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leflunomide and Postoperative Complications

leflunomide has been researched along with Postoperative Complications in 10 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Research Excerpts

ExcerptRelevanceReference
" We describe a case of a cytomegalovirus (CMV)-seronegative kidney transplant recipient from a CMV-seropositive donor, whose course was complicated during valganciclovir prophylaxis by CMV disease, ultimately progressing to ganciclovir, foscarnet, and cidofovir resistance."7.85Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report. ( Agrawal, N; Beltran, D; Echenique, IA; Najafian, N; Ramirez-Ruiz, L, 2017)
"Leflunomide was selected as a last resort to avoid the nephrotoxicity of cidofovir."5.34Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. ( Abdelhalim, A; Almyroudis, NG; Battiwalla, M; Becker, J; Elefante, A; McCarthy, A; McCarthy, PL; Paplham, P; Segal, BH; Smith, P, 2007)
" We describe a case of a cytomegalovirus (CMV)-seronegative kidney transplant recipient from a CMV-seropositive donor, whose course was complicated during valganciclovir prophylaxis by CMV disease, ultimately progressing to ganciclovir, foscarnet, and cidofovir resistance."3.85Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report. ( Agrawal, N; Beltran, D; Echenique, IA; Najafian, N; Ramirez-Ruiz, L, 2017)
"Leflunomide treatment for CMV disease in renal transplant recipients is effective, simple, and economical."2.71A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients. ( Balakrishnan, N; Chandy, S; Chandy, SJ; Fleming, DH; Jacob, CK; John, GT; Kirubakaran, MG; Krishnamurthy, K; Manivannan, J; Peter, S, 2005)
" The dosage and time of therapy need to be explored in the future; additional studies of large samples are needed."1.42BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. ( Chen, JS; Cheng, DR; Ji, SM; Li, X; Liu, ZH; Wen, JQ; Wu, D; Xie, KN; Zhang, MC, 2015)
"Leflunomide was selected as a last resort to avoid the nephrotoxicity of cidofovir."1.34Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. ( Abdelhalim, A; Almyroudis, NG; Battiwalla, M; Becker, J; Elefante, A; McCarthy, A; McCarthy, PL; Paplham, P; Segal, BH; Smith, P, 2007)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's5 (50.00)29.6817
2010's4 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Echenique, IA1
Beltran, D1
Ramirez-Ruiz, L1
Najafian, N1
Agrawal, N1
Velázquez Benito, A1
Bellosta Diago, E1
Santos Lasaosa, S1
Pascual Millán, LF1
Wu, D1
Zhang, MC1
Chen, JS1
Li, X1
Cheng, DR1
Xie, KN1
Ji, SM1
Liu, ZH1
Wen, JQ1
Jung, YH1
Moon, KC1
Ha, JW1
Kim, SJ1
Ha, IS1
Cheong, HI1
Kang, HG1
John, GT1
Manivannan, J1
Chandy, S1
Peter, S1
Fleming, DH1
Chandy, SJ1
Balakrishnan, N1
Krishnamurthy, K1
Kirubakaran, MG1
Jacob, CK1
Josephson, MA1
Javaid, B1
Kadambi, PV1
Meehan, SM1
Williams, JW1
Fuerst, M1
Möhl, H1
Baumgärtel, K1
Rüther, W1
Duclos, AJ1
Krishnamurthi, V1
Lard, M1
Poggio, E1
Kleeman, M1
Winans, C1
Fatica, R1
Nurko, S1
Battiwalla, M1
Paplham, P1
Almyroudis, NG1
McCarthy, A1
Abdelhalim, A1
Elefante, A1
Smith, P1
Becker, J1
McCarthy, PL1
Segal, BH1
Gregory, CR1

Reviews

3 reviews available for leflunomide and Postoperative Complications

ArticleYear
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation.
    Pediatric transplantation, 2013, Volume: 17, Issue:2

    Topics: Antiviral Agents; BK Virus; Child; Female; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantati

2013
Leflunomide in solid organ transplantation and polyoma virus infection.
    Advances in experimental medicine and biology, 2006, Volume: 577

    Topics: Antiviral Agents; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Organ Transplantation;

2006
Immunosuppressive approaches to the prevention of graft vascular disease.
    Transplantation proceedings, 1998, Volume: 30, Issue:3

    Topics: Coronary Disease; Cyclosporine; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase I

1998

Trials

1 trial available for leflunomide and Postoperative Complications

ArticleYear
A prospective evaluation of leflunomide therapy for cytomegalovirus disease in renal transplant recipients.
    Transplantation proceedings, 2005, Volume: 37, Issue:10

    Topics: Adult; Antiviral Agents; Cytomegalovirus Infections; Female; Humans; Isoxazoles; Kidney Transplantat

2005

Other Studies

6 other studies available for leflunomide and Postoperative Complications

ArticleYear
Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report.
    Transplantation proceedings, 2017, Volume: 49, Issue:7

    Topics: Aged; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Dose-Respo

2017
[Acute sensory-motor axonal neuropathy (Guillain-Barre syndrome) following vertebroplasty].
    Medicina clinica, 2014, Sep-15, Volume: 143, Issue:6

    Topics: Accidental Falls; Arthritis, Rheumatoid; Female; Guillain-Barre Syndrome; Humans; Immunocompromised

2014
BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen.
    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2015, Volume: 13, Issue:6

    Topics: Adult; Antineoplastic Agents; BK Virus; Bortezomib; Female; Humans; Isoxazoles; Kidney Diseases; Kid

2015
Leflunomide increases the risk of early healing complications in patients with rheumatoid arthritis undergoing elective orthopedic surgery.
    Rheumatology international, 2006, Volume: 26, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Combined Modality Thera

2006
Prevalence and clinical course of BK virus nephropathy in pancreas after kidney transplant patients.
    Transplantation proceedings, 2006, Volume: 38, Issue:10

    Topics: Antiviral Agents; BK Virus; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Isoxazoles

2006
Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation.
    Transplant infectious disease : an official journal of the Transplantation Society, 2007, Volume: 9, Issue:1

    Topics: Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Therapy, Co

2007