leflunomide has been researched along with Polymyalgia Rheumatica in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Polymyalgia Rheumatica: A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A man (age: 76 years) on prednisone and leflunomide for polymyalgia rheumatica developed spontaneous severe haematomas." | 3.76 | [Rituximab in the treatment of acquired haemophilia A in a patient with polymyalgia rheumatica]. ( Braunert, L; Bruegel, M; Niederwieser, D; Pfrepper, C; Thiery, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamantopoulos, AP | 1 |
| Hetland, H | 1 |
| Myklebust, G | 1 |
| Braunert, L | 1 |
| Bruegel, M | 1 |
| Pfrepper, C | 1 |
| Thiery, J | 1 |
| Niederwieser, D | 1 |
| Adizie, T | 1 |
| Christidis, D | 1 |
| Dharmapaliah, C | 1 |
| Borg, F | 1 |
| Dasgupta, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Randomized Placebo Controlled Treatment Study of Leflunomide in Polymyalgia Rheumatica[NCT03576794] | Phase 3 | 94 participants (Anticipated) | Interventional | 2019-03-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for leflunomide and Polymyalgia Rheumatica
| Article | Year |
|---|---|
Leflunomide as a corticosteroid-sparing agent in giant cell arteritis and polymyalgia rheumatica: a case series.
Topics: Adrenal Cortex Hormones; Aged; Female; Giant Cell Arteritis; Giant Cells; Humans; Isoxazoles; Leflun | 2013 |
[Rituximab in the treatment of acquired haemophilia A in a patient with polymyalgia rheumatica].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Murine-Derived; Cyclophospham | 2010 |
Efficacy and tolerability of leflunomide in difficult-to-treat polymyalgia rheumatica and giant cell arteritis: a case series.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Case-Control Studies; Female; Giant Cell Arteritis; H | 2012 |