leflunomide has been researched along with Sepsis in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Wistar albino type rats were randomly divided into five groups: control, sham, leflunomide, sepsis, and sepsis + leflunomide." | 7.80 | Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis. ( Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M, 2014) |
| "To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand." | 7.74 | Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007) |
| "Wistar albino type rats were randomly divided into five groups: control, sham, leflunomide, sepsis, and sepsis + leflunomide." | 3.80 | Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis. ( Fadillioglu, E; Karaman, A; Ozturk, E; Samdancı, E; Surucu, M, 2014) |
| "To determine the prevalence of severe infections in patients with rheumatoid arthritis (RA) prescribed leflunomide in North Canterbury, New Zealand." | 3.74 | Leflunomide-associated infections in rheumatoid arthritis. ( Chapman, PT; Jenks, KA; O'Donnell, JL; Savage, RL; Stamp, LK, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozturk, E | 2 |
| Surucu, M | 2 |
| Karaman, A | 1 |
| Samdancı, E | 1 |
| Fadillioglu, E | 2 |
| Demirbilek, S | 1 |
| Begec, Z | 1 |
| Kirimlioglu, H | 1 |
| Ersoy, MO | 1 |
| Jenks, KA | 1 |
| Stamp, LK | 1 |
| O'Donnell, JL | 1 |
| Savage, RL | 1 |
| Chapman, PT | 1 |
3 other studies available for leflunomide and Sepsis
| Article | Year |
|---|---|
Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biomarkers; Catalase; Cecum; Disease | 2014 |
Does leflunomide attenuate the sepsis-induced acute lung injury?
Topics: Acute Lung Injury; Adjuvants, Immunologic; Animals; Disease Models, Animal; Glutathione; Immunosuppr | 2008 |
Leflunomide-associated infections in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cellulitis; Female; Hospitalization; Human | 2007 |