leptin and Intracranial-Hemorrhages

leptin has been researched along with Intracranial-Hemorrhages* in 3 studies

Reviews

1 review(s) available for leptin and Intracranial-Hemorrhages

ArticleYear
Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction.
    Advances in neurobiology, 2017, Volume: 19

    Despite the well-known global impact of overweight and obesity in the incidence of cerebrovascular disease, many aspects of this association are still inconsistently defined. In this chapter we aim to present a critical review on the links between obesity and both ischemic and hemorrhagic stroke and discuss its influence on functional outcomes, survival, and current treatments to acute and chronic stroke. The role of cerebrovascular endothelial function and respective modulation is also described as well as its laboratory and clinical assessment. In this context, the major contributing mechanisms underlying obesity-induced cerebral endothelial function (adipokine secretion, insulin resistance, inflammation, and hypertension) are discussed. A special emphasis is given to the participation of adipokines in the pathophysiology of stroke, namely adiponectin, leptin, resistin, apelin, and visfatin.

    Topics: Adipokines; Adiponectin; Apelin; Brain Ischemia; Cerebrovascular Disorders; Endothelium, Vascular; Humans; Hypertension; Inflammation; Insulin Resistance; Intracranial Hemorrhages; Leptin; Nicotinamide Phosphoribosyltransferase; Obesity; Resistin; Stroke

2017

Other Studies

2 other study(ies) available for leptin and Intracranial-Hemorrhages

ArticleYear
The emerging role of leptin, Adiponectin and Visfatin in Ischemic/Hemorrhagic stroke.
    British journal of neurosurgery, 2019, Volume: 33, Issue:5

    Topics: Adiponectin; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Brain Ischemia; Cytokines; Female; Humans; Intracranial Hemorrhages; Leptin; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Stroke; Treatment Outcome

2019
Leptin plays a role in ruptured human brain arteriovenous malformations.
    Acta neurochirurgica. Supplement, 2008, Volume: 105

    Intracerebral hemorrhage (ICH) is one of the most common clinical manifestations of human brain arteriovenous malformation (BAVM). However, the hemorrhagic mechanism of BAVM is still unclear. Leptin, first discovered in obesity research, has not been systematically studied in BAVM and ICH. We investigated expression and effect of leptin on human BAVM.. Specimens were obtained from 6 BAVM patients, who had been divided into either hemorrhagic or non-hemorrhagic groups. Leptin, leptin receptor, and signal transducers and activators of transcription-3 (STAT3) were analyzed by different methods, such as gene chips, reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry, and Western blot. Perinidal brain tissue around each BAVM served as control.. Gene chips and RT-PCR found transcriptional leptin raised at least 2 levels in hemorrhagic BAVM. Immunohistochemical slices also showed higher expression of leptin, leptin receptor, and STAT3 on nidus part of hemorrhagic BAVM than non-hemorrhagic ones. On Western blot analysis, hemorrhagic BAVMs had higher levels of leptin (p < 0.01).. The transcriptional and translational levels of leptin, leptin receptor, and STAT3 were higher in hemorrhagic BAVM, suggesting that leptin may play an important role in the hemorrhagic mechanism of BAVM.

    Topics: Adolescent; Adult; Female; Gene Expression Regulation; Humans; Intracranial Arteriovenous Malformations; Intracranial Hemorrhages; Leptin; Male; Microarray Analysis; Middle Aged; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor

2008
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