leflunomide and Plica Syndrome
leflunomide has been researched along with Plica Syndrome in 6 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Leflunomide and methotrexate have proven to be efficacious in reducing joint inflammation and slowing destruction in clinical trials of patients with rheumatoid arthritis (RA)." | 9.09 | Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine ( Barg, EC; Breedveld, FC; Emery, P; Farnell, J; Kraan, MC; Reece, RJ; Rosenburg, R; Smeets, TJ; Tak, PP; Veale, DJ, 2000) |
"Leflunomide treatment was associated with a significantly greater improvement in IRE compared with methotrexate treatment (P < 0." | 6.70 | Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. ( Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ, 2002) |
"Leflunomide and methotrexate have proven to be efficacious in reducing joint inflammation and slowing destruction in clinical trials of patients with rheumatoid arthritis (RA)." | 5.09 | Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine ( Barg, EC; Breedveld, FC; Emery, P; Farnell, J; Kraan, MC; Reece, RJ; Rosenburg, R; Smeets, TJ; Tak, PP; Veale, DJ, 2000) |
"Leflunomide treatment was associated with a significantly greater improvement in IRE compared with methotrexate treatment (P < 0." | 2.70 | Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging. ( Breedveld, FC; Emery, P; Gibbon, WW; Kraan, MC; O'Connor, PJ; Radjenovic, A; Reece, RJ; Ridgway, JP; Tak, PP; Veale, DJ, 2002) |
"Leflunomide is a drug used clinically in the treatment of rheumatoid arthritis." | 1.34 | Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. ( Nakayamada, S; Ra, C; Saito, K; Sawamukai, N; Tanaka, Y; Yamaoka, K, 2007) |
Research
Studies (6)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (50.00) | 29.6817 |
2010's | 2 (33.33) | 24.3611 |
2020's | 1 (16.67) | 2.80 |
Authors
Authors | Studies |
---|---|
Li, Z | 1 |
Liu, S | 1 |
Liu, Y | 1 |
Ma, M | 1 |
Li, L | 1 |
Li, C | 1 |
Harman, H | 1 |
Tekeoğlu, I | 1 |
Kaban, N | 1 |
Harman, S | 1 |
Davis, JM | 1 |
Matteson, EL | 1 |
Sawamukai, N | 1 |
Saito, K | 1 |
Yamaoka, K | 1 |
Nakayamada, S | 1 |
Ra, C | 1 |
Tanaka, Y | 1 |
Kraan, MC | 2 |
Reece, RJ | 2 |
Barg, EC | 1 |
Smeets, TJ | 1 |
Farnell, J | 1 |
Rosenburg, R | 1 |
Veale, DJ | 2 |
Breedveld, FC | 2 |
Emery, P | 2 |
Tak, PP | 2 |
Radjenovic, A | 1 |
O'Connor, PJ | 1 |
Ridgway, JP | 1 |
Gibbon, WW | 1 |
Reviews
1 review available for leflunomide and Plica Syndrome
Article | Year |
---|---|
My treatment approach to rheumatoid arthritis.
Topics: Abatacept; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Muri | 2012 |
Trials
2 trials available for leflunomide and Plica Syndrome
Article | Year |
---|---|
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind M | 2000 |
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis, by dynamic enhanced magnetic resonance imaging.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Humans; Immunosuppressive Agents; | 2002 |
Other Studies
3 other studies available for leflunomide and Plica Syndrome
Article | Year |
---|---|
Successful treatment of nail involvement using leflunomide in a patient with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome.
Topics: Acne Vulgaris; Humans; Hyperostosis; Leflunomide; Osteitis; Synovitis | 2023 |
Factors influencing ultrasonographic remission in patients with rheumatoid arthritis.
Topics: Adalimumab; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic A | 2015 |
Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells.
Topics: Aniline Compounds; Apoptosis; Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Chronic Disease | 2007 |