lenalidomide has been researched along with Myelodysplastic Syndromes in 405 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 94 (23.21) | 29.6817 |
2010's | 256 (63.21) | 24.3611 |
2020's | 55 (13.58) | 2.80 |
Authors | Studies |
---|---|
Boultwood, J; Cattan, H; Christensson, B; Emanuelsson, EK; Forsblom, AM; Hellström-Lindberg, E; Jädersten, M; Merup, M; Nilsson, L; Pellagatti, A; Samuelsson, J; Sander, B; Wainscoat, JS | 1 |
Abedi, M; Hoeg, R; Krishnan, R; Pham, B; Richman, C; Tuscano, J | 1 |
Bourbon, E; Groarke, EM; Heiblig, M; Patel, BA; Sujobert, P | 1 |
Ali, NA; Chan, O; Komrokji, R; Lancet, J; Padron, E; Sallman, D | 1 |
Bernard, E; Cavelier, L; Dybedal, I; Ebeling, F; Ejerblad, E; Flogegård, M; Garelius, H; Göhring, G; Grønbaek, K; Hellström-Lindberg, E; Jädersten, M; Kittang, AO; Lorenz, F; Marcher, CW; Möllgård, L; Nilsson, L; Nørgaard, JM; Öster Fernström, A; Papaemmanuil, E; Rasmussen, B; Saft, L; Tobiasson, M | 1 |
Goede, JS; Wilk, CM | 1 |
Bazinet, A; Bravo, GM | 1 |
Aul, C; Bock, O; Buesche, G; Ebert, BL; Ganser, A; Germing, U; Giagounidis, A; Göhring, G; Kreipe, H; Ribezzo, F; Schlegelberger, B; Schneider, RK; Teoman, H | 1 |
Seymour, JF; Wei, AH | 1 |
Buzoianu, AD; Ciechanover, A; Dima, D; Drula, R; Ghiaur, G; Gulei, D; Iluta, S; Iuga, C; Tomuleasa, C | 1 |
Beach, CL; Fenaux, P; Franco-Villalobos, C; Giagounidis, A; Hu, A; Morison, J; Pelligra, CG; Platzbecker, U; Santini, V; Tang, D | 1 |
Arai, A; Miura, I; Sakai, H | 1 |
Abdelmagid, M; Al-Kali, A; Badar, T; Begna, K; Elliott, MA; Fleti, F; Foran, JM; Gangat, N; Ketterling, RP; Khera, N; Pardanani, A; Reichard, KK; Singh, A; Tefferi, A | 1 |
Bonanni, F; Breccia, M; Buccisano, F; Cicconi, L; Criscuolo, M; Di Veroli, A; Fenu, S; Fianchi, L; Gumenyuk, S; Gurnari, C; Latagliata, R; Maciejewski, JP; Maiorana, G; Maurillo, L; Niscola, P; Piccioni, AL; Piciocchi, A; Piedimonte, M; Salutari, P; Santopietro, M; Sarlo, C; Scalzulli, E; Soddu, S; Tafuri, A; Voso, MT | 1 |
Ichikawa, M | 3 |
Invernizzi, R | 1 |
Berdeja, J; Bhagat, P; Braunschweig, I; Donnellan, WB; Fehn, K; Goldfinger, M; Gonzalez-Lugo, JD; Gritsman, K; Jasra, S; Kambhampati, S; Kazemi, M; Kim, M; Kornblum, N; Mantzaris, I; Pradhan, K; Remy, C; Shah, N; Shastri, A; Sica, RA; Steidl, U; Verma, A; Will, B; Yacoub, A | 1 |
Abe, S; Furukawa, H; Kameoka, J; Kobayashi, M; Kodera, T; Murakami, K; Nomura, J; Oka, Y; Okitsu, Y; Shirota, Y; Takahashi, S; Takeda, T | 1 |
Graafsma, J; Hoogendoorn, M; Kibbelaar, R; Rozema, J; van Roon, E; Veeger, N | 1 |
Garcia-Manero, G; Komrokji, RS; Volpe, VO | 1 |
Gattermann, N; Germing, U; Kobbe, G; Nachtkamp, K | 1 |
Astolfi, A; Boultwood, J; Casalin, I; Cavo, M; Cocco, L; De Stefano, A; Finelli, C; Follo, MY; Indio, V; Manzoli, L; McCubrey, JA; Mongiorgi, S; Paolini, S; Parisi, S; Pellagatti, A; Pession, A; Ratti, S; Suh, PG | 1 |
Sallman, DA; Wang, C | 1 |
Borthakur, G; Siddiqui, M | 1 |
Cadeddu, RP; Christopeit, M; Drusenheimer, N; Esseling, E; Germing, U; Haas, R; Holtick, U; Jäger, P; Klein, S; Kobbe, G; Kröger, N; Mikesch, JH; Rautenberg, C; Scheid, C; Schroeder, T; Stelljes, M; Trenschel, R | 1 |
Garcia-Manero, G | 3 |
Aoki, Y; Minehata, K; Motegi, Y; Uno, S | 1 |
Park, S | 1 |
Al-Harbi, S; Lucero, J; Yee, KWL | 1 |
Furihata, H; Imai, Y; Kosako, H; Miyakawa, T; Nagaoka, K; Nagasaka, T; Nishino, K; Sawasaki, T; Shibata, N; Shoya, Y; Tanokura, M; Taya, A; Usui, M; Yamanaka, S; Yanagihara, Y; Yoshida, S | 1 |
Abou Dalle, I; Bannon, SA; Bhalla, K; DiNardo, CD; Garcia-Manero, G; Hu, S; Kanagal-Shamanna, R; Kantarjian, H; Patel, KP; Routbort, M | 1 |
Ades, L; Fenaux, P; Platzbecker, U | 1 |
Paumgartten, FJR | 1 |
Casadevall, N; Gerds, AT; Kelaidi, C; Meunier, M; Park, S; Platzbecker, U | 1 |
Steensma, DP | 1 |
Patel, BJ; Sekeres, MA | 1 |
A von dem Borne, P; Bargetzi, M; Biemond, BJ; Breems, DA; Chalandon, Y; Cloos, J; de Jongh, E; de Weerdt, O; Deeren, D; Fehr, M; Gjertsen, B; Graux, C; Huls, G; Janssen, JJJW; Jaspers, A; Jongen-Lavrencic, M; Klein, SK; Löwenberg, B; Maertens, J; Manz, M; Michaux, L; Ossenkoppele, GJ; Pabst, T; Stuessi, G; Tick, L; Valk, P; van der Klift, M; van der Poel, MWM; van der Velden, WJFM; van Marwijk Kooy, M; van Norden, Y; van Rhenen, A; Vekemans, MC | 1 |
Almeida, A; Beach, CL; Fenaux, P; Giagounidis, A; Santini, V; Skikne, B; Tu, N; Weaver, J | 1 |
Gore, S; Gorshein, E; Weber, UM | 1 |
Bewersdorf, JP; Zeidan, AM | 1 |
Adema, V; Alvarez, S; Benito, R; Diez-Campelo, M; Fenaux, P; Fontenay, M; Fuster-Tormo, F; Hernandez-Sanchez, JM; Ibañez, M; Kosmider, O; Larrayoz, MJ; Maciejewski, JP; Maietta, P; Neef, A; Palomo, L; Salgado, R; Sole, F; Such, E; Toma, A; Xicoy, B | 1 |
Deng, Y; Docking, TR; Fuller, M; Gharaee, N; Hellström-Lindberg, E; Jädersten, M; Jiang, J; Karsan, A; Kulasekararaj, A; Li, J; List, AF; Malcovati, L; Martinez-Høyer, S; Mo, A; Parker, J; Platzbecker, U; Umlandt, P | 1 |
Menssen, AJ; Walter, MJ | 1 |
Dou, A; Fang, J; Feng, S; Halene, S; Hawkins, C; He, X; Lawley, L; Mizukawa, B; Patel, A; Roman-Rivera, A; Wunderlich, M; Zhang, J | 1 |
Greenberg, P; Hellström-Lindberg, E; Tobiasson, M | 1 |
Simon, JC; Treudler, R; Vucinic, V; Zader, J | 1 |
Almeida, A; Beach, CL; Fenaux, P; Giagounidis, A; Haferlach, T; List, AF; MacBeth, KJ; Mavrommatis, K; Platzbecker, U; Santini, V; Wu, C; Zhong, J | 1 |
Chen, J; Qin, TJ; Qu, SQ; Xiao, ZJ; Xu, ZF | 1 |
Carraway, HE; Saygin, C | 1 |
Avilés, A; Candelaria, M; Fabian-Morales, E; Gutierrez, O; Palacios-Campos, A | 1 |
Altman, JK; Artz, AS; Bennett, JM; Cheema, PS; Claxton, DF; Komrokji, RS; List, AF; Litzow, MR; Luger, SM; Maciejewski, J; Mattison, RJ; McGraw, K; Schiffer, CA; Sun, Z; Tallman, MS; Verma, A; Wassenaar, TR | 1 |
Döhner, K; Gabdoulline, R; Ganser, A; Ganster, C; Germing, U; Göhring, G; Gutermuth, A; Haase, D; Haferlach, C; Haferlach, T; Heuser, M; Kandziora, C; Klement, P; Klesse, S; Kobbe, G; Koenecke, C; Kröger, N; Krönke, J; Kubasch, AS; Meggendorfer, M; Mies, A; Panagiota, V; Platzbecker, U; Schiller, J; Schlegelberger, B; Schroeder, T; Shahswar, R; Shirneshan, K; Sperr, WR; Thiede, C; Thol, F; Valent, P | 1 |
Bewersdorf, JP; Gore, SD; Huntington, SF; Ma, X; Podoltsev, NA; Wang, R; Wang, X; Zeidan, AM; Zhang, C | 1 |
Bug, G; Büsche, G; Fey, S; Germing, U; Giagounidis, A; Götze, KS; Haase, D; Haferlach, T; Hecht, A; Hofmann, WK; Jann, JC; Letsch, A; Lübbert, M; Metzgeroth, G; Meyer, JA; Müller, N; Nolte, F; Nowak, D; Nowak, V; Obländer, J; Reinwald, M; Schafhausen, P; Schlenk, RF; Schuler, E; Sockel, K; Thol, F | 1 |
Belli, CB; Larripa, IB; Lincango Yupanki, M; Metrebian, F; Narbaitz, M; Rahhal, M; Rocca, GS; Sarmiento, M; Zubieta, M | 1 |
Al Ali, N; Basiorka, AA; Fenaux, P; Fontenay, M; Komrokji, R; Kosmider, O; Lancet, JE; List, AF; McGraw, KL; McLemore, AF; Padron, E; Sallman, DA; Wang, C | 1 |
Azevedo, RS; Bassolli, L; Belli, C; Buccheri, V; Castelli, JB; Enrico, A; Ferri, L; Junior, W; Magalhaes, SM; Pereira, T; Perusini, MA; Pinheiro, RF; Rocha, V; Schuster, S; Traina, F; Velloso, E | 1 |
Balleari, E; Bernal, T; Beyne-Rauzy, O; Bordessoule, D; Calabuig, M; Cametti, G; Campelo, MD; Cheze, S; Cony-Makhoul, P; Dreyfus, F; Fenaux, P; Fensterl, J; Ferrero, D; Gaidano, G; Germing, U; Gioia, D; Götze, K; Guerci-Bresler, A; Hamel, JF; Kaivers, J; Kelaidi, C; Komrokji, R; Kotsianidis, I; Müller-Thomas, C; Pane, F; Park, S; Ramos, F; Roboz, GJ; Rose, C; Sanna, A; Santini, V; Sanz, GF; Sapena, R; Sekeres, MA; Stamatoullas, A; Steensma, DP; Thépot, S; Toma, A; Vey, N; Wattel, E | 1 |
Bacher, U; Braulke, F; Brümmendorf, TH; Bug, G; Büsche, G; Ganser, A; Germing, U; Giagounidis, A; Götze, K; Haas, R; Haase, D; Hofmann, WK; Letsch, A; Lübbert, M; Nolte, F; Platzbecker, U; Schafhausen, P; Schanz, J; Schlenk, RF; Schuler, E; Schulz, X; Shirneshan, K; Trümper, L | 1 |
Blijlevens, NMA; Cermak, J; Chiba, K; da Silva-Coelho, P; de Graaf, AO; de Witte, T; Dugas, M; Huls, G; Jansen, JH; Knops, R; Koorenhof-Scheele, TN; Kroeze, LI; Massop, M; Miyano, S; Muus, P; Ogawa, S; Sandmann, S; Shiraishi, Y; Stevens-Kroef, MJ; Tanaka, H; van de Locht, LT; van der Reijden, BA; Yoshida, K | 1 |
Appelbaum, FR; Atallah, E; Attar, EC; Bloomfield, CD; Buckstein, R; Cook, EK; Cull, AH; Erba, HP; Fang, M; Gaur, R; Gore, SD; List, AF; Litzow, MR; Moseley, A; Nazha, A; Odenike, O; Othus, M; Rauh, MJ; Roulston, D; Sekeres, MA; Stone, RM; Velasco, MR; Zhang, Y | 1 |
An, J; Donovan, KA; Fischer, ES; Ponthier, CM; Sack, R; Seebacher, J; Stadler, MB | 1 |
Craddock, C | 1 |
Bug, G; Fabarius, A; Fey, S; Ganser, A; Germing, U; Giagounidis, A; Götze, K; Haase, D; Haferlach, C; Hofmann, WK; Jann, JC; Letsch, A; Lübbert, M; Mossner, M; Nolte, F; Nowak, D; Nowak, V; Obländer, J; Palme, I; Platzbecker, U; Pressler, J; Schlenk, R; Xanthopoulos, C | 1 |
Beyne-Rauzy, O; Deeg, HJ; Del Cañizo, C; Fenaux, P; Giagounidis, A; Greenberg, PL; Guerci-Bresler, A; Hellström-Lindberg, E; List, AF; Mittelman, M; Muus, P; Nimer, SD; Powell, BL; Sekeres, MA; Selleslag, D; Shammo, JM; Skikne, B; Yu, X | 1 |
Miyazaki, Y | 2 |
Chen, N; Connarn, JN; Gao, Y; Hwang, R; Palmisano, M | 1 |
Bwire, R; Castaneda, C; Chan-Liston, M; Freeman, J; Hirsch, D; McWilliams, R; Mezo, M; Minton, N; Phillips, L; Sheehan, P | 1 |
Binder, G; Broder, MS; Chang, E; Cogle, CR; McGuire, M; Papoyan, E; Reddy, SR | 1 |
Cortelezzi, A; Fattizzo, B; Ferla, V; Fracchiolla, NS; Freyrie, A; Iurlo, A; Reda, G | 1 |
List, A; Sallman, D; Talati, C | 1 |
Dodillet, H; Kreuzer, KA; Monsef, I; Skoetz, N | 1 |
Thakral, B; Wang, SA | 1 |
Becht, E; Boeva, V; Cagnard, N; Chapuis, N; Chesnais, V; Chevret, S; Dumont, F; Fenaux, P; Fontenay, M; Fridman, WH; Kerdivel, G; Kosmider, O; Rousseau, A; Toma, A | 1 |
Ades, L; Auberger, P; Basiorka, AA; Cluzeau, T; Fenaux, P; Irvine, B; List, A; Maciejewski, J; Masala, E; McGraw, KL; Santini, V; Wei, S | 1 |
Binder, G; DeZern, AE; McGuire, M; Ni, Q; Smith, BD | 1 |
Giagounidis, A | 2 |
Béné, MC; Cartron, G; Commes-Maerten, T; Delaunay, J; Eveillard, M; Flet, L; Gagez, AL; Godmer, P; Godon, C; Le Bris, Y; Lodé, L; Loirat, M; Luycx, O; Ménard, A; Pellat-Deceunynck, C; Peterlin, P; Richebourg, S; Soussi, T; Theisen, O; Villemagne, B | 1 |
Almeida, A; Beach, CL; Castaneda, C; Fenaux, P; Garcia-Manero, G; Goldberg, SL; Gröpper, S; Jonasova, A; Santini, V; Vey, N; Zhong, J | 1 |
Shallis, RM; Zeidan, AM | 1 |
Almeida, A; Altincatal, A; Beach, CL; Buckstein, R; Fenaux, P; Giagounidis, A; Guo, S; Platzbecker, U; Santini, V; Wu, C | 1 |
Abe, M; Arai, N; Ariizumi, H; Baba, Y; Fujiwara, S; Harada, H; Hattori, N; Kabasawa, N; Kawaguchi, Y; Murai, S; Nakamaki, T; Saito, B; Sasaki, Y; Shimada, S; Tsukamoto, H; Uto, Y; Yanagisawa, K | 1 |
Ebert, BL; Fenaux, P; List, A | 1 |
Arcioni, F; Covezzoli, A; Cundari, S; Di Battista, V; Mecucci, C; Roncadori, A; Tura, S | 1 |
Belickova, M; Cmunt, E; Fuchs, O; Jonasova, A; Michalova, K; Minarik, L; Moudra, A; Neuwirtova, R; Polackova, H; Siskova, M; Stopka, T; Zemanova, Z | 1 |
Abel, GA; Brunner, AM; Cronin, A; Fathi, AT; Graubert, T; Habib, AR; Steensma, DP; Stone, R; Weng, S | 1 |
Kiselev, P; Ma, X; Scott, BL; Steensma, DP; Sugrue, MM; Swern, AS | 1 |
Adams, DN; Carr, SA; Chen, M; Ebert, BL; Fink, EC; Guirguis, AA; Haldar, SD; Kennedy, JA; Liddicoat, B; Mani, DR; McConkey, M; Nguyen, AT; Svinkina, T; Udeshi, ND | 1 |
Finke, CM; Gangat, N; Idossa, D; Ketterling, RP; Lasho, TL; Pardanani, A; Patnaik, MM; Tefferi, A | 1 |
Fenaux, P; Giagounidis, A; Göhring, G; Li, JS; List, AF; Mittelman, M; Schlegelberger, B; Sekeres, MA; Selleslag, D; Sugrue, MM; Swern, AS | 1 |
Al-Kali, A; Alkharabsheh, OA; Alkhateeb, HB; Begna, KH; Elliott, MA; Gangat, N; Hogan, WJ; Litzow, MR; Patnaik, MS; Saadeh, SS; Zblewski, DL | 1 |
Ali, A; Montoro, J; Raza, A; Yerlikaya, A | 1 |
Platzbecker, U; Sockel, K | 1 |
Burgos, S; Fuente, L; Garcia-Manero, G; Jabbour, EJ; Kanagal-Shamanna, R; Mela-Osorio, MJ; Montalban-Bravo, G; Soltysiak, KA | 1 |
Feinberg, B; Klink, AJ; McGuire, M; Zeidan, AM | 1 |
