leflunomide has been researched along with Uveitis in 7 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)." | 7.81 | [Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015) |
| "To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats." | 7.79 | Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013) |
| "Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man." | 7.69 | Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994) |
| "Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision." | 5.42 | Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015) |
| "To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)." | 3.81 | [Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015) |
| "To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats." | 3.79 | Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013) |
| "Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man." | 3.69 | Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994) |
| "Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE)." | 1.43 | [Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus]. ( Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS, 2016) |
| "Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision." | 1.42 | Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Brunelli, JB | 1 |
| Silva, CA | 1 |
| Pasoto, SG | 1 |
| Saa, CGS | 1 |
| Kozu, KT | 1 |
| Goldenstein-Schainberg, C | 1 |
| Leon, EP | 1 |
| Vendramini, MBG | 1 |
| Fontoura, N | 1 |
| Bonfa, E | 1 |
| Aikawa, NE | 1 |
| Fang, CB | 1 |
| Zhou, DX | 1 |
| Zhan, SX | 1 |
| He, Y | 2 |
| Lin, Z | 2 |
| Huang, C | 2 |
| Li, J | 2 |
| Silva-Fernández, L | 1 |
| Pérez-Vicente, S | 1 |
| Martín-Martínez, MA | 1 |
| López-González, R | 1 |
| Bichler, J | 1 |
| Benseler, SM | 1 |
| Krumrey-Langkammerer, M | 1 |
| Haas, JP | 1 |
| Hügle, B | 1 |
| Fang, C | 1 |
| Zhou, D | 1 |
| Zhan, S | 1 |
| Wang, L | 1 |
| Yang, Y | 1 |
| Jia, Y | 1 |
| Miao, H | 1 |
| Zhou, YS | 1 |
| Zhang, XY | 1 |
| Robertson, SM | 1 |
| Lang, LS | 1 |
7 other studies available for leflunomide and Uveitis
| Article | Year |
|---|---|
Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching.
Topics: Adalimumab; Adolescent; Adult; Antibodies; Antibody Formation; Antirheumatic Agents; Arthritis, Juve | 2020 |
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regul | 2013 |
Variability in the prescription of non-biologic disease-modifying antirheumatic drugs for the treatment of spondyloarthritis in Spain.
Topics: Adult; Antimalarials; Antirheumatic Agents; Azathioprine; Cohort Studies; Cyclophosphamide; Cyclospo | 2015 |
Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chronic Disease; Cohort Studies; | 2015 |
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats].
Topics: Animals; Autoimmune Diseases; Cyclosporine; Down-Regulation; Eye Proteins; Immunosuppressive Agents; | 2015 |
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinucle | 2016 |
Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats.
Topics: Administration, Oral; Administration, Topical; Animals; Antibodies; Antigens; Arrestin; Autoimmune D | 1994 |