leptin and Lymphatic-Abnormalities

leptin has been researched along with Lymphatic-Abnormalities* in 1 studies

Other Studies

1 other study(ies) available for leptin and Lymphatic-Abnormalities

Article	Year
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nature genetics, 2005, Volume: 37, Issue:10 Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. Topics: Alleles; Animals; Disease Models, Animal; Gene Deletion; Homeodomain Proteins; Insulin; Leptin; Lipid Metabolism; Lipids; Liver; Lymph; Lymphatic Abnormalities; Lymphatic Vessels; Mice; Mice, Knockout; Obesity; Tumor Suppressor Proteins	2005

Article

Year

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.

Nature genetics, 2005, Volume: 37, Issue:10

Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.

Topics: Alleles; Animals; Disease Models, Animal; Gene Deletion; Homeodomain Proteins; Insulin; Leptin; Lipid Metabolism; Lipids; Liver; Lymph; Lymphatic Abnormalities; Lymphatic Vessels; Mice; Mice, Knockout; Obesity; Tumor Suppressor Proteins

2005