Akyüz, N; Asemissen, AM; Binder, M; Bonzanni, N; Fuchs, P; Germing, U; Hofmann, WK; Jann, JC; Mährle, T; Nolte, F; Nowak, D; Simnica, D | 1 |
Platzbecker, U | 1 |
Almeida, A; Fenaux, P; Garcia-Manero, G; Gattermann, N; Giagounidis, A; Goldberg, SL; Ozawa, K; Santini, V; Weaver, J | 1 |
Armstrong, RN; Bochicchio, MT; Boultwood, J; Cavo, M; Cocco, L; De Fanti, S; Finelli, C; Follo, MY; Gobbi, M; Luiselli, D; Manzoli, L; Martinelli, G; McCubrey, JA; Miglino, M; Mongiorgi, S; Parisi, S; Pellagatti, A; Ratti, S; Russo, D; Suh, PG | 1 |
Al Ali, NH; Cogle, C; Komrokji, RS; Lancet, JE; Lis, AF; Padron, E; Sallman, D; Tinsley, S | 1 |
Chisti, MM; Fennell, T; Sanders, DS | 1 |
Abbasi, T; Abbott, D; Cogle, CR; Drusbosky, L; Fullerton, A; Gutman, JA; Hammes, A; Hemenway, G; Jordan, CT; Miltgen, N; Pollyea, DA; Schatz, D; Singh, NK; Smith, C; Stevens, B; Vali, S; Wei, Q; Winters, A | 1 |
Cho, SH; Choi, CW; Choi, Y; Kim, H; Kim, I; Kim, KH; Kim, SY; Kim, YJ; Lee, HS; Lee, JH; Lee, WS; Moon, JH; Park, J; Shin, HJ | 1 |
Kunacheewa, C; Owattanapanich, W; Thongthang, P; Ungprasert, P; Utchariyaprasit, E | 1 |
Bewersdorf, JP; Stahl, M; Zeidan, AM | 1 |
Adès, L; Alary, AS; Alsafadi, S; Bondu, S; Bouscary, D; Boussaid, I; Bousta, A; Cagnard, N; Cluzeau, T; Droin, N; Fontenay, M; Ganz, T; Guillonneau, F; Gyan, E; Houy, A; Hunault, M; Jung, G; Kaltenbach, S; Karim, Z; Kautz, L; Kosmider, O; Kubasch, AS; Lefebvre, T; Lefèvre, C; Margueron, R; Mayeux, P; Nemeth, E; Park, S; Perrier, P; Platzbecker, U; Puy, H; Rombaut, D; Rousseau, A; Santini, V; Stamatoullas, A; Stern, MH; Toma, A; Wassef, M; Winter, S | 1 |
Gattermann, N; Germing, U; Kaivers, J; Kobbe, G; Kündgen, A; Schroeder, T | 1 |
Alati, C; Alimena, G; Aloe Spiriti, MA; Balleari, E; Breccia, M; Cortelezzi, A; D'Errigo, MG; Finelli, C; Galimberti, S; Laganà, C; Latagliata, R; Morabito, F; Nobile, F; Oliva, EN; Palumbo, G; Poloni, A; Rodà, F; Sanpaolo, G; Specchia, G; Volpe, A | 1 |
Ades, L; Bally, C; Chesnais, V; Dreyfus, F; Fenaux, P; Fontenay, M; Kaltenbach, S; Kosmider, O; Leschi, C; Park, S; Rouquette, A; Santini, V; Sardnal, V; Toma, A | 1 |
Chang, C; He, Q; Li, X; Wu, L; Xu, F; Zhang, Z | 1 |
Matsumura, I; Morita, Y; Tanaka, H | 1 |
Adès, L; Fenaux, P | 3 |
Abdallah, AO; Bailey, C; Barlogie, B; Chauhan, N; Cottler-Fox, M; Crowley, J; Epstein, J; Heuck, CJ; Hoering, A; Johann, D; Muzaffar, J; Petty, N; Rosenthal, A; Sawyer, J; Sexton, R; Singh, Z; Usmani, SZ; van Rhee, F; Waheed, S; Yaccoby, S | 1 |
Alvarez, S; Arenillas, L; Calasanz, MJ; Cervera, J; Cigudosa, JC; Costa, D; Del Rey, M; Diez-Campelo, M; Florensa, L; González-Martínez, T; Hernández, JM; Ibáñez, M; Jerez, A; Larráyoz, MJ; Lumbreras, E; Maciejewski, J; Mallo, M; Marugán, I; Nomdedeu, M; Pedro, C; Solé, F; Such, E | 1 |
Blau, IW; Böhme, A; Braulke, F; Brümmendorf, TH; Bug, G; Detken, S; Ganster, C; Germing, U; Giagounidis, AA; Götze, K; Haase, D; Hofmann, WK; Jentsch-Ullrich, K; Jung, K; Lübbert, M; Metz, M; Müller-Thomas, C; Ottmann, O; Pfeiffer, S; Platzbecker, U; Schafhausen, P; Schanz, J; Schlenk, RF; Schmidt, B; Seraphin, J; Shirneshan, K; Stadler, M; Trümper, L | 1 |
Germing, U; Platzbecker, U | 1 |
Bornhäuser, M; Brocard, B; Ehninger, G; Ferrer, RA; Hofbauer, LC; List, C; Mohr, B; Platzbecker, U; Rauner, M; Schmitz, M; Schönefeldt, C; Stiehler, M; Wehner, R; Wobus, M | 1 |
Amrein, PC; Attar, EC; Ballen, KK; Deangelo, DJ; Fathi, AT; Foster, J; Fraser, JW; McAfee, S; Neuberg, D; Steensma, DP; Stone, RM; Wadleigh, M | 1 |
Scott, LJ; Syed, YY | 1 |
Baer, MR; Davidoff, AJ; Gore, SD; Hendrick, F; Mahmoud, D; McNally, DL; Zeidan, AM | 1 |
Cuzzola, M; Gentile, M; Morabito, F; Morabito, L; Recchia, AG; Vigna, E | 1 |
Fenaux, P; Germing, U; Giagounidis, A; List, A; MacBeth, KJ; Mufti, GJ | 1 |
Al Ali, NH; Basiorka, A; Boultwood, J; Caceres, G; Daugherty, FJ; Fulp, WJ; Johnson, J; Komrokji, RS; Lee, JH; List, AF; Littleton, N; Liu, K; McGraw, K; Pellagatti, A; Smith, LJ; Sokol, L; Wei, S; Wells, RA; Yip, BH; Zhang, L; Zhang, LM | 1 |
Bennett, JM; Fu, T; Giagounidis, A; Knight, RD; List, AF; Nimer, SD; Sekeres, MA; Shammo, JM; Skikne, B | 1 |
Gattermann, N; Germing, U; Haas, R; Kobbe, G | 1 |
Ardanaz, MT; Arrizabalaga, B; Azaceta, G; Bargay, J; Cabrero, M; Calabuig, M; Cedena, T; Cerveró, C; Collado, R; del Cañizo, C; Díez-Campelo, M; García, M; Luño, E; Morell, MJ; Muñoz, JA; Nomdedeu, B; Pedro, C; Rodríguez, MJ; Rojas, SM; Simiele, A; Xicoy, B | 1 |
Kharfan-Dabaja, MA; Komrokji, RS; Zeidan, AM | 1 |
Ishikawa, T | 2 |
Kuendgen, A | 1 |
Tohyama, K | 2 |
Ebert, BL; Komrokji, RS; List, AF; Padron, E | 1 |
Aoyama, Y; Furukawa, Y; Harada, N; Kumura, T; Manabe, M; Mugitani, A; Ohta, T; Okita, J; Tarakuwa, T | 1 |
Besa, EC; Gaballa, MR | 1 |
Bhagat, T; Braunschweig, I; Roth, M; Schinke, C; Steidl, U; Tamari, R; Verma, A; Will, B | 1 |
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Stone, RM | 2 |
Estey, E; Scott, BL | 1 |
Hellström-Lindberg, E; Jädersten, M | 1 |
Hanson, CA; Ketterling, RP; Knudson, RA; Mesa, RA; Schwager, S; Tefferi, A | 1 |
Ehninger, G; Mohr, B; Oelschlaegel, U; Platzbecker, U; Stewart, MM; Thiede, C | 1 |
Brandenburg, NA; Bwire, R; Freeman, J; Knight, RD; Salomon, ML; Yang, X; Zeldis, JB | 1 |
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Aul, C; Büsche, G; Giagounidis, A; Göhring, G; Hellström-Lindberg, E; Kreipe, HH; Schlegelberger, B; Zimmermann, M | 1 |
Aprile, L; Bocchia, M; Chitarrelli, I; Defina, M; Fabbri, A; Gozzetti, A; Lauria, F; Rondoni, M | 1 |
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Chen, W; Fan, L; Li, W; Liu, L; Liu, X; Xiong, B; Zou, P | 1 |
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Sirulnik, LA; Stone, RM | 1 |
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Himmelmann, A; Tchinda, J | 1 |
Chen, DT; Epling-Burnette, PK; Fulp, W; List, AF; McDaniel, JM; Zou, JX | 1 |
Banos, A; Baracco, F; Besson, C; Blanc, M; Cannas, G; Corm, S; Fenaux, P; Perrier, H; Prebet, T; Sibon, D; Slama, B; Vey, N; Wattel, E | 1 |
Akuthota, P; Kelly, E; Roberts, DH; Rosenthal, ES; Theisen-Toupal, J; Zwicker, JI | 1 |
Afable, M; Guinta, K; Jankowska, A; Jerez, A; List, AF; Maciejewski, J; Makishima, H; McGraw, KL; O'Keefe, CL; Sekeres, MA; Sugimoto, Y; Szpurka, H; Tiu, R; Traina, F; Visconte, V | 1 |
Jin, X; Zhang, YZ | 1 |
Akpek, G; Brauer, DL; Edelman, B; Hess, JR; Rapoport, AP | 1 |
Diez-Campelo, M; Giraldo, P; Hernández, MT; López-Corral, L; Matarraz, S; Mateos, MV; Orfao, A; Paiva, B; Pérez, E; San Miguel, JF | 1 |
Billingsley, D; Caceres, G; Chen, X; Clark, J; Djeu, J; Eksioglu, EA; Epling-Burnette, PK; Fortenbery, N; Komrokji, R; Lancet, J; List, A; Maciejewski, JP; McGraw, K; Sallman, D; Sekeres, M; Sokol, L; Wang, H; Wei, S; Zhang, L; Zhou, J | 1 |
Boccia, R; Brown, GL; Galili, N; Garcia-Manero, G; Lyons, RM; Mesa, RA; Mulford, D; Raza, A; Sekeres, MA; Smith, SE; Steensma, DP | 1 |
Alimena, G; Breccia, M; Colafigli, G; Federico, V; Finsinger, P; Latagliata, R; Loglisci, G; Petrucci, L; Salaroli, A; Santopietro, M; Serrao, A | 1 |
Matsuoka, A; Tohyama, K; Tohyama, Y; Tsujioka, T | 1 |
Borthakur, G; Chen, Y; Cortes, J; Estrov, Z; Faderl, S; Kantarjian, H; Ravandi, F; Rey, K | 1 |
Belickova, M; Caniga, M; Cechova, E; Cermak, J; Dostalova Merkerova, M; Jonasova, A; Krejcik, Z; Michalova, K; Neuwirtova, R; Vesela, J; Votavova, H; Zemanova, Z | 1 |
Somani, N | 1 |
Cluzeau, T; Fenaux, P | 1 |
Lentzsch, S; Pan, B | 1 |
Brower, V | 1 |
Buckstein, R; Leitch, HA; Shamy, A; Storring, JM | 1 |
Advani, AS; Afable, M; Cuthbertson, D; Englehaupt, R; Jerez, A; Juersivich, J; Komrokji, R; Lancet, J; List, AF; Maciejewski, JP; Makishima, H; Paleveda, J; Paquette, R; Sekeres, MA; Tabarroki, A; Tiu, RV; Visconte, V | 1 |
Caceres, G; Deeg, HJ; Karsan, A; List, AF; Nevill, TJ; Platzbecker, U; Scott, BL; Sokol, L; Sung, S; Venner, CP; Woltosz, JW | 1 |
Chen, N; Komrokji, RS; Lancet, JE; List, AF; Lush, R; Paleveda, J; Saba, HI; Swern, AS | 1 |
List, AF | 6 |
Abouyahya, I; Alhan, C; Coenen, JL; de Kruijf, EJ; de Wolf, JT; Heyning, FH; Huls, GA; Imholz, AL; Kappers-Klunne, MC; Koedam, J; Koene, HR; Muus, P; Ossenkoppele, GJ; Planken, EV; Segeren, CM; te Boekhorst, PA; van de Loosdrecht, AA; van der Velden, AM; Vasmel, WL; Velders, GA; Veth, G; Westers, TM | 1 |
Alimena, G; Aloe Spiriti, MA; Breccia, M; Cortelezzi, A; Cuzzola, M; Finelli, C; Galimberti, S; Ghio, R; Laganà, C; Latagliata, R; Morabito, F; Nobile, F; Oliva, EN; Palumbo, GA; Poloni, A; Ricco, A; Rigolino, C; Rodà, F; Sanpaolo, G; Volpe, A | 1 |
Espinal-Witter, R; Geyer, JT; Knowles, DM; Mathew, S; Orazi, A; Racchumi, J; Subramaniyam, S; Verma, S; Wang, YL | 1 |
Giagounidis, AA | 1 |
Blaise, D; Charbonnier, A; Gelsi-Boyer, V; Mozziconacci, MJ; Prebet, T; Vey, N | 1 |
Gandhi, S; Hu, K; Larson, RA; Liu, D; Lyons, RM; Matei, C; Scott, B; Wang, ES; Yang, AS | 1 |
Dai, L; Gollin, SM; Lentzsch, S; Mapara, MY; Monaghan, SA; Normolle, DP | 1 |
Rizzieri, DA | 1 |
Backstrom, J; Brandenburg, NA; Fenaux, P; Germing, U; Giagounidis, AA; Glasmacher, A; Hasford, J; Kuendgen, A; Lauseker, M; List, AF | 1 |
Brandenburg, NA; Fenaux, P; Knight, R; Muus, P; Revicki, DA; Yu, R | 1 |
Bornhäuser, M; Braulke, F; Bug, G; Ehninger, G; Germing, U; Giagounidis, A; Götze, K; Haase, D; Hofmann, WK; Kündgen, A; Naumann, R; Neesen, J; Platzbecker, U; Röllig, C; Schönefeldt, C; Shirneshan, K; Wermke, M | 1 |
Aul, C; Boultwood, J; Germing, U; Giagounidis, AA; Wainscoat, JS | 1 |
Cazzola, M; Malcovati, L | 1 |
Buresh, A; Fuchs, D; Heaton, R; Knight, R; Kurtin, S; List, A; Mahadevan, D; Rimsza, L; Roe, DJ; Zeldis, JB | 1 |
Bauters, F; Berthon, C; Facon, T; Guieze, R; Kuhnovsky, F; Leleu, X; Micol, JB; Moreau, AS; Terriou, L; Yakoub-Agha, I | 1 |
Aul, C; Germing, U; Giagounidis, AA; Heinsch, M; Hildebrandt, B; Strupp, C | 1 |
Chng, WJ | 1 |
Ganser, A; Stadler, M | 1 |
Knight, R | 1 |
Teo, SK | 1 |
Bartlett, JB; Stirling, D; Tozer, A; Zeldis, JB | 1 |
Hellström-Lindberg, E | 1 |
Crane, E; List, A | 1 |
Hammond, JM; Maier, SK | 1 |
Nimer, SD | 1 |
Fortenbaugh, C | 1 |
Li, CY; Mesa, RA; Steensma, DP; Tefferi, A | 1 |
Bennett, J; Dewald, G; Feldman, E; Giagounidis, A; Greenberg, P; Knight, R; List, A; Patin, J; Powell, B; Raza, A; Reeder, C; Schmidt, M; Stone, R; Thomas, D; Wride, K; Zeldis, J | 1 |
Kale, V; List, AF | 1 |
Aul, C; Giagounidis, AA; Göhring, G; Haase, S; Heinsch, M; Schlegelberger, B | 1 |
Fenaux, P; Kelaidi, C | 1 |
Le Beau, MM; Olney, HJ | 1 |
Baker, AF; Bellamy, W; Green, S; List, AF | 1 |
Goss, TF; Hellström-Lindberg, E; Jädersten, M; Knight, R; List, AF; Schaefer, C; Szende, A; Totten, PJ | 1 |
Kurtin, S; Sokol, L | 1 |
Kale, V; List, A; Melchert, M | 1 |
Dimopoulos, MA; Kastritis, E | 1 |
Steensma, DP; Tefferi, A | 1 |
Deeg, HJ; Mhyre, AJ | 1 |
Schiffer, CA | 2 |
Baz, R; Kalmadi, S; Mahindra, A | 1 |
List, A; Melchert, M; Williams, C | 1 |
Kurtin, S | 1 |
Shah, SR; Tran, TM | 1 |
Snively, A | 1 |
Oestreicher, P | 1 |
Bennett, JM; Curtin, PT; Deeg, HJ; Dewald, GW; Dreisbach, L; Feldman, EJ; Greenberg, PL; Klimek, VM; Knight, RD; List, AF; Raza, A; Reeves, JA; Schiffer, CA; Schmidt, M; Shammo, JM; Stone, RM; Thomas, D; Wride, K; Zeldis, JB | 1 |
List, A; Ortega, J | 1 |
Sloand, EM | 1 |
Garcia-Manero, G; Jagasia, M; Yang, AS | 1 |
Eclache, V; Fenaux, P; Kelaidi, C | 1 |
Bargou, R; Cosgrove, D; Einsele, H; Knop, S; List, A | 1 |
Da Rocha, A; Eclache, V; Fenaux, P; Le Roux, G | 1 |
Cripe, L; Fenaux, P; Giagounidis, A; Mufti, GJ; Muus, P; Platzbecker, U; Sanz, G; Von Lilienfeld-Toal, M; Wells, RA | 1 |
Bosco, J; Ebert, BL; Galili, N; Golub, TR; Ladd-Acosta, C; Mak, R; Pretz, J; Raza, A; Stone, R; Tamayo, P; Tanguturi, S | 1 |
Ohyashiki, K | 1 |
Mitani, K | 1 |
135 review(s) available for lenalidomide and Myelodysplastic Syndromes
Article | Year |
---|---|
New Approaches to Myelodysplastic Syndrome Treatment.
Topics: Anemia; Antineoplastic Agents; Azacitidine; Humans; Lenalidomide; Myelodysplastic Syndromes; Quality of Life | 2022 |
Exploiting the ubiquitin system in myeloid malignancies. From basic research to drug discovery in MDS and AML.
