leflunomide has been researched along with Pre-Eclampsia in 2 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Mycophenolate and leflunomide are teratogenic drugs and should be withdrawn before conception in case of programmed pregnancy or should be rapidly discontinued in case of unexpected pregnancy." | 4.91 | Immunosuppression in pregnant women with systemic lupus erythematosus. ( Moroni, G; Ponticelli, C, 2015) |
| "Leflunomide is a drug used in rheumatoid arthritis with teratogenic and fetotoxic effects." | 1.35 | A pair of twins born after maternal exposure to leflunomide. ( Heine, K; Poets, CF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ponticelli, C | 1 |
| Moroni, G | 1 |
| Heine, K | 1 |
| Poets, CF | 1 |
1 review available for leflunomide and Pre-Eclampsia
| Article | Year |
|---|---|
Immunosuppression in pregnant women with systemic lupus erythematosus.
Topics: Contraindications; Cyclosporine; Female; Glucocorticoids; Humans; Hypertension; Immunosuppression Th | 2015 |
1 other study available for leflunomide and Pre-Eclampsia
| Article | Year |
|---|---|
A pair of twins born after maternal exposure to leflunomide.
Topics: Adult; Antirheumatic Agents; Female; Fetal Growth Retardation; Humans; Infant, Newborn; Isoxazoles; | 2008 |