leflunomide has been researched along with Premature Birth in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Maternal exposure to leflunomide during pregnancy was not associated with statistically significant increased risk of MCMs, prematurity, LBW or spontaneous abortions." | 7.88 | Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes. ( Bérard, A; Colilla, S; Shui, I; Zhao, JP, 2018) |
| "Maternal exposure to leflunomide during pregnancy was not associated with statistically significant increased risk of MCMs, prematurity, LBW or spontaneous abortions." | 3.88 | Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes. ( Bérard, A; Colilla, S; Shui, I; Zhao, JP, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hammad, I | 1 |
| Porter, TF | 1 |
| Bérard, A | 1 |
| Zhao, JP | 1 |
| Shui, I | 1 |
| Colilla, S | 1 |
1 review available for leflunomide and Premature Birth
| Article | Year |
|---|---|
An Update on Biologic Agents During Pregnancy.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humani | 2020 |
1 other study available for leflunomide and Premature Birth
| Article | Year |
|---|---|
Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antirheumatic Agents; Female; Humans; Inf | 2018 |