals; China; Dydrogesterone; Endometriosis; Female; Humans; Letrozole; Randomized Controlled Tria | 2021 |
The benefits of other treatments than in vitro fertilization to aid conception in minimal and mild endometriosis.
Topics: Clomiphene; Endometriosis; Female; Fertility Agents, Female; Fertilization in Vitro; Humans; Inferti | 2016 |
Future targets in endometriosis treatment: targeting the endometriotic implant.
Topics: Anastrozole; Angiogenesis Inhibitors; Animals; Aromatase Inhibitors; Clinical Trials as Topic; Endom | 2009 |
Endometriosis: in search of optimal treatment.
Topics: Adalimumab; Anastrozole; Angiogenesis Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antibodie | 2010 |
Aromatase inhibitors in recurrent ovarian endometriomas: report of five cases with literature review.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Female; Humans; Letrozole; Nitriles; Remission Induction | 2011 |
The emerging use of aromatase inhibitors for endometriosis treatment.
Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Endometrium; Estr | 2011 |
Use of aromatase inhibitors to treat endometriosis-related pain symptoms: a systematic review.
Topics: Anastrozole; Aromatase Inhibitors; Clinical Trials as Topic; Endometriosis; Female; Humans; Letrozol | 2011 |
14 trials available for letrozole and Endometriosis
| Article | Year |
|---|---|
Letrozole combined with oral contraceptives versus oral contraceptives alone in the treatment of endometriosis-related pain symptoms: a pilot study.
Topics: Adult; Aromatase Inhibitors; Contraceptives, Oral, Hormonal; Desogestrel; Drug Therapy, Combination; | 2021 |
Ovulation induction with clomiphene citrate or letrozole following laparoscopy in infertile women with minimal to mild endometriosis: a prospective randomised controlled trial.
Topics: Clomiphene; Endometriosis; Female; Fertility Agents, Female; Humans; Infertility, Female; Laparoscop | 2022 |
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bayes Theorem; beta Catenin; Biomarkers, Tumo | 2015 |
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bayes Theorem; beta Catenin; Biomarkers, Tumo | 2015 |
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bayes Theorem; beta Catenin; Biomarkers, Tumo | 2015 |
Phase II study of everolimus and letrozole in patients with recurrent endometrial carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bayes Theorem; beta Catenin; Biomarkers, Tumo | 2015 |
Reduction in Endometrioma Size with Three Months of Aromatase Inhibition and Progestin Add-Back.
Topics: Adult; Aromatase Inhibitors; Cohort Studies; Drug Therapy, Combination; Endometriosis; Female; Human | 2015 |
Aromatase inhibitors prevent the estrogen rise associated with the flare effect of gonadotropins in patients treated with GnRH agonists.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Estrogens; Female; Follicle Stimulating Hormone; Gonadot | 2009 |
Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis.
Topics: Adult; Analgesics, Non-Narcotic; Aromatase Inhibitors; Drug Therapy, Combination; Dysmenorrhea; Dysp | 2009 |
A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis.
Topics: Adult; Aromatase Inhibitors; Endometriosis; Female; Gonadotropin-Releasing Hormone; Humans; Infertil | 2011 |
Letrozole and norethisterone acetate versus letrozole and triptorelin in the treatment of endometriosis related pain symptoms: a randomized controlled trial.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Dyspareunia; Endometriosis; Female; Humans; | 2011 |
Randomized comparison of superovulation with letrozole vs. clomiphene citrate in an IUI program for women with recently surgically treated minimal to mild endometriosis.
Topics: Adult; Aromatase Inhibitors; Clomiphene; Drug Administration Schedule; Endometriosis; Female; Fertil | 2012 |
Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: a randomized controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aromatase Inhibitors; Drug Administration Schedule; Endomet | 2012 |
Changes in the size of rectovaginal endometriotic nodules infiltrating the rectum during hormonal therapies.
Topics: Adult; Aromatase Inhibitors; Calcium; Cholecalciferol; Contraceptives, Oral, Sequential; Contracepti | 2013 |
Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study.
Topics: Adult; Analysis of Variance; Aromatase Inhibitors; Bone Density; Contraceptives, Oral, Synthetic; En | 2004 |
Letrozole vs. clomiphene citrate in patients with ovulatory infertility.
Topics: Administration, Oral; Adult; Anovulation; Clomiphene; Endometriosis; Female; Fertility Agents, Femal | 2006 |
Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis.
Topics: Adult; Aromatase Inhibitors; Contraceptives, Oral, Synthetic; Desogestrel; Drug Therapy, Combination | 2007 |
27 other studies available for letrozole and Endometriosis
| Article | Year |
|---|---|
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosi | 2015 |
Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis.
Topics: Animals; Embryo Implantation; Endometriosis; Endometrium; Female; Homeobox A10 Proteins; Humans; Inf | 2022 |
Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat.
Topics: Animals; Apoptosis; Atorvastatin; bcl-2-Associated X Protein; Endometriosis; Female; Humans; Inflamm | 2022 |
Ovulation induction and controlled ovarian stimulation using letrozole gonadotropin combination: A single center retrospective cohort study.
