Page last updated: 2024-10-30

leflunomide and Urinary Bladder Neoplasms

leflunomide has been researched along with Urinary Bladder Neoplasms in 2 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.

Research Excerpts

ExcerptRelevanceReference
"Leflunomide markedly inhibited the growth of both bladder cancer cell lines and induced apoptosis and cell cycle arrest in S phase."7.96Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells. ( Cheng, L; Huang, H; Lin, J; Wang, H; Wang, Z; Zhuo, D, 2020)
"Angiogenesis plays an important role in bladder cancer (BCa)."5.48Inhibition of angiogenesis by leflunomide via targeting the soluble ephrin-A1/EphA2 system in bladder cancer. ( Chu, M; Zhang, C, 2018)
"Leflunomide markedly inhibited the growth of both bladder cancer cell lines and induced apoptosis and cell cycle arrest in S phase."3.96Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells. ( Cheng, L; Huang, H; Lin, J; Wang, H; Wang, Z; Zhuo, D, 2020)
"Angiogenesis plays an important role in bladder cancer (BCa)."1.48Inhibition of angiogenesis by leflunomide via targeting the soluble ephrin-A1/EphA2 system in bladder cancer. ( Chu, M; Zhang, C, 2018)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Cheng, L1
Wang, H1
Wang, Z1
Huang, H1
Zhuo, D1
Lin, J1
Chu, M1
Zhang, C1

Other Studies

2 other studies available for leflunomide and Urinary Bladder Neoplasms

ArticleYear
Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells.
    Drug design, development and therapy, 2020, Volume: 14

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Dose-Response Relationship, Dru

2020
Inhibition of angiogenesis by leflunomide via targeting the soluble ephrin-A1/EphA2 system in bladder cancer.
    Scientific reports, 2018, 01-24, Volume: 8, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Coculture Techniques; Disease Models, Animal; En

2018