leflunomide has been researched along with Still's Disease, Adult-Onset in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Still's Disease, Adult-Onset: Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 4 (66.67) | 29.6817 |
2010's | 2 (33.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Sayarlioglu, M | 2 |
Sahin, M | 1 |
Cetin, GY | 1 |
Avan, R | 1 |
Cerit, M | 1 |
Nordström, D | 1 |
Knight, A | 1 |
Luukkainen, R | 1 |
van Vollenhoven, R | 1 |
Rantalaiho, V | 1 |
Kajalainen, A | 1 |
Brun, JG | 1 |
Proven, A | 1 |
Ljung, L | 1 |
Kautiainen, H | 1 |
Pettersson, T | 1 |
Pirildar, T | 1 |
Cefle, A | 1 |
Ucmak, H | 1 |
Ozkaya, M | 1 |
Ucar, MA | 1 |
Sayarlioglu, H | 1 |
Lamparter, S | 1 |
Dittrich, C | 1 |
Koehler, HH | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
An Open, Randomized Study Treating Refractory Adult-onset Still's Disease With Interleukin-1 Receptor Antagonist Anakinra (Kineret), Compared to an Established, Single Anti-rheumatic Drug Treatment[NCT01033656] | Phase 2 | 23 participants (Actual) | Interventional | 2005-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 trial available for leflunomide and Still's Disease, Adult-Onset
Article | Year |
---|---|
Beneficial effect of interleukin 1 inhibition with anakinra in adult-onset Still's disease. An open, randomized, multicenter study.
Topics: Adult; Antirheumatic Agents; Azathioprine; Female; Humans; Interleukin 1 Receptor Antagonist Protein | 2012 |
5 other studies available for leflunomide and Still's Disease, Adult-Onset
Article | Year |
---|---|
Maternal exposure to leflunomide and methotrexate in a patient with adult-onset Still's disease.
Topics: Antirheumatic Agents; Cesarean Section; Female; Humans; Infant, Newborn; Isoxazoles; Leflunomide; Ma | 2010 |
Treatment of adult-onset Still's disease with leflunomide and chloroquine combination in two patients.
Topics: Adult; Antirheumatic Agents; Chloroquine; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide | 2003 |
Leflunomide and azathioprine combination in refractory adult-onset Still's disease.
Topics: Adult; Azathioprine; Drug Therapy, Combination; Female; Humans; Isoxazoles; Leflunomide; Still's Dis | 2005 |
Leflunomide and methotrexate combination in refractory adult-onset Still's disease.
Topics: Adult; Drug Therapy, Combination; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Still's Disea | 2007 |
Exacerbation of Whipple disease by immunosuppressants.
Topics: Aged; Diagnostic Errors; Glucocorticoids; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; | 2008 |