leflunomide has been researched along with Pneumonia in 8 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Pneumonia: Infection of the lung often accompanied by inflammation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After adjustment for covariates, prednisone use increased the risk of pneumonia hospitalization (hazard ratio [HR] 1." | 7.73 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy. ( Caplan, L; Michaud, K; Wolfe, F, 2006) |
| "Leflunomide is a disease-modifying antirheumatic drug (DMARD) that has been available in Japan since August 2003." | 5.33 | Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. ( Hirabayashi, Y; Kobayashi, N; Kudo, K; Shimizu, H, 2006) |
| "After adjustment for covariates, prednisone use increased the risk of pneumonia hospitalization (hazard ratio [HR] 1." | 3.73 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy. ( Caplan, L; Michaud, K; Wolfe, F, 2006) |
| "Two patients had previous MTX-induced pneumonitis (MTX-P) prior to initiation of LEF; both died from LEIP." | 2.45 | Clinical expression of leflunomide-induced pneumonitis. ( Chikura, B; Dawson, JK; Lane, S, 2009) |
| "In nine of these 12 patients pneumonitis occurred after leflunomide was added to methotrexate, usually within 12-20 weeks." | 1.33 | Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports. ( Boyd, IW; Chapman, P; Highton, J; Savage, RL, 2006) |
| "Leflunomide is a disease-modifying antirheumatic drug (DMARD) that has been available in Japan since August 2003." | 1.33 | Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis. ( Hirabayashi, Y; Kobayashi, N; Kudo, K; Shimizu, H, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chikura, B | 1 |
| Lane, S | 1 |
| Dawson, JK | 1 |
| Nesheiwat, JP | 1 |
| Dillon, K | 1 |
| McGlothan, K | 1 |
| Zaman, M | 1 |
| Carbone, LD | 1 |
| Savage, RL | 2 |
| Klatt, JC | 1 |
| Gröbe, A | 1 |
| Schmelzle, R | 1 |
| Atac, A | 1 |
| Heiland, M | 1 |
| Blessmann, M | 1 |
| Pohlenz, P | 1 |
| Vallbracht, II | 1 |
| Popper, HH | 1 |
| Rieber, J | 1 |
| Nowak, F | 1 |
| Gallenberger, S | 1 |
| Piper, B | 1 |
| Helmke, K | 1 |
| Wolfe, F | 1 |
| Caplan, L | 1 |
| Michaud, K | 1 |
| Highton, J | 1 |
| Boyd, IW | 1 |
| Chapman, P | 1 |
| Hirabayashi, Y | 1 |
| Shimizu, H | 1 |
| Kobayashi, N | 1 |
| Kudo, K | 1 |
1 review available for leflunomide and Pneumonia
| Article | Year |
|---|---|
Clinical expression of leflunomide-induced pneumonitis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; | 2009 |
7 other studies available for leflunomide and Pneumonia
| Article | Year |
|---|---|
An elderly man with rheumatoid arthritis and dyspnea.
Topics: Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Isoxazoles; Leflunomide; Mal | 2009 |
Leflunomide in combination therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infection | 2010 |
A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation.
Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Transplantati | 2011 |
Lethal pneumonitis under leflunomide therapy.
Topics: Antirheumatic Agents; Fatal Outcome; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male | 2005 |
Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agen | 2006 |
Pneumonitis associated with leflunomide: a profile of New Zealand and Australian reports.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Australia; Cohort Studies; | 2006 |
Leflunomide-induced pneumonitis in a patient with rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Aged; Arthritis, Rheumatoid; Female; Humans; Isoxazoles; Leflunomide; Lung; | 2006 |