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leflunomide and Pancreatic Neoplasms

leflunomide has been researched along with Pancreatic Neoplasms in 2 studies

Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.

Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Research Excerpts

ExcerptRelevanceReference
"A high incidence of pancreatic cancer (PCa) in patients exposed to was observed in the German biologics register."1.37Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers. ( Arkema, E; Askling, J; Davies, R; Hyrich, K; Listing, J; Neovius, M; Simard, J; Strangfeld, A; Symmons, D; Watson, K; Zink, A, 2011)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yu, M1
Nguyen, ND1
Huang, Y1
Lin, D1
Fujimoto, TN1
Molkentine, JM1
Deorukhkar, A1
Kang, Y1
San Lucas, FA1
Fernandes, CJ1
Koay, EJ1
Gupta, S1
Ying, H1
Koong, AC1
Herman, JM1
Fleming, JB1
Maitra, A1
Taniguchi, CM1
Strangfeld, A1
Hyrich, K1
Askling, J1
Arkema, E1
Davies, R1
Listing, J1
Neovius, M1
Simard, J1
Symmons, D1
Watson, K1
Zink, A1

Other Studies

2 other studies available for leflunomide and Pancreatic Neoplasms

ArticleYear
Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer.
    JCI insight, 2019, 07-23, Volume: 5

    Topics: Animals; Carcinoma, Pancreatic Ductal; CRISPR-Cas Systems; Disease Models, Animal; Dynamins; Enzyme

2019
Detection and evaluation of a drug safety signal concerning pancreatic cancer: lessons from a joint approach of three European biologics registers.
    Rheumatology (Oxford, England), 2011, Volume: 50, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Biomarkers; Cohort St

2011
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