Topics: Bortezomib; Deubiquitinating Enzymes; Drug Discovery; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Proteasome Endopeptidase Complex; Thalidomide; Ubiquitin | 2022 |
SOHO State of the Art Updates and Next Questions: Treatment of Lower Risk Myelodysplastic Syndromes.
Topics: Anemia; Humans; Lenalidomide; Myelodysplastic Syndromes; Neutropenia; Risk Factors | 2023 |
Myelodysplastic Syndromes: New Methods of Diagnosis, Prognostication, and Treatment
Topics: Erythropoietin; Female; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Quality of Life | 2023 |
Current Therapeutic Landscape in Lower Risk Myelodysplastic Syndromes.
Topics: Anemia; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Quality of Life | 2023 |
Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Topics: Aged; Bone Marrow; Clinical Trials, Phase III as Topic; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Prognosis | 2023 |
[Treatment of lower risk myelodysplastic syndromes].
Topics: Anemia; Hematinics; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk; Thrombocytopenia | 2023 |
Management of Patients with Lower-Risk Myelodysplastic Neoplasms (MDS).
Topics: Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Neoplasms; Prognosis; Risk | 2023 |
How we manage adults with myelodysplastic syndrome.
Topics: Activin Receptors, Type II; Adult; Antilymphocyte Serum; Bridged Bicyclo Compounds, Heterocyclic; Erythrocyte Transfusion; Female; Humans; Immunoglobulin Fc Fragments; Lenalidomide; Male; Mutation; Myelodysplastic Syndromes; Recombinant Fusion Proteins; Sulfonamides | 2020 |
The prognostic value of serum erythropoietin in patients with lower-risk myelodysplastic syndromes: a review of the literature and expert opinion.
Topics: Activin Receptors, Type II; Bone Marrow Cells; Erythropoietin; Female; Ferritins; Hemoglobins; Humans; Immunoglobulin Fc Fragments; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Recombinant Fusion Proteins; Risk Factors | 2020 |
Does early diagnosis and treatment of myelodysplastic syndromes make a difference?
Topics: Allografts; Azacitidine; Decitabine; Early Diagnosis; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk Factors | 2019 |
Lowering the boom on lower-risk myelodysplastic syndromes.
Topics: Activin Receptors, Type II; Aged; Antilymphocyte Serum; Benzoates; Bone Marrow Cells; Female; Hematinics; Humans; Hydrazines; Immunoglobulin Fc Fragments; Lenalidomide; Mutation; Myelodysplastic Syndromes; Pyrazoles; Recombinant Fusion Proteins; Risk Factors; Thrombocytopenia | 2019 |
Higher-risk myelodysplastic syndromes with del(5q): does the del(5q) matter?
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk Factors; Tumor Suppressor Protein p53 | 2020 |
Evolving therapies for lower-risk myelodysplastic syndromes.
Topics: Anemia; Blood Transfusion; Chelation Therapy; Clinical Trials as Topic; Cri-du-Chat Syndrome; Drugs, Investigational; Forecasting; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Iron Overload; Lenalidomide; Molecular Targeted Therapy; Multicenter Studies as Topic; Myelodysplastic Syndromes; Precision Medicine; Prognosis; Risk Assessment; Severity of Illness Index | 2020 |
Genetics of progression from MDS to secondary leukemia.
Topics: Cell Count; Clonal Evolution; Disease Progression; DNA Methylation; DNA Mutational Analysis; Epigenesis, Genetic; Exome Sequencing; Hematopoietic Stem Cells; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Myelopoiesis; Neoplastic Stem Cells; Prognosis; Tumor Burden; Whole Genome Sequencing | 2020 |
Myelodysplastic syndromes: moving towards personalized management.
Topics: Anemia; Erythropoiesis; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | 2020 |
[Lenalidomide for myelodysplastic syndrome with excess blasts with germline DDX41 mutation: a case report and literatures review].
Topics: Blood Cell Count; DEAD-box RNA Helicases; Germ Cells; Germ-Line Mutation; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes | 2020 |
Lenalidomide: Myelodysplastic syndromes with del(5q) and beyond.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2017 |
Thrombopoietin mimetics for patients with myelodysplastic syndromes.
Topics: Adult; Azacitidine; Benzoates; Blood Transfusion; Decitabine; Female; Hemorrhage; Humans; Hydrazines; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Pyrazoles; Quality of Life; Randomized Controlled Trials as Topic; Receptors, Fc; Recombinant Fusion Proteins; Thalidomide; Thrombocytopenia; Thrombopoietin | 2017 |
Current treatment algorithm for the management of lower-risk MDS.
Topics: Algorithms; Allografts; Erythrocyte Transfusion; Erythropoietin; Hematinics; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Stem Cell Transplantation; Thalidomide; Transforming Growth Factor beta | 2017 |
A decade of progress in myelodysplastic syndrome with chromosome 5q deletion.
Topics: Animals; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Management; Disease Progression; Drug Development; Genetic Heterogeneity; Genetic Predisposition to Disease; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Prognosis; Treatment Outcome; Tumor Suppressor Protein p53 | 2018 |
Improving Treatment for Myelodysplastic Syndromes Patients.
Topics: Aging; Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Enzyme Inhibitors; Humans; Lenalidomide; Myelodysplastic Syndromes; Stem Cell Transplantation; Transplantation, Homologous | 2018 |
Current and Future Treatment Options for Myelodysplastic Syndromes: More Than Hypomethylating Agents and Lenalidomide?
Topics: Disease Progression; DNA Methylation; Humans; Immunotherapy; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Transplantation, Homologous | 2018 |
Treatment of MDS.
Topics: Disease Progression; Erythropoiesis; Hematology; Hematopoietic Stem Cell Transplantation; Humans; Intercellular Signaling Peptides and Proteins; Iron Chelating Agents; Lenalidomide; Methylation; Myelodysplastic Syndromes; Prognosis; Risk; Severity of Illness Index; Translational Research, Biomedical; Transplantation, Homologous | 2019 |
A systematic review and meta
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cohort Studies; Female; Hematologic Diseases; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Male; Middle Aged; Myelodysplastic Syndromes; Treatment Outcome | 2019 |
Novel therapies in low- and high-risk myelodysplastic syndrome.
Topics: Activin Receptors, Type II; Anemia; Antineoplastic Agents; Azacitidine; Bridged Bicyclo Compounds, Heterocyclic; Decitabine; Erythrocyte Transfusion; Hematinics; Humans; Immunoglobulin Fc Fragments; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Oligonucleotides; Prognosis; Recombinant Fusion Proteins; Risk Assessment; Stem Cell Transplantation; Sulfonamides; Thalidomide; Thrombopoietin; Transplantation, Homologous | 2019 |
How we treat lower-risk myelodysplastic syndromes.
Topics: Anemia; Angiogenesis Inhibitors; Antineoplastic Agents; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk Factors; Thalidomide | 2013 |
Combination of azacitidine and lenalidomide in myelodysplastic syndromes or acute myeloid leukemia-a wise liaison?
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Trials as Topic; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2013 |
Lenalidomide: a review of its use in patients with transfusion-dependent anaemia due to low- or intermediate-1-risk myelodysplastic syndrome associated with 5q chromosome deletion.
Topics: Anemia; Anemia, Macrocytic; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythrocyte Transfusion; Humans; Lenalidomide; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Thalidomide; Treatment Outcome | 2013 |
Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes.
Topics: Angiogenesis Inhibitors; Apoptosis; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Clone Cells; Disease Progression; Erythropoiesis; Gene Dosage; Genes, Tumor Suppressor; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Myelodysplastic Syndromes; Survival Analysis; Thalidomide; Treatment Outcome; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2014 |
Myelodysplastic syndromes: diagnosis, prognosis, and treatment.
Topics: Blood Transfusion; Combined Modality Therapy; Humans; Immunologic Factors; Incidence; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Risk Factors; Stem Cell Transplantation; Survival Rate; Thalidomide | 2013 |
Beyond hypomethylating agents failure in patients with myelodysplastic syndromes.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; DNA Methylation; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Prognosis; Recurrence; Retreatment; Thalidomide; Transplantation, Homologous; Treatment Failure; Treatment Outcome | 2014 |
Novel therapeutic strategies using hypomethylating agents in the treatment of myelodysplastic syndrome.
Topics: Azacitidine; Benzamides; Decitabine; DNA Methylation; Humans; Imatinib Mesylate; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Piperazines; Pyrimidines; Thalidomide | 2014 |
[Myelodysplastic syndromes: treatment strategy up-to-date].
Topics: Antilymphocyte Serum; Azacitidine; Benzoates; Cyclosporine; Cytarabine; Deferasirox; Disease Progression; Drug Discovery; Drug Therapy, Combination; Erythropoietin; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Idarubicin; Immunosuppressive Agents; Iron Chelating Agents; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Quality of Life; Risk Assessment; Thalidomide; Triazoles | 2014 |
Deletion 5q MDS: molecular and therapeutic implications.
Topics: Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythropoiesis; Haploinsufficiency; Humans; Lenalidomide; Megakaryocytes; MicroRNAs; Myelodysplastic Syndromes; Phenotype; Ribosomal Proteins; Thalidomide; Tumor Suppressor Protein p53 | 2013 |
der(5;17)(p10;q10) is a recurrent but rare whole-arm translocation in patients with hematological neoplasms: a report of three cases.
Topics: Aged; Aged, 80 and over; Anemia, Refractory, with Excess of Blasts; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 5; Contraindications; Fatal Outcome; Female; Hematologic Neoplasms; Humans; Karyotype; Lenalidomide; Leukemia, Myelomonocytic, Chronic; Lymphoma, T-Cell, Peripheral; Male; Megakaryocytes; Myelodysplastic Syndromes; Neoplasms, Second Primary; Recurrence; Remission Induction; Thalidomide; Translocation, Genetic | 2014 |
Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Gene Expression; Haploinsufficiency; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; MicroRNAs; Myelodysplastic Syndromes; Practice Guidelines as Topic; Ribosomal Proteins; Thalidomide; Tumor Suppressor Protein p53 | 2014 |
Lenalidomide.
Topics: Animals; Antineoplastic Agents; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Thalidomide | 2014 |
Update on the pharmacotherapy for myelodysplastic syndromes.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Decitabine; DNA Modification Methylases; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Remission Induction; Risk Assessment; Thalidomide | 2014 |
The myelodysplastic syndromes: the era of understanding.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Azacitidine; Blood Transfusion; Erythropoietin; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Myelodysplastic Syndromes; Neoplasm Proteins; Prognosis; Spliceosomes; Thalidomide; Transplantation, Homologous | 2015 |
[Treatment of MDS].
Topics: Allografts; Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Autografts; Azacitidine; Enzyme Inhibitors; Erythrocyte Transfusion; Erythropoietin; Hematopoietic Stem Cell Transplantation; Histocompatibility; HLA Antigens; Humans; Immunologic Factors; Immunosuppressive Agents; Induction Chemotherapy; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Recombinant Proteins; Thalidomide; Transplantation Conditioning | 2014 |
More is better: combination therapies for myelodysplastic syndromes.
Topics: Antineoplastic Agents; Azacitidine; Benzamides; Clinical Trials as Topic; Decitabine; Disease Progression; Drug Therapy, Combination; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pyrimidines; Thalidomide; Valproic Acid; Vorinostat | 2015 |
Refractory anemia with ring sideroblasts and RARS with thrombocytosis.
Topics: Anemia, Refractory; Anemia, Sideroblastic; Angiogenesis Inhibitors; Aspirin; Female; Humans; Iron Overload; Janus Kinase 2; Lenalidomide; Male; Mutation; Myelodysplastic Syndromes; Phosphoproteins; Platelet Aggregation Inhibitors; Receptors, Thrombopoietin; Ribonucleoprotein, U2 Small Nuclear; Risk Factors; RNA Splicing Factors; Thalidomide; Thrombocytosis | 2015 |
Pushing the envelope-nonmyeloablative and reduced intensity preparative regimens for allogeneic hematopoietic transplantation.
Topics: Allografts; Bortezomib; Chemoradiotherapy; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide; Transplantation Conditioning | 2015 |
New therapeutic approaches in myelodysplastic syndromes: Hypomethylating agents and lenalidomide.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials, Phase III as Topic; Decitabine; Humans; Lenalidomide; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Thalidomide; Translational Research, Biomedical | 2015 |
Where Does Lenalidomide Fit in Non-del(5q) MDS?
Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Deletion; Chromosomes, Human, Pair 5; Combined Modality Therapy; Humans; Immunologic Factors; Iron Chelating Agents; Iron Overload; Lenalidomide; Myelodysplastic Syndromes; Patient Selection; Thalidomide; Treatment Outcome | 2015 |
Myelodysplastic syndromes: 2015 Update on diagnosis, risk-stratification and management.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow; Decitabine; Disease Management; Disease Progression; Hematopoietic Stem Cell Transplantation; Humans; Intercellular Signaling Peptides and Proteins; Karyotype; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Research Design; Thalidomide; Transplantation, Homologous | 2015 |
The novel mechanism of lenalidomide activity.
Topics: Animals; Humans; Ikaros Transcription Factor; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Proteasome Endopeptidase Complex; Proteolysis; Thalidomide; Ubiquitin-Protein Ligases | 2015 |
Short- and long-term benefits of lenalidomide treatment in patients with lower-risk del(5q) myelodysplastic syndromes.
Topics: Angiogenesis Inhibitors; Chromosome Deletion; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk; Thalidomide; Treatment Outcome | 2016 |
Lenalidomide: deciphering mechanisms of action in myeloma, myelodysplastic syndrome and beyond.
Topics: Angiogenesis Inhibitors; Animals; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Substrate Specificity; Thalidomide; Transcription, Genetic; Ubiquitination | 2015 |
The molecular mechanism of thalidomide analogs in hematologic malignancies.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Casein Kinase I; Gene Expression Regulation, Neoplastic; Humans; Ikaros Transcription Factor; Interleukin-2; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Peptide Hydrolases; Protein Binding; Proteolysis; Signal Transduction; Thalidomide; Ubiquitin-Protein Ligases; Ubiquitination | 2016 |
Hypomethylating agent combination strategies in myelodysplastic syndromes: hopes and shortcomings.
Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; DNA Methylation; Histone Deacetylase Inhibitors; Humans; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Protein Kinase Inhibitors; Thalidomide; Treatment Outcome | 2017 |
Efficacy and Safety of Lenalidomide for Treatment of Low-/Intermediate-1-Risk Myelodysplastic Syndromes with or without 5q Deletion: A Systematic Review and Meta-Analysis.
Topics: Anemia, Macrocytic; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2016 |
Treatment of low-risk myelodysplastic syndromes.
Topics: Allografts; Blood Transfusion; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Myelodysplastic Syndromes; Risk Factors; Thalidomide | 2016 |
Treatment options for patients with myelodysplastic syndromes after hypomethylating agent failure.
Topics: Azacitidine; Drug Resistance; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2016 |
5q- syndrome-like features as the first manifestation of myelodysplastic syndrome in a patient with an unbalanced whole-arm translocation der(5;19)(p10;q10).
Topics: Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Translocation, Genetic | 2017 |
Lenalidomide use in myelodysplastic syndromes: Insights into the biologic mechanisms and clinical applications.
Topics: Anemia; Antimetabolites, Antineoplastic; Azacitidine; Chromosomes, Human, Pair 5; Disease Progression; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2017 |
[Novel medical treatment modalities in hematology].
Topics: Aminoglycosides; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzamides; Benzoates; Boronic Acids; Bortezomib; Carbazoles; Carrier Proteins; Cyclophosphamide; Dasatinib; Furans; Gemtuzumab; Hematologic Diseases; Humans; Hydrazines; Imatinib Mesylate; Immunologic Factors; Indoles; Lenalidomide; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Piperazines; Purpura, Thrombocytopenic; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Rituximab; Thalidomide; Thiazoles; Thrombopoietin; Vidarabine | 2008 |
[Pathogenesis of and therapeutic progress for myelodysplastic syndromes].
Topics: Azacitidine; Clinical Trials as Topic; Decitabine; Deoxycytidine; DNA Methylation; Drug Design; Gene Targeting; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Tumor Necrosis Factor-alpha | 2008 |
Treatment of hematologic neoplasms with new immunomodulatory drugs (IMiDs).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Combined Modality Therapy; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Factors; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Salvage Therapy; Thalidomide; Venous Thromboembolism; Young Adult | 2009 |
Van-den Berghe's 5q- syndrome in 2008.
Topics: Antineoplastic Agents; Chromosomes, Human, Pair 5; Cytogenetics; Gene Deletion; Genes, Tumor Suppressor; Humans; Lenalidomide; Myelodysplastic Syndromes; Ribosomal Proteins; Thalidomide | 2009 |
Are new agents really making a difference in MDS?
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2008 |
Management of myelodysplastic syndromes: 2008 update.
Topics: Antilymphocyte Serum; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Clinical Trials as Topic; Decitabine; Disease-Free Survival; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Factors; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Survival Analysis; Thalidomide; Treatment Outcome | 2008 |
Myelodysplastic syndromes: biology and treatment.
Topics: Antineoplastic Agents; Blood Transfusion; Chromosomes, Human, Pair 5; Disease Progression; Erythropoietin; Female; Humans; Immunosuppressive Agents; Iron Chelating Agents; Lenalidomide; Male; Myelodysplastic Syndromes; Recombinant Proteins; Sequence Deletion; Thalidomide; World Health Organization | 2009 |
How I treat patients with myelodysplastic syndromes.
Topics: Acute Disease; Aged; Azacitidine; Chelation Therapy; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Decitabine; Disease Progression; DNA Methylation; Erythropoietin; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cell Transplantation; Humans; Iron Chelating Agents; Lenalidomide; Leukemia, Myeloid; Myelodysplastic Syndromes; Severity of Illness Index; Thalidomide; Transplantation, Homologous | 2009 |
Optimal sequencing of treatments for patients with myelodysplastic syndromes.
Topics: Azacitidine; Decitabine; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Transplantation, Homologous | 2009 |
Novel biospecific agents for the treatment of myelodysplastic syndromes.
Topics: Arsenic Trioxide; Arsenicals; Azacitidine; Decitabine; Etanercept; Farnesyltranstransferase; Humans; Immunoglobulin G; Lenalidomide; Myelodysplastic Syndromes; Oxides; Receptors, Tumor Necrosis Factor; Thalidomide | 2003 |
Lenalidomide--a transforming therapeutic agent in myelodysplastic syndromes.
Topics: Antineoplastic Agents; Chromosome Deletion; Clinical Trials as Topic; Disease Progression; Humans; Immunosuppression Therapy; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Medical Oncology; Myelodysplastic Syndromes; Risk; Thalidomide; Treatment Outcome | 2009 |
The clinical utility of lenalidomide in multiple myeloma and myelodysplastic syndromes.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Costs; Drug Interactions; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2010 |
[Novel therapeutic agents for myelodysplastic syndrome].
