leptin and Angina--Unstable

Leptin and total homocysteine (tHcy) may participate in the pathogenesis of coronary artery disease (CAD) through nitric oxide (NO) depletion. We sought to investigate whether leptin, tHcy and NO are suitable predictors of CAD.. This study contained 50 control subjects and 50 stable and 50 unstable angina patients. Plasma leptin, tHcy and NO levels were determined using enzyme immunoassay, HPLC fluorescence and spectrophotometric methods, respectively. Other conventional risk factors were also determined.. Leptin and tHcy levels were highest in unstable angina patients, followed by stable angina patients and then controls (p < 0.001). Controls had significantly higher NO than patients (p <0.001). Leptin and tHcy had a positive and NO a negative association with the presence of CAD.. Some athrogenic effects of leptin may be mediated by affecting tHcy and NO levels. Plasma leptin, tHcy and NO levels showed significant contribution to CAD prediction and discrimination.

Topics: Aged; Angina, Stable; Angina, Unstable; Chromatography, High Pressure Liquid; Coronary Artery Disease; Female; Homocysteine; Humans; Immunoenzyme Techniques; Leptin; Male; Middle Aged; Nitric Oxide; Odds Ratio; Risk Factors; ROC Curve; Spectrometry, Fluorescence

Angiographically visible complex lesions which are associated with plaque vulnerability have been shown to correlate strongly with clinical severity of unstable angina (UA). By activating different immune/inflammatory cells or directly acting on the vessel wall leptin has been shown to play a potential role in the development of acute coronary syndrome. However, the relationship between leptin and simple or complex lesion morphology in UA has not been investigated. Therefore, we designed this study to determine the association between plasma leptin level and simple or complex lesions in patients with UA and to see any correlation between leptin and other inflammatory markers in these patients.. Plasma concentrations of leptin, interleukin (IL)-6, IL-10 and high-sensitivity C-Reactive Protein (hsCRP) were analyzed in 47 patients with UA. These patients were also angiographically studied and divided into two groups: simple lesion (n=18) and complex lesion (n=29) based on the coronary plaque morphology. We further compared them with 20 control subjects having no evidence of coronary artery diseases.. Plasma leptin concentrations were higher in patients having complex lesions compared to those having simple lesions as well as normal controls. Similarly IL-6 and hsCRP were also higher in complex lesion group compared to simple lesion group and controls, and leptin was positively correlated with IL-6 and hsCRP. Concentrations of IL-10 were lower in simple and complex lesion groups compared to the controls and leptin was negatively correlated with IL-10, but no significant difference between simple and complex lesions was found. Furthermore, leptin was found to be an independent predictor for the complex lesion morphology in UA patients.. These findings suggested that angiographically visible complex lesions are associated with increased concentrations of leptin, and thus leptin can be a useful biomarker for risk stratification in UA.

Topics: Adult; Aged; Angina, Unstable; Biomarkers; Coronary Angiography; Female; Humans; Leptin; Male; Middle Aged; Risk Factors

Prolactin and leptin are newly recognized platelet co-stimulators due to enhancement of ADP-induced platelet aggregation. The aim of our study was to assess whether both hormones prolactin and leptin play a role as co-activators of platelet activation in patients with acute coronary syndromes. Twenty-one patients with acute coronary syndromes, 10 with stable angina pectoris and 10 controls were studied. Patients with acute coronary syndromes showed significantly higher prolactin and leptin values and a significant increased P-selectin expression on platelets compared to patients with stable angina pectoris or controls. However, patients with acute myocardial infarction as a subgroup of acute coronary syndromes showed the highest prolactin levels as well as ADP stimulated P-selectin expression. In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r (2)=0.41; p=0.025), whereas leptin was not correlated. Our data indicate an association between increased prolactin values and enhanced P-selectin expression on platelets in patients with acute coronary syndromes. Therefore, the stress hormone prolactin could be a co-stimulator of platelet activation in these patients. In contrast, the putative platelet activator leptin does not seem to play a major role in acute coronary syndromes.

Topics: Adenosine Diphosphate; Aged; Angina, Unstable; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Humans; Leptin; Male; Myocardial Infarction; P-Selectin; Prolactin

The purpose of the study was to verify whether the currently reported relationship between leptinemia and adipose tissue mass can be applied to cases of acute coronary attack. An increased number of cytokines has been reported in severe acute myocardial infarctions so that correlation between cytokines and leptin was investigated. Correlation between standard coronary markers and leptinemia was also studied. We examined 48 probands, patients of the Coronary Unit, Hospital, Sternberk, who were hospitalized for acute myocardial infarction (AMI--16 probands) or for unstable angina pectoris (UAP--22 probands). The persons with AMI had leptinemia and a higher concentration of interleukine-6 (Il-6) and of cardial troponine-I (cTn-I) than individuals without coronary accident (UAP). Early after the acute coronary lesion, leptinemia in persons with AMI displayed a statistically significant positive correlation with concentration of interleukine-6 and subsequently of markers of coronary lesion severity (cTnI). No correlation between leptinemia and body weight was found in those probands. This study proved that leptinemia in the AMI individuals is influenced directly by concentration of cytokines which leads to leptin superproduction by fat cells and leptin resistance.

Topics: Adipose Tissue; Adult; Aged; Aged, 80 and over; Angina, Unstable; Female; Humans; Interleukin-6; Leptin; Male; Middle Aged; Myocardial Infarction; Proteins; Troponin I