Page last updated: 2024-10-30

letrozole and Dwarfism

letrozole has been researched along with Dwarfism in 4 studies

Dwarfism: A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.

Research Excerpts

ExcerptRelevanceReference
" ISS boys with letrozole-induced hypergonadotropic hyperandrogenism had, after 12 months of therapy, higher INSL3 levels than did placebo treated (0."5.12Serum insulin-like factor 3 levels during puberty in healthy boys and boys with Klinefelter syndrome. ( Andersson, AM; Bay, K; Dunkel, L; Hero, M; Wikström, AM, 2006)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Ma, Y1
Jia, R1
Xia, B1
Tang, B1
Xu, Z1
Cui, YP1
Wang, XL1
Mauras, N1
Ross, JL1
Gagliardi, P1
Yu, YM1
Hossain, J1
Permuy, J1
Damaso, L1
Merinbaum, D1
Singh, RJ1
Gaete, X1
Mericq, V1
Wikström, AM1
Bay, K1
Hero, M1
Andersson, AM1
Dunkel, L1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial Of The Use Of Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature[NCT01248416]Phase 376 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Body Mass Index

(NCT01248416)
Timeframe: 0 to 24 months

Interventionkg/m^2 (Mean)
Aromatase Inhibitor2.5
Growth Hormone1.7
Aromatase Inhibitor and Growth Hormone2.5

Change in Bone Density z Score Adjusted for Height

(NCT01248416)
Timeframe: 0 to 24 months

Interventionz-score (Least Squares Mean)
Aromatase Inhibitor-1.061
Growth Hormone-0.586
Aromatase Inhibitor and Growth Hormone-0.605

Change in Estradiol

Those taking AI alone or AI/GH combined were grouped by type, either anastrozole or letrozole. (NCT01248416)
Timeframe: 0 to 24 months

Interventionpg/mL (Mean)
Anastrozole8
Letrozole4

Change in Estrone

(NCT01248416)
Timeframe: 0 to 24 months

Interventionpg/mL (Mean)
Aromatase Inhibitor0.0
Growth Hormone6.1
Aromatase Inhibitor and Growth Hormone-0.9

Change in Height

Differences in height gains (NCT01248416)
Timeframe: 0 to 24 months

InterventionCentimeters (Mean)
Aromatase Inhibitor14
Growth Hormone17.1
Aromatase Inhibitor and Growth Hormone18.9

Change in IGF-I Concentrations

(NCT01248416)
Timeframe: 0 to 24 months

Interventionng/mL (Mean)
Aromatase Inhibitor158
Growth Hormone280
Aromatase Inhibitor and Growth Hormone303

Change in Lean Body Mass

(NCT01248416)
Timeframe: 0 to 24 months

Interventionkg (Mean)
Aromatase Inhibitor42.2
Growth Hormone42.0
Aromatase Inhibitor and Growth Hormone46.5

Change in Predicted Height

Primary efficacy end point: change in predicted height (cm) from baseline at 24 months based on change in bone age (years) (NCT01248416)
Timeframe: 0 to 24 months

Interventioncentimeters (Least Squares Mean)
Aromatase Inhibitor0.5
Growth Hormone4.9
Aromatase Inhibitor and Growth Hormone7.4

Change in Testosterone

(NCT01248416)
Timeframe: 0 to 24 months

Interventionng/dL (Mean)
Aromatase Inhibitor737
Growth Hormone372
Aromatase Inhibitor and Growth Hormone668

Trials

2 trials available for letrozole and Dwarfism

ArticleYear
Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature.
    The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:12

    Topics: Adolescent; Anastrozole; Aromatase Inhibitors; Body Composition; Body Height; Drug Therapy, Combinat

2016
Serum insulin-like factor 3 levels during puberty in healthy boys and boys with Klinefelter syndrome.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:11

    Topics: Adolescent; Age Determination by Skeleton; Aromatase Inhibitors; Body Height; Child; Dwarfism; Healt

2006

Other Studies

2 other studies available for letrozole and Dwarfism

ArticleYear
Adult height in pubertal boys with short stature treated with GH/letrozole: a hospital record-based retrospective study.
    BMC pediatrics, 2022, 06-28, Volume: 22, Issue:1

    Topics: Adult; Dwarfism; Growth Hormone; Hospital Records; Human Growth Hormone; Humans; Letrozole; Male; Re

2022
[Clinical effect of letrozole in treatment of idiopathic short stature in adolescent boys].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2019, Volume: 21, Issue:10

    Topics: Adolescent; Body Height; Dwarfism; Growth Disorders; Human Growth Hormone; Humans; Letrozole; Male;

2019
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