Page last updated: 2024-10-30

leflunomide and Uveitis

leflunomide has been researched along with Uveitis in 7 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)."7.81[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015)
"To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats."7.79Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013)
"Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man."7.69Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994)
"Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision."5.42Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015)
"To investigate the protective efficacy of leflunomide on the Lewis rats with experimental autoimmune uveitis (EAU)."3.81[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats]. ( Fang, C; He, Y; Huang, C; Li, J; Lin, Z; Zhan, S; Zhou, D, 2015)
"To investigate the efficacy of leflunomide in experimental autoimmune uveitis (EAU) in rats."3.79Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats. ( Fang, CB; He, Y; Huang, C; Li, J; Lin, Z; Zhan, SX; Zhou, DX, 2013)
"Leflunomide (LEF) is a novel immunomodulator which has been reported to be efficacious in experimental models of systemic autoimmune diseases and in treating rheumatoid arthritis in man."3.69Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats. ( Lang, LS; Robertson, SM, 1994)
"Episcleritis and scleritis are relatively rare ocular diseases, which are commonly associated with rheumatic diseases including systemic lupus erythematosus (SLE)."1.43[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus]. ( Jia, Y; Miao, H; Wang, L; Yang, Y; Zhang, XY; Zhou, YS, 2016)
"Chronic anterior uveitis is a serious complication of juvenile idiopathic arthritis (JIA); disease flares are highly associated with loss of vision."1.42Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis. ( Benseler, SM; Bichler, J; Haas, JP; Hügle, B; Krumrey-Langkammerer, M, 2015)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Brunelli, JB1
Silva, CA1
Pasoto, SG1
Saa, CGS1
Kozu, KT1
Goldenstein-Schainberg, C1
Leon, EP1
Vendramini, MBG1
Fontoura, N1
Bonfa, E1
Aikawa, NE1
Fang, CB1
Zhou, DX1
Zhan, SX1
He, Y2
Lin, Z2
Huang, C2
Li, J2
Silva-Fernández, L1
Pérez-Vicente, S1
Martín-Martínez, MA1
López-González, R1
Bichler, J1
Benseler, SM1
Krumrey-Langkammerer, M1
Haas, JP1
Hügle, B1
Fang, C1
Zhou, D1
Zhan, S1
Wang, L1
Yang, Y1
Jia, Y1
Miao, H1
Zhou, YS1
Zhang, XY1
Robertson, SM1
Lang, LS1

Other Studies

7 other studies available for leflunomide and Uveitis

ArticleYear
Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching.
    Clinical rheumatology, 2020, Volume: 39, Issue:2

    Topics: Adalimumab; Adolescent; Adult; Antibodies; Antibody Formation; Antirheumatic Agents; Arthritis, Juve

2020
Amelioration of experimental autoimmune uveitis by leflunomide in Lewis rats.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Animals; Autoimmune Diseases; Chemokines; Disease Models, Animal; Eye; Female; Gene Expression Regul

2013
Variability in the prescription of non-biologic disease-modifying antirheumatic drugs for the treatment of spondyloarthritis in Spain.
    Seminars in arthritis and rheumatism, 2015, Volume: 44, Issue:6

    Topics: Adult; Antimalarials; Antirheumatic Agents; Azathioprine; Cohort Studies; Cyclophosphamide; Cyclospo

2015
Leflunomide is associated with a higher flare rate compared to methotrexate in the treatment of chronic uveitis in juvenile idiopathic arthritis.
    Scandinavian journal of rheumatology, 2015, Volume: 44, Issue:4

    Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Child, Preschool; Chronic Disease; Cohort Studies;

2015
[Effects of leflunomide on experimental autoimmune uveitis in Lewis rats].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2015, Volume: 51, Issue:10

    Topics: Animals; Autoimmune Diseases; Cyclosporine; Down-Regulation; Eye Proteins; Immunosuppressive Agents;

2015
[Clinical characteristics of 4 cases of scleritis associated with systemic lupus erythematosus].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2016, 12-18, Volume: 48, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinucle

2016
Leflunomide: inhibition of S-antigen induced autoimmune uveitis in Lewis rats.
    Agents and actions, 1994, Volume: 42, Issue:3-4

    Topics: Administration, Oral; Administration, Topical; Animals; Antibodies; Antigens; Arrestin; Autoimmune D

1994