leflunomide has been researched along with Rheumatoid Nodule in 5 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first description of the development of rheumatoid nodules in 3 rheumatoid arthritis patients following leflunomide therapy." | 7.72 | [Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy]. ( Becker-Capeller, D; Braun, MG; Van Rhee, R, 2004) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 5.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| "Leflunomide (LEF) is indicated in adults for the treatment of active rheumatoid arthritis (RA)." | 3.73 | Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. ( Balbir-Gurman, A; Guralnik, L; Keidar, Z; Nahir, AM; Rozenbaum, M; Rozin, A; Vlodavsky, E; Yigla, M, 2006) |
| "This is the first description of the development of rheumatoid nodules in 3 rheumatoid arthritis patients following leflunomide therapy." | 3.72 | [Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy]. ( Becker-Capeller, D; Braun, MG; Van Rhee, R, 2004) |
| "Rheumatoid nodules are common extra-articular findings occurring in 20% RA patients." | 2.43 | Laryngeal involvement in rheumatoid arthritis. ( Assimakopoulos, D; Bai, M; Drosos, AA; Papazisi, D; Voulgari, PV; Zagorianakou, P, 2005) |
| "Rheumatoid nodules are well established manifestations of rheumatoid arthritis but in the lungs they are very rare according to the literature." | 1.35 | Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide. ( Csiki, Z; Horvath, IF; Szanto, A; Szodoray, P; Zeher, M, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cunnane, G | 1 |
| Warnock, M | 1 |
| Fye, KH | 1 |
| Daikh, DI | 1 |
| Braun, MG | 1 |
| Van Rhee, R | 1 |
| Becker-Capeller, D | 1 |
| Voulgari, PV | 1 |
| Papazisi, D | 1 |
| Bai, M | 1 |
| Zagorianakou, P | 1 |
| Assimakopoulos, D | 1 |
| Drosos, AA | 1 |
| Rozin, A | 1 |
| Yigla, M | 1 |
| Guralnik, L | 1 |
| Keidar, Z | 1 |
| Vlodavsky, E | 1 |
| Rozenbaum, M | 1 |
| Nahir, AM | 1 |
| Balbir-Gurman, A | 1 |
| Horvath, IF | 1 |
| Szanto, A | 1 |
| Csiki, Z | 1 |
| Szodoray, P | 1 |
| Zeher, M | 1 |
1 review available for leflunomide and Rheumatoid Nodule
| Article | Year |
|---|---|
Laryngeal involvement in rheumatoid arthritis.
Topics: Aged; Anti-Inflammatory Agents; Arytenoid Cartilage; Cricoid Cartilage; Cyclosporine; Drug Therapy, | 2005 |
4 other studies available for leflunomide and Rheumatoid Nodule
| Article | Year |
|---|---|
Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Immuno | 2002 |
[Development and/or increase of rheumatoid nodules in RA patients following leflunomide therapy].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; D | 2004 |
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Lung Diseases; M | 2006 |
Intrapulmonary rheumatoid nodules in a patient with long-standing rheumatoid arthritis treated with leflunomide.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Female; Humans; Isoxazoles; Leflunomide; Lung Disease | 2008 |