leflunomide has been researched along with Stevens-Johnson Syndrome in 4 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis." | 7.74 | Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis. ( Baaj, M; El Haouri, M; Hadri, L; Hassikou, H; Safi, S; Tabache, F, 2008) |
| "Leflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis." | 3.74 | Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis. ( Baaj, M; El Haouri, M; Hadri, L; Hassikou, H; Safi, S; Tabache, F, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Wang, F | 1 |
| Li, H | 1 |
| Hao, X | 1 |
| Shen, G | 1 |
| Sun, Y | 1 |
| Xia, J | 1 |
| Hassikou, H | 1 |
| El Haouri, M | 1 |
| Tabache, F | 1 |
| Baaj, M | 1 |
| Safi, S | 1 |
| Hadri, L | 1 |
| Schmutz, JL | 1 |
| Barbaud, A | 1 |
| Tréchot, P | 1 |
| Teraki, Y | 1 |
| Hitomi, K | 1 |
| Sato, Y | 1 |
| Hamamatsu, Y | 1 |
| Izaki, S | 1 |
4 other studies available for leflunomide and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Toxic Epidermal Necrolysis Induced by Leflunomide in a Patient With Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Humans; Leflunomide; Stevens-Johnson Syndrome | 2021 |
Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Adult; Arthritis, Rheumatoid; Cholestyramine Resin; Female; Glucocorticoids; | 2008 |
[Leflunomide and Lyell syndrome].
Topics: Adult; Arthritis, Rheumatoid; Fatal Outcome; Female; Humans; Immunosuppressive Agents; Isoxazoles; L | 2009 |
Leflunomide-induced toxic epidermal necrolysis.
Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Middle Aged; | 2006 |