leflunomide has been researched along with Sjogren's Syndrome in 12 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this work was to clarify the effect of leflunomide (LEF) on the eye dryness in patients with secondary Sjögren's syndrome associated with rheumatoid arthritis (RA-sSS) and in patients with rheumatoid arthritis (RA)." | 7.80 | The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients. ( El-Agha, S; El-Azkalany, GS; Shahin, AA, 2014) |
| "Leflunomide treatment suppressed cytokine release from circulating immune cells." | 6.77 | Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression. ( Bijlsma, JW; Bikker, A; Kruize, AA; Lafeber, FP; van der Wurff-Jacobs, KM; van Roon, JA; van Woerkom, JM, 2012) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 5.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "The aim of this work was to clarify the effect of leflunomide (LEF) on the eye dryness in patients with secondary Sjögren's syndrome associated with rheumatoid arthritis (RA-sSS) and in patients with rheumatoid arthritis (RA)." | 3.80 | The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients. ( El-Agha, S; El-Azkalany, GS; Shahin, AA, 2014) |
| "Leflunomide treatment suppressed cytokine release from circulating immune cells." | 2.77 | Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression. ( Bijlsma, JW; Bikker, A; Kruize, AA; Lafeber, FP; van der Wurff-Jacobs, KM; van Roon, JA; van Woerkom, JM, 2012) |
| "A total of 1069 adult systemic lupus erythematosus (SLE) patients who were hospitalized for the first time in 26 hospitals in Jiangsu Province from 1999 to 2009 were retrospectively analyzed." | 1.72 | Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort. ( Da, Z; Ding, F; Ding, X; Feng, X; Hu, H; Li, J; Li, M; Liang, J; Liu, L; Pan, W; Qian, X; Sun, L; Tan, J; Tao, J; Wang, M; Wei, H; Wen, L; Wu, J; Wu, M; Zhang, H; Zhang, M; Zou, Y, 2022) |
| "Four months later widespread prunosus skin rash appeared on her skin." | 1.35 | Severe cutaneous adverse drug reaction to leflunomide: a report of two cases. ( Guo, G; Jian, X; Li, X; Lin, D; Ruan, Y, 2008) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 1.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| "Leflunomide is a new oral disease modifying antirheumatic drug with a good safety profile." | 1.33 | Lupus erythematosus with leflunomide: induction or reactivation? ( Gensburger, D; Kanitakis, J; Kawashima, M; Marotte, H; Miossec, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, M | 1 |
| Liang, J | 1 |
| Pan, W | 1 |
| Liu, L | 1 |
| Wu, M | 1 |
| Ding, F | 1 |
| Hu, H | 1 |
| Ding, X | 1 |
| Wei, H | 1 |
| Zou, Y | 1 |
| Qian, X | 1 |
| Wang, M | 1 |
| Wu, J | 1 |
| Tao, J | 1 |
| Tan, J | 1 |
| Da, Z | 1 |
| Zhang, M | 1 |
| Li, J | 1 |
| Feng, X | 1 |
| Wen, L | 1 |
| Zhang, H | 1 |
| Sun, L | 1 |
| Hamkour, S | 1 |
| van der Heijden, EH | 1 |
| Lopes, AP | 1 |
| Blokland, SLM | 1 |
| Bekker, CPJ | 1 |
| Van Helden-Meeuwsen, CG | 1 |
| Versnel, MA | 1 |
| Kruize, AA | 3 |
| Radstake, TR | 1 |
| Leavis, HL | 1 |
| Hillen, MR | 1 |
| van Roon, JA | 3 |
| Shahin, AA | 1 |
| El-Agha, S | 1 |
| El-Azkalany, GS | 1 |
| Adamski, H | 1 |
| Lopez, L | 1 |
| Polard, E | 1 |
| Chevrant-Breton, J | 1 |
| Dupuy, A | 1 |
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Bikker, A | 1 |
| van Woerkom, JM | 2 |
| van der Wurff-Jacobs, KM | 1 |
| Bijlsma, JW | 2 |
| Lafeber, FP | 1 |
| Gensburger, D | 1 |
| Kawashima, M | 1 |
| Marotte, H | 1 |
| Kanitakis, J | 1 |
| Miossec, P | 1 |
| Scagliusi, P | 1 |
| Minenna, G | 1 |
| D'Amore, M | 1 |
| Scagliusi, A | 1 |
| Geenen, R | 1 |
| van Roon, EN | 1 |
| Goldschmeding, R | 1 |
| Verstappen, SM | 1 |
| Jian, X | 1 |
| Guo, G | 1 |
| Ruan, Y | 1 |
| Lin, D | 1 |
| Li, X | 1 |
| Horvath, IF | 1 |
| Szanto, A | 1 |
| Csiki, Z | 1 |
| Szodoray, P | 1 |
| Zeher, M | 1 |
| Fox, RI | 1 |
2 reviews available for leflunomide and Sjogren's Syndrome
| Article | Year |
|---|---|
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Sjögren's syndrome: current therapies remain inadequate for a common disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Dental Caries; Enzyme Inhibitors; H | 2000 |
2 trials available for leflunomide and Sjogren's Syndrome
| Article | Year |
|---|---|
Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression.
Topics: Adult; Antirheumatic Agents; CD4-Positive T-Lymphocytes; CD40 Ligand; Cells, Cultured; Cytokines; Fe | 2012 |
Safety and efficacy of leflunomide in primary Sjögren's syndrome: a phase II pilot study.
Topics: Adult; Aniline Compounds; Crotonates; Diarrhea; Facial Dermatoses; Fatigue; Female; Humans; Hydroxyb | 2007 |
8 other studies available for leflunomide and Sjogren's Syndrome
| Article | Year |
|---|---|
Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort.
Topics: Adult; Antibodies, Antinuclear; C-Reactive Protein; China; Creatinine; Humans; Leflunomide; Lupus Er | 2022 |
Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren's syndrome that show potential to predict and monitor clinical response.
Topics: Biomarkers; Humans; Hydroxychloroquine; Interferon Type I; Leflunomide; Leukocytes, Mononuclear; Pro | 2023 |
The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheum | 2014 |
Photodistributed eruption with rhabdomyolisis due to leflunomide.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Le | 2011 |
Lupus erythematosus with leflunomide: induction or reactivation?
Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, | 2005 |
[New therapeutic perspectives in Sjögren syndrome: leflunomide].
Topics: Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Sjogren's Syndrome | 2005 |
Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.
Topics: Adolescent; Anti-Inflammatory Agents; Blister; Drug Eruptions; Exanthema; Female; Glucocorticoids; H | 2008 |
Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Isoxazoles; Leflunomide; Lung Disease | 2008 |