leflunomide has been researched along with Still's Disease, Adult-Onset in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Still's Disease, Adult-Onset: Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sayarlioglu, M | 2 |
| Sahin, M | 1 |
| Cetin, GY | 1 |
| Avan, R | 1 |
| Cerit, M | 1 |
| Nordström, D | 1 |
| Knight, A | 1 |
| Luukkainen, R | 1 |
| van Vollenhoven, R | 1 |
| Rantalaiho, V | 1 |
| Kajalainen, A | 1 |
| Brun, JG | 1 |
| Proven, A | 1 |
| Ljung, L | 1 |
| Kautiainen, H | 1 |
| Pettersson, T | 1 |
| Pirildar, T | 1 |
| Cefle, A | 1 |
| Ucmak, H | 1 |
| Ozkaya, M | 1 |
| Ucar, MA | 1 |
| Sayarlioglu, H | 1 |
| Lamparter, S | 1 |
| Dittrich, C | 1 |
| Koehler, HH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open, Randomized Study Treating Refractory Adult-onset Still's Disease With Interleukin-1 Receptor Antagonist Anakinra (Kineret), Compared to an Established, Single Anti-rheumatic Drug Treatment[NCT01033656] | Phase 2 | 23 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for leflunomide and Still's Disease, Adult-Onset
| Article | Year |
|---|---|
Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still's disease. An open, randomized, multicenter study.
Topics: Adult; Antirheumatic Agents; Azathioprine; Female; Humans; Interleukin 1 Receptor Antagonist Protein | 2012 |
5 other studies available for leflunomide and Still's Disease, Adult-Onset
| Article | Year |
|---|---|
Maternal exposure to leflunomide and methotrexate in a patient with adult-onset Still's disease.
Topics: Antirheumatic Agents; Cesarean Section; Female; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Ma | 2010 |
Treatment of adult-onset Still's disease with leflunomide and chloroquine combination in two patients.
Topics: Adult; Antirheumatic Agents; Chloroquine; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide | 2003 |
Leflunomide and azathioprine combination in refractory adult-onset Still's disease.
Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Still's Dis | 2005 |
Leflunomide and methotrexate combination in refractory adult-onset Still's disease.
Topics: Adult; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Still's Disea | 2007 |
Exacerbation of Whipple disease by immunosuppressants.
Topics: Aged; Diagnostic Errors; Glucocorticoids; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; | 2008 |