Topics: Antineoplastic Agents; Azacitidine; Clinical Trials as Topic; Decitabine; Drug Discovery; Drug Therapy, Combination; Erythropoietin; Humans; Lenalidomide; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Remission Induction; Thalidomide | 2009 |
Treatment of MDS: something old, something new, something borrowed...
Topics: Azacitidine; Benzoates; Blood Transfusion; Bone Marrow Diseases; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Combined Modality Therapy; Decitabine; DNA-Cytosine Methylases; Glutathione; Hematinics; Humans; Hydrazines; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Pyrazoles; Randomized Controlled Trials as Topic; Receptors, Fc; Recombinant Fusion Proteins; Risk; Thalidomide; Thrombopoietin | 2009 |
Lenalidomide-induced acute liver failure.
Topics: Adenine; Aged, 80 and over; Antineoplastic Agents; Antiviral Agents; Hepatitis B, Chronic; Humans; Lenalidomide; Liver Failure, Acute; Male; Myelodysplastic Syndromes; Organophosphonates; Thalidomide | 2009 |
Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.
Topics: Antineoplastic Agents; Benzoates; Enzyme Inhibitors; Humans; Hydrazines; Lenalidomide; Methyltransferases; Myelodysplastic Syndromes; Pyrazoles; Quality of Life; Thalidomide; Treatment Outcome | 2010 |
Lenalidomide for treatment of myelodysplastic syndromes: current status and future directions.
Topics: Aged; Anemia; Animals; Apoptosis; Blood Transfusion; Bone Marrow; cdc25 Phosphatases; Cell Nucleus; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Clone Cells; Combined Modality Therapy; Erythropoiesis; Forecasting; G2 Phase; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Rats; Receptors, Erythropoietin; Thalidomide | 2010 |
Lenalidomide (Revlimid, CC-5013) in myelodysplastic syndromes: Is it any good?
Topics: Blood Transfusion; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Immunologic Factors; Lenalidomide; Multicenter Studies as Topic; Myelodysplastic Syndromes; Survival Analysis; Thalidomide; Treatment Outcome | 2006 |
Lenalidomide in myelodysplastic syndromes: an erythropoiesis-stimulating agent or more?
Topics: Anemia; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Clone Cells; Combined Modality Therapy; Disease Progression; Erythropoiesis; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Risk; Survival Analysis; Thalidomide | 2010 |
Pharmacotherapy of myelodysplastic syndromes.
Topics: Azacitidine; Decitabine; DNA Methylation; Drug Approval; Erythropoietin; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Recombinant Proteins; Thalidomide; United States; United States Food and Drug Administration | 2010 |
The lower risk MDS patient at risk of rapid progression.
Topics: Age Factors; alpha Catenin; Antigens, Differentiation; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Caspase 3; Chromosome Aberrations; Cyclin-Dependent Kinase Inhibitor p15; Cytokines; DNA Methylation; Erythrocyte Transfusion; Female; Ferritins; Fibrosis; Gene Expression Regulation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Inhibitor of Apoptosis Proteins; Lenalidomide; Leukocyte Count; Lipoproteins, LDL; Lymphoid Enhancer-Binding Factor 1; Male; Microtubule-Associated Proteins; Mutation; Myelodysplastic Syndromes; Platelet Count; Prognosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptor Protein-Tyrosine Kinases; Risk Factors; Sex Factors; Survivin; Thalidomide | 2010 |
Current and future management options for myelodysplastic syndromes.
Topics: Adenine Nucleotides; Anemia; Arabinonucleosides; Benzamides; Bone Marrow; Clofarabine; DNA Methylation; Drugs, Investigational; Farnesyltranstransferase; Histone Deacetylase Inhibitors; Humans; Imatinib Mesylate; Immunosuppressive Agents; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Piperazines; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Risk Factors; Thalidomide; Thrombopoietin | 2010 |
[Current treatment options for myelodysplastic syndromes].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Azacitidine; Blood Transfusion; Bone Marrow Transplantation; Chelation Therapy; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Iron Overload; Lenalidomide; Leukemia, Myeloid, Acute; Long-Term Care; Male; Middle Aged; Myelodysplastic Syndromes; Palliative Care; Thalidomide | 2010 |
Lenalidomide: a synthetic compound with an evolving role in cancer management.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Hematologic Diseases; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Thalidomide; Treatment Outcome | 2010 |
Pleiotropic mechanisms of action of lenalidomide efficacy in del(5q) myelodysplastic syndromes.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythropoiesis; Genes; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2010 |
Hypomethylating agents and other novel strategies in myelodysplastic syndromes.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Epoetin Alfa; Erythropoietin; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Recombinant Proteins; Thalidomide; Transplantation, Homologous | 2011 |
Treatment of myelodysplastic syndromes in elderly patients.
Topics: Aged; Anemia, Macrocytic; Antineoplastic Agents; Azacitidine; Blood Component Transfusion; Case Management; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Contraindications; Hematinics; Hematopoietic Stem Cell Transplantation; Histocompatibility; Humans; Immunomodulation; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Palliative Care; Quality of Life; Risk Assessment; Survival Rate; Thalidomide | 2011 |
Management of lower-risk myelodysplastic syndromes: the art and evidence.
Topics: Aged; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythrocyte Transfusion; Female; Humans; Immunosuppressive Agents; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Risk Factors; Thalidomide | 2011 |
[Molecular mechanisms of lenalidomide for the treatment of myelodysplastic syndromes].
Topics: Anemia, Macrocytic; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Genes, p53; Haploidy; Humans; Lenalidomide; MicroRNAs; Molecular Targeted Therapy; Myelodysplastic Syndromes; Ribosomal Proteins; Thalidomide | 2011 |
[IMiDs in hematology].
Topics: Chronic Disease; Hematologic Neoplasms; Humans; Immunologic Factors; Lenalidomide; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Primary Myelofibrosis; Thalidomide; Waldenstrom Macroglobulinemia | 2011 |
Cytogenetic and molecular abnormalities in myelodysplastic syndrome.
Topics: Animals; Antineoplastic Agents; Azacitidine; Chromosome Aberrations; Humans; Lenalidomide; Mutation; Myelodysplastic Syndromes; Thalidomide | 2011 |
Role of lenalidomide in the treatment of myelodysplastic syndromes.
Topics: Anemia, Macrocytic; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Molecular Targeted Therapy; Myelodysplastic Syndromes; Neutropenia; Thalidomide; Thrombocytopenia | 2011 |
Treatment of higher-risk myelodysplastic syndrome.
Topics: Algorithms; Antineoplastic Agents; Azacitidine; Combined Modality Therapy; Decitabine; DNA Methylation; Drug Therapy, Combination; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lenalidomide; Myelodysplastic Syndromes; Patient Selection; Stem Cell Transplantation; Thalidomide | 2011 |
A critical review of the molecular pathophysiology of lenalidomide sensitivity in 5q - myelodysplastic syndromes.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Haploinsufficiency; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2012 |
[Novel therapeutics for myelodysplastic syndromes].
Topics: Azacitidine; Decitabine; DNA Methylation; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2011 |
Antiangiogenesis in myelodysplastic syndrome.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Arsenic Trioxide; Arsenicals; Bevacizumab; Enzyme Inhibitors; Farnesyltranstransferase; Humans; Lenalidomide; Myelodysplastic Syndromes; Neovascularization, Pathologic; Oxides; Receptors, Vascular Endothelial Growth Factor; Thalidomide | 2011 |
The clinical safety of lenalidomide in multiple myeloma and myelodysplastic syndromes.
Topics: Administration, Oral; Antineoplastic Agents; Disease Progression; Dose-Response Relationship, Drug; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Product Surveillance, Postmarketing; Renal Insufficiency; Thalidomide; Time Factors | 2012 |
Immunomodulating drugs in myelodysplastic syndromes.
Topics: Chromosome Deletion; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Risk Factors; Thalidomide | 2011 |
[MDS].
Topics: Azacitidine; Benzoates; Clinical Trials as Topic; Cytokines; Deferasirox; Drug Therapy, Combination; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Thrombopoietin; Treatment Outcome; Triazoles | 2012 |
[Lenalidomide in hematological malignancies---review].
Topics: Angiogenesis Inhibitors; Hematologic Neoplasms; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2012 |
Lenalidomide for treatment of myelodysplastic syndromes.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Erythrocyte Transfusion; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2012 |
Approach to new therapeutics: investigation by the use of MDS-derived cell lines.
Topics: Animals; Cell Line; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Profiling; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide | 2012 |
Myelodysplastic syndromes: a challenging disease for patients and physicians.
Topics: Antineoplastic Agents; Blood Transfusion; Cytogenetics; Hematinics; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Stem Cell Transplantation; Thalidomide | 2012 |
[New tools and treatments in myelodysplastic syndromes].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Blood Transfusion; Cytogenetics; Decitabine; Flow Cytometry; Gene Expression Profiling; Humans; Immunologic Factors; Lenalidomide; Mutation; Myelodysplastic Syndromes; Prognosis; Thalidomide | 2013 |
The application and biology of immunomodulatory drugs (IMiDs) in cancer.
Topics: Humans; Immunologic Factors; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Second Primary; Thalidomide | 2012 |
The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes: a clinical practice guideline.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Immunologic Factors; Karyotype; Lenalidomide; Myelodysplastic Syndromes; Practice Guidelines as Topic; Thalidomide | 2013 |
New therapeutics for myelodysplastic syndromes.
Topics: Antineoplastic Agents; Azacitidine; Bone Marrow; Chromosomes, Human, Pair 5; Glycine; Humans; Hydroxamic Acids; Lenalidomide; Myelodysplastic Syndromes; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Sequence Deletion; Sulfones; Thalidomide; Transforming Growth Factor beta; Tumor Microenvironment | 2012 |
Lenalidomide for del(5q) and non-del(5q) myelodysplastic syndromes.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2012 |
Novel therapeutic strategies: hypomethylating agents and beyond.
Topics: Aged; Aged, 80 and over; Algorithms; Cell Transformation, Neoplastic; Comorbidity; Cytogenetics; DNA Methylation; Erythropoiesis; Hematology; Humans; Immunosuppressive Agents; Karyotyping; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Predictive Value of Tests; Prognosis; Remission Induction; Thalidomide; Treatment Outcome | 2012 |
[Thalidomide: mechanisms of action and new insights in hematology].
Topics: Amyloidosis; Angiogenesis Inhibitors; Clinical Trials as Topic; Cytokines; Follow-Up Studies; Forecasting; Hematologic Diseases; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Primary Myelofibrosis; Recurrence; Thalidomide; Time Factors; Waldenstrom Macroglobulinemia | 2005 |
Lenalidomide (Revlimid, CC-5013) in myelodysplastic syndromes: is it any good?
Topics: Aged; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Cytokines; Female; Hematologic Diseases; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Multicenter Studies as Topic; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2005 |
Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS).
Topics: Chromosome Aberrations; Erythroid Cells; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2005 |
IMiDs: a novel class of immunomodulators.
Topics: Angiogenesis Inhibitors; Clinical Trials, Phase I as Topic; Humans; Immunologic Factors; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2005 |
Properties of thalidomide and its analogues: implications for anticancer therapy.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Cell Adhesion Molecules; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cytokines; Drug Screening Assays, Antitumor; Endothelium, Vascular; Humans; Immunologic Factors; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Lenalidomide; Lymphocyte Activation; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; T-Lymphocyte Subsets; Thalidomide | 2005 |
Recent clinical studies of the immunomodulatory drug (IMiD) lenalidomide.
Topics: Clinical Trials as Topic; Humans; Immunologic Factors; Immunosuppressive Agents; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2005 |
Immunomodulatory drugs.
Topics: Humans; Immunosuppressive Agents; Interleukin-12; Lenalidomide; Lymphoma, B-Cell, Marginal Zone; Multiple Myeloma; Myelodysplastic Syndromes; Neovascularization, Pathologic; T-Lymphocytes; Thalidomide | 2005 |
Role of lenalidomide in the treatment of multiple myeloma and myelodysplastic syndrome.
Topics: Animals; Clinical Trials as Topic; Humans; Immunologic Factors; Lenalidomide; MEDLINE; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2006 |
Clinical management of myelodysplastic syndromes with interstitial deletion of chromosome 5q.
Topics: Anemia, Hypochromic; Azacitidine; Bone Marrow; Chromosome Aberrations; Chromosomes, Human, Pair 5; Erythrocyte Transfusion; Erythropoiesis; Erythropoietin; Gene Deletion; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Recombinant Proteins; Thalidomide | 2006 |
Immunomodulatory drugs in myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Animals; Apoptosis; Blood Transfusion; Cell Lineage; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Cytokines; Drug Evaluation, Preclinical; Drugs, Investigational; Erythrocyte Transfusion; Erythropoiesis; Female; Hematopoietic Stem Cells; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; NF-kappa B; Pilot Projects; Thalidomide; Thrombocytopenia; Tumor Necrosis Factor-alpha | 2006 |
MDS: navigating the complex course.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Bone Marrow Transplantation; Combined Modality Therapy; Humans; Immunosuppressive Agents; Lenalidomide; Medical History Taking; Myelodysplastic Syndromes; Neoplasm Staging; Nurse's Role; Nursing Assessment; Oncology Nursing; Physical Examination; Thalidomide | 2006 |
Immunomodulatory drugs (IMiDs): a new treatment option for myelodysplastic syndromes.
Topics: Drug Delivery Systems; Drug Design; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2006 |
Treatment of the 5q- syndrome.
Topics: Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2006 |
Evaluation of recurring cytogenetic abnormalities in the treatment of myelodysplastic syndromes.
Topics: Chromosome Aberrations; Chromosomes, Human, Pair 5; Humans; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Thalidomide | 2007 |
Lenalidomide: targeted anemia therapy for myelodysplastic syndromes.
Topics: Anemia; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Delivery Systems; Erythropoiesis; Erythropoietin; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Recombinant Proteins; Thalidomide; Treatment Outcome | 2006 |
Evolving applications of lenalidomide in the management of anemia in myelodysplastic syndromes.
Topics: Algorithms; Anemia; Antineoplastic Agents; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Delivery Systems; Humans; Lenalidomide; Medical Oncology; Myelodysplastic Syndromes; Practice Guidelines as Topic; Risk Factors; Thalidomide | 2006 |
The role of lenalidomide in the treatment of patients with chromosome 5q deletion and other myelodysplastic syndromes.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2007 |
The evolving role of lenalidomide in the treatment of hematologic malignancies.
Topics: Amyloidosis; Antineoplastic Agents; Hematologic Neoplasms; Humans; Lenalidomide; Leukemia; Myelodysplastic Syndromes; Thalidomide | 2007 |
Risk-based management of myelodysplastic syndrome.
Topics: Anemia, Sideroblastic; Antilymphocyte Serum; Azacitidine; Benzoates; Decitabine; Deferasirox; DNA Modification Methylases; Enzyme Inhibitors; Erythropoietin; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Histone Deacetylase Inhibitors; Humans; Immunosuppressive Agents; Interleukin-11; Iron Chelating Agents; Lenalidomide; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Prognosis; Risk; Stem Cell Transplantation; Thalidomide; Triazoles | 2007 |
Control of hematopoiesis and apoptosis in MDS: more than FLIPing the coin.
Topics: Antigens, Differentiation; Antineoplastic Agents; Apoptosis; Azacitidine; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Differentiation; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lenalidomide; Monocytes; Myelodysplastic Syndromes; Signal Transduction; Stromal Cells; T-Lymphocytes; Thalidomide | 2007 |
Myelodysplasia: the good, the fair and the ugly.
Topics: Antilymphocyte Serum; Antineoplastic Agents; Azacitidine; Bone Marrow Transplantation; Clinical Trials as Topic; Decitabine; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2007 |
Lenalidomide: the emerging role of a novel targeted agent in malignancies.
Topics: Antineoplastic Agents; Clinical Trials, Phase II as Topic; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Thalidomide | 2007 |
Lenalidomide in myelodysplastic syndrome and multiple myeloma.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dexamethasone; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2007 |
Immunomodulatory drugs in the treatment of myelodysplastic syndromes.
Topics: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Humans; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2007 |
Evaluating new treatment options for MDS.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials as Topic; Decitabine; Epigenesis, Genetic; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Survival Analysis; Thalidomide | 2007 |
The role of lenalidomide in the management of myelodysplasia with del 5q.
Topics: Anemia, Refractory; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetics; Humans; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Thalidomide; Treatment Outcome | 2008 |
Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes.
Topics: Antineoplastic Agents; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Humans; Lenalidomide; Myelodysplastic Syndromes; Practice Guidelines as Topic; Thalidomide | 2008 |
[Development trend in new therapeutic approaches for anemia].
Topics: Anemia; Benzoates; Clinical Trials as Topic; Darbepoetin alfa; Deferasirox; Erythropoietin; Hematinics; Humans; Iron Chelating Agents; Iron Overload; Lenalidomide; Myelodysplastic Syndromes; Neoplasms; Thalidomide; Triazoles | 2008 |
[Myelodysplastic syndrome].
Topics: alpha Catenin; Antineoplastic Agents; Azacitidine; Cholecalciferol; Cyclosporine; Decitabine; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Thalidomide; Vitamin K 2; World Health Organization | 2008 |
55 trial(s) available for lenalidomide and Myelodysplastic Syndromes
Article | Year |
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Safety and tolerability of lenalidomide maintenance in post-transplant acute myeloid leukemia and high-risk myelodysplastic syndrome.
Topics: Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Transplantation, Homologous | 2021 |
"Randomized phase II study of azacitidine ± lenalidomide in higher-risk myelodysplastic syndromes and acute myeloid leukemia with a karyotype including Del(5q)".
Topics: Azacitidine; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Karyotype; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | 2022 |
Lenalidomide and Eltrombopag for Treatment of Low- or Intermediate-Risk Myelodysplastic Syndrome: Result of a Phase II Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Hemorrhage; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Thrombocytopenia; Treatment Outcome | 2023 |
Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Follow-Up Studies; Humans; Induction Chemotherapy; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Prognosis; Remission Induction; Survival Rate | 2020 |
Lenalidomide-Epoetin Alfa Versus Lenalidomide Monotherapy in Myelodysplastic Syndromes Refractory to Recombinant Erythropoietin.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Epoetin Alfa; Female; Follow-Up Studies; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Prognosis; Recombinant Proteins; Survival Rate | 2021 |
Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; DNA Methylation; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Treatment Outcome | 2021 |
Peripheral blood cytogenetics allows treatment monitoring and early identification of treatment failure to lenalidomide in MDS patients: results of the LE-MON-5 trial.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antigens, CD34; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease-Free Survival; Female; Germany; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Leukemia, Myeloid; Leukocytes, Mononuclear; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Thalidomide; Treatment Failure | 2017 |
Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Humans; Hydroxamic Acids; Lenalidomide; Leukemia, Myelomonocytic, Chronic; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Vorinostat | 2017 |
Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q).
