leptin has been researched along with Parkinsonian-Disorders* in 2 studies
2 other study(ies) available for leptin and Parkinsonian-Disorders
| Article | Year |
|---|---|
Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re-establishing autophagic flux via promoting leptin signalling in a 6-hydroxydopamine rat model of Parkinson's disease.
Previous studies reveal that hydrogen sulphide (H Topics: Animals; Apoptosis; Autophagosomes; Autophagy; Hydrogen Sulfide; Leptin; Male; Microscopy, Electron, Transmission; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2022 |
Leptin mediates protection of hydrogen sulfide against 6-hydroxydopamine-induced Parkinson's disease: Involving enhancement in Warburg effect.
Hydrogen sulfide (H. To determine whether the mechanism underlying protection of H. We set a PD model via unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA) in Sprague Dawley rat. PD-like behavior was analyzed by apomorphine-induced rotations, open field activity test, stepping test and cylinder test. Dopaminergic neurons were detected by immunohistochemistry. The expressions of Hexokinase-2, pyruvate kinase M-2, lactate dehydrogenase, pyruvate dehydrogenase kinase, pyruvate dehydrogenase, and leptin were measured by Western blot. Lactate dehydrogenase (LDHA) activity was monitored by ELISA. The lactate content was measured by lactate assay kit.. We showed that NaHS (a donor of H. These data indicated that leptin mediates the protection of H Topics: Animals; Dose-Response Relationship, Drug; Hydrogen Sulfide; Leptin; Male; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Warburg Effect, Oncologic | 2020 |