Page last updated: 2024-10-30

leflunomide and Reperfusion Injury

leflunomide has been researched along with Reperfusion Injury in 5 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
"Leflunomide is an isoxazole derivative, and a unique immunomodulatory agent."5.33Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. ( Fadillioglu, E; Karaman, A; Tas, E; Turkmen, E; Yilmaz, Z, 2006)
"Leflunomide treatment increased regulatory T cells (Tregs; forkhead box P3+) and IL-10-positive cells but reduced IL-17- and IL-23-expressing cells in both the peripheral blood and kidney cells, indicative of down-regulation of inflammatory responses."1.38Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of Tregs and stem cells. ( Baban, B; Liu, JY; Mozaffari, MS, 2012)
"Leflunomide is an isoxazole derivative, and a unique immunomodulatory agent."1.33Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver. ( Fadillioglu, E; Karaman, A; Tas, E; Turkmen, E; Yilmaz, Z, 2006)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yildiz, Y1
Kose, H1
Cecen, S1
Ergin, K1
Demir, EM1
Serter, M1
Bloudícková, S1
Rajnoch, J1
Lodererová, A1
Honsová, E1
Viklický, O1
Baban, B1
Liu, JY1
Mozaffari, MS1
Karaman, A2
Fadillioglu, E2
Turkmen, E2
Tas, E2
Yilmaz, Z1
Gursul, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Mechanistic Studies of Teriflunomide in Relapsing Remitting Multiple Sclerosis: Regulatory B Lymphocytes as Central Mediators of the Therapeutic Effects of Teriflunomide in MS[NCT03464448]30 participants (Actual)Observational2018-04-17Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for leflunomide and Reperfusion Injury

ArticleYear
Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion.
    Digestive diseases and sciences, 2010, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catalase; Disease Models, Animal; Dose-Response Re

2010
Leflunomide derivate FK 778 in accelerated renal injury in transgenic rat.
    Folia biologica, 2010, Volume: 56, Issue:2

    Topics: Alkynes; Animals; Blood Pressure; Disease Models, Animal; Immunosuppressive Agents; Isoxazoles; Kidn

2010
Aryl hydrocarbon receptor agonist, leflunomide, protects the ischemic-reperfused kidney: role of Tregs and stem cells.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Volume: 303, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Gene Expression Regulation; Inflammatio

2012
Protective effects of leflunomide against ischemia-reperfusion injury of the rat liver.
    Pediatric surgery international, 2006, Volume: 22, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Female; Hepatocytes; Isoxazoles; Lef

2006
Prevention of renal ischemia/reperfusion-induced injury in rats by leflunomide.
    International journal of urology : official journal of the Japanese Urological Association, 2006, Volume: 13, Issue:11

    Topics: Animals; Antioxidants; Aspartate Aminotransferases; Blood Urea Nitrogen; Catalase; Creatinine; Femal

2006