leflunomide has been researched along with Uveitis in 7 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Excerpt | Relevance | Reference |
---|---|---|
"To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)." | 7.81 | [Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015) |
"To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats." | 7.79 | Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013) |
"Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man." | 7.69 | Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994) |
"Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision." | 5.42 | Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015) |
"To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)." | 3.81 | [Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015) |
"To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats." | 3.79 | Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013) |
"Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man." | 3.69 | Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994) |
"Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE)." | 1.43 | [Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus]. ( Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS, 2016) |
"Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision." | 1.42 | Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (14.29) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 1 (14.29) | 2.80 |
Authors | Studies |
---|---|
Brunelli, JB | 1 |
Silva, CA | 1 |
Pasoto, SG | 1 |
Saa, CGS | 1 |
Kozu, KT | 1 |
Goldenstein-Schainberg, C | 1 |
Leon, EP | 1 |
Vendramini, MBG | 1 |
Fontoura, N | 1 |
Bonfa, E | 1 |
Aikawa, NE | 1 |
Fang, CB | 1 |
Zhou, DX | 1 |
Zhan, SX | 1 |
He, Y | 2 |
Lin, Z | 2 |
Huang, C | 2 |
Li, J | 2 |
Silva-Fernández, L | 1 |
Pérez-Vicente, S | 1 |
Martín-Martínez, MA | 1 |
López-González, R | 1 |
Bichler, J | 1 |
Benseler, SM | 1 |
Krumrey-Langkammerer, M | 1 |
Haas, JP | 1 |
Hügle, B | 1 |
Fang, C | 1 |
Zhou, D | 1 |
Zhan, S | 1 |
Wang, L | 1 |
Yang, Y | 1 |
Jia, Y | 1 |
Miao, H | 1 |
Zhou, YS | 1 |
Zhang, XY | 1 |
Robertson, SM | 1 |
Lang, LS | 1 |
7 other studies available for leflunomide and Uveitis
Article | Year |
---|---|
Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching.
Topics: Adalimumab; Adolescent; Adult; Antibodies; Antibody Formation; Antirheumatic Agents; Arthritis, Juve | 2020 |
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regul | 2013 |
Variability in the prescription of non-biologic disease-modifying antirheumatic drugs for the treatment of spondyloarthritis in Spain.
Topics: Adult; Antimalarials; Antirheumatic Agents; Azathioprine; Cohort Studies; Cyclophosphamide; Cyclospo | 2015 |
Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chronic Disease; Cohort Studies; | 2015 |
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats].
Topics: Animals; Autoimmune Diseases; Cyclosporine; Down-Regulation; Eye Proteins; Immunosuppressive Agents; | 2015 |
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinucle | 2016 |
Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats.
Topics: Administration, Oral; Administration, Topical; Animals; Antibodies; Antigens; Arrestin; Autoimmune D | 1994 |