Topics: Adult; Drug Therapy, Combination; Endometriosis; Female; Fertility Agents, Female; Follicle Stimulat | 2017 |
Effects of silymarin, cabergoline and letrozole on rat model of endometriosis.
Topics: Animals; Antioxidants; Aromatase Inhibitors; Cabergoline; Disease Models, Animal; Dopamine Agonists; | 2018 |
Preparation of letrozole dispersed pHEMA/AAm-g-LDPE drug release system: In-vitro release kinetics for the treatment of endometriosis.
Topics: Acrylamide; Animals; Cell Death; Cell Survival; Drug Liberation; Endometriosis; Female; Kinetics; Le | 2019 |
[Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats].
Topics: Animals; Apoptosis; Aromatase; Aromatase Inhibitors; bcl-2-Associated X Protein; Cyclooxygenase 2; E | 2013 |
Norethisterone acetate versus norethisterone acetate combined with letrozole for the treatment of ovarian endometriotic cysts: a patient preference study.
Topics: Adult; Aromatase Inhibitors; Drug Therapy, Combination; Dysmenorrhea; Dyspareunia; Endometriosis; Fe | 2014 |
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Disease Models, Animal; Disease P | 2015 |
Aromatase inhibitor regulates let-7 expression and let-7f-induced cell migration in endometrial cells from women with endometriosis.
Topics: Aromatase; Aromatase Inhibitors; Cell Line; Cell Movement; Dose-Response Relationship, Drug; Endomet | 2016 |
Effects of cisplatin and letrozole on surgically induced endometriosis and comparison of the two medications in a rat model.
Topics: Animals; Cisplatin; Disease Models, Animal; Endometriosis; Female; Letrozole; Nitriles; Rats; Triazo | 2016 |
Successful treatment of refractory endometriosis-related chronic pelvic pain with aromatase inhibitors in premenopausal patients.
Topics: Adult; Anastrozole; Aromatase Inhibitors; Chronic Disease; Dose-Response Relationship, Drug; Endomet | 2009 |
Aromatase inhibitor for treatment of a recurrent abdominal wall endometrioma in a postmenopausal woman.
Topics: Abdominal Wall; Aromatase Inhibitors; Endometriosis; Female; Humans; Letrozole; Middle Aged; Nitrile | 2009 |
Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis.
Topics: Anastrozole; Animals; Apoptosis; Aromatase; Aromatase Inhibitors; Ascitic Fluid; Cell Proliferation; | 2010 |
The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study.
Topics: Algorithms; Animals; Antineoplastic Agents; Antioxidants; Drug Evaluation, Preclinical; Endometriosi | 2010 |
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model.
Topics: Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Hypoglycemic Agents; L | 2010 |
Letrozole and norethisterone acetate in colorectal endometriosis.
Topics: Abdominal Pain; Aromatase Inhibitors; Colonic Diseases; Diarrhea; Drug Therapy, Combination; Dyspare | 2010 |
Aromatase inhibitors in the treatment of bladder endometriosis.
Topics: Adult; Aromatase Inhibitors; Calcium; Cholecalciferol; Cystectomy; Drug Therapy, Combination; Endome | 2011 |
Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model.
Topics: Animals; Antibodies, Monoclonal; Aromatase Inhibitors; Ascitic Fluid; Disease Models, Animal; Endome | 2011 |
Effect of letrozole on estradiol production and P450 aromatase messenger RNA expression of cultured luteinized granulosa cells from women with and without endometriosis.
Topics: Aromatase; Aromatase Inhibitors; Case-Control Studies; Cells, Cultured; Endometriosis; Estradiol; Fe | 2012 |
Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons.
Topics: Animals; Aromatase; Aromatase Inhibitors; Disease Models, Animal; Disease Progression; Endometriosis | 2013 |
Treatment of severe recurrent endometriosis with an aromatase inhibitor in a young ovariectomised woman.
Topics: Administration, Oral; Adult; Aromatase Inhibitors; Dyspareunia; Endometriosis; Enzyme Inhibitors; Fe | 2004 |
Successful treatment of an aggressive recurrent post-menopausal endometriosis with an aromatase inhibitor.
Topics: Aromatase Inhibitors; Colon, Sigmoid; Endometriosis; Female; Humans; Hysterectomy; Letrozole; Middle | 2005 |
Aromatase inhibitors in the treatment of severe endometriosis.
Topics: Androstadienes; Aromatase Inhibitors; Chronic Disease; Endometriosis; Estrogen Replacement Therapy; | 2007 |
Letrozole stimulates the growth of human endometrial explants cultured in three-dimensional fibrin matrix.
Topics: Aromatase Inhibitors; Cell Culture Techniques; Cell Division; Dose-Response Relationship, Drug; Endo | 2009 |
Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Drug Therapy, Combination; Endometriosis; Female; | 2009 |
Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue.
Topics: Animals; Aromatase; Aromatase Inhibitors; Cell Division; Choristoma; Endometriosis; Enzyme Inhibitor | 2002 |