letrozole has been researched along with Depression in 10 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Purpose The Letrozole (Femara) Versus Anastrozole Clinical Evaluation (FACE) study compared the efficacy and safety of adjuvant letrozole versus anastrozole in postmenopausal patients with hormone receptor (HR) -positive and node-positive early breast cancer (eBC)." | 9.24 | Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation ( Amadori, D; Burris, H; Comarella, L; De Boer, R; Dowsett, M; Ejlertsen, B; Gnant, M; Hart, L; Jonat, W; McIntyre, K; O'Shaughnessy, J; Poggio, S; Pritchard, KI; Salomon, H; Smith, I; Wamil, B; Yardley, D, 2017) |
| "Purpose The Letrozole (Femara) Versus Anastrozole Clinical Evaluation (FACE) study compared the efficacy and safety of adjuvant letrozole versus anastrozole in postmenopausal patients with hormone receptor (HR) -positive and node-positive early breast cancer (eBC)." | 5.24 | Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation ( Amadori, D; Burris, H; Comarella, L; De Boer, R; Dowsett, M; Ejlertsen, B; Gnant, M; Hart, L; Jonat, W; McIntyre, K; O'Shaughnessy, J; Poggio, S; Pritchard, KI; Salomon, H; Smith, I; Wamil, B; Yardley, D, 2017) |
| "Ketamine has been recently approved to treat resistant depression; however preclinical studies showed sex differences in its efficacy." | 4.31 | Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy. ( García-Fuster, MJ; Jornet-Plaza, J; Ledesma-Corvi, S, 2023) |
| "We conducted a secondary analysis of a multicenter, randomized clinical trial (Pregnancy in Polycystic Ovary Syndrome II, NCT00719186) comparing clomiphene citrate vs letrozole in the treatment of infertility." | 3.88 | Association among depression, symptom experience, and quality of life in polycystic ovary syndrome. ( Cedars, MI; Greenwood, EA; Huddleston, HG; Legro, RS; Pasch, LA, 2018) |
| "Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator." | 2.87 | Insulin resistance is associated with depression risk in polycystic ovary syndrome. ( Cedars, MI; Eisenberg, E; Greenwood, EA; Huddleston, HG; Legro, RS; Pasch, LA, 2018) |
| " Thus, to clarify the effects of letrozole on the hippocampus and behavior, we examined how chronic administration affects hippocampal neurogenesis and depressive-like behavior in middle-aged, intact female mice." | 1.51 | Chronic aromatase inhibition increases ventral hippocampal neurogenesis in middle-aged female mice. ( Chaiton, JA; Galea, LA; Wong, SJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, H | 1 |
| Zhang, X | 1 |
| Xu, C | 1 |
| An, S | 1 |
| Ma, XM | 1 |
| Qiao, H | 1 |
| Ledesma-Corvi, S | 1 |
| Jornet-Plaza, J | 1 |
| García-Fuster, MJ | 1 |
| Kokras, N | 1 |
| Pastromas, N | 1 |
| Papasava, D | 1 |
| de Bournonville, C | 1 |
| Cornil, CA | 1 |
| Dalla, C | 1 |
| Greenwood, EA | 2 |
| Pasch, LA | 2 |
| Cedars, MI | 2 |
| Legro, RS | 2 |
| Eisenberg, E | 1 |
| Huddleston, HG | 2 |
| Chaiton, JA | 1 |
| Wong, SJ | 1 |
| Galea, LA | 1 |
| Mao, JJ | 1 |
| Farrar, JT | 1 |
| Bruner, D | 1 |
| Zee, J | 1 |
| Bowman, M | 1 |
| Seluzicki, C | 1 |
| DeMichele, A | 1 |
| Xie, SX | 1 |
| Smith, I | 1 |
| Yardley, D | 1 |
| Burris, H | 1 |
| De Boer, R | 1 |
| Amadori, D | 1 |
| McIntyre, K | 1 |
| Ejlertsen, B | 1 |
| Gnant, M | 1 |
| Jonat, W | 1 |
| Pritchard, KI | 1 |
| Dowsett, M | 1 |
| Hart, L | 1 |
| Poggio, S | 1 |
| Comarella, L | 1 |
| Salomon, H | 1 |
| Wamil, B | 1 |
| O'Shaughnessy, J | 1 |
| Meng, FT | 1 |
| Ni, RJ | 1 |
| Zhang, Z | 1 |
| Zhao, J | 1 |
| Liu, YJ | 1 |
| Zhou, JN | 1 |
| Rodríguez, J | 1 |
| Castañeda, G | 1 |
