leptin and Acne-Vulgaris

Topics: Acne Vulgaris; Adiponectin; Adolescent; Adult; Age Factors; Biomarkers; Disease Progression; Female; Humans; Leptin; Male; Prognosis; Sensitivity and Specificity; Severity of Illness Index; Sex Factors; Young Adult

Topics: Acne Vulgaris; Animals; Cell Proliferation; Dermatitis, Seborrheic; Humans; Hypoxia; Inflammation; Keratinocytes; Leptin; Mechanistic Target of Rapamycin Complex 1; Mice; Multiprotein Complexes; Sebaceous Glands; TOR Serine-Threonine Kinases

The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting.. The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines.. Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment.. In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin resistance and BMI did not differ after ISO treatment.. ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels.

Topics: Acne Vulgaris; Adiponectin; Administration, Topical; Adolescent; Dermatologic Agents; Female; Humans; Insulin Resistance; Isotretinoin; Leptin; Male; Retinol-Binding Proteins, Plasma; Young Adult

Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-beta (IL-1beta) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with acne, compared to obese females without acne and non-obese subjects, had significantly higher serum triglycerides, low-density lipoprotein cholesterol and apolipoprotein-B (apo-B) (mean +/- SD: 197 +/- 13.7 vs 171 +/- 11.5, 128 +/- 8.3 vs 116 +/- 7.7, 96 +/- 13.7 vs 85 +/- 10.3 mg/dL, respectively) but significantly lower high-density lipoprotein cholesterol and apo-A1 levels (40 +/- 3.3 vs 33 +/- 3.5 and 126 +/- 12 vs 147 +/- 13 mg/dL). Serum testosterone, insulin and leptin levels were significantly higher in obese subjects with or without acne compared to non-obese females with or without acne (3 +/- 0.5 vs 2.1 +/- 0.47, 15.5 +/- 3.3 vs 11.6 +/- 3, 0.9 +/- 0.2 vs 0.6 +/- 0.15 nmol/mL, respectively). Serum IL-1b was significantly elevated in obese and non-obese subjects with acne compared to subjects without acne; in those without acne, these levels were higher in obese than non-obese subjects (2.4 +/- 0.2, 1.4 +/- 0.1 vs 1.8 +/- 0.12 and 1.3 +/- 0.11 pg/mL, respectively). Our results indicate that there is a relationship between obesity (BMI >27) and acne. By early recognition, the etiology and treatment protocol of acne may prevent unwanted conditions.

Topics: Acne Vulgaris; Adolescent; Body Mass Index; Case-Control Studies; Female; Hormones; Humans; Incidence; Insulin; Interleukin-1beta; Leptin; Lipids; Obesity; Saudi Arabia; Severity of Illness Index; Testosterone; Young Adult

Several isolated observations have suggested that acne can develop in groups when a high glycemic index diet is adopted.. This study was designed to examine associations among daily diet glycemic index, glycemic loads, serum insulin levels, and acne.. A total of 49 patients with acne and 42 healthy control subjects were included in the study. At the initial visit, fasting glucose, insulin, insulin-like growth factor-I, insulin-like growth factor binding protein 3, and leptin levels were measured. A voluntary self-completed questionnaire was administered and participants were asked how frequently they consumed the specified amount of food. Overall glycemic index and dietary glycemic load were calculated.. No significant differences were observed between patients with acne and control subjects in serum glucose, insulin, leptin levels, overall glycemic index, or dietary glycemic load.. The information and data obtained from this questionnaire were limited to patients' own recollections.. Results of this study indicate that dietary glycemic index, glycemic load, and insulin levels do not have a role in pathogenesis of acne in younger patients.

Topics: Acne Vulgaris; Adult; Blood Glucose; Diet; Female; Glycemic Index; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Leptin; Male; Surveys and Questionnaires