leflunomide has been researched along with Peripheral Nerve Diseases in 11 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cases of toxic neuropathy have been observed during treatment of rheumatoid arthritis with leflunomide." | 3.74 | Peripheral neuropathy associated with leflunomide: is there a risk patient profile? ( Bentaberry, F; Dehais, J; Dumoulin, C; Haramburu, F; Martin, K; Miremont-Salamé, G; Schaeverbeke, T, 2007) |
| "Two cases of leflunomide-induced peripheral neuropathy are described; in a 60-year-old woman with sero-negative polyarthralgia-myalgia syndrome and a 65-year-old man with sero-negative rheumatoid arthritis, both treated with leflunomide at 20mg/day." | 3.74 | Leflunomide-induced peripheral neuropathy. ( Kermode, AG; Kho, LK, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weimer, LH | 1 |
| Sachdev, N | 1 |
| Carulli, MT | 1 |
| Davies, UM | 1 |
| Bonnel, RA | 1 |
| Graham, DJ | 1 |
| Bharadwaj, A | 1 |
| Haroon, N | 1 |
| Holden, WL | 1 |
| Scarazzini, LJ | 1 |
| Martin, K | 2 |
| Bentaberry, F | 2 |
| Dumoulin, C | 2 |
| Longy-Boursier, M | 1 |
| Lifermann, F | 1 |
| Haramburu, F | 2 |
| Dehais, J | 2 |
| Schaeverbeke, T | 2 |
| Bégaud, B | 1 |
| Moore, N | 1 |
| Kopp, HG | 1 |
| Moerike, K | 1 |
| Kanz, L | 1 |
| Hartmann, JT | 1 |
| Umapathi, T | 1 |
| Chaudhry, V | 1 |
| Metzler, C | 1 |
| Arlt, AC | 1 |
| Gross, WL | 1 |
| Brandt, J | 1 |
| Miremont-Salamé, G | 1 |
| Kho, LK | 1 |
| Kermode, AG | 1 |
2 reviews available for leflunomide and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Update on medication-induced peripheral neuropathy.
Topics: Acetamides; Anti-Infective Agents; Antibodies, Monoclonal; Antirheumatic Agents; Clinical Trials as | 2009 |
Toxic neuropathy.
Topics: Animals; Boronic Acids; Bortezomib; Clinical Trials as Topic; Epothilones; Genetic Therapy; Humans; | 2005 |
9 other studies available for leflunomide and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Peripheral neuropathy: an unwanted effect of leflunomide?
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Sedimentation; Female; H | 2002 |
Peripheral neuropathy in patients treated with leflunomide.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Chi-Square Distribution; Female; Humans; Isoxazoles; | 2004 |
Peripheral neuropathy in patients on leflunomide.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Follow-Up Studies; Humans; Isoxazoles; Leflunomide; Per | 2004 |
Postmarketing surveillance for drug safety.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Related Side Effects and Adverse Reactions; Humans; Is | 2004 |
Neuropathy associated with leflunomide: a case series.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Female; | 2005 |
Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administra | 2005 |
Peripheral neuropathy in patients with systemic rheumatic diseases treated with leflunomide.
Topics: Adult; Aged; Antirheumatic Agents; Female; Humans; Isoxazoles; Leflunomide; Male; Middle Aged; Perip | 2005 |
Peripheral neuropathy associated with leflunomide: is there a risk patient profile?
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Diabetes Complications; | 2007 |
Leflunomide-induced peripheral neuropathy.
Topics: Adjuvants, Immunologic; Aged; Antirheumatic Agents; Arthralgia; Arthritis, Rheumatoid; Female; Human | 2007 |