| Muñoz, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 20 Week Double-Blind Randomized Trial of Clomiphene Citrate and Letrozole for the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT00719186] | Phase 3 | 750 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome measure is the occurrence of a live birth during the study period. Safety measures will be the number and type of reported adverse events in subjects and offspring. (NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Arm A: Clomiphene Citrate | 72 |
| Arm B: Letrozole | 103 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | ovulations (Number) |
|---|---|
| Arm A: Clomiphene Citrate | 331 |
| Arm B: Letrozole | 388 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Arm A: Clomiphene Citrate | 103 |
| Arm B: Letrozole | 154 |
(NCT00719186)
Timeframe: as few as 5 months, up to 16 months
| Intervention | events (Number) |
|---|---|
| Arm A: Clomiphene Citrate | 13 |
| Arm B: Letrozole | 22 |
(NCT00719186)
Timeframe: September 2008 - December 2011
| Intervention | participants (Number) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Neonatal jaundice | Neonatal respiratory distress syndrome | Neonatal hospitalization >3 days | Intrauterine growth restriction | Neonatal infectin | Minor birth defect | Other complication | Congenital anomaly | Neonatal death | |
| Arm A: Clomiphene Citrate | 17 | 2 | 4 | 1 | 2 | 0 | 4 | 1 | 2 |
| Arm B: Letrozole | 27 | 7 | 4 | 5 | 2 | 1 | 5 | 4 | 1 |
3 trials available for letrozole and Depression
| Article | Year |
|---|---|
Insulin resistance is associated with depression risk in polycystic ovary syndrome.
Topics: Adult; Clomiphene; Depression; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; P | 2018 |
Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: a randomized trial.
Topics: Aged; Anastrozole; Androstadienes; Anxiety; Aromatase Inhibitors; Arthralgia; Breast Neoplasms; Depr | 2014 |
Comparative Efficacy and Safety of Adjuvant Letrozole Versus Anastrozole in Postmenopausal Patients With Hormone Receptor-Positive, Node-Positive Early Breast Cancer: Final Results of the Randomized Phase III Femara Versus Anastrozole Clinical Evaluation
Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Arthralgia; Breast Neoplasms; Chemotherapy, Adju | 2017 |
7 other studies available for letrozole and Depression
| Article | Year |
|---|---|
Endogenous hippocampal estrogen is involved in stress-induced depression-like behaviors and spine plasticity in male rats.
Topics: Animals; Depression; Estradiol; Estrogens; Female; Hippocampus; Letrozole; Male; Rats; Stress, Psych | 2022 |
Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy.
Topics: Animals; Antidepressive Agents; Aromatase; Depression; Estrogens; Female; Ketamine; Letrozole; Male; | 2023 |
Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats.
Topics: Animals; Antidepressive Agents; Aromatase; Aromatase Inhibitors; Behavior, Animal; Brain; Castration | 2018 |
Association among depression, symptom experience, and quality of life in polycystic ovary syndrome.
Topics: Adult; Aromatase Inhibitors; Case-Control Studies; Clomiphene; Depression; Female; Fertility Agents, | 2018 |
Chronic aromatase inhibition increases ventral hippocampal neurogenesis in middle-aged female mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; Behavior, Animal; Cell Proliferation; Dentate Gyrus; Depre | 2019 |
Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice.
Topics: Animals; Anxiety; Aromatase Inhibitors; Depression; Disease Models, Animal; Estradiol; Female; Hippo | 2011 |
Rapid determination of letrozole, citalopram and their metabolites by high performance liquid chromatography-fluorescence detection in urine: Method validation and application to real samples.
Topics: Antidepressive Agents, Second-Generation; Antineoplastic Agents; Breast Neoplasms; Chromatography, H | 2013 |