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Chromosomes, Human, Pair 5; Cytogenetics; Disease Progression; Erythrocyte Transfusion; Female; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Risk Factors; Thalidomide; Treatment Outcome | 2017 |
Safety profile of lenalidomide in patients with lower-risk myelodysplastic syndromes without del(5q): results of a phase 3 trial.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Diarrhea; Exanthema; Fatigue; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Risk Factors; Spasm | 2018 |
The Effect of Lenalidomide on Health-Related Quality of Life in Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes: Results From the MDS-005 Study.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Double-Blind Method; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Outcome Assessment, Health Care; Quality of Life; Risk Factors; Surveys and Questionnaires | 2018 |
Lenalidomide treatment of myelodysplastic syndromes with chromosome 5q deletion: Results from the National Registry of the Italian Drug Agency.
Topics: Aged; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Immunologic Factors; Italy; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prospective Studies; Registries; Remission Induction; Retrospective Studies; Thalidomide | 2018 |
Frequency of venous thrombotic events in patients with myelodysplastic syndrome and 5q deletion syndrome during lenalidomide therapy.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Incidence; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Risk Factors; Venous Thrombosis | 2019 |
Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide.
Topics: Aged; Antigens, Neoplasm; Antineoplastic Agents; Bone Marrow; Case-Control Studies; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Follow-Up Studies; High-Throughput Nucleotide Sequencing; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; T-Lymphocyte Subsets; Tumor Microenvironment | 2019 |
Clinical Benefit-Risk Profile of Lenalidomide in Patients With Lower-risk Myelodysplastic Syndromes Without del(5q): Results of a Phase III Trial.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Erythrocyte Transfusion; Female; Hematinics; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Risk Assessment; Treatment Outcome | 2019 |
Lenalidomide and Prednisone in Low and Intermediate-1 IPSS Risk, Non-Del(5q) Patients With Myelodysplastic Syndromes: Phase 2 Clinical Trial.
Topics: Administration, Oral; Aged; Anemia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Hematinics; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Prednisone; Treatment Outcome | 2019 |
Sequential azacitidine and lenalidomide for patients with relapsed and refractory acute myeloid leukemia: Clinical results and predictive modeling using computational analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Computational Biology; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Predictive Value of Tests; Retrospective Studies; Salvage Therapy; Survival Rate; Young Adult | 2019 |
A variant erythroferrone disrupts iron homeostasis in
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Blood Transfusion; Cell Line; Cell Lineage; Cell Survival; Clone Cells; Erythroid Cells; Hepcidins; Homeostasis; Humans; Iron; Lenalidomide; Mice; Mutation; Myelodysplastic Syndromes; Peptide Hormones; Phosphoproteins; Protein Biosynthesis; RNA Splice Sites; RNA Splicing Factors; RNA, Messenger; Up-Regulation | 2019 |
Lenalidomide in International Prognostic Scoring System Low and Intermediate-1 risk myelodysplastic syndromes with del(5q): an Italian phase II trial of health-related quality of life, safety and efficacy.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Quality of Life; Thalidomide; Treatment Outcome | 2013 |
Low RPS14 expression in MDS without 5q - aberration confers higher apoptosis rate of nucleated erythrocytes and predicts prolonged survival and possible response to lenalidomide in lower risk non-5q- patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Apoptosis; Bone Marrow Cells; Chromosome Aberrations; Chromosomes, Human, Pair 5; Disease-Free Survival; Erythroblasts; Female; Gene Expression Regulation; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Ribosomal Proteins; Survival Rate; Thalidomide | 2013 |
Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chromosome Aberrations; Chromosome Banding; Female; Follow-Up Studies; Germany; Humans; In Situ Hybridization, Fluorescence; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prospective Studies; Thalidomide; Time Factors; Treatment Outcome | 2013 |
Phase I dose escalation study of bortezomib in combination with lenalidomide in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Female; Follow-Up Studies; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Prognosis; Pyrazines; Remission Induction; Survival Rate; Thalidomide | 2013 |
Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Disease Progression; Drug Administration Schedule; Erythrocyte Transfusion; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Risk; Survival Analysis; Thalidomide; Treatment Outcome | 2014 |
Lenalidomide and metronomic melphalan for CMML and higher risk MDS: a phase 2 clinical study with biomarkers of angiogenesis.
Topics: Aged; Aged, 80 and over; Biomarkers; Endothelial Cells; Humans; Lenalidomide; Leukemia, Myelomonocytic, Chronic; Melphalan; Middle Aged; Myelodysplastic Syndromes; Neovascularization, Pathologic; Prospective Studies; Thalidomide; Vascular Endothelial Growth Factor A | 2014 |
Lenalidomide treatment induced the normalization of marker protein levels in blood plasma of patients with 5q-myelodysplastic syndrome.
Topics: Adult; Aged; Anemia, Macrocytic; Biomarkers; Blood Proteins; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Myelodysplastic Syndromes; Reproducibility of Results; Sensitivity and Specificity; Thalidomide; Treatment Outcome | 2015 |
Sequential azacitidine plus lenalidomide in previously treated elderly patients with acute myeloid leukemia and higher risk myelodysplastic syndrome.
Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; BH3 Interacting Domain Death Agonist Protein; Biomarkers; Bone Marrow; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Retreatment; Thalidomide; Treatment Outcome | 2016 |
Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion.
Topics: Aged; Anemia; Angiogenesis Inhibitors; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Therapy, Combination; Erythropoietin; Female; Follow-Up Studies; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasm Staging; Prognosis; Prospective Studies; Risk Factors; Thalidomide | 2016 |
Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion.
Topics: Aged; Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Chromosome Deletion; Chromosomes, Human, Pair 5; Clonal Evolution; Clone Cells; DNA Mutational Analysis; Erythropoietin; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Recombinant Proteins; Thalidomide; Treatment Outcome | 2016 |
Results of a multicenter prospective phase II trial investigating the safety and efficacy of lenalidomide in patients with myelodysplastic syndromes with isolated del(5q) (LE-MON 5).
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Immunologic Factors; Kaplan-Meier Estimate; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Proportional Hazards Models; Prospective Studies; Thalidomide; Treatment Outcome | 2016 |
Prevalence, clonal dynamics and clinical impact of TP53 mutations in patients with myelodysplastic syndrome with isolated deletion (5q) treated with lenalidomide: results from a prospective multicenter study of the german MDS study group (GMDS).
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Prevalence; Prospective Studies; Thalidomide; Tumor Suppressor Protein p53 | 2016 |
Randomized Phase III Study of Lenalidomide Versus Placebo in RBC Transfusion-Dependent Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes and Ineligible for or Refractory to Erythropoiesis-Stimulating Agents.
Topics: Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Double-Blind Method; Drug Resistance; Erythrocyte Transfusion; Erythropoiesis; Female; Gene Expression; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Quality of Life; Thalidomide | 2016 |
Azacitidine-lenalidomide (ViLen) combination yields a high response rate in higher risk myelodysplastic syndromes (MDS)-ViLen-01 protocol.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antimetabolites; Azacitidine; Bone Marrow; Disease-Free Survival; DNA Methylation; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prospective Studies; Quality of Life; Risk; Thalidomide; Treatment Outcome | 2016 |
A phase 2 trial of high dose lenalidomide in patients with relapsed/refractory higher-risk myelodysplastic syndromes and acute myeloid leukaemia with trilineage dysplasia.
Topics: Aged; Aged, 80 and over; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Salvage Therapy; Survival Rate; Thalidomide; Treatment Failure; Treatment Outcome | 2017 |
Efficacy and safety of lenalidomide in intermediate-2 or high-risk myelodysplastic syndromes with 5q deletion: results of a phase 2 study.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Risk Factors; Survival Rate; Thalidomide; Treatment Outcome | 2009 |
Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Erythrocyte Transfusion; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Thalidomide; Thrombocytopenia | 2008 |
Lenalidomide is active in Japanese patients with symptomatic anemia in low- or intermediate-1 risk myelodysplastic syndromes with a deletion 5q abnormality.
Topics: Aged; Aged, 80 and over; Anemia; Antineoplastic Agents; Asian People; Chromosome Deletion; Chromosomes, Human, Pair 5; Chronic Disease; Female; Humans; Japan; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Risk Factors; Thalidomide; Treatment Outcome | 2009 |
Lenalidomide on alternative days is effective in myelodysplastic syndrome with 5q- deletion.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Administration Schedule; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2010 |
Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes.
Topics: Aged; Azacitidine; Chromosome Aberrations; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Karyotyping; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Precancerous Conditions; Risk Assessment; Thalidomide; Time Factors; Treatment Outcome; United States | 2010 |
Changes in RPS14 expression levels during lenalidomide treatment in Low- and Intermediate-1-risk myelodysplastic syndromes with chromosome 5q deletion.
Topics: Aged; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Female; Gene Expression Regulation, Neoplastic; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Ribosomal Proteins; Risk Factors; Thalidomide; Transcription, Genetic | 2010 |
Safety, pharmacokinetics, and immunomodulatory effects of lenalidomide in children and adolescents with relapsed/refractory solid tumors or myelodysplastic syndrome: a Children's Oncology Group Phase I Consortium report.
Topics: Adolescent; Antineoplastic Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Immunity, Cellular; Infant; Lenalidomide; Maximum Tolerated Dose; Myelodysplastic Syndromes; Neoplasms; Recurrence; Salvage Therapy; Thalidomide; Young Adult | 2011 |
Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Base Sequence; Biomarkers, Tumor; Chromosome Aberrations; Chromosomes, Human, Pair 5; Female; Gene Expression Regulation, Leukemic; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Oncogene Protein p21(ras); Thalidomide; Treatment Outcome; Tumor Suppressor Protein p53; WT1 Proteins | 2011 |
A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with del5q.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Double-Blind Method; Erythrocyte Transfusion; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Survival Analysis; Thalidomide | 2011 |
Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Administration Schedule; Drug Therapy, Combination; Female; Hematinics; Humans; Karyotype; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Recurrence; Thalidomide; Treatment Failure; Treatment Outcome | 2012 |
Phase 1 dose-ranging study of ezatiostat hydrochloride in combination with lenalidomide in patients with non-deletion (5q) low to intermediate-1 risk myelodysplastic syndrome (MDS).
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Therapy, Combination; Female; Glutathione; Glutathione Transferase; Humans; Lenalidomide; Male; Maximum Tolerated Dose; Middle Aged; Myelodysplastic Syndromes; Prognosis; Thalidomide | 2012 |
A phase II study of lenalidomide alone in relapsed/refractory acute myeloid leukemia or high-risk myelodysplastic syndromes with chromosome 5 abnormalities.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Recurrence; Risk Factors; Thalidomide; Treatment Outcome | 2012 |
Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cohort Studies; DNA Mutational Analysis; Female; Humans; Karyotyping; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2012 |
Combined treatment with lenalidomide and epoetin alfa in lower-risk patients with myelodysplastic syndrome.
Topics: Aged; Antineoplastic Agents; Area Under Curve; Drug Administration Schedule; Drug Therapy, Combination; Erythropoietin; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Recombinant Proteins; Risk; Severity of Illness Index; Thalidomide; Thrombocytopenia; Treatment Outcome | 2012 |
Biological activity of lenalidomide in myelodysplastic syndromes with del5q: results of gene expression profiling from a multicenter phase II study.
Topics: Aged; Anemia, Macrocytic; Apoptosis; Bone Marrow Cells; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Forkhead Transcription Factors; Gene Dosage; Gene Expression Profiling; Gene Expression Regulation; Genetic Association Studies; Humans; Immunity, Innate; Lenalidomide; Male; MicroRNAs; Models, Genetic; Myelodysplastic Syndromes; Ribosomal Proteins; Signal Transduction; Thalidomide | 2013 |
A randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Placebos; Receptors, Fc; Recombinant Fusion Proteins; Thalidomide; Thrombopoietin | 2012 |
Health-related quality of life outcomes of lenalidomide in transfusion-dependent patients with Low- or Intermediate-1-risk myelodysplastic syndromes with a chromosome 5q deletion: results from a randomized clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Antineoplastic Agents; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Combined Modality Therapy; Cross-Over Studies; Double-Blind Method; Female; Health Status; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Placebos; Quality of Life; Risk; Severity of Illness Index; Thalidomide; Treatment Outcome | 2013 |
Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2013 |
Efficacy of lenalidomide in myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Refractory; Angiogenesis Inhibitors; Bone Marrow; Female; Gene Deletion; Hematopoiesis; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Thalidomide; Thrombocytopenia | 2005 |
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion.
Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Erythrocyte Transfusion; Female; Follow-Up Studies; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Thalidomide | 2006 |
Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Karyotyping; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Risk Factors; Thalidomide; Treatment Outcome | 2008 |
Adjusted dose lenalidomide is safe and effective in patients with deletion (5q) myelodysplastic syndrome and severe renal impairment.
Topics: Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Kidney Diseases; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2008 |
215 other study(ies) available for lenalidomide and Myelodysplastic Syndromes
Article | Year |
---|---|
Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 5; Clone Cells; Erythroblasts; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Humans; Lenalidomide; Myelodysplastic Syndromes; Osteonectin; Thalidomide; Tumor Cells, Cultured | 2007 |
Toward a pathophysiology inspired treatment of VEXAS syndrome.
Topics: Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Mutation; Myelodysplastic Syndromes; Transplantation, Homologous | 2021 |
Therapeutic Outcomes and Prognostic Impact of Gene Mutations Including TP53 and SF3B1 in Patients with Del(5q) Myelodysplastic Syndromes (MDS).
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Mutation; Myelodysplastic Syndromes; Phosphoproteins; Prognosis; Retrospective Studies; RNA Splicing Factors; Thalidomide; Treatment Outcome; Tumor Suppressor Protein p53 | 2022 |
[MDS with deletion 5q - a distinct subtype of myelodysplastic syndromes].
Topics: Chromosome Deletion; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2022 |
Evolution of severe (transfusion-dependent) anaemia in myelodysplastic syndromes with 5q deletion is characterized by a macrophage-associated failure of the eythropoietic niche.
Topics: Anemia; Animals; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Macrophages; Mice; Myelodysplastic Syndromes; Thalidomide | 2022 |
Enhancing our chances of picking a winner in higher-risk myelodysplastic syndromes.
Topics: Azacitidine; Clinical Trials, Phase II as Topic; Humans; Idarubicin; Lenalidomide; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Valproic Acid | 2022 |
Impact of Lenalidomide Treatment on Overall Survival in Patients With Lower-Risk, Transfusion-Dependent Myelodysplastic Syndromes.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Ferritins; Humans; Lenalidomide; Myelodysplastic Syndromes; Prospective Studies; Thalidomide; Treatment Outcome | 2022 |
Quantitative evaluation of treatment response to lenalidomide by applying fluorescence in situ hybridization for peripheral blood granulocytes in a patient with 5q- syndrome.
Topics: Aged, 80 and over; Anemia, Macrocytic; Chromosome Deletion; Chromosomes, Human, Pair 5; Cri-du-Chat Syndrome; Female; Granulocytes; Humans; In Situ Hybridization, Fluorescence; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Trisomy | 2022 |
Lenalidomide therapy for primary myelodysplastic syndromes with isolated del(5q): Determinants of response and survival in a real-world setting.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2022 |
Myelodysplastic syndromes with del(5q): A real-life study of determinants of long-term outcomes and response to lenalidomide.
Topics: Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2022 |
[Updated treatment strategies for myelodysplastic syndromes].
Topics: Antineoplastic Agents; Azacitidine; Hematopoietic Stem Cell Transplantation; Humans; Iron Chelating Agents; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes | 2022 |
Images from the Haematologica Atlas of Hematologic Cytology: myelodysplastic syndrome with isolated del(5q).
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes | 2022 |
Suspected Immune Thrombocytopenic Purpura Induced by Lenalidomide for the Treatment of Myelodysplastic Syndrome with Deletion of Chromosome 5q: A Case Report.
Topics: Aged; Chromosomes; Humans; Lenalidomide; Male; Multiple Myeloma; Myelodysplastic Syndromes; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia | 2023 |
Treatment patterns in older patients with myelodysplastic syndromes: A population-based analysis reflecting the real world.
Topics: Aged; Female; Humans; Kaplan-Meier Estimate; Lenalidomide; Male; Myelodysplastic Syndromes; Treatment Failure; Treatment Outcome | 2023 |
A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes.
Topics: Azacitidine; DNA Methylation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; MicroRNAs; Myelodysplastic Syndromes; Proto-Oncogene Proteins c-bcl-2 | 2023 |
What value do cell cycle inhibitors have in the treatment of myelodysplastic syndrome?
Topics: Cell Cycle; Humans; Lenalidomide; Myelodysplastic Syndromes | 2023 |
Azacitidine, lenalidomide and donor lymphocyte infusions for relapse of myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia after allogeneic transplant: the Azalena-Trial.
Topics: Adult; Azacitidine; Chronic Disease; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphocyte Transfusion; Myelodysplastic Syndromes; Recurrence; T-Lymphocytes; Transplantation, Homologous | 2023 |
Lenalidomide treatment of Japanese patients with myelodysplastic syndromes with 5q deletion: a post-marketing surveillance study.
Topics: Aged; Aged, 80 and over; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; East Asian People; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Product Surveillance, Postmarketing; Thalidomide; Treatment Outcome | 2023 |
Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation.
Topics: Chromosome Aberrations; Female; Hematologic Neoplasms; Humans; Immunomodulating Agents; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Pregnancy; Proteolysis; Proteolysis Targeting Chimera | 2023 |
[Current state of treatment for myelodysplastic syndromes].
Topics: Azacitidine; Genome-Wide Association Study; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Prognosis | 2023 |
Successful lenalidomide treatment in high risk myelodysplastic syndrome with germline DDX41 mutation.
Topics: DEAD-box RNA Helicases; Germ-Line Mutation; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Risk Factors | 2020 |
The tale of lenalidomide clinical superiority over thalidomide and regulatory and cost-effectiveness issues.
Topics: Angiogenesis Inhibitors; Brazil; Cost-Benefit Analysis; Drug and Narcotic Control; Drug Costs; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Randomized Controlled Trials as Topic; Thalidomide; Treatment Outcome | 2019 |
Achievement of red blood cell transfusion independence in red blood cell transfusion-dependent patients with lower-risk non-del(5q) myelodysplastic syndromes correlates with serum erythropoietin levels.
Topics: Erythrocyte Transfusion; Erythropoietin; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2020 |
Distinct mutational pattern of myelodysplastic syndromes with and without 5q- treated with lenalidomide.
