leflunomide has been researched along with Polyomavirus Infections in 50 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Polyomavirus Infections: Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation." | 7.80 | Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study. ( Chao, YH; Peng, CT; Sheu, JN; Weng, T; Wu, HP; Wu, KH, 2014) |
| "Leflunomide is an immunosuppressive drug with antiviral activity and has been used in treating BKV-associated nephropathy after renal transplantation." | 5.39 | Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. ( Chen, XC; He, C; Huang, R; Li, JJ; Liu, T; Meng, WT, 2013) |
| "Treatment with leflunomide seemed to be associated with a new toxicity, hemolysis, seen in four of the 27 patients so treated." | 5.35 | Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. ( Davis, CL; de Boer, IH; Jefferson, JA; Kendrick, EA; Kowalewska, J; Leca, N; Muczynski, KA; Pichler, R, 2008) |
| " Patients with significant viremia and/or biopsy-proven BKPVAN were treated with immunosuppression reduction and leflunomide." | 3.85 | Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy. ( Bodson-Clermont, P; Cardinal, H; Fortin, MC; Girardin, C; Hébert, MJ; Lévesque, R; Pâquet, MR; Renoult, E; Simard-Meilleur, MC; St-Louis, G, 2017) |
| "This analysis demonstrates for the first time that, used in a stepwise fashion, ciprofloxacin and leflunomide are effective and safe treatments for BK viremia in PRTR." | 3.80 | A novel treatment regimen for BK viremia. ( Cheam, H; Ettenger, RB; Malekzadeh, MH; Tsai, EW; Zaman, RA, 2014) |
| "Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation." | 3.80 | Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study. ( Chao, YH; Peng, CT; Sheu, JN; Weng, T; Wu, HP; Wu, KH, 2014) |
| "Leflunomide has shown promising results in BKVAN." | 2.66 | Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review. ( Dräger, DL; Hakenberg, OW; Kranz, J; Neumann, T; Schneidewind, L, 2020) |
| "Leflunomide is an immunosuppressive drug with in vitro and initial observational evidence of antiviral activity against BK virus (BKV), a pathogen that causes opportunistic infection upon reactivation in renal transplant recipients." | 2.55 | Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature. ( Ensom, MHH; Leung, M; Ng, JCY; Wright, AJ, 2017) |
| "Leflunomide has been used off-label in renal transplantation because of the attractive combination of antiviral and immunosuppressive effects." | 2.45 | Leflunomide use in renal transplantation. ( Leca, N, 2009) |
| "BK viremia and nephritis are increasing problems in renal transplant recipients." | 2.43 | BK virus nephritis after renal transplantation. ( Hariharan, S, 2006) |
| "Treatment with leflunomide was continued until BK virus was undetectable by polymerase chain reaction in at least 2 blood samples 2 weeks apart." | 1.91 | Effect of Leflunomide on Treatment of Pediatric Renal Transplant Recipients With BK Virus Infection. ( Askiti, V; Darema, M; Gole, E; Malakasioti, G; Mitsioni, A, 2023) |
