leflunomide has been researched along with Pancytopenia in 9 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To estimate the incidence of pancytopenia in patients taking leflunomide with or without methotrexate in Australia." | 7.74 | The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. ( Calcino, LJ; Hill, RL; McEwen, J; Purcell, PM; Riley, CG, 2007) |
| "A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy." | 7.74 | Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. ( Kingetsu, I; Kurosaka, D; Toyokawa, Y; Yamada, A; Yasuda, C; Yasuda, J; Yoshida, K, 2007) |
| "Leflunomide is a novel drug recently introduced for treatment of rheumatoid arthritis as a DMARD (disease-modifying antirheumatic drug)." | 7.70 | Severe pancytopenia after leflunomide in rheumatoid arthritis. ( Allinger, S; Auer, J; Hinterreiter, M; Kirchgatterer, A; Knoflach, P, 2000) |
| "To estimate the incidence of pancytopenia in patients taking leflunomide with or without methotrexate in Australia." | 3.74 | The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate. ( Calcino, LJ; Hill, RL; McEwen, J; Purcell, PM; Riley, CG, 2007) |
| "A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy." | 3.74 | Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. ( Kingetsu, I; Kurosaka, D; Toyokawa, Y; Yamada, A; Yasuda, C; Yasuda, J; Yoshida, K, 2007) |
| "Leflunomide is a novel drug recently introduced for treatment of rheumatoid arthritis as a DMARD (disease-modifying antirheumatic drug)." | 3.70 | Severe pancytopenia after leflunomide in rheumatoid arthritis. ( Allinger, S; Auer, J; Hinterreiter, M; Kirchgatterer, A; Knoflach, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miszewska-Szyszkowska, D | 1 |
| Mikołajczyk, N | 1 |
| Komuda-Leszek, E | 1 |
| Wieczorek-Godlewska, R | 1 |
| Świder, R | 1 |
| Dęborska-Materkowska, D | 1 |
| Szmidt, J | 1 |
| Durlik, M | 1 |
| Savage, RL | 1 |
| Klatt, JC | 1 |
| Gröbe, A | 1 |
| Schmelzle, R | 1 |
| Atac, A | 1 |
| Heiland, M | 1 |
| Blessmann, M | 1 |
| Pohlenz, P | 1 |
| Hill, RL | 2 |
| Topliss, DJ | 1 |
| Purcell, PM | 2 |
| Marchesoni, A | 1 |
| Arreghini, M | 1 |
| Panni, B | 1 |
| Battafarano, N | 1 |
| Uziel, L | 1 |
| McEwen, J | 1 |
| Calcino, LJ | 1 |
| Riley, CG | 1 |
| Finn, S | 1 |
| Bond, J | 1 |
| McCarthy, D | 1 |
| Sheahan, K | 1 |
| Quinn, C | 1 |
| Toyokawa, Y | 1 |
| Kingetsu, I | 1 |
| Yasuda, C | 1 |
| Yasuda, J | 1 |
| Yoshida, K | 1 |
| Kurosaka, D | 1 |
| Yamada, A | 1 |
| Auer, J | 1 |
| Hinterreiter, M | 1 |
| Allinger, S | 1 |
| Kirchgatterer, A | 1 |
| Knoflach, P | 1 |
9 other studies available for leflunomide and Pancytopenia
| Article | Year |
|---|---|
Severe cytomegalovirus infection in a second kidney transplant recipient treated with ganciclovir, leflunomide, and immunoglobulins, with complications including seizures, acute HCV infection, drug-induced pancytopenia, diabetes, cholangitis, and multi-or
Topics: Adult; Antiviral Agents; Cholangitis; Cytomegalovirus Infections; Diabetes Mellitus, Type 2; Fatal O | 2015 |
Leflunomide in combination therapy for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Australia; Drug Therapy, Combination; Humans; Infection | 2010 |
A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation.
Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow Transplantati | 2011 |
Pancytopenia associated with leflunomide and methotrexate.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ster | 2003 |
Life-threatening reversible bone marrow toxicity in a rheumatoid arthritis patient switched from leflunomide to infliximab.
Topics: Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; | 2003 |
The incidence of pancytopenia in patients taking leflunomide alone or with methotrexate.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; An | 2007 |
Angioinvasive aspergillosis presenting as neutropenic colitis.
Topics: Adalimumab; Adjuvants, Immunologic; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodi | 2006 |
Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient.
Topics: Aged; Anemia, Macrocytic; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, | 2007 |
Severe pancytopenia after leflunomide in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Bone Marrow; Female; Filgrastim; Gra | 2000 |