leptin and Nail-Diseases

Acrocyanosis is undoubtedly the most commonplace acrosyndrome, both in terms of pathogenesis and prognosis. Patients experience functional impairment and an esthetic prejudice that must not be neglected. Adopting the nosological classifications described for Raynaud's syndrome, primary acrocyanosis must be distinguished from exceptional secondary phenomena that have a radically different clinical course. Primary acrocyanosis is generally observed in a young woman who appears thin or has recently lost weight. No paroxysmal episode (syncope, cyanosis, suspicious event involving the fingers) is found. The physical examination is negative and no complementary explorations are needed. Current pathophysiological hypotheses remain insufficient but suggest that vasospasticity rather than hemorheology is involved. The hypothesis that a thermoregulation disorder could be associated with weight loss deserves further study. Symptomatic care relies on dietary and hygiene counseling, emphasizing the importance of warm clothing. The psychological element must also be considered even in the most common forms.

Topics: Adult; Arteritis; Body Temperature Regulation; Cold Temperature; Cyanosis; Diagnosis, Differential; Female; Fingers; Hemorheology; Humans; Hypothalamus; Ischemia; Leptin; Muscle Spasticity; Muscle, Smooth, Vascular; Nail Diseases; Nails; Prevalence; Raynaud Disease; Retrospective Studies; Vasoconstriction; Weight Loss