leflunomide has been researched along with Sensitivity and Specificity in 9 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "New treatment options for patients with methotrexate (MTX)-naive rheumatoid arthritis (RA) have become available." | 7.71 | A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis. ( Choi, HK; Kuntz, KM; Seeger, JD, 2002) |
| "New treatment options for patients with methotrexate (MTX)-naive rheumatoid arthritis (RA) have become available." | 3.71 | A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis. ( Choi, HK; Kuntz, KM; Seeger, JD, 2002) |
| "Leflunomide was found to be completely degraded when subjected to alkaline degradation producing one alkaline product." | 1.51 | Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures. ( El-Bagary, RI; El-Hakeem, MM; Mahrouse, MA; Megally, AB; Mohamed, AA, 2019) |
| " The proposed method was successfully applied to the analysis of these drugs in dosage forms." | 1.46 | Bioanalytical method for the estimation of co-administered esomeprazole, leflunomide and ibuprofen in human plasma and in pharmaceutical dosage forms using micellar liquid chromatography. ( Talaat, W, 2017) |
| "Treatment with leflunomide, FK778, or MPA may bear the risk to enhance HBV replication in infected patients." | 1.38 | The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro. ( Hoppe-Seyler, F; Hoppe-Seyler, K; Lohrey, C; Sauer, P, 2012) |
| "Leflunomide is a disease-modifying antirheumatic drug, which is bioactivated by formation of A77 1726." | 1.32 | A rapid and simple determination of A77 1726 in human serum by high-performance liquid chromatography and its application for optimization of leflunomide therapy. ( Brouwers, JR; Jansen, TL; Raemaekers, J; van Roon, EN; van Wanrooy, M; Yska, JP, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| El-Bagary, RI | 1 |
| Mahrouse, MA | 1 |
| El-Hakeem, MM | 1 |
| Megally, AB | 1 |
| Mohamed, AA | 1 |
| Talaat, W | 1 |
| Parekh, JM | 1 |
| Vaghela, RN | 1 |
| Sutariya, DK | 1 |
| Sanyal, M | 1 |
| Yadav, M | 1 |
| Shrivastav, PS | 1 |
| Hoppe-Seyler, K | 1 |
| Sauer, P | 1 |
| Lohrey, C | 1 |
| Hoppe-Seyler, F | 1 |
| van Roon, EN | 1 |
| Yska, JP | 1 |
| Raemaekers, J | 1 |
| Jansen, TL | 1 |
| van Wanrooy, M | 1 |
| Brouwers, JR | 1 |
| Yeniceli, D | 1 |
| Dogrukol-Ak, D | 1 |
| Tuncel, M | 1 |
| Wolfe, F | 1 |
| Choi, HK | 1 |
| Seeger, JD | 1 |
| Kuntz, KM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study[NCT02758288] | 0 participants (Actual) | Observational | 2015-09-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for leflunomide and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures.
Topics: Anthraquinones; Calibration; Diclofenac; Drug Combinations; Drug Stability; Leflunomide; Limit of De | 2019 |
Bioanalytical method for the estimation of co-administered esomeprazole, leflunomide and ibuprofen in human plasma and in pharmaceutical dosage forms using micellar liquid chromatography.
Topics: Adult; Calibration; Chromatography, Liquid; Drug Therapy, Combination; Esomeprazole; Ethylamines; Hu | 2017 |
Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry.
Topics: Acetates; Adult; Chromatography, Liquid; Crotonates; Drug Stability; High-Throughput Screening Assay | 2010 |
The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro.
Topics: Alkynes; Cells, Cultured; Enzyme Inhibitors; HEK293 Cells; Hep G2 Cells; Hepatitis B virus; Humans; | 2012 |
A rapid and simple determination of A77 1726 in human serum by high-performance liquid chromatography and its application for optimization of leflunomide therapy.
Topics: Aniline Compounds; Antirheumatic Agents; Buffers; Chromatography, High Pressure Liquid; Crotonates; | 2004 |
Determination of leflunomide in tablets by high performance liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calibration; Chemistry Techniques, Analytical; Chemistry, P | 2006 |
Which HAQ is best? A comparison of the HAQ, MHAQ and RA-HAQ, a difficult 8 item HAQ (DHAQ), and a rescored 20 item HAQ (HAQ20): analyses in 2,491 rheumatoid arthritis patients following leflunomide initiation.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disability Evaluation; Female; | 2001 |
A cost effectiveness analysis of treatment options for methotrexate-naive rheumatoid arthritis.
Topics: Analysis of Variance; Arthritis, Rheumatoid; Cohort Studies; Cost-Benefit Analysis; Decision Making; | 2002 |