leflunomide has been researched along with Takayasu Arteritis in 13 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Takayasu Arteritis: A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy and safety of leflunomide (LEF) versus tofacitinib (TOF) in Takayasu arteritis (TAK) patients." | 8.12 | Efficacy and safety of tofacitinib versus leflunomide with glucocorticoids treatment in Takayasu arteritis: A prospective study. ( Chen, H; Dai, X; Ding, Z; Ji, Z; Jiang, L; Jin, X; Kong, X; Ma, L; Wang, J; Wu, S, 2022) |
| "To evaluate the efficacy and safety of leflunomide (LEF) as induction treatment in a series of Takayasu arteritis (TA) patients based on a Chinese cohort." | 7.96 | Efficacy and safety of leflunomide treatment in Takayasu arteritis: Case series from the East China cohort. ( Cui, X; Dai, X; Ding, J; Dong, Z; Feng, X; Fu, W; Jiang, L; Li, S; Lin, H; Lin, J; Lu, Y; Lv, P; Ma, L; Sun, X; Tan, W; Wang, C; Wang, L; Wang, Y; Wu, M; Wu, R; Yang, C; Zhang, L; Zhang, Z; Zhou, Z; Zou, Y, 2020) |
| "To evaluate the efficacy of leflunomide in controlling disease activity in patients with Takayasu arteritis (TA) refractory or intolerant to conventional treatment." | 7.78 | Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study. ( da Silva, MD; de Souza, AW; Machado, LS; Oliveira, AC; Pinheiro, FA; Sato, EI, 2012) |
| " This report aims to assess the effectiveness and safety of leflunomide (LEF) in Takayasu arteritis (TA) and giant cell arteritis (GCA)." | 5.41 | Efficacy and safety of leflunomide in the management of large vessel vasculitis: A systematic review and metaanalysis of cohort studies. ( Brugarolas, E; Estrada, P; LLop, D; Maymó-Paituvi, P; Narváez, J; Nolla, JM; Palacios-Olid, J; Vidal-Montal, P, 2023) |
| " Results of in-vitro studies on Janus kinase (JAK)/signal transducers and activators of transcription and mammalian target of rapamycin (mTOR) pathways, comparative studies with leflunomide as an induction therapy, and a long-term follow-up study with tocilizumab may contribute to the management of Takayasu arteritis." | 5.12 | Aortitis: an update. ( Erdogan, M, 2021) |
| "To investigate the efficacy and safety of leflunomide (LEF) versus tofacitinib (TOF) in Takayasu arteritis (TAK) patients." | 4.12 | Efficacy and safety of tofacitinib versus leflunomide with glucocorticoids treatment in Takayasu arteritis: A prospective study. ( Chen, H; Dai, X; Ding, Z; Ji, Z; Jiang, L; Jin, X; Kong, X; Ma, L; Wang, J; Wu, S, 2022) |
| "To evaluate the efficacy and safety of leflunomide (LEF) as induction treatment in a series of Takayasu arteritis (TA) patients based on a Chinese cohort." | 3.96 | Efficacy and safety of leflunomide treatment in Takayasu arteritis: Case series from the East China cohort. ( Cui, X; Dai, X; Ding, J; Dong, Z; Feng, X; Fu, W; Jiang, L; Li, S; Lin, H; Lin, J; Lu, Y; Lv, P; Ma, L; Sun, X; Tan, W; Wang, C; Wang, L; Wang, Y; Wu, M; Wu, R; Yang, C; Zhang, L; Zhang, Z; Zhou, Z; Zou, Y, 2020) |
| "To evaluate the efficacy of leflunomide in controlling disease activity in patients with Takayasu arteritis (TA) refractory or intolerant to conventional treatment." | 3.78 | Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study. ( da Silva, MD; de Souza, AW; Machado, LS; Oliveira, AC; Pinheiro, FA; Sato, EI, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 7 (53.85) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 2 |
| Dai, X | 3 |
| Ma, L | 5 |
| Wu, S | 2 |
| Jin, X | 1 |
| Ji, Z | 2 |
| Chen, H | 2 |
| Ding, Z | 1 |
| Jiang, L | 3 |
| Kong, X | 2 |
| Sun, Y | 1 |
| Hou, J | 1 |
| Wang, L | 2 |
| Gong, Y | 1 |
| Sun, X | 2 |
| Narváez, J | 1 |
| Estrada, P | 1 |
| LLop, D | 1 |
| Vidal-Montal, P | 1 |
| Brugarolas, E | 1 |
