leptin and Asthma--Occupational

In search of inflammatory molecular markers helpful in detection of increased risk and prognosis of severity of syntropic occupational bronchial asthma and metabolic syndrome, the authors conducted a study covering 140 examinees with confirmed occupational bronchial asthma. According to IDF criteria (2005), the patients were assigned into a group with combined occupational bronchial asthma and metabolic syndrome, and a group of occupational bronchial asthma without metabolic syndrome. All the examinees underwent studies of inflammation markers - biochemical (C-reactive protein, leptine) and molecular-genetic ( polymorphism of Gln223Arg gene of leptine receptor (LEPR), polymorphism of C174G gene of interleukin-6 (IL-6), polymorphism of G308A gene of (TNF-a) tumor necrosis factor alpha). Evidences are that the patients with combined bronchial asthma and metabolic syndrome demonstrate higher activity of inflammatory processes (higher level of C-reactive protein, leptine) - that manifests in clinically more severe course of bronchopulmonary disease. Moleculary-genetic markers revealed are associated with higher activity of inflammation and therefore with increased risk of occupational bronchial asthma associated with metabolic syndrome and diabetess mellitus 2 type (polymorphisms of LEPR gene, IL-6 gene).

Topics: Air Pollutants, Occupational; Asthma, Occupational; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Leptin; Male; Metabolic Syndrome; Middle Aged; Russia