lergotrile and Parkinson-Disease

lergotrile has been researched along with Parkinson-Disease* in 3 studies

Reviews

1 review(s) available for lergotrile and Parkinson-Disease

Article	Year
Psychiatric disorders in parkinsonism: 2. Organic cerebral states and drug reactions. Psychosomatics, 1986, Volume: 27, Issue:3 Topics: Amantadine; Antiparkinson Agents; Atrophy; Brain; Bromocriptine; Cognition; Dementia; Dreams; Drug Interactions; Ergolines; Humans; Levodopa; Libido; Memory; Parasympatholytics; Parkinson Disease; Receptors, Dopamine; Sexual Behavior; Substance-Related Disorders; Visual Perception	1986

Article

Year

Psychiatric disorders in parkinsonism: 2. Organic cerebral states and drug reactions.

Psychosomatics, 1986, Volume: 27, Issue:3

Topics: Amantadine; Antiparkinson Agents; Atrophy; Brain; Bromocriptine; Cognition; Dementia; Dreams; Drug Interactions; Ergolines; Humans; Levodopa; Libido; Memory; Parasympatholytics; Parkinson Disease; Receptors, Dopamine; Sexual Behavior; Substance-Related Disorders; Visual Perception

1986

Other Studies

2 other study(ies) available for lergotrile and Parkinson-Disease

Article	Year
Comparative efficacy of two dopamine agonists, pergolide and lergotrile, in Parkinson disease. New York state journal of medicine, 1988, Volume: 88, Issue:8 Topics: Adult; Aged; Drug Therapy, Combination; Ergolines; Humans; Levodopa; Middle Aged; Parkinson Disease; Pergolide; Retrospective Studies	1988
Pergolide-induced circling in rats with 6-hydroxydopamine lesions in the nigrostriatal pathway. Neurology, 1982, Volume: 32, Issue:12 In rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal system we compared the behavioral effects of pergolide with those of L-dopa, bromocriptine, and lergotrile. In this animal model of parkinsonism, doses of 0.25 mg per kilogram pergolide (free base) induced vigorous circling for 24 hours. Pergolide was more potent than bromocriptine or lergotrile. Pretreatment with alpha-methylparatyrosine nearly abolished the effects of bromocriptine, markedly diminished the effects of lergotrile, and only partially diminished the effects of pergolide. These findings suggest that pergolide should be more effective than bromocriptine in the treatment of parkinsonism. Topics: Animals; Behavior, Animal; Brain Diseases; Bromocriptine; Ergolines; Female; Hydroxydopamines; Oxidopamine; Parkinson Disease; Pergolide; Rats; Rats, Inbred Strains	1982

Article

Year

Comparative efficacy of two dopamine agonists, pergolide and lergotrile, in Parkinson disease.

New York state journal of medicine, 1988, Volume: 88, Issue:8

Topics: Adult; Aged; Drug Therapy, Combination; Ergolines; Humans; Levodopa; Middle Aged; Parkinson Disease; Pergolide; Retrospective Studies

1988

Pergolide-induced circling in rats with 6-hydroxydopamine lesions in the nigrostriatal pathway.

Neurology, 1982, Volume: 32, Issue:12

In rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal system we compared the behavioral effects of pergolide with those of L-dopa, bromocriptine, and lergotrile. In this animal model of parkinsonism, doses of 0.25 mg per kilogram pergolide (free base) induced vigorous circling for 24 hours. Pergolide was more potent than bromocriptine or lergotrile. Pretreatment with alpha-methylparatyrosine nearly abolished the effects of bromocriptine, markedly diminished the effects of lergotrile, and only partially diminished the effects of pergolide. These findings suggest that pergolide should be more effective than bromocriptine in the treatment of parkinsonism.

Topics: Animals; Behavior, Animal; Brain Diseases; Bromocriptine; Ergolines; Female; Hydroxydopamines; Oxidopamine; Parkinson Disease; Pergolide; Rats; Rats, Inbred Strains

1982