| Maymó-Paituvi, P | 1 |
| Palacios-Olid, J | 1 |
| Nolla, JM | 1 |
| Sebastian, A | 2 |
| Kayani, A | 2 |
| Dasgupta, B | 2 |
| Erdogan, M | 1 |
| Tomelleri, A | 1 |
| Coath, F | 1 |
| Prieto-Pena, D | 1 |
| Mo, J | 1 |
| Keser, G | 1 |
| Aksu, K | 1 |
| Direskeneli, H | 3 |
| Machado, LSG | 1 |
| Oliveira, ACD | 1 |
| Semedo-Kuriki, P | 1 |
| de Souza, AWS | 1 |
| Sato, EI | 2 |
| Cui, X | 1 |
| Yang, C | 1 |
| Tan, W | 1 |
| Zhang, L | 1 |
| Zhang, Z | 1 |
| Feng, X | 1 |
| Wu, R | 1 |
| Zou, Y | 1 |
| Zhou, Z | 1 |
| Lu, Y | 1 |
| Wang, Y | 1 |
| Wu, M | 1 |
| Li, S | 1 |
| Lin, H | 1 |
| Dong, Z | 1 |
| Fu, W | 1 |
| Wang, C | 1 |
| Ding, J | 1 |
| Lv, P | 1 |
| Lin, J | 1 |
| Alibaz-Oner, F | 2 |
| de Souza, AW | 1 |
| da Silva, MD | 1 |
| Machado, LS | 1 |
| Oliveira, AC | 1 |
| Pinheiro, FA | 1 |
| Unizony, S | 1 |
| Stone, JH | 1 |
| Stone, JR | 1 |
| Aydin, SZ | 1 |
6 reviews available for leflunomide and Takayasu Arteritis
| Article | Year |
|---|---|
Efficacy and safety of leflunomide in the management of large vessel vasculitis: A systematic review and metaanalysis of cohort studies.
Topics: Antirheumatic Agents; Cohort Studies; Giant Cell Arteritis; Glucocorticoids; Humans; Leflunomide; Me | 2023 |
Aortitis: an update.
Topics: Antibodies, Monoclonal, Humanized; Aorta; Aortitis; Female; Follow-Up Studies; Giant Cell Arteritis; | 2021 |
Takayasu arteritis: an update
Topics: Antibodies, Monoclonal, Humanized; Biomarkers; Endovascular Procedures; Guidelines as Topic; Humans; | 2018 |
Update on Takayasu's arteritis.
Topics: Adrenal Cortex Hormones; Antibodies, Monoclonal, Humanized; Biological Products; Biomarkers; Diagnos | 2015 |
New treatment strategies in large-vessel vasculitis.
Topics: Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Arteritis; Giant Cell Art | 2013 |
Advances in the diagnosis, assessment and outcome of Takayasu's arteritis.
Topics: Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Fluorodeoxyglucose F18; Humans; Isoxazoles; | 2013 |
7 other studies available for leflunomide and Takayasu Arteritis
| Article | Year |
|---|---|
Efficacy and safety of tofacitinib versus leflunomide with glucocorticoids treatment in Takayasu arteritis: A prospective study.
Topics: Glucocorticoids; Humans; Immunosuppressive Agents; Leflunomide; Piperidines; Prospective Studies; Py | 2022 |
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta.
Topics: Adventitia; Aorta; Extracellular Matrix; Fibroblasts; Fibrosis; Humans; Leflunomide; Macrophages; Me | 2023 |
Excellent Response to Leflunomide in a Case of Large-Vessel Giant Cell Arteritis Demonstrated Simultaneously by Clinical, Laboratory, Ultrasound, and Positron Emission Tomography/Computed Tomography Parameters.
Topics: Aged; Female; Fluorodeoxyglucose F18; Giant Cell Arteritis; Humans; Laboratories; Leflunomide; Posit | 2021 |
Long-Term Efficacy and Safety of Leflunomide in Large-Vessel Giant Cell Arteritis: A Single-Center, 10-Year Experience.
Topics: Giant Cell Arteritis; Humans; Leflunomide; Takayasu Arteritis | 2022 |
Endothelial progenitor cells and vascular endothelial growth factor in patients with Takayasu's arteritis.
Topics: Adult; Anti-Inflammatory Agents; Brazil; Case-Control Studies; Cell Count; Cross-Sectional Studies; | 2018 |
Efficacy and safety of leflunomide treatment in Takayasu arteritis: Case series from the East China cohort.
Topics: Adolescent; Adult; China; Cyclophosphamide; Disease Progression; Female; Humans; Immunosuppressive A | 2020 |
Short-term effect of leflunomide in patients with Takayasu arteritis: an observational study.
Topics: Adult; Blood Sedimentation; C-Reactive Protein; Drug Therapy, Combination; Female; Follow-Up Studies | 2012 |