leptin and Central-Nervous-System-Diseases

leptin has been researched along with Central-Nervous-System-Diseases* in 2 studies

Reviews

2 review(s) available for leptin and Central-Nervous-System-Diseases

Article	Year
The role of leptin in central nervous system diseases. Neuroreport, 2016, Mar-23, Volume: 27, Issue:5 Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway. Although most studies focus on its role in energy intake and expenditure, leptin also plays a critical role in many central nervous system diseases. Topics: Animals; Central Nervous System Diseases; Humans; Leptin; Signal Transduction	2016
[An approach toward CNS dysfunction associated with metabolic syndrome; implication of leptin, which is a key molecule of obesity, in depression associated with obesity]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2012, Volume: 32, Issue:5-6 Obesity is the most critical factor in the pathology of metabolic syndrome (MetS), and is associated with an increased risk of depression. The imbalance of hormones and neural peptides which are involved in energy regulation are observed in obesity. It becomes evident that these hormones and neural peptides also affect mood. Leptin plays a pivotal role in energy regulation mainly acting in the hypothalamus of the brain. Although obese humans and rodents usually have high circulating levels of leptin, leptin neither reduces food intake nor increases energy expenditure. This paradoxical situation in obesity has been termed "leptin resistance", which is considered to be a central dogma for obesity. Based on these observations, we examined the functional significance of leptin in the regulation of the depressive state in diet-induced obese (DIO) mice. Our recent study demonstrated that DIO mice showed severe depressive behavior without response to the antidepressant effect of leptin, which is, in part, due to the impairment of leptin action in the hippocampus (Yamada, et al., Endocrinology, 2011). MetS and CNS dysfunction might have common pathological bases vulnerable to these disorders. Our future direction is to investigate a new treatment strategy of MetS by analyzing CNS dysfunction associated with obesity. Topics: Animals; Central Nervous System Diseases; Depression; Disease Models, Animal; Humans; Leptin; Metabolic Syndrome; Obesity	2012

Article

Year

The role of leptin in central nervous system diseases.

Neuroreport, 2016, Mar-23, Volume: 27, Issue:5

Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway. Although most studies focus on its role in energy intake and expenditure, leptin also plays a critical role in many central nervous system diseases.

Topics: Animals; Central Nervous System Diseases; Humans; Leptin; Signal Transduction

2016

[An approach toward CNS dysfunction associated with metabolic syndrome; implication of leptin, which is a key molecule of obesity, in depression associated with obesity].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2012, Volume: 32, Issue:5-6

Obesity is the most critical factor in the pathology of metabolic syndrome (MetS), and is associated with an increased risk of depression. The imbalance of hormones and neural peptides which are involved in energy regulation are observed in obesity. It becomes evident that these hormones and neural peptides also affect mood. Leptin plays a pivotal role in energy regulation mainly acting in the hypothalamus of the brain. Although obese humans and rodents usually have high circulating levels of leptin, leptin neither reduces food intake nor increases energy expenditure. This paradoxical situation in obesity has been termed "leptin resistance", which is considered to be a central dogma for obesity. Based on these observations, we examined the functional significance of leptin in the regulation of the depressive state in diet-induced obese (DIO) mice. Our recent study demonstrated that DIO mice showed severe depressive behavior without response to the antidepressant effect of leptin, which is, in part, due to the impairment of leptin action in the hippocampus (Yamada, et al., Endocrinology, 2011). MetS and CNS dysfunction might have common pathological bases vulnerable to these disorders. Our future direction is to investigate a new treatment strategy of MetS by analyzing CNS dysfunction associated with obesity.

Topics: Animals; Central Nervous System Diseases; Depression; Disease Models, Animal; Humans; Leptin; Metabolic Syndrome; Obesity

2012