leflunomide has been researched along with Sicca Syndrome in 12 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this work was to clarify the effect of leflunomide (LEF) on the eye dryness in patients with secondary Sjögren's syndrome associated with rheumatoid arthritis (RA-sSS) and in patients with rheumatoid arthritis (RA)." | 7.80 | The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients. ( El-Agha, S; El-Azkalany, GS; Shahin, AA, 2014) |
| "Leflunomide treatment suppressed cytokine release from circulating immune cells." | 6.77 | Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression. ( Bijlsma, JW; Bikker, A; Kruize, AA; Lafeber, FP; van der Wurff-Jacobs, KM; van Roon, JA; van Woerkom, JM, 2012) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 5.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| " The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease." | 4.87 | [Systemic autoimmune disorders and pregnancy]. ( Kiss, CG; Kiss, E; Poór, G, 2011) |
| "The aim of this work was to clarify the effect of leflunomide (LEF) on the eye dryness in patients with secondary Sjögren's syndrome associated with rheumatoid arthritis (RA-sSS) and in patients with rheumatoid arthritis (RA)." | 3.80 | The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients. ( El-Agha, S; El-Azkalany, GS; Shahin, AA, 2014) |
| "Leflunomide treatment suppressed cytokine release from circulating immune cells." | 2.77 | Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression. ( Bijlsma, JW; Bikker, A; Kruize, AA; Lafeber, FP; van der Wurff-Jacobs, KM; van Roon, JA; van Woerkom, JM, 2012) |
| "A total of 1069 adult systemic lupus erythematosus (SLE) patients who were hospitalized for the first time in 26 hospitals in Jiangsu Province from 1999 to 2009 were retrospectively analyzed." | 1.72 | Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort. ( Da, Z; Ding, F; Ding, X; Feng, X; Hu, H; Li, J; Li, M; Liang, J; Liu, L; Pan, W; Qian, X; Sun, L; Tan, J; Tao, J; Wang, M; Wei, H; Wen, L; Wu, J; Wu, M; Zhang, H; Zhang, M; Zou, Y, 2022) |
| "Four months later widespread prunosus skin rash appeared on her skin." | 1.35 | Severe cutaneous adverse drug reaction to leflunomide: a report of two cases. ( Guo, G; Jian, X; Li, X; Lin, D; Ruan, Y, 2008) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 1.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| "Leflunomide is a new oral disease modifying antirheumatic drug with a good safety profile." | 1.33 | Lupus erythematosus with leflunomide: induction or reactivation? ( Gensburger, D; Kanitakis, J; Kawashima, M; Marotte, H; Miossec, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, M | 1 |
| Liang, J | 1 |
| Pan, W | 1 |
| Liu, L | 1 |
| Wu, M | 1 |
| Ding, F | 1 |
| Hu, H | 1 |
| Ding, X | 1 |
| Wei, H | 1 |
| Zou, Y | 1 |
| Qian, X | 1 |
| Wang, M | 1 |
| Wu, J | 1 |
| Tao, J | 1 |
| Tan, J | 1 |
| Da, Z | 1 |
| Zhang, M | 1 |
| Li, J | 1 |
| Feng, X | 1 |
| Wen, L | 1 |
| Zhang, H | 1 |
| Sun, L | 1 |
| Hamkour, S | 1 |
| van der Heijden, EH | 1 |
| Lopes, AP | 1 |
| Blokland, SLM | 1 |
| Bekker, CPJ | 1 |
| Van Helden-Meeuwsen, CG | 1 |
| Versnel, MA | 1 |
| Kruize, AA | 3 |
| Radstake, TR | 1 |
| Leavis, HL | 1 |
| Hillen, MR | 1 |
| van Roon, JA | 3 |
| Shahin, AA | 1 |
| El-Agha, S | 1 |
| El-Azkalany, GS | 1 |
| Adamski, H | 1 |
| Lopez, L | 1 |
| Polard, E | 1 |
| Chevrant-Breton, J | 1 |
| Dupuy, A | 1 |
| Kiss, E | 1 |
| Kiss, CG | 1 |
| Poór, G | 1 |
| Bikker, A | 1 |
| van Woerkom, JM | 2 |
| van der Wurff-Jacobs, KM | 1 |
| Bijlsma, JW | 2 |
| Lafeber, FP | 1 |
| Gensburger, D | 1 |
| Kawashima, M | 1 |
| Marotte, H | 1 |
| Kanitakis, J | 1 |
| Miossec, P | 1 |
| Scagliusi, P | 1 |
| Minenna, G | 1 |
| D'Amore, M | 1 |
| Scagliusi, A | 1 |
| Geenen, R | 1 |
| van Roon, EN | 1 |
| Goldschmeding, R | 1 |
| Verstappen, SM | 1 |
| Jian, X | 1 |
| Guo, G | 1 |
| Ruan, Y | 1 |
| Lin, D | 1 |
| Li, X | 1 |
| Horvath, IF | 1 |
| Szanto, A | 1 |
| Csiki, Z | 1 |
| Szodoray, P | 1 |
| Zeher, M | 1 |
| Fox, RI | 1 |
2 reviews available for leflunomide and Sicca Syndrome
| Article | Year |
|---|---|
[Systemic autoimmune disorders and pregnancy].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Antiphospholipid Syndrome; Arthrit | 2011 |
Sjögren's syndrome: current therapies remain inadequate for a common disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Dental Caries; Enzyme Inhibitors; H | 2000 |
2 trials available for leflunomide and Sicca Syndrome
| Article | Year |
|---|---|
Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression.
Topics: Adult; Antirheumatic Agents; CD4-Positive T-Lymphocytes; CD40 Ligand; Cells, Cultured; Cytokines; Fe | 2012 |
Safety and efficacy of leflunomide in primary Sjögren's syndrome: a phase II pilot study.
Topics: Adult; Aniline Compounds; Crotonates; Diarrhea; Facial Dermatoses; Fatigue; Female; Humans; Hydroxyb | 2007 |
8 other studies available for leflunomide and Sicca Syndrome
| Article | Year |
|---|---|
Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort.
Topics: Adult; Antibodies, Antinuclear; C-Reactive Protein; China; Creatinine; Humans; Leflunomide; Lupus Er | 2022 |
Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren's syndrome that show potential to predict and monitor clinical response.
Topics: Biomarkers; Humans; Hydroxychloroquine; Interferon Type I; Leflunomide; Leukocytes, Mononuclear; Pro | 2023 |
The effect of leflunomide on the eye dryness in secondary Sjögren's syndrome associated with rheumatoid arthritis and in rheumatoid arthritis patients.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Adult; Aged; Antirheumatic Agents; Arthritis, Rheum | 2014 |
Photodistributed eruption with rhabdomyolisis due to leflunomide.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Le | 2011 |
Lupus erythematosus with leflunomide: induction or reactivation?
Topics: Antirheumatic Agents; Drug Eruptions; Female; Humans; Isoxazoles; Leflunomide; Lupus Erythematosus, | 2005 |
[New therapeutic perspectives in Sjögren syndrome: leflunomide].
Topics: Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Sjogren's Syndrome | 2005 |
Severe cutaneous adverse drug reaction to leflunomide: a report of two cases.
Topics: Adolescent; Anti-Inflammatory Agents; Blister; Drug Eruptions; Exanthema; Female; Glucocorticoids; H | 2008 |
Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Isoxazoles; Leflunomide; Lung Disease | 2008 |