Page last updated: 2024-10-30

leflunomide and Still's Disease, Adult-Onset

leflunomide has been researched along with Still's Disease, Adult-Onset in 6 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Still's Disease, Adult-Onset: Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sayarlioglu, M2
Sahin, M1
Cetin, GY1
Avan, R1
Cerit, M1
Nordström, D1
Knight, A1
Luukkainen, R1
van Vollenhoven, R1
Rantalaiho, V1
Kajalainen, A1
Brun, JG1
Proven, A1
Ljung, L1
Kautiainen, H1
Pettersson, T1
Pirildar, T1
Cefle, A1
Ucmak, H1
Ozkaya, M1
Ucar, MA1
Sayarlioglu, H1
Lamparter, S1
Dittrich, C1
Koehler, HH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open, Randomized Study Treating Refractory Adult-onset Still's Disease With Interleukin-1 Receptor Antagonist Anakinra (Kineret), Compared to an Established, Single Anti-rheumatic Drug Treatment[NCT01033656]Phase 223 participants (Actual)Interventional2005-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for leflunomide and Still's Disease, Adult-Onset

ArticleYear
Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still's disease. An open, randomized, multicenter study.
    The Journal of rheumatology, 2012, Volume: 39, Issue:10

    Topics: Adult; Antirheumatic Agents; Azathioprine; Female; Humans; Interleukin 1 Receptor Antagonist Protein

2012

Other Studies

5 other studies available for leflunomide and Still's Disease, Adult-Onset

ArticleYear
Maternal exposure to leflunomide and methotrexate in a patient with adult-onset Still's disease.
    Rheumatology (Oxford, England), 2010, Volume: 49, Issue:9

    Topics: Antirheumatic Agents; Cesarean Section; Female; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Ma

2010
Treatment of adult-onset Still's disease with leflunomide and chloroquine combination in two patients.
    Clinical rheumatology, 2003, Volume: 22, Issue:2

    Topics: Adult; Antirheumatic Agents; Chloroquine; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide

2003
Leflunomide and azathioprine combination in refractory adult-onset Still's disease.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:4

    Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Still's Dis

2005
Leflunomide and methotrexate combination in refractory adult-onset Still's disease.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:7

    Topics: Adult; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Still's Disea

2007
Exacerbation of Whipple disease by immunosuppressants.
    Journal of clinical gastroenterology, 2008, Volume: 42, Issue:6

    Topics: Aged; Diagnostic Errors; Glucocorticoids; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide;

2008