Topics: Humans; Lenalidomide; Mutation; Myelodysplastic Syndromes | 2020 |
Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome.
Topics: Cell Differentiation; Cell Line; Chromosomes, Human, Pair 5; Core Binding Factor Alpha 2 Subunit; Down-Regulation; GATA2 Transcription Factor; HEK293 Cells; Humans; Lenalidomide; Megakaryocytes; Mutation; Myelodysplastic Syndromes; Tumor Suppressor Protein p53 | 2020 |
Cyclosporine enhances the sensitivity to lenalidomide in MDS/AML in vitro.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cyclosporine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Humans; Ikaros Transcription Factor; Lenalidomide; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Muscle Proteins; Myelodysplastic Syndromes; Neoplasm Proteins; Up-Regulation; Xenograft Model Antitumor Assays | 2020 |
Recalcitrant pemphigus successfully treated with lenalidomide.
Topics: Aged, 80 and over; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Pemphigus; Remission Induction | 2020 |
Impact of somatic mutations on response to lenalidomide in lower-risk non-del(5q) myelodysplastic syndromes patients.
Topics: Biomarkers, Tumor; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Mutation; Myelodysplastic Syndromes; Prognosis; Survival Rate | 2021 |
[Management of lower-risk myelodysplastic syndromes].
Topics: Anemia, Macrocytic; Darbepoetin alfa; Humans; Japan; Lenalidomide; Myelodysplastic Syndromes; Risk Assessment | 2020 |
Therapy for lower-risk MDS.
Topics: Activin Receptors, Type II; Aged; Anemia; Blood Transfusion; Disease Management; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin Fc Fragments; Lenalidomide; Male; Mutation; Myelodysplastic Syndromes; Receptors, Fc; Recombinant Fusion Proteins; Thrombocytopenia; Thrombopoietin | 2020 |
Transitory response of a myelodysplastic syndrome with deletion of chromosome 5q to thalidomide. Report of one case.
Topics: Aged; Anemia, Macrocytic; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2020 |
Impact of PPM1D mutations in patients with myelodysplastic syndrome and deletion of chromosome 5q.
Topics: Abnormal Karyotype; Adult; Aged; Aged, 80 and over; Alleles; Anemia, Macrocytic; Chromosome Deletion; Chromosomes, Human, Pair 5; Clonal Evolution; Disease Progression; Drug Resistance, Neoplasm; Female; Genes, p53; Humans; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Protein Phosphatase 2C; Retrospective Studies | 2021 |
Clinical effectiveness of DNA methyltransferase inhibitors and lenalidomide in older patients with refractory anemia with ring sideroblasts: a population-based study in the United States.
Topics: Aged; Anemia, Refractory; Chromosome Deletion; Chromosomes, Human, Pair 5; DNA; Humans; Lenalidomide; Medicare; Methyltransferases; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome; United States | 2021 |
Efficacy of lenalidomide in a patient with systemic mastocytosis associated with
Topics: Humans; Lenalidomide; Mastocytosis, Systemic; Mutation; Myelodysplastic Syndromes; Phosphoproteins; RNA Splicing Factors | 2021 |
Dual pyroptotic biomarkers predict erythroid response in lower-risk non-del(5q) myelodysplastic syndromes treated with lenalidomide and recombinant erythropoietin.
Topics: Biomarkers; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythropoietin; Humans; Lenalidomide; Myelodysplastic Syndromes | 2022 |
Age, Blasts, Performance Status and Lenalidomide Therapy Influence the Outcome of Myelodysplastic Syndrome With Isolated Del(5q): A Study of 58 South American Patients.
Topics: Age Factors; Aged; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Survival Analysis; Treatment Outcome | 2022 |
Outcome of Lower-Risk Patients With Myelodysplastic Syndromes Without 5q Deletion After Failure of Erythropoiesis-Stimulating Agents.
Topics: Aged; Aged, 80 and over; Anemia; Antilymphocyte Serum; Antineoplastic Agents; Arsenic; Azacitidine; Chromosome Deletion; Chromosomes, Human, Pair 5; Cyclosporine; Cytarabine; Decitabine; Disease Progression; Enzyme Inhibitors; Erythrocyte Transfusion; Female; Hematinics; Humans; Hydroxyurea; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Recurrence; Retreatment; Retrospective Studies; Risk Factors; Survival Rate; Thalidomide; Treatment Failure; Tretinoin; Valproic Acid | 2017 |
Clonal evolution in myelodysplastic syndromes.
Topics: Aged; Angiogenesis Inhibitors; Biomarkers, Tumor; Bone Marrow Cells; Clonal Evolution; Disease Management; Disease Progression; Drug Resistance, Neoplasm; Exome Sequencing; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Lenalidomide; Male; Membrane Proteins; Middle Aged; Monitoring, Physiologic; Mutation; Myelodysplastic Syndromes; Proto-Oncogene Proteins p21(ras); Thalidomide; Tumor Suppressor Protein p53 | 2017 |
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Antineoplastic Agents; Gene Deletion; HCT116 Cells; HEK293 Cells; Humans; Lenalidomide; Mass Spectrometry; Mice; Multiple Myeloma; Myelodysplastic Syndromes; Peptide Hydrolases; Proteomics; Substrate Specificity; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination; Zinc Fingers | 2017 |
Improving Outcomes in High-Risk Myelodysplasia: Festina Lente.
Topics: Azacitidine; Humans; Lenalidomide; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; United States; Vorinostat | 2017 |
Accurate quantification of chromosomal lesions via short tandem repeat analysis using minimal amounts of DNA.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; DNA; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Microsatellite Repeats; Middle Aged; Multiplex Polymerase Chain Reaction; Myelodysplastic Syndromes; Reproducibility of Results; Thalidomide; Uniparental Disomy | 2017 |
JSH Guideline for Tumors of Hematopoietic and Lymphoid Tissues: Leukemia: 6. Myelodysplastic syndromes (MDS).
Topics: Algorithms; Allografts; Azacitidine; Blood Transfusion; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Japan; Lenalidomide; Myelodysplastic Syndromes; Practice Guidelines as Topic; Prognosis; Risk; Thalidomide | 2017 |
Population Pharmacokinetics of Lenalidomide in Healthy Volunteers and Patients With Hematologic Malignancies.
Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Body Weight; Clinical Trials as Topic; Creatinine; Female; Healthy Volunteers; Humans; Lenalidomide; Male; Middle Aged; Models, Theoretical; Multiple Myeloma; Myelodysplastic Syndromes; Young Adult | 2018 |
False-positive pregnancy tests in females of reproductive potential receiving lenalidomide in the United States.
Topics: Abnormalities, Drug-Induced; Adult; Ectromelia; False Positive Reactions; Female; Humans; Lenalidomide; Lymphoma, Mantle-Cell; Maternal-Fetal Exchange; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Pregnancy; Pregnancy Tests; United States | 2018 |
Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence.
Topics: Aged; Aged, 80 and over; Azacitidine; Blood Transfusion; Decitabine; Female; Hematinics; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Secondary Prevention; Thalidomide; Time Factors | 2017 |
Concomitant Occurrence of Blastic Plasmacytoid Dendritic Cell Neoplasm and Acute Myeloid Leukaemia after Lenalidomide Treatment for.
Topics: Chromosome Deletion; Dendritic Cells; Humans; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Neoplasms, Plasma Cell; Thalidomide; Treatment Outcome | 2017 |
"Hof" in pronormoblasts: pure erythroid leukemia mimicking plasma cell myeloma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cyclophosphamide; Cytoplasm; Dexamethasone; Diagnostic Errors; Erythroblasts; Fatal Outcome; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Erythroblastic, Acute; Male; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2017 |
Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling.
Topics: Aged; Aged, 80 and over; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Treatment Outcome | 2018 |
Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes.
Topics: Calgranulin B; Erythropoiesis; Erythropoietin; Hep G2 Cells; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Tumor Necrosis Factor-alpha | 2017 |
Relationship between lenalidomide dose modification, duration of therapy, and long-term outcomes in patients with myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Case-Control Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Thalidomide; Time Factors | 2017 |
Emergence and evolution of
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Prognosis; Tumor Suppressor Protein p53 | 2018 |
Lenalidomide in non-deletion 5q lower-risk myelodysplastic syndromes: a glass quarter full or three quarters empty?
Topics: Abnormalities, Multiple; Chromosome Deletion; Chromosomes, Human, Pair 2; Humans; Lenalidomide; Myelodysplastic Syndromes | 2018 |
Association of red cell distribution width with clinical outcomes in myelodysplastic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Erythroblasts; Erythrocyte Indices; Erythropoiesis; Erythropoietin; Female; Hematopoietic Stem Cell Transplantation; Hemoglobins; Humans; Immunosuppressive Agents; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Survival Analysis; Young Adult | 2018 |
Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin ± prednisone addition to lenalidomide in refractory or relapsed patients).
Topics: Aged; Aged, 80 and over; Chromosomes, Human, Pair 5; Czech Republic; Erythropoietin; Female; Genes, p53; Glucocorticoids; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prednisone; Recurrence; Remission Induction; Risk Factors | 2018 |
Impact of lenalidomide use among non-transfusion dependent patients with myelodysplastic syndromes.
Topics: Aged; Aged, 80 and over; Blood Transfusion; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Off-Label Use; Survival Analysis | 2018 |
Selection of patients with myelodysplastic syndromes from a large electronic medical records database and a study of the use of disease-modifying therapy in the United States.
Topics: Aged; Aged, 80 and over; Anemia; Azacitidine; Databases, Factual; Decitabine; Electronic Health Records; Enzyme Inhibitors; Female; Hematinics; Humans; Immunologic Factors; Iron Chelating Agents; Lenalidomide; Male; Middle Aged; Multivariate Analysis; Myelodysplastic Syndromes; Proportional Hazards Models; Recurrence; Retrospective Studies; Thalidomide; Treatment Outcome; United States | 2018 |
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Casein Kinase I; Disease Models, Animal; Female; Hematopoiesis; Lenalidomide; Male; Mice; Mice, Inbred C57BL; Myelodysplastic Syndromes; Nerve Tissue Proteins; Point Mutation; Thalidomide | 2018 |
Mutations and karyotype predict treatment response in myelodysplastic syndromes.
Topics: Aged; Antimetabolites, Antineoplastic; Dioxygenases; DNA-Binding Proteins; Female; Humans; Karyotype; Lenalidomide; Male; Mutation; Myelodysplastic Syndromes; Phosphoproteins; Prognosis; Proto-Oncogene Proteins; Repressor Proteins; RNA Splicing Factors; Splicing Factor U2AF; Treatment Outcome | 2018 |
The impact of lenalidomide exposure on response and outcomes in patients with lower-risk myelodysplastic syndromes and del(5q).
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Treatment Outcome | 2018 |
Novel EZH2 mutation in a patient with secondary B-cell acute lymphocytic leukemia after deletion 5q myelodysplastic syndrome treated with lenalidomide: A case report.
Topics: Aged; Anemia; Angiogenesis Inhibitors; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; B-Lymphocytes; Bone Marrow; Chromosome Deletion; Cyclophosphamide; Dexamethasone; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Humans; Lenalidomide; Male; Mutation; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thrombocytopenia; Treatment Outcome | 2019 |
Treatment sequence of lenalidomide and hypomethylating agents and the impact on clinical outcomes for patients with myelodysplastic syndromes.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Decision-Making; Disease Management; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Treatment Outcome | 2019 |
Response of high-risk MDS to azacitidine and lenalidomide is impacted by baseline and acquired mutations in a cluster of three inositide-specific genes.
Topics: Aged; Aged, 80 and over; Azacitidine; Cell Differentiation; Cell Proliferation; Disease-Free Survival; Female; Humans; Inositol; Kaplan-Meier Estimate; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes | 2019 |
MDS with 5q deletion and rare
Topics: Anemia, Macrocytic; Biopsy; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Hematologic Neoplasms; Humans; Immunologic Factors; Lenalidomide; Male; Mastocytosis; Middle Aged; Mutation; Myelodysplastic Syndromes | 2019 |
Lenalidomide as a second-line therapy after failure of hypomethylating agents in patients with myelodysplastic syndrome.
Topics: Angiogenesis Inhibitors; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Progression-Free Survival; Survival Analysis | 2019 |
One plus one does not always equal two, especially with regard to hypomethylating agents: the question of synergy of azacitidine and lenalidomide for treatment of relapsed acute myeloid leukemia and myelodysplastic syndromes post allogeneic hematopoietic
Topics: Antigens, CD; Azacitidine; CD8-Positive T-Lymphocytes; Clinical Trials as Topic; Drug Therapy, Combination; Female; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Lymphocyte Activation Gene 3 Protein; Male; Middle Aged; Myelodysplastic Syndromes; Programmed Cell Death 1 Receptor; Recurrence; Transplantation, Homologous | 2019 |
A G polymorphism in the CRBN gene acts as a biomarker of response to treatment with lenalidomide in low/int-1 risk MDS without del(5q).
Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Biomarkers, Tumor; Chromosome Deletion; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Peptide Hydrolases; Polymorphism, Genetic; Risk; Thalidomide; Ubiquitin-Protein Ligases | 2013 |
[Molecular target therapy for myelodysplastic syndrome].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytokines; Decitabine; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2012 |
Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Chromosome Aberrations; Female; Follow-Up Studies; Humans; Incidence; Lenalidomide; Leukemia; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Recurrence, Local; Prognosis; Pyrazines; Risk Factors; Thalidomide; Young Adult | 2013 |
Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations.
Topics: Aged; Aged, 80 and over; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Immunologic Factors; In Situ Hybridization, Fluorescence; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Polymorphism, Single Nucleotide; Thalidomide; Treatment Outcome | 2013 |
Mesenchymal stromal cells from patients with myelodyplastic syndrome display distinct functional alterations that are modulated by lenalidomide.
Topics: Aged; Cell Proliferation; Coculture Techniques; Cohort Studies; Female; Humans; Lenalidomide; Male; Mesenchymal Stem Cells; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2013 |
Lenalidomide performance in the real world: patterns of use and effectiveness in a Medicare population with myelodysplastic syndromes.
Topics: Aged; Aged, 80 and over; Angiogenesis Inhibitors; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Cohort Studies; Female; Humans; Lenalidomide; Male; Medicare; Myelodysplastic Syndromes; Practice Patterns, Physicians'; Thalidomide; Treatment Outcome; United States | 2013 |
Erythroid but not cytogenetic response in a case with 5q- syndrome: a delayed effect of lenalidomide or a consequence of deferasirox treatment?
Topics: Aged; Anemia, Macrocytic; Benzoates; Chromosome Deletion; Chromosomes, Human, Pair 5; Deferasirox; Erythroid Cells; Erythropoiesis; Female; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome; Triazoles | 2014 |
TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients.
Topics: Base Sequence; Dexamethasone; Drug Resistance; Erythroid Precursor Cells; Erythropoiesis; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lenalidomide; Molecular Sequence Data; Myelodysplastic Syndromes; Oligonucleotides; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Statistics, Nonparametric; Thalidomide; Treatment Outcome; Tumor Suppressor Protein p53 | 2013 |
Extended survival and reduced risk of AML progression in erythroid-responsive lenalidomide-treated patients with lower-risk del(5q) MDS.
Topics: Aged; Chromosome Deletion; Disease Progression; Erythrocyte Transfusion; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Survival Analysis; Thalidomide | 2014 |
Transfusion dependence development and disease evolution in patients with MDS and del(5q) and without transfusion needs at diagnosis.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Agents; Biomarkers, Tumor; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Lenalidomide; Male; Middle Aged; Multivariate Analysis; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Survival Analysis; Thalidomide; Time Factors | 2014 |
The difficulty to define progression patterns in patients with early stage myelodysplastic syndromes and deletion 5q--new prognostic markers are needed.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Humans; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Survival Analysis; Thalidomide | 2014 |
Eltrombopag can overcome the anti-megakaryopoietic effects of lenalidomide without increasing proliferation of the malignant myelodysplastic syndrome/acute myelogenous leukemia clone.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Benzoates; Cell Line, Tumor; Cell Proliferation; Clonal Evolution; Female; Humans; Hydrazines; Lenalidomide; Leukemia, Myeloid, Acute; Male; Megakaryocyte Progenitor Cells; Middle Aged; Myelodysplastic Syndromes; Pyrazoles; Thalidomide; Thrombopoiesis | 2014 |
Multivariate time-dependent comparison of the impact of lenalidomide in lower-risk myelodysplastic syndromes with chromosome 5q deletion.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Drug Evaluation; Erythrocyte Transfusion; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lenalidomide; Male; Middle Aged; Multivariate Analysis; Myelodysplastic Syndromes; Prognosis; Retrospective Studies; Thalidomide; Treatment Outcome | 2014 |
[CME myelodysplasia - a frequent hematologic neoplasia in the elderly].
Topics: Aged, 80 and over; Anemia, Aplastic; Azacitidine; Bone Marrow; Bone Marrow Examination; Cell Proliferation; Cell Transformation, Neoplastic; Decitabine; Diagnosis, Differential; Disease Progression; Hematopoiesis; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Prognosis; Thalidomide | 2014 |
Impacts of new agents for multiple myeloma on development of secondary myelodysplastic syndrome and acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Chromosome Aberrations; Female; Humans; Immunosuppressive Agents; Lenalidomide; Leukemia, Myeloid, Acute; Male; Melphalan; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Second Primary; Pyrazines; Retrospective Studies; Thalidomide; Time Factors | 2014 |
Successful treatment of an essential thrombocythemia patient complicated by Sweet's syndrome with combination of chemotherapy and lenalidomide.
Topics: Aged; Blood Cell Count; Bone Marrow; Drug Therapy, Combination; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Nitrosourea Compounds; Skin; Sweet Syndrome; Thalidomide; Thrombocythemia, Essential; Treatment Outcome | 2014 |
[Myelodysplastic syndromes (MDS)].
Topics: Azacitidine; Humans; Lenalidomide; Molecular Targeted Therapy; Myelodysplastic Syndromes; Thalidomide | 2014 |
Role of lenalidomide in the management of myelodysplastic syndromes with del(5q) associated with pure red cell aplasia (PRCA).
Topics: Adult; Aged; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Red-Cell Aplasia, Pure; Thalidomide | 2015 |
Validation of the IPSS-R in lenalidomide-treated, lower-risk myelodysplastic syndrome patients with del(5q).
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease-Free Survival; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Risk Factors; Survival Rate; Thalidomide | 2014 |
Therapy-related myelodysplastic syndrome/acute leukemia after multiple myeloma in the era of novel agents.
Topics: Acute Disease; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Agents; Bortezomib; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Stem Cell Transplantation; Thalidomide; Transplantation, Autologous | 2015 |
High level of full-length cereblon mRNA in lower risk myelodysplastic syndrome with isolated 5q deletion is implicated in the efficacy of lenalidomide.
Topics: Adaptor Proteins, Signal Transducing; Anemia, Macrocytic; Case-Control Studies; Chromosome Deletion; Chromosomes, Human, Pair 5; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Lenalidomide; Leukocytes, Mononuclear; Myelodysplastic Syndromes; Peptide Hydrolases; Polymorphism, Single Nucleotide; RNA Splicing; RNA, Messenger; Signal Transduction; Thalidomide; Treatment Outcome; Ubiquitin-Protein Ligases | 2015 |
Genome-wide miRNA profiling in myelodysplastic syndrome with del(5q) treated with lenalidomide.
Topics: Aged; Anemia, Macrocytic; Case-Control Studies; Chromosome Deletion; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 5; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Loci; Genome-Wide Association Study; Haploinsufficiency; Humans; Immunologic Factors; Lenalidomide; Leukocytes, Mononuclear; Male; MicroRNAs; Middle Aged; Myelodysplastic Syndromes; Primary Cell Culture; RNA Splicing; Signal Transduction; Thalidomide | 2015 |
Myelodysplastic syndromes with a deletion 5q display a characteristic immunophenotypic profile suitable for diagnostics and response monitoring.
Topics: Antigens, CD; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Cohort Studies; Drug Monitoring; Female; Gene Expression; Humans; Immunologic Factors; Immunophenotyping; Lenalidomide; Lymphocytes; Male; Myelodysplastic Syndromes; Myeloid Cells; Thalidomide | 2015 |
Lenalidomide induces lipid raft assembly to enhance erythropoietin receptor signaling in myelodysplastic syndrome progenitors.
Topics: Actins; Aged; Aged, 80 and over; Amides; Cell Line, Tumor; Drug Evaluation, Preclinical; Erythroid Precursor Cells; Female; Humans; Immunologic Factors; Lenalidomide; Male; Membrane Microdomains; Myelodysplastic Syndromes; Protein Multimerization; Pyridines; Receptors, Erythropoietin; rho-Associated Kinases; Signal Transduction; Thalidomide | 2014 |
Myelodysplastic syndromes (MDS).
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Humans; Immunologic Factors; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2015 |
Lenalidomide in patients with red blood cell transfusion-dependent myelodysplastic syndrome and del(5q): a single-centre "real-world" experience.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Comorbidity; Disease Progression; Erythrocyte Transfusion; Female; Follow-Up Studies; Gene Expression; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Prognosis; Thalidomide; Treatment Outcome; Tumor Suppressor Protein p53 | 2015 |
Aberrant expression of the microRNA cluster in 14q32 is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment.
Topics: Angiogenesis Inhibitors; Case-Control Studies; Chromosome Deletion; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 5; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Lenalidomide; MicroRNAs; Myelodysplastic Syndromes; Oligonucleotide Array Sequence Analysis; Sequence Deletion; Thalidomide | 2015 |
Lenalidomide for myelodysplastic syndromes with del(5q): how long should it last?
Topics: Aged; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Hematologic Diseases; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Pain; Remission Induction; Thalidomide; Time Factors; Treatment Outcome | 2015 |
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Topics: Amino Acid Sequence; Animals; Casein Kinase I; Cell Line; Gene Expression Regulation; HEK293 Cells; Humans; Immunologic Factors; Jurkat Cells; K562 Cells; Lenalidomide; Mice; Molecular Sequence Data; Myelodysplastic Syndromes; Peptide Hydrolases; Proteolysis; Sequence Alignment; Sequence Deletion; Species Specificity; Thalidomide; Ubiquitin-Protein Ligases; Ubiquitination | 2015 |
Polish experience of lenalidomide in the treatment of lower risk myelodysplastic syndrome with isolated del(5q).
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Poland; Retrospective Studies; Thalidomide; Treatment Outcome | 2015 |
Influence of total genomic alteration and chromosomal fragmentation on response to a combination of azacitidine and lenalidomide in a cohort of patients with very high risk MDS.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Chromosome Aberrations; Female; Humans; Kaplan-Meier Estimate; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Oligonucleotide Array Sequence Analysis; Proportional Hazards Models; Thalidomide; Tumor Suppressor Protein p53 | 2015 |
Lenalidomide for the Treatment of Low- or Intermediate-1-Risk Myelodysplastic Syndromes Associated with Deletion 5q Cytogenetic Abnormality: An Evidence Review of the NICE Submission from Celgene.
Topics: Anemia, Macrocytic; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Cost-Benefit Analysis; Health Care Costs; Humans; Lenalidomide; Models, Economic; Myelodysplastic Syndromes; Quality-Adjusted Life Years; Technology Assessment, Biomedical; Thalidomide | 2016 |
Early lenalidomide treatment for low and intermediate-1 International Prognostic Scoring System risk myelodysplastic syndromes with del(5q) before transfusion dependence.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Follow-Up Studies; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Quality of Life; Thalidomide; Treatment Outcome | 2015 |
Treatment of Patients With Myelodysplastic Syndrome With Lenalidomide in Clinical Routine in Austria.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Angiogenesis Inhibitors; Austria; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Comorbidity; Disease Progression; Erythrocyte Transfusion; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Standard of Care; Survival Analysis; Thalidomide; Treatment Outcome | 2015 |
Lenalidomide Treatment for Lower Risk Nondeletion 5q Myelodysplastic Syndromes Patients Yields Higher Response Rates When Used Before Azacitidine.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Kaplan-Meier Estimate; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retreatment; Retrospective Studies; Thalidomide; Treatment Failure; Treatment Outcome | 2015 |
Myelodysplastic Syndromes in the Elderly: Treatment Options and Personalized Management.
Topics: Aged; Aged, 80 and over; Disease Management; Drug Therapy; Erythrocyte Transfusion; Female; Geriatric Assessment; Hematinics; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppressive Agents; Iron Chelating Agents; Lenalidomide; Male; Myelodysplastic Syndromes; Precision Medicine; Thalidomide; Thrombopoiesis | 2015 |
Nine years without a new FDA-approved therapy for MDS: how can we break through the impasse?
Topics: Algorithms; Azacitidine; Clinical Trials as Topic; Decitabine; Drug Approval; Drug Industry; Humans; Karyotyping; Lenalidomide; Methylation; Mutation; Myelodysplastic Syndromes; Prognosis; Risk Assessment; Thalidomide; United States; United States Food and Drug Administration | 2015 |
Myelodysplastic syndrome.
Topics: Aged; Anemia, Macrocytic; Bone Marrow; Erythropoietin; Fatigue; Humans; Lenalidomide; Myelodysplastic Syndromes; Stem Cell Transplantation; Thalidomide | 2016 |
[Lenalidomide treatment in myelodysplastic syndrome with 5q deletion--Czech MDS group experience].
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2015 |
Autoimmune diseases and myelodysplastic syndromes.
Topics: Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Azacitidine; Comorbidity; Disease Progression; Disease Susceptibility; Female; Follow-Up Studies; Hashimoto Disease; Humans; Immunocompromised Host; Immunosuppressive Agents; Kaplan-Meier Estimate; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Prevalence; Proportional Hazards Models; Retrospective Studies; Thalidomide; Thyroiditis, Autoimmune; Young Adult | 2016 |
Subsequent primary malignancies and acute myelogenous leukemia transformation among myelodysplastic syndrome patients treated with or without lenalidomide.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Cell Transformation, Neoplastic; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasms, Second Primary; Registries; Retrospective Studies; Risk Factors; Thalidomide | 2016 |
A study of high-dose lenalidomide induction and low-dose lenalidomide maintenance therapy for patients with hypomethylating agent refractory myelodysplastic syndrome.
Topics: Aged; Aged, 80 and over; DNA Methylation; Drug Resistance, Neoplasm; Female; Humans; Immunologic Factors; Lenalidomide; Maintenance Chemotherapy; Male; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Retreatment; Thalidomide; Treatment Outcome | 2016 |
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Calcium; Calcium-Binding Proteins; Calpain; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Ikaros Transcription Factor; Immunologic Factors; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Peptide Hydrolases; Receptors, G-Protein-Coupled; RNA Interference; Thalidomide; Ubiquitin-Protein Ligases | 2016 |
Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity.
Topics: Adaptor Proteins, Signal Transducing; Basigin; Cell Cycle Proteins; Humans; Immunologic Factors; Immunosuppressive Agents; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Oncogene Proteins; Peptide Hydrolases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Teratogenesis; Thalidomide; Ubiquitin-Protein Ligases | 2016 |
Molecular predictors of response in patients with myeloid neoplasms treated with lenalidomide.
Topics: Adult; Aged; Aged, 80 and over; Chromosomes, Human, Pair 5; Cohort Studies; Female; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Thalidomide; Young Adult | 2016 |
Computational drug treatment simulations on projections of dysregulated protein networks derived from the myelodysplastic mutanome match clinical response in patients.
Topics: Chromosome Aberrations; Cohort Studies; Computational Biology; Computer Simulation; Drug Resistance, Neoplasm; Humans; Lenalidomide; Myelodysplastic Syndromes; Protein Interaction Maps; Retrospective Studies; Thalidomide; Treatment Outcome | 2017 |
Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.
Topics: Aged; Aged, 80 and over; Biomarkers; Chromosome Deletion; Chromosomes, Human, Pair 5; Computational Biology; Disease Progression; Female; Gene Expression; Gene Expression Profiling; Hematopoietic Stem Cells; Humans; Lenalidomide; Male; Mesenchymal Stem Cells; Middle Aged; Mutation; Myelodysplastic Syndromes; Prognosis; Stem Cell Niche; Thalidomide; Treatment Outcome | 2017 |
Refractory primary immune thrombocytopenia with subsequent del(5q) MDS: complete remission of both after lenalidomide.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Resistance; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Purpura, Thrombocytopenic, Idiopathic; Remission Induction; Thalidomide | 2017 |
Outcome of patients treated for myelodysplastic syndromes without deletion 5q after failure of lenalidomide therapy.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Angiogenesis Inhibitors; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Female; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Prognosis; Survival Analysis; Thalidomide; Treatment Outcome; Young Adult | 2017 |
Reactive granulomatous dermatitis presenting as subcutaneous nodules and cords in a patient with advanced myelodysplastic syndrome.
Topics: Aged; Blood Transfusion; Comorbidity; Fatal Outcome; Female; Granuloma; Histiocytes; Humans; Lenalidomide; Multiple Organ Failure; Myelodysplastic Syndromes; Neutrophils; Paraneoplastic Syndromes; Prednisone; Thalidomide | 2017 |
Myelodysplastic syndrome with concomitant del(5q) and JAK2 V617F mutation transformed to acute myeloid leukemia with an additional chromosomal abnormality after a long-term treatment with lenalidomide.
Topics: Aged; Biomarkers, Tumor; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Janus Kinase 2; Lenalidomide; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Prognosis | 2017 |
Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis.
Topics: Adult; Blood Platelets; Chemistry, Pharmaceutical; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials as Topic; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Male; Myelodysplastic Syndromes; Stem Cells; Syndrome; Thalidomide | 2008 |
The costs of drugs used to treat myelodysplastic syndromes following National Comprehensive Cancer Network Guidelines.
Topics: Anemia; Antineoplastic Agents; Azacitidine; Cost of Illness; Costs and Cost Analysis; Darbepoetin alfa; Decision Support Techniques; Deferoxamine; Drug Costs; Drug Therapy; Epoetin Alfa; Erythropoietin; Hematinics; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Practice Guidelines as Topic; Recombinant Proteins; Siderophores; Thalidomide; United States | 2008 |
[Myelodysplastic syndromes: therapeutic advances and promising future].
Topics: Antineoplastic Agents; Azacitidine; Decitabine; Forecasting; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2008 |
Myelodysplastic syndromes with del(5q): indications and strategies for cytogenetic testing.
Topics: Algorithms; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Humans; In Situ Hybridization, Fluorescence; Lenalidomide; Myelodysplastic Syndromes; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Prognosis; Spectral Karyotyping; Thalidomide | 2008 |
Trisomy 13: prevalence and clinicopathologic correlates of another potentially lenalidomide-sensitive cytogenetic abnormality.
Topics: Antineoplastic Agents; Chromosomes, Human, Pair 13; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Primary Myelofibrosis; Retrospective Studies; Thalidomide; Trisomy | 2009 |
The response to lenalidomide of myelodysplastic syndrome patients with deletion del(5q) can be sequentially monitored in CD34+ progenitor cells.
Topics: Aged; Antigens, CD34; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Female; Hematopoietic Stem Cells; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2009 |
Venous thromboembolism in myelodysplastic syndrome patients receiving lenalidomide: results from postmarketing surveillance and data mining techniques.
Topics: Aged; Aged, 80 and over; Algorithms; Antineoplastic Agents; Databases, Factual; Erythropoiesis; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Product Surveillance, Postmarketing; Pulmonary Embolism; Risk Assessment; Thalidomide; United States; United States Food and Drug Administration; Venous Thromboembolism | 2009 |
Recent advances in low- and intermediate-1-risk myelodysplastic syndrome: developing a consensus for optimal therapy.
Topics: Age Factors; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Blood Transfusion; Clinical Trials as Topic; Consensus; Decitabine; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Prognosis; Risk Factors; Thalidomide | 2008 |
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide.
Topics: Antineoplastic Agents; Apoptosis; cdc25 Phosphatases; Chromosome Deletion; Chromosomes, Human, Pair 5; G2 Phase; Humans; Lenalidomide; Myelodysplastic Syndromes; Protein Phosphatase 2; Thalidomide; U937 Cells | 2009 |
Durable long-term responses in patients with myelodysplastic syndromes treated with lenalidomide.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosomes, Human, Pair 5; Erythrocyte Transfusion; Erythropoietin; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Thalidomide; Treatment Outcome | 2009 |
Lenalidomide in 5q minus myelodysplastic syndrome: how long is enough?
Topics: Aged; Female; Follow-Up Studies; Gene Deletion; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2010 |
A delayed yet durable response to very short lenalidomide therapy and unexpected clone redistribution in a case of myelodysplastic syndrome with del(5q) and del(20q).
Topics: Aged; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 20; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2009 |
Successful treatment of MDS with lenalidomide, complicated by transient autoimmune hemolysis.
Topics: Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Female; Humans; Immunoglobulins; Lenalidomide; Methylprednisolone; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2010 |
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Topics: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Monosomy; Myelodysplastic Syndromes; Prognosis; Risk; Survival Analysis; Thalidomide | 2009 |
Clinical implications of gene expression profiling in myelodysplastic syndromes: recognition of ribosomal and translational gene dysregulation and development of predictive assays.
Topics: Antigens, CD34; Azacitidine; Cell Proliferation; Decitabine; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lenalidomide; Myelodysplastic Syndromes; Protein Biosynthesis; Ribosomes; Thalidomide | 2009 |
Clinical roundtable monograph. Combination therapies for MDS.
Topics: Azacitidine; Carrier Proteins; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Colony-Stimulating Factors; Enzyme Inhibitors; Etanercept; Humans; Hydroxamic Acids; Immunoglobulin G; Lenalidomide; Myelodysplastic Syndromes; Platelet Transfusion; Receptors, Fc; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Thalidomide; Thrombopoietin; Valproic Acid; Vorinostat | 2009 |
Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Bone Marrow Cells; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 5; Colony-Forming Units Assay; Cytokines; Female; Flow Cytometry; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2010 |
Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression.
Topics: Aged; Antineoplastic Agents; Bone Marrow Cells; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pair 5; Clone Cells; Disease Progression; Female; Gene Expression Profiling; Genetic Heterogeneity; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Mutation; Myelodysplastic Syndromes; Thalidomide; Tumor Suppressor Protein p53 | 2009 |
Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Erythroid Cells; Female; Follow-Up Studies; Humans; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Risk Factors; Thalidomide; Treatment Failure | 2010 |
Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; CD3 Complex; Cytokines; Female; Humans; Lenalidomide; Longitudinal Studies; Male; Middle Aged; Myelodysplastic Syndromes; Natural Killer T-Cells; Thalidomide | 2010 |
Efficacy of lenalidomide treatment and complete cytogenetic remission in a case of myelodysplastic syndrome with del(5q) and del(9q).
Topics: Aged; Angiogenesis Inhibitors; Bone Marrow; Chromosome Deletion; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 9; Female; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Neoplasm, Residual; Remission Induction; Thalidomide | 2010 |
Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Division; Cell Proliferation; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytokinesis; Fluorescent Antibody Technique; Gene Expression Profiling; Humans; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thalidomide; Tumor Cells, Cultured | 2010 |
[Lenalidomide in the treatment of transfusion dependent myelodysplastic syndromes].
Topics: Antineoplastic Agents; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Prognosis; Risk Factors; Thalidomide; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2010 |
Clinical management of myelodysplastic syndromes: update of SIE, SIES, GITMO practice guidelines.
Topics: Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2010 |
Pathophysiology and treatment of the myelodysplastic syndrome with isolated 5q deletion.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2010 |
Response to lenalidomide in patients with myelodysplastic syndrome with deletion 5q: clinical and cytogenetic analysis of a single centre series.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Clinical Trials as Topic; Cytogenetic Analysis; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Trisomy | 2010 |
Oral Ezatiostat HCl (TLK199) and Myelodysplastic syndrome: a case report of sustained hematologic response following an abbreviated exposure.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 5; Erythroid Cells; Glutathione; Hemoglobins; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Remission Induction; Thalidomide; Treatment Outcome | 2010 |
Myelodysplastic syndrome: An update on diagnosis and therapy.
Topics: Antineoplastic Agents; Azacitidine; Cytogenetic Analysis; Decitabine; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Immunohistochemistry; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Severity of Illness Index; Thalidomide | 2009 |
Management of myelodysplastic syndromes in the geriatric patient.
Topics: Aged; Anemia; Antineoplastic Agents; Azacitidine; Decitabine; Erythrocyte Transfusion; Erythropoietin; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Neutropenia; Thalidomide; Thrombocytopenia | 2009 |
Lenalidomide in myelodysplastic syndromes: where do we go from here?
Topics: Antineoplastic Agents; Chromosome Deletion; Humans; Lenalidomide; Myelodysplastic Syndromes; Stem Cell Transplantation; Thalidomide | 2008 |
Antiangiogenic therapy in myelodysplastic syndromes: is there a role?
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Arsenic Trioxide; Arsenicals; Bevacizumab; Clinical Trials as Topic; Drug Approval; Farnesyltranstransferase; Hematologic Neoplasms; Humans; Lenalidomide; Myelodysplastic Syndromes; Neovascularization, Pathologic; Oxides; Protein-Tyrosine Kinases; Thalidomide | 2008 |
Lenalidomide induces remission and mixed quantitative chimerism fluctuations in refractory and relapsed myeloid malignancy with del (5).
Topics: Adult; Antineoplastic Agents; Chimerism; Chromosome Deletion; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Remission Induction; Salvage Therapy; Sequence Deletion; Thalidomide | 2010 |
Efficacy of the association of lenalidomide to erythropoiesis-stimulating agents in del (5q) MDS patients refractory to single-agent lenalidomide.
Topics: Aged; Anemia; Antineoplastic Agents; Cell Survival; Drug Therapy, Combination; Female; Hematinics; Hemoglobins; Humans; Lenalidomide; Myelodysplastic Syndromes; Sequence Deletion; Thalidomide | 2010 |
Identification of disease- and therapy-associated proteome changes in the sera of patients with myelodysplastic syndromes and del(5q).
Topics: Adult; Aged; Antineoplastic Agents; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Megakaryocytes; Middle Aged; Myelodysplastic Syndromes; Protein Array Analysis; Proteome; Sequence Deletion; Thalidomide; Treatment Failure; Treatment Outcome | 2010 |
Persistent malignant stem cells in del(5q) myelodysplasia in remission.
Topics: ADP-ribosyl Cyclase 1; Aged; Aged, 80 and over; Antigens, CD34; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Drug Resistance; Female; Gene Expression; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neoplastic Stem Cells; Phenotype; Remission Induction; Thalidomide; Thy-1 Antigens | 2010 |
Response to lenalidomide in a patient with myelodysplastic syndrome with isolated del(5q) and JAK2 V617F mutation.
Topics: Aged, 80 and over; Amino Acid Substitution; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Janus Kinase 2; Lenalidomide; Mutation; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2010 |
Myelodysplastic syndromes--many new drugs, little therapeutic progress.
Topics: Age Distribution; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Benzoates; Deferasirox; Humans; Iron Chelating Agents; Lenalidomide; Myelodysplastic Syndromes; Survival Analysis; Thalidomide; Triazoles | 2010 |
Cytogenetic follow-up by karyotyping and fluorescence in situ hybridization: implications for monitoring patients with myelodysplastic syndrome and deletion 5q treated with lenalidomide.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cohort Studies; Follow-Up Studies; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Remission Induction; Risk Factors; Survival Rate; Thalidomide | 2011 |
Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5.
Topics: Aged; Chromosome Banding; Chromosome Mapping; Chromosomes, Artificial, Bacterial; Chromosomes, Human, Pair 5; Cytogenetics; Gene Rearrangement; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide | 2010 |
Sudden acute leukemia transformation in a MDS patient with del(5q) in complete cytogenetic remission after lenalidomide.
Topics: Acute Disease; Aged; Antineoplastic Agents; Cell Transformation, Neoplastic; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Leukemia, Myeloid; Male; Myelodysplastic Syndromes; Spectral Karyotyping; Thalidomide | 2011 |
Clonal evolution in myelodysplastic syndromes with isolated del(5q): the importance of genetic monitoring.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Clone Cells; Humans; Lenalidomide; Myelodysplastic Syndromes; Remission Induction; Thalidomide | 2011 |
Myelodysplastic syndrome presenting as generalized granulomatous dermatitis.
Topics: Aged; Antineoplastic Agents; Biopsy; Blood Cell Count; Dermatitis; Disease Progression; Granuloma; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Pruritus; Thalidomide; Time Factors | 2011 |
Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Myelodysplastic Syndromes; Remission Induction; Thalidomide; Treatment Outcome | 2011 |
[The 5q- syndrome].
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Thalidomide | 2010 |
Dexamethasone and lenalidomide have distinct functional effects on erythropoiesis.
Topics: Anemia, Diamond-Blackfan; Coculture Techniques; Dexamethasone; Drug Therapy, Combination; Erythroid Precursor Cells; Erythropoiesis; Gene Expression Profiling; Humans; Lenalidomide; Myelodysplastic Syndromes; Ribosomal Proteins; Stromal Cells; Thalidomide | 2011 |
Very short-term lenalidomide treatment associated with durable resolution of anemia in a patient with myelodysplastic syndrome with chromosome 5q deletion.
Topics: Aged; Anemia; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2012 |
Haematological and cytogenetic responses after only 7 days of Lenalidomide in a patient with myelodysplastic syndrome and chromosome 5q deletion.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetic Analysis; Hematologic Tests; Humans; Lenalidomide; Myelodysplastic Syndromes; Remission Induction; Thalidomide; Time Factors; Treatment Outcome | 2011 |
Treatment by Lenalidomide in lower risk myelodysplastic syndrome with 5q deletion--the GFM experience.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Risk Factors; Thalidomide; Thrombocytopenia; Transfusion Reaction; Treatment Outcome | 2011 |
Lenalidomide in del 5q MDS: responses and side effects revisited.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide; Transfusion Reaction | 2011 |
Efficacy of lenalidomide in a patient with myelodysplastic syndrome with isolated del(5q) and JAK2V617F mutation.
Topics: Amino Acid Substitution; Anemia, Macrocytic; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Janus Kinase 2; Lenalidomide; Middle Aged; Mutation, Missense; Myelodysplastic Syndromes; Phenylalanine; Thalidomide; Treatment Outcome; Valine | 2011 |
Telomere shortening, clonal evolution and disease progression in myelodysplastic syndrome patients with 5q deletion treated with lenalidomide.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Humans; Lenalidomide; Myelodysplastic Syndromes; Telomere; Thalidomide | 2012 |
Long-term transfusion independence in del(5q) MDS patients who discontinue lenalidomide.
Topics: Aged; Antineoplastic Agents; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide | 2012 |
The 5q- syndrome: biology and treatment.
Topics: Anemia, Macrocytic; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2011 |
Treatment with lenalidomide does not appear to increase the risk of progression in lower risk myelodysplastic syndromes with 5q deletion. A comparative analysis by the Groupe Francophone des Myelodysplasies.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Cohort Studies; Disease Progression; Female; France; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Survival Rate; Thalidomide; Treatment Outcome | 2012 |
Interest of the association azacitidine-lenalidomide as frontline therapy in high-risk myelodysplasia or acute myeloid leukemia with complex karyotype.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Female; Humans; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Risk; Thalidomide | 2012 |
[Myelodysplastic syndrome in the elderly: comprehensive geriatric assessment and therapeutic recommendations].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Blood Transfusion; Decision Support Techniques; Deferoxamine; Erythropoietin; Health Status Indicators; Humans; Lenalidomide; Myelodysplastic Syndromes; Prognosis; Siderophores; Thalidomide | 2012 |
[Myelodysplastic syndrome. What can be achieved with supportive therapy and new approaches].
Topics: Alemtuzumab; Anti-Bacterial Agents; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Combined Modality Therapy; Erythrocyte Transfusion; Hematopoietic Stem Cell Transplantation; Hemochromatosis; Humans; Lenalidomide; Myelodysplastic Syndromes; Platelet Transfusion; Thalidomide | 2011 |
Myeloma and second primary cancers.
Topics: Antineoplastic Agents; Humans; Lenalidomide; Leukemia, Myeloid; Melphalan; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Second Primary; Probability; Risk Assessment; Thalidomide | 2011 |
Morphologic analysis in myelodysplastic syndromes with del(5q) treated with lenalidomide. A Japanese multiinstitutional study.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Erythropoiesis; Humans; Lenalidomide; Megakaryocytes; Myelodysplastic Syndromes; Thalidomide | 2012 |
Long-term transfusion independence in del(5q) MDS patients after short term therapy with lenalidomide: 2 new cases.
Topics: Aged; Blood Transfusion; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide | 2012 |
Reversal of T-cell tolerance in myelodysplastic syndrome through lenalidomide immune modulation.
Topics: Antineoplastic Agents; Humans; Immune Tolerance; Lenalidomide; Myelodysplastic Syndromes; Prognosis; T-Lymphocytes; Thalidomide | 2012 |
Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide.
Topics: Aged; Antineoplastic Agents; Fatal Outcome; Humans; Immunocompromised Host; Lenalidomide; Lung Diseases, Fungal; Male; Myelodysplastic Syndromes; Thalidomide; Zygomycosis | 2012 |
Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.
Topics: Aged; Aged, 80 and over; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; DNA Methyltransferase 3A; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Mutation; Myelodysplastic Syndromes; Myeloproliferative Disorders; Polymorphism, Single Nucleotide; Prognosis; Thalidomide | 2012 |
Plasma exchange and rituximab treatment for lenalidomide-associated cold agglutinin disease.
Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Combined Modality Therapy; Humans; Immunologic Factors; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Plasma Exchange; Rituximab; Thalidomide | 2012 |
Myelodysplasia-associated immunophenotypic alterations of bone marrow cells in myeloma: are they present at diagnosis or are they induced by lenalidomide?
Topics: Antigens, CD; Antineoplastic Agents; Bone Marrow Cells; Female; Humans; Immunophenotyping; Lenalidomide; Male; Multiple Myeloma; Myelodysplastic Syndromes; Thalidomide | 2012 |
Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion.
Topics: Animals; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Mice; Myelodysplastic Syndromes; Proto-Oncogene Proteins c-mdm2; Thalidomide; Tumor Suppressor Protein p53; Ubiquitination | 2013 |
Deferasirox treatment for myelodysplastic syndromes: "real-life" efficacy and safety in a single-institution patient population.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Azacitidine; Benzoates; Chelating Agents; Deferasirox; Drug Eruptions; Drug Evaluation; Drug Therapy, Combination; Female; Follow-Up Studies; Gastrointestinal Diseases; Hematinics; Humans; Iron Overload; Kidney Diseases; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Retrospective Studies; Thalidomide; Treatment Outcome; Triazoles | 2012 |
Changes associated with lenalidomide treatment in the gene expression profiles of patients with del(5q).
Topics: Actin-Related Protein 2-3 Complex; Aged; Case-Control Studies; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Gene Expression; Humans; Interleukin-1beta; Lenalidomide; Lipopolysaccharide Receptors; Male; Middle Aged; Monocytes; Myelodysplastic Syndromes; Prognosis; Proto-Oncogene Proteins c-jun; Signal Transduction; Stem Cell Niche; Thalidomide; Transcriptome; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Improving the outlook for myelodysplastic syndrome.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Decitabine; Disease Progression; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Methyltransferases; Molecular Targeted Therapy; Myelodysplastic Syndromes; Phosphoproteins; Point Mutation; Prognosis; Ribonucleoprotein, U2 Small Nuclear; Risk Assessment; RNA Splicing; RNA Splicing Factors; Spliceosomes; Thalidomide | 2012 |
Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34(+) cells from patients with del(5q) myelodysplastic syndrome.
Topics: Animals; Antigens, CD34; Chromosome Deletion; Chromosomes, Human, Pair 5; Gene Expression Regulation; Gene Knockdown Techniques; Hematopoietic Stem Cells; Humans; Lenalidomide; Mice; MicroRNAs; Myelodysplastic Syndromes; RNA, Messenger; Thalidomide; Treatment Outcome | 2013 |
Treatment with lenalidomide in myelodysplastic syndromes with deletion 5q: results from the Dutch named patient program.
Topics: Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Myelodysplastic Syndromes; Netherlands; Thalidomide; Treatment Outcome; White People | 2013 |
Bone marrow morphology predicts additional chromosomal abnormalities in patients with myelodysplastic syndrome with del(5q).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone Marrow; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosomes, Human, Pair 5; Female; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Janus Kinase 2; Kaplan-Meier Estimate; Karyotyping; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Prognosis; Sequence Deletion; Thalidomide | 2013 |
Lenalidomide treatment for patients with myelodysplastic syndrome and low blast count acute myeloid leukemia after azacitidine failure.
Topics: Azacitidine; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Thalidomide; Treatment Failure; Treatment Outcome | 2013 |
Longitudinal bone marrow evaluations for myelodysplasia in patients with myeloma before and after treatment with lenalidomide.
Topics: Aged; Biopsy; Bone Marrow; Cytogenetic Analysis; Female; Humans; Immunologic Factors; In Situ Hybridization, Fluorescence; Lenalidomide; Longitudinal Studies; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Retrospective Studies; Thalidomide | 2013 |
MDS: unraveling the mystery.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Female; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide | 2012 |
Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Disease Progression; Erythrocyte Transfusion; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Proportional Hazards Models; Retrospective Studies; Risk; Thalidomide | 2013 |
The 5q- syndrome.
Topics: Age Factors; Antigens, CD; Chromosome Deletion; Chromosomes, Human, Pair 5; Cytogenetics; Erythropoietin; Female; Gene Deletion; Genes, Tumor Suppressor; Humans; Immunosuppressive Agents; Lenalidomide; Male; Myelodysplastic Syndromes; Prognosis; Sex Factors; Thalidomide | 2004 |
Myelodysplastic syndromes--coping with ineffective hematopoiesis.
Topics: Angiogenesis Inhibitors; Hematopoiesis; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2005 |
Prognosis of patients with del(5q) MDS and complex karyotype and the possible role of lenalidomide in this patient subgroup.
Topics: Adult; Aged; Aged, 80 and over; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Karyotyping; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Prognosis; Remission Induction; Survival Rate; Thalidomide | 2005 |
Treatment of myelodysplastic syndromes.
Topics: Angiogenesis Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2005 |
Treatment of myelodysplastic syndromes.
Topics: Angiogenesis Inhibitors; Antilymphocyte Serum; Blood Transfusion; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2005 |
New drug induces long-term MDS remission.
Topics: Chromosomes, Human, Pair 5; Gene Deletion; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2005 |
Update on supportive care and new therapies: immunomodulatory drugs, growth factors and epigenetic-acting agents.
Topics: Angiogenesis Inhibitors; Antilymphocyte Serum; Antineoplastic Agents; Blood Transfusion; Cyclosporine; Granulocyte Colony-Stimulating Factor; Growth Substances; Hemoglobins; Humans; Immunosuppressive Agents; Lenalidomide; Myelodysplastic Syndromes; Quality of Life; Risk Assessment; Thalidomide | 2005 |
New agents in the treatment of MDS.
Topics: Angiogenesis Inhibitors; Antimetabolites, Antineoplastic; Azacitidine; Clinical Trials, Phase III as Topic; Decitabine; Enzyme Inhibitors; Humans; Indoles; Lenalidomide; Myelodysplastic Syndromes; Predictive Value of Tests; Thalidomide; Treatment Outcome | 2005 |
Lenalidomide (Revlimid) for anemia of myelodysplastic syndrome.
Topics: Anemia; Chromosome Deletion; Chromosomes, Human, Pair 5; Contraindications; Female; Humans; Lenalidomide; Myelodysplastic Syndromes; Pregnancy; Pregnancy Complications; Thalidomide; Transfusion Reaction | 2006 |
Hematologic and cytogenetic response to lenalidomide monotherapy in acute myeloid leukemia arising from JAK2(V617F) positive, del(5)(q13q33) myelodysplastic syndrome.
Topics: Acute Disease; Aged, 80 and over; Chromosome Deletion; Chromosomes, Human, Pair 5; Female; Humans; Janus Kinase 2; Lenalidomide; Leukemia, Myeloid; Myelodysplastic Syndromes; Point Mutation; Thalidomide | 2006 |
Lenalidomide in the context of complex karyotype or interrupted treatment: case reviews of del(5q)MDS patients with unexpected responses.
Topics: Adult; Aged; Chromosome Deletion; Female; Humans; Karyotyping; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Treatment Outcome | 2007 |
Lenalidomide: from bench to bedside (part 1).
Topics: Anemia; Antineoplastic Agents; Humans; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2006 |
Cost effectiveness of lenalidomide in the treatment of transfusion-dependent myelodysplastic syndromes in the United States.
Topics: Antineoplastic Agents; Blood Transfusion; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 5; Cost-Benefit Analysis; Decision Support Techniques; Erythropoietin; Humans; Lenalidomide; Medical Oncology; Models, Econometric; Myelodysplastic Syndromes; Outcome Assessment, Health Care; Quality-Adjusted Life Years; Recombinant Proteins; Risk Factors; Thalidomide; United States | 2006 |
Practical considerations in the use of lenalidomide therapy for myelodysplastic syndromes.
Topics: Anemia; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Dexamethasone; Drug Therapy, Combination; Humans; Lenalidomide; Medical Oncology; Myelodysplastic Syndromes; Thalidomide | 2006 |
Remitting activity of lenalidomide in treatment-induced myelodysplastic syndrome.
Topics: Aged; Antineoplastic Agents; Chromosome Deletion; Chromosomes, Human, Pair 5; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Thalidomide | 2007 |
Managing myelodysplastic syndromes.
Topics: Aged; Antineoplastic Agents; Bone Marrow Examination; Clinical Trials as Topic; Cytogenetic Analysis; Drug Monitoring; Erythrocyte Transfusion; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Oncology Nursing; Thalidomide | 2007 |
Advances in MDS.
Topics: Antineoplastic Agents; Erythropoietin; Female; Granulocyte Precursor Cells; Hematopoietic Stem Cell Transplantation; Humans; Lenalidomide; Male; Myelodysplastic Syndromes; Thalidomide | 2007 |
Advances in the treatment of MDS, multiple myeloma, and CLL.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Drug Monitoring; Humans; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Myelodysplastic Syndromes; Nurse's Role; Oncology Nursing; Prognosis; Pyrazines; Risk Assessment; Thalidomide | 2007 |
Lenalidomide, a thalidomide derivative, shows promise in various applications.
Topics: Antineoplastic Agents; Drug Monitoring; Humans; Lenalidomide; Multiple Myeloma; Myelodysplastic Syndromes; Terminology as Topic; Thalidomide | 2007 |
Myelodysplastic syndromes: introduction.
Topics: Azacitidine; Decitabine; Hematopoietic Stem Cell Transplantation; Humans; Intercellular Signaling Peptides and Proteins; Lenalidomide; Myelodysplastic Syndromes; Thalidomide | 2008 |
Unusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide.
Topics: Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 5; Drug Resistance; Female; Humans; Lenalidomide; Middle Aged; Myelodysplastic Syndromes; Sequence Deletion; Thalidomide | 2008 |
An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.
Topics: Adult; Aged; Aged, 80 and over; Cell Differentiation; Cells, Cultured; Chromosome Deletion; Chromosomes, Human, Pair 5; Clinical Trials, Phase II as Topic; Erythroid Precursor Cells; Erythropoiesis; Gene Expression Profiling; Genetic Markers; Hematopoietic Stem Cells; Humans; Lenalidomide; Male; Middle Aged; Myelodysplastic Syndromes; Predictive Value of Tests; Thalidomide | 2008 |
Lenalidomide in myelodysplastic syndromes.
Topics: Clinical Trials as Topic; Gene Deletion; Humans; Immunologic Factors; Lenalidomide; Myelodysplastic Syndromes; Remission Induction; Thalidomide | 2008 |