| "Leflunomide has both antiviral and immunosuppressive effects, and clinical research has demonstrated its clinical efficacy against BKVN." | 1.56 | Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series. ( Shirai, H; Tojimbara, T; Yamazaki, T, 2020) |
| "Treatment with leflunomide was started after a mean of 1." | 1.51 | Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study. ( Bouvier, N; Caillard, S; Conrad, A; Duquennoy, S; Fafi-Kremer, S; Hurault De Ligny, B; Keller, N; Morelon, E; Moulin, B, 2019) |
| " The dosage of mycophenolate sodium was tapered from 720 to 360 mg daily and that of everolimus increased from 0." | 1.51 | Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report. ( Chen, HA; Chen, YW; Hsu, YH; Hung, LY; Lee, CH; Wu, MS; Wu, MY, 2019) |
| " The dosage and time of therapy need to be explored in the future; additional studies of large samples are needed." | 1.42 | BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen. ( Chen, JS; Cheng, DR; Ji, SM; Li, X; Liu, ZH; Wen, JQ; Wu, D; Xie, KN; Zhang, MC, 2015) |
| "Leflunomide is an immunosuppressive drug with antiviral activity and has been used in treating BKV-associated nephropathy after renal transplantation." | 1.39 | Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. ( Chen, XC; He, C; Huang, R; Li, JJ; Liu, T; Meng, WT, 2013) |
| "Treatment with leflunomide reduced serum viral titres and stabilized renal function." | 1.38 | Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia. ( Gray, M; Leonard, N; McCrory, R; Smyth, J; Woodman, A, 2012) |
| "Leflunomide has been studied for the treatment of BK viremia and nephropathy, but there are limited data on the utility of leflunomide therapeutic drug monitoring." | 1.38 | Leflunomide efficacy and pharmacodynamics for the treatment of BK viral infection. ( Baliga, P; Bratton, C; Chavin, K; Krisl, JC; McGillicuddy, J; Pilch, N; Taber, DJ; Thomas, B, 2012) |
| "Treatment with leflunomide seemed to be associated with a new toxicity, hemolysis, seen in four of the 27 patients so treated." | 1.35 | Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. ( Davis, CL; de Boer, IH; Jefferson, JA; Kendrick, EA; Kowalewska, J; Leca, N; Muczynski, KA; Pichler, R, 2008) |
| "Leflunomide is an immune suppressive drug with anti viral activity in vitro and in animals." | 1.33 | Treatment of renal allograft polyoma BK virus infection with leflunomide. ( Atwood, W; Foster, P; Garfinkel, M; Gillen, D; Harland, R; Javaid, B; Jordan, J; Josephson, MA; Kadambi, P; Meehan, S; Millis, MJ; Sadhu, M; Thistlethwaite, RJ; Williams, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (32.00) | 29.6817 |
| 2010's | 27 (54.00) | 24.3611 |
| 2020's | 7 (14.00) | 2.80 |
| Authors | Studies |
|---|---|
| Favi, E | 1 |
| Signorini, L | 1 |
| Villani, S | 1 |
| Dolci, M | 1 |
| Ticozzi, R | 1 |
| Basile, G | 1 |
| Ferrante, P | 1 |
| Ferraresso, M | 1 |
| Delbue, S | 1 |
| Kurašová, E | 1 |
| Štěpán, J | 1 |
| Krejčí, K | 1 |
| Mrázek, F | 1 |
| Sauer, P | 1 |
| Janečková, J | 1 |
| Tichý, T | 1 |
| Rasaei, N | 1 |
| Malekmakan, L | 1 |
| Gholamabbas, G | 1 |
| Abdizadeh, P | 1 |
| Gole, E | 1 |
| Mitsioni, A | 1 |
| Darema, M | 1 |
| Malakasioti, G | 1 |
| Askiti, V | 1 |
| Alfano, G | 1 |
| Fontana, F | 1 |
| Guaraldi, G | 1 |
| Cappelli, G | 1 |
| Mussini, C | 1 |
| Schneidewind, L | 1 |
| Neumann, T | 1 |
| Dräger, DL | 1 |
| Kranz, J | 1 |
| Hakenberg, OW | 1 |
| Yamazaki, T | 1 |
| Shirai, H | 1 |
| Tojimbara, T | 1 |
| Kassar, R | 1 |
| Chang, J | 1 |
| Chan, AW | 1 |
| Lilly, LB | 1 |
| Al Habeeb, A | 1 |
| Rotstein, C | 1 |
| Keller, N | 1 |
| Duquennoy, S | 1 |
| Conrad, A | 1 |
| Fafi-Kremer, S | 1 |
| Morelon, E | 1 |
| Bouvier, N | 1 |
| Moulin, B | 1 |
| Hurault De Ligny, B | 1 |
| Caillard, S | 1 |
| Wu, MY | 1 |
| Chen, YW | 1 |
| Hung, LY | 1 |
| Lee, CH | 1 |
| Chen, HA | 1 |
| Hsu, YH | 1 |
| Wu, MS | 1 |
| Chen, XC | 1 |
| Liu, T | 1 |
| Li, JJ | 1 |
| He, C | 1 |
| Meng, WT | 1 |
| Huang, R | 1 |
| Kuppachi, S | 1 |
| Thomas, B | 2 |
| Kokko, KE | 1 |
| Hüttemann, M | 1 |
| Shipkova, M | 1 |
| Klett, C | 1 |
| Hasche, G | 1 |
| Wilhelm, J | 1 |
| Bolley, R | 1 |
| Olbricht, C | 1 |
| Wieland, E | 1 |
| Mutlu, D | 1 |
| Sağlık, I | 1 |
| Koyun, M | 1 |
| Comak, E | 1 |
| Mutlu, E | 1 |
| Uslu Gökçeoğlu, A | 1 |
| Cağla Doğan, S | 1 |
| Dinçkan, A | 1 |
| Akbaş, SH | 1 |
| Akkaya, B | 1 |
| Akman, S | 1 |
| Süleymanlar, G | 1 |
| Colak, D | 1 |
| Zaman, RA | 1 |
| Ettenger, RB | 1 |
| Cheam, H | 1 |
| Malekzadeh, MH | 1 |
| Tsai, EW | 1 |
| Wu, KH | 1 |
| Weng, T | 1 |
| Wu, HP | 1 |
| Peng, CT | 1 |
| Sheu, JN | 1 |
| Chao, YH | 1 |
| Halim, MA | 1 |
| Al-Otaibi, T | 1 |
| Gheith, O | 1 |
| Zkaria, Z | 1 |
| Mosaad, A | 1 |
| Said, T | 1 |
| Nair, P | 1 |
| Nampoory, N | 1 |
| Verhoeven, Y | 1 |
| Kemperman, H | 1 |
| Abrahams, AC | 1 |
| Wu, D | 1 |
| Zhang, MC | 1 |
| Chen, JS | 1 |
| Li, X | 1 |
| Cheng, DR | 1 |
| Xie, KN | 1 |
| Ji, SM | 1 |
| Liu, ZH | 1 |
| Wen, JQ | 1 |
| Gagneux-Brunon, A | 1 |
| Pillet, S | 1 |
| Laurent, B | 1 |
| Mariat, C | 1 |
| Michalet, M | 1 |
| Lucht, F | 1 |
| Botelho-Nevers, E | 1 |
| Lamarche, C | 1 |
| Boucher, A | 1 |
| Dandavino, R | 1 |
| Senécal, L | 1 |
| Collette, S | 1 |
| Tran, D | 1 |
| Vallée, M | 1 |
| Yang, D | 1 |
| Keys, B | 1 |
| J Conti, D | 1 |
| Foulke, L | 1 |
| Stellrecht, K | 1 |
| Cook, L | 1 |
| Lopez-Soler, RI | 1 |
| Simard-Meilleur, MC | 1 |
| Bodson-Clermont, P | 1 |
| St-Louis, G | 1 |
| Pâquet, MR | 1 |
| Girardin, C | 1 |
| Fortin, MC | 1 |
| Cardinal, H | 1 |
| Hébert, MJ | 1 |
| Lévesque, R | 1 |
| Renoult, E | 1 |
| Ng, JCY | 1 |
| Leung, M | 1 |
| Wright, AJ | 1 |
| Ensom, MHH | 1 |
| Jaw, J | 1 |
| Hill, P | 1 |
| Goodman, D | 1 |
| Mazzucco, G | 1 |
| Costa, C | 1 |
| Bergallo, M | 1 |
| Segoloni, GP | 1 |
| Monga, G | 1 |
| Wu, JK | 1 |
| Harris, MT | 1 |
| Lu, MC | 1 |
| Yu, CL | 1 |
| Yin, WY | 1 |
| Tung, CH | 1 |
| Huang, KY | 1 |
| Liu, SQ | 1 |
| Lai, NS | 1 |
| Araya, CE | 2 |
| Garin, EH | 1 |
| Neiberger, RE | 1 |
| Dharnidharka, VR | 2 |
| Canivet, C | 1 |
| Rostaing, L | 2 |
| Galvani, S | 1 |
| Böhler, T | 1 |
| Gandia, P | 1 |
| Mengelle, C | 2 |
| Guilbeau-Frugier, C | 2 |
| Thomsen, M | 1 |
| Salvayre, R | 1 |
| Negre-Salvayre, A | 1 |
| Kamar, N | 2 |
| Leca, N | 2 |
| Egli, A | 2 |
| Köhli, S | 1 |
| Dickenmann, M | 1 |
| Hirsch, HH | 3 |
| Sobhani, K | 1 |
| Garrett, DA | 1 |
| Liu, DP | 1 |
| Rainey, PM | 1 |
| Helmersen, DS | 1 |
| Taub, K | 1 |
| Johnson, A | 1 |
| Liacini, A | 1 |
| Seamone, ME | 1 |
| Muruve, DA | 1 |
| Tibbles, LA | 1 |
| Abdulnour, HA | 1 |
| Dheir, H | 1 |
| Sahin, S | 1 |
| Uyar, M | 1 |
| Gurkan, A | 1 |
| Turunc, V | 1 |
| Kacar, S | 1 |
| Bayirli Turan, D | 1 |
| Basdemir, G | 1 |
| McCrory, R | 1 |
| Gray, M | 1 |
| Leonard, N | 1 |
| Smyth, J | 1 |
| Woodman, A | 1 |
| Krisl, JC | 1 |
| Taber, DJ | 1 |
| Pilch, N | 1 |
| Chavin, K | 1 |
| Bratton, C | 1 |
| McGillicuddy, J | 1 |
| Baliga, P | 1 |
| Jung, YH | 1 |
| Moon, KC | 1 |
| Ha, JW | 1 |
| Kim, SJ | 1 |
| Ha, IS | 1 |
| Cheong, HI | 1 |
| Kang, HG | 1 |
| Williams, JW | 2 |
| Javaid, B | 2 |
| Kadambi, PV | 1 |
| Gillen, D | 2 |
| Harland, R | 2 |
| Thistlewaite, JR | 1 |
| Garfinkel, M | 2 |
| Foster, P | 2 |
| Atwood, W | 2 |
| Millis, JM | 1 |
| Meehan, SM | 1 |
| Josephson, MA | 3 |
| Hariharan, S | 1 |
| Kadambi, P | 1 |
| Meehan, S | 1 |
| Thistlethwaite, RJ | 1 |
| Jordan, J | 1 |
| Sadhu, M | 1 |
| Millis, MJ | 1 |
| Williams, J | 1 |
| Teschner, S | 1 |
| Geyer, M | 1 |
| Wilpert, J | 1 |
| Schwertfeger, E | 1 |
| Schenk, T | 1 |
| Walz, G | 1 |
| Donauer, J | 1 |
| Chandraker, A | 1 |
| Randhawa, PS | 1 |
| Duclos, AJ | 1 |
| Krishnamurthi, V | 1 |
| Lard, M | 1 |
| Poggio, E | 1 |
| Kleeman, M | 1 |
| Winans, C | 1 |
| Fatica, R | 1 |
| Nurko, S | 1 |
| Faguer, S | 1 |
| Ribes, D | 1 |
| Guitard, J | 1 |
| Esposito, L | 1 |
| Cointault, O | 1 |
| Modesto, A | 1 |
| Lavit, M | 1 |
| Muczynski, KA | 1 |
| Jefferson, JA | 1 |
| de Boer, IH | 1 |
| Kowalewska, J | 1 |
| Kendrick, EA | 1 |
| Pichler, R | 1 |
| Davis, CL | 1 |
| Mannon, RB | 1 |
| Ott, U | 1 |
| Steiner, T | 1 |
| Busch, M | 1 |
| Gerth, J | 1 |
| Wolf, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BK Viremia and BK Virus Nephropathy Post Kidney Transplant Comparison of New Practices With Traditional Approach: A Combined Retrospective Chart Review and Prospective Observational Study[NCT02758288] | 0 participants (Actual) | Observational | 2015-09-30 | Withdrawn | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for leflunomide and Polyomavirus Infections
| Article | Year |
|---|---|
Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review.
Topics: BK Virus; Humans; Kidney; Kidney Diseases; Leflunomide; Polyomavirus Infections; Tumor Virus Infecti | 2020 |
BK virus in the kidney transplant patient.
Topics: BK Virus; Graft Rejection; Humans; Immunosuppressive Agents; Isoxazoles; Kidney; Kidney Transplantat | 2013 |
JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.
Topics: Biopsy; BK Virus; Creatinine; Graft Rejection; Humans; Immunoglobulins, Intravenous; Immunosuppressi | 2017 |
Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature.
Topics: Animals; BK Virus; Clinical Decision-Making; Humans; Isoxazoles; Kidney Transplantation; Leflunomide | 2017 |
Use of leflunomide in the treatment of polyomavirus BK-associated nephropathy.
Topics: BK Virus; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomavirus Inf | 2008 |
Leflunomide use in renal transplantation.
Topics: Animals; Antiviral Agents; BK Virus; Graft Survival; Humans; Immunosuppressive Agents; Isoxazoles; K | 2009 |
The BK virus in renal transplant recipients-review of pathogenesis, diagnosis, and treatment.
Topics: Antiviral Agents; BK Virus; Child; Cidofovir; Cytosine; Humans; Immunosuppressive Agents; Isoxazoles | 2011 |
Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation.
Topics: Antiviral Agents; BK Virus; Child; Female; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantati | 2013 |
BK virus nephritis after renal transplantation.
Topics: Antibodies, Viral; Antiviral Agents; BK Virus; Cidofovir; Cytosine; DNA, Viral; Graft Survival; Huma | 2006 |
Polyomavirus-associated nephropathy: update on antiviral strategies.
Topics: Animals; Antiviral Agents; Cidofovir; Cytosine; Humans; Isoxazoles; Kidney Diseases; Kidney Transpla | 2006 |
1 trial available for leflunomide and Polyomavirus Infections
| Article | Year |
|---|---|
Comparative Study of Intravenous Immunoglobulin and Leflunomide Combination Therapy With Intravenous Immunoglobulin Single Therapy in Kidney Transplant Patients With BK Virus Infection: Single-Center Clinical Trial.
Topics: Antiviral Agents; BK Virus; Humans; Immunoglobulins, Intravenous; Immunosuppressive Agents; Kidney T | 2023 |
39 other studies available for leflunomide and Polyomavirus Infections
| Article | Year |
|---|---|
In Vitro Study Evaluating the Effect of Different Immunosuppressive Agents on Human Polyomavirus BK Replication.
Topics: Antiviral Agents; BK Virus; Everolimus; Humans; Immunosuppressive Agents; Kidney Transplantation; Le | 2022 |
Current Status, Prevention and Treatment of BK Virus Nephropathy.
Topics: BK Virus; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Transplantation; Leflunomide; Po | 2022 |
Effect of Leflunomide on Treatment of Pediatric Renal Transplant Recipients With BK Virus Infection.
Topics: BK Virus; Child; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Leflunomide; Poly | 2023 |
Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient.
Topics: AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; BK Virus; CD4 Lymphocy | 2020 |
Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series.
Topics: Antiviral Agents; BK Virus; Everolimus; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Tr | 2020 |
Leflunomide for the treatment of trichodysplasia spinulosa in a liver transplant recipient.
Topics: Adrenal Cortex Hormones; Adult; Cyclosporine; Diagnosis, Differential; Hair Diseases; Hair Follicle; | 2017 |
Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study.
Topics: Adult; Aged; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Diseases; Kid | 2019 |
Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report.
Topics: BK Virus; Everolimus; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Kidney Trans | 2019 |
Efficacy and safety of leflunomide for the treatment of BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients.
Topics: Adult; BK Virus; Cystitis; Enzyme Inhibitors; Female; Hematopoietic Stem Cell Transplantation; Hemor | 2013 |
Total and free plasma concentrations of the active metabolite of leflunomide in relation to therapeutic outcome in kidney transplant recipients with BK-virus nephropathy.
Topics: Adult; Aged; Antiviral Agents; BK Virus; Female; Glomerular Filtration Rate; Humans; Isoxazoles; Kid | 2013 |
[BK virus infections in pediatric kidney transplant recipients].
Topics: Adolescent; Antiviral Agents; BK Virus; Child; Cidofovir; Cytosine; DNA, Viral; Female; Graft Reject | 2013 |
A novel treatment regimen for BK viremia.
Topics: Adolescent; BK Virus; Child; Ciprofloxacin; Female; Fluoroquinolones; Glomerular Filtration Rate; Hu | 2014 |
Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: a pilot study.
Topics: Adolescent; BK Virus; Child; Cystitis; Female; Hematopoietic Stem Cell Transplantation; Hematuria; H | 2014 |
Active management versus minimization of immunosuppressives of BK virus-associated nephropathy after a kidney transplant.
Topics: Adult; Antiviral Agents; Biopsy; BK Virus; Ciprofloxacin; Drug Substitution; Drug Therapy, Combinati | 2014 |
Falsely decreased ionized calcium levels in kidney transplant recipients with polyomavirus-associated nephropathy treated with leflunomide.
Topics: Aged; Antiviral Agents; Biomarkers; BK Virus; Calcium; Female; Humans; Immunocompromised Host; Isoxa | 2015 |
BK Virus-Associated Nephropathy with Plasma Cell-Rich Infiltrates Treated by Bortezomib-Based Regimen.
Topics: Adult; Antineoplastic Agents; BK Virus; Bortezomib; Female; Humans; Isoxazoles; Kidney Diseases; Kid | 2015 |
A case of BK virus nephropathy in a stem cell transplant recipient: a rare or under-recognized cause for Acute Kidney injury.
Topics: Acute Kidney Injury; Anti-Bacterial Agents; BK Virus; Ciprofloxacin; Cord Blood Stem Cell Transplant | 2015 |
Treatment of Polyomavirus-Associated Nephropathy With the Association of Sirolimus and Leflunomide.
Topics: Antiviral Agents; Humans; Isoxazoles; Kidney Diseases; Kidney Transplantation; Leflunomide; Polyomav | 2015 |
Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy.
Topics: Adult; Allografts; Antiviral Agents; Biopsy; BK Virus; DNA, Viral; Female; Follow-Up Studies; Glomer | 2017 |
Combination of Leflunomide and Everolimus for treatment of BK virus nephropathy.
Topics: Aged; BK Virus; Drug Substitution; Drug Therapy, Combination; Everolimus; Female; Graft Rejection; G | 2017 |
Severe crescentic BK virus nephropathy with favourable outcome in a transplanted patient treated with Leflunomide.
Topics: Adult; Antiviral Agents; BK Virus; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Glomerulus; | 2008 |
Increased prevalence of polyomavirus BK viruria that correlates with thrombocytopenia in patients with systemic lupus erythematosus on intensive immunosuppressive therapy.
Topics: Adult; Antiviral Agents; BK Virus; Female; Humans; Immunosuppression Therapy; Isoxazoles; Leflunomid | 2009 |
Leflunomide therapy for BK virus allograft nephropathy in pediatric and young adult kidney transplant recipients.
Topics: Antiviral Agents; BK Virus; Child; DNA, Viral; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2010 |
Polyoma BK virus-associated nephropathy in kidney-transplant patients: Effects of leflunomide on T-cell functions and disease outcome.
Topics: Adult; Aged; Antigens, CD; BK Virus; Cell Proliferation; Disease Progression; Female; Follow-Up Stud | 2009 |
Inhibition of polyomavirus BK-specific T-Cell responses by immunosuppressive drugs.
Topics: Adult; Aged; BK Virus; Cyclosporine; Female; Humans; Immunosuppressive Agents; Interferon-gamma; Iso | 2009 |
A rapid and simple high-performance liquid chromatography assay for the leflunomide metabolite, teriflunomide (A77 1726), in renal transplant recipients.
Topics: BK Virus; Chromatography, High Pressure Liquid; Crotonates; Drug Monitoring; Humans; Hydroxybutyrate | 2010 |
Renal failure five years after lung transplantation due to polyomavirus BK-associated nephropathy.
Topics: Adult; Aged; Cidofovir; Cytosine; Female; Humans; Isoxazoles; Kidney Diseases; Leflunomide; Lung Tra | 2010 |
Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection.
Topics: Antigens, Viral; Antigens, Viral, Tumor; Antiviral Agents; BK Virus; Cell Line; Drug Therapy, Combin | 2010 |
Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance.
Topics: Adult; Antiviral Agents; Cidofovir; Cytosine; Female; Graft Rejection; Graft Survival; Humans; Immun | 2011 |
Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia.
Topics: Aged; BK Virus; DNA, Viral; Humans; Immunosuppressive Agents; Isoxazoles; Kidney Diseases; Leflunomi | 2012 |
Leflunomide efficacy and pharmacodynamics for the treatment of BK viral infection.
Topics: Adult; Aniline Compounds; Antiviral Agents; Biotransformation; BK Virus; Chi-Square Distribution; Cr | 2012 |
Leflunomide for polyomavirus type BK nephropathy.
Topics: Aniline Compounds; Antiviral Agents; BK Virus; Crotonates; Humans; Hydroxybutyrates; Isoxazoles; Kid | 2005 |
Treatment of renal allograft polyoma BK virus infection with leflunomide.
Topics: Aniline Compounds; BK Virus; Blood; Cells, Cultured; Creatinine; Crotonates; Female; Humans; Hydroxy | 2006 |
Remission of polyomavirus-induced graft nephropathy treated with low-dose leflunomide.
Topics: Adult; Antiviral Agents; Humans; Immunoglobulins; Immunosuppressive Agents; Isoxazoles; Kidney Disea | 2006 |
Prevalence and clinical course of BK virus nephropathy in pancreas after kidney transplant patients.
Topics: Antiviral Agents; BK Virus; Drug Therapy, Combination; Humans; Immunosuppression Therapy; Isoxazoles | 2006 |
Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation.
Topics: Adult; Antiviral Agents; BK Virus; Female; Humans; Immunosuppression Therapy; Isoxazoles; Kidney Dis | 2007 |
Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients.
Topics: Adult; Aged; Antiviral Agents; BK Virus; Dose-Response Relationship, Drug; Female; Graft Rejection; | 2008 |
Leflunomide therapy in kidney transplantation: ready for prime time?
Topics: Antiviral Agents; BK Virus; Dose-Response Relationship, Drug; Graft Rejection; Hemolysis; Humans; Im | 2008 |
A single-center experience with BK virus nephropathy.
Topics: Adult; Aged; Antiviral Agents; BK Virus; Cidofovir; Cytosine; Female; Graft Survival; Humans; Immuno | 2008 |