leflunomide has been researched along with Vasospasm, Intracranial in 1 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Though cerebral vasospasm is one of the most serious complications of subarachnoid haemorrhage (SAH), its complex pathogenesis is poorly understood and available clinical treatment options are unsatisfactory." | 1.34 | Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage. ( Belen, D; Besalti, O; Bolay, H; Kösemehmetoğlu, K; Simşek, S; Yiğitkanli, K, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belen, D | 1 |
| Besalti, O | 1 |
| Yiğitkanli, K | 1 |
| Kösemehmetoğlu, K | 1 |
| Simşek, S | 1 |
| Bolay, H | 1 |
1 other study available for leflunomide and Vasospasm, Intracranial
| Article | Year |
|---|---|
Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Basilar Artery; Disease Models, Animal; Fibromuscu | 2007 |