Page last updated: 2024-10-30

leflunomide and Plica Syndrome

leflunomide has been researched along with Plica Syndrome in 6 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Research Excerpts

ExcerptRelevanceReference
"Leflunomide and methotrexate have proven to be efficacious in reducing joint inflammation and slowing destruction in clinical trials of patients with rheumatoid arthritis (RA)."9.09Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine ( Barg, EC; Breedveld, FC; Emery, P; Farnell, J; Kraan, MC; Reece, RJ; Rosenburg, R; Smeets, TJ; Tak, PP; Veale, DJ, 2000)
"Leflunomide treatment was associated with a significantly greater improvement in IRE compared with methotrexate treatment (P < 0."6.70Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. ( Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ, 2002)
"Leflunomide and methotrexate have proven to be efficacious in reducing joint inflammation and slowing destruction in clinical trials of patients with rheumatoid arthritis (RA)."5.09Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine ( Barg, EC; Breedveld, FC; Emery, P; Farnell, J; Kraan, MC; Reece, RJ; Rosenburg, R; Smeets, TJ; Tak, PP; Veale, DJ, 2000)
"Leflunomide treatment was associated with a significantly greater improvement in IRE compared with methotrexate treatment (P < 0."2.70Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. ( Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ, 2002)
"Leflunomide is a drug used clinically in the treatment of rheumatoid arthritis."1.34Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. ( Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K, 2007)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Li, Z1
Liu, S1
Liu, Y1
Ma, M1
Li, L1
Li, C1
Harman, H1
Tekeoğlu, I1
Kaban, N1
Harman, S1
Davis, JM1
Matteson, EL1
Sawamukai, N1
Saito, K1
Yamaoka, K1
Nakayamada, S1
Ra, C1
Tanaka, Y1
Kraan, MC2
Reece, RJ2
Barg, EC1
Smeets, TJ1
Farnell, J1
Rosenburg, R1
Veale, DJ2
Breedveld, FC2
Emery, P2
Tak, PP2
Radjenovic, A1
O'Connor, PJ1
Ridgway, JP1
Gibbon, WW1

Reviews

1 review available for leflunomide and Plica Syndrome

ArticleYear
My treatment approach to rheumatoid arthritis.
    Mayo Clinic proceedings, 2012, Volume: 87, Issue:7

    Topics: Abatacept; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Muri

2012

Trials

2 trials available for leflunomide and Plica Syndrome

ArticleYear
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine
    Arthritis and rheumatism, 2000, Volume: 43, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind M

2000
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:2

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents;

2002

Other Studies

3 other studies available for leflunomide and Plica Syndrome

ArticleYear
Successful treatment of nail involvement using leflunomide in a patient with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome.
    The Australasian journal of dermatology, 2023, Volume: 64, Issue:1

    Topics: Acne Vulgaris; Humans; Hyperostosis; Leflunomide; Osteitis; Synovitis

2023
Factors influencing ultrasonographic remission in patients with rheumatoid arthritis.
    Rheumatology international, 2015, Volume: 35, Issue:3

    Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic A

2015
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Nov-15, Volume: 179, Issue:10

    Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease

2007